Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors

Journal of Neuroscience

Volumn 25, Issue 10, 2005, Pages 2682-2686

  Priel, Avi ^a   Kolleker, Alexander ^b   Ayalon, Gai ^a,c   Gillor, Moshe ^a   Osten, Pavel ^b   Stern Bach, Yael ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

AMPA receptors; Desensitization; Heterologous expression; Patch clamp; Stargazin; Trafficking

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; ION CHANNEL; PROTEIN STARGAZIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BIOTINYLATION; HETEROLOGOUS EXPRESSION; HUMAN EMBRYO; KIDNEY CELL; NERVE CELL PLASTICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; CALCIUM CHANNELS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; PROTEIN BINDING; RECEPTORS, AMPA; XENOPUS LAEVIS;

EID: 14944366485     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4834-04.2005     Document Type: Article

References (26)

1. Armstrong N, Gouaux E (2000) Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28:165-181.
2. Ayalon G, Stern-Bach Y (2001) Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron 31:103-113.
3. 2+ channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res 9:1204-1213.
4. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA (2000) Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408:936-943.
5. Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll RA (2003) Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4- isoxazolepropionate and kainate receptors. Mol Pharmacol 64:703-706.
6. Cuadra AE, Kuo SH, Kawasaki Y, Bredt DS, Chetkovich DM (2004) AMPA receptor synaptic targeting regulated by Stargazin interactions with the Golgi-resident PDZ protein nPIST. J Neurosci 24:7491-7502.
7. Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7-61.
8. Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (1998) SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21:727-739.
9. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
10. Hashimoto K, Fukaya M, Qiao X, Sakimura K, Watanabe M, Kano M (1999) Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J Neurosci 19:6027-6036.
11. Horning MS, Mayer ML (2004) Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41:379-388.
12. Jonas P (1995) Fast application of agonists to isolated membrane patches. In: Single-channel recording, Ed 2 (Sakmann B, Neher E, eds), pp 231-243. New York: Plenum.
13. Jones MV, Westbrook GL (1996) The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci 19:96-101.
14. Klugbauer N, Dai S, Specht V, Lacinova L, Marais E, Bohn G, Hofmann F (2000) A family of gamma-like calcium channel subunits. FEBS Lett 470:189-197.
15. Lerma J (1992) Spermine regulates N-methyl-D-aspartate receptor desensitization. Neuron 8:343-352.
16. 2+-channel gamma subunit. Nat Genet 19:340-347.
17. O'Brien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P (1999) Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23:309-323.
18. Patneau DK, Vyklicky Jr L, Mayer ML (1993) Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J Neurosci 13:3496-3509.
19. Priel A, Silberberg SD (2004) Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol 123:281-293.
20. Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA (2002) Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci USA 99:13902-13907.
21. Shi S, Hayashi Y, Esteban JA, Malinow R (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105:331-343.
22. Stern-Bach Y, Russo S, Neuman M, Rosenmund C (1998) A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron 21:907-918.
23. Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E (2002) Mechanism of glutamate receptor desensitization. Nature 417:245-253.
24. Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS (2003) Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol 161:805-816.
25. Tomita S, Fukata M, Nicoll RA, Bredt DS (2004) Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303:1508-1511.
26. Zamanillo D, Sprengel R, Hvalby O, Jensen V, Burnashev N, Rozov A, Kaiser KM, Koster HJ, Borchardt T, Worley P, Lubke J, Frotscher M, Kelly PH, Sommer B, Andersen P, Seeburg PH, Sakmann B (1999) Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science 284:1805-1811.