Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A

Nature Neuroscience

Volumn 4, Issue 9, 2001, Pages 894-901

  Zheng, F ^a   Erreger, K ^a   Low, C M ^a,b   Banke, T ^a   Lee, C J ^a   Conn, P J ^a,c   Traynelis, S F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; UNCLASSIFIED DRUG; ZINC;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DESENSITIZATION; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; LIGAND BINDING; NERVE CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CELL LINE; EDETIC ACID; ELECTRIC CONDUCTIVITY; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GLUTAMIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; PEPTIDE FRAGMENTS; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; ZINC;

EID: 0034867583     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn0901-894     Document Type: Article

References (42)

1. The glutamate receptor ion channels
2. N-methyl-D-aspartic acid receptor structure and function
3. Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine
4. Kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones
5. Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons
6. Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones
7. Regulation of glycine-insensitive desensitization of the NMDA receptor in outside-out patches
8. Synaptic desensitization of NMDA receptors by calcineurin
9. The effect of agonist concentration, membrane voltage and calcium on N-methyl-D-aspartate receptor desensitization
10. Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones
11. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
12. Calcium-induced actin depolymerization reduces NMDA channel activity
13. 2+ and ATP
14. N-terminal domains in the NR2 subunit control desensitization of NMDA receptors
15. Glycine-independent NMDA receptor desensitization: Localization of structural determinants
16. Differential sensitivity of recombinant N-Methyl-D-Aspartate receptor subtypes to zinc inhibition
17. Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific
18. 2+-dependent inactivation of NMDA receptors
19. Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells
20. Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors
21. An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones
22. Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition
23. High-affinity zinc inhibition of NMDA NR1-NR2A receptors
24. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition
25. Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit
26. A practical guide to the preparation of Ca buffers
27. Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells
28. 2+ inhibition of the NMDA receptor
29. Molecular determinants of coordinated proton and zinc inhibition of NR1/NR2A receptors
30. 2+ binding to NMDA receptors
31. Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit
32. On the nature of allosteric transitions: A plausible model
33. The NR2B-speciflc interactions of polyamines and protons with the N-methyl-D-aspartate receptor
34. An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors
35. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurons
36. NMDA channel behavior depends on agonist affinity
37. High-efficiency transformation of mammalian cells by plasmid DNA
38. Green fluorescent protein as a marker for gene expression
39. Improved patchclamp techniques for high-resolution current recording from cells and cell-free membrane patches
40. Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin
41. Software based correction of single compartment series resistance errors