New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors

Journal of Medicinal Chemistry

Volumn 53, Issue 4, 2010, Pages 1700-1711

  Francotte, Pierre ^a   Goffin, Eric ^a   Fraikin, Pierre ^a   Lestage, Pierre ^b   Van Heugen, Jean Claude ^c   Gillotin, Florian ^c   Danober, Laurence ^b   Thomas, Jean Yves ^b   Chiap, Patrice ^c   Caignard, Daniel Henri ^b   Pirotte, Bernard ^a   De Tullio, Pascal ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Institut de Recherches   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE DERIVATIVE; 2 (2,2,2 TRIFLUOROETHYLAMINO) 5 NITROBENZENESULFONAMIDE; 2 AMINO 3 (3 HYDROXY 5 METHYLISOXAZOL 4 YL)PROPIONIC ACID RECEPTOR; 4 (2 FLUOROETHYL) 7 IODO 3, DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 IODO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 METHOXY 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 METHYL 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 METHYL 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 NITRO 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 NITRO 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,2 DIOXIDE; 4 (2 FLUOROETHYL) 7 NITRO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 TRIFLUOROMETHYL 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2 FLUOROETHYL) 7 TRIFLUOROMETHYL 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2,2,2 TRIFLUOROETHYL) 7 NITRO 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 4 (2,2,2 TRIFLUOROETHYL) 7 NITRO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 5 CHLORO 2 (2,2 DIFLUOROACETAMIDO)BENZENESULFONAMIDE; 5 CHLORO 2 (2,2 DIFLUOROETHYLAMINO)BENZENESULFONAMIDE; 7 AMINO 4 (2,2,2 TRIFLUOROETHYL) 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 BROMO 4 (2 FLUOROETHYL) 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 BROMO 4 (2 FLUOROETHYL) 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 CHLORO 4 (2 FLUOROETHYL) 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 CHLORO 4 (2 FLUOROETHYL) 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE,; 7 CHLORO 4 (2 FLUOROETHYL) 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 CHLORO 4 (2,2 DIFLUOROETHYL) 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 CHLORO 4 (2,2 DIFLUOROETHYL) 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 FLUORO 4 (2 FLUOROETHYL) 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 7 FLUORO 4 (2 FLUOROETHYL) 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; AMPA RECEPTOR; PROPIONIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BENZOTHIADIAZINES; CELLS, CULTURED; CYCLIC S-OXIDES; EXCITATORY AMINO ACID AGENTS; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MALE; MICROSOMES, LIVER; NEURONS; NOOTROPIC AGENTS; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECOGNITION (PSYCHOLOGY); STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77649208693     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901495t     Document Type: Article

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