Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

Journal of Medicinal Chemistry

Volumn 51, Issue 5, 2008, Pages 1459-1463

  Beich Frandsen, Mads ^a,b   Pickering, Darryl S ^a   Mirza, Osman ^a   Johansen, Tommy N ^a   Greenwood, Jeremy ^a   Vestergaard, Bente ^a   Schousboe, Arne ^a   Gajhede, Michael ^a   Liljefors, Tommy ^a   Kastrup, Jette S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (4 HYDROXY 1,2,5 THIADIAZOL 3 YL)PROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR 2; KAINIC ACID RECEPTOR; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONFORMATION; ENANTIOMER; NONHUMAN; PROTEIN DOMAIN; RECEPTOR BINDING; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ALANINE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, AMPA; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 41749125709     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701126w     Document Type: Article

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