Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain

Journal of Neuroscience

Volumn 24, Issue 20, 2004, Pages 4728-4736

  Yelshansky, Maria V ^a   Sobolevsky, Alexander I ^a   Jatzke, Claudia ^a,b   Wollmuth, Lonnie P ^a  

^a Stony Brook University   (United States)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Channel gating; Desensitization; Ligand binding domain; M3 segment; M3 S2 linker; Substituted cysteine accessibility method

Indexed keywords

AMPA RECEPTOR; ARGININE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; ION CHANNEL; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; THIOL DERIVATIVE;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DESENSITIZATION; ELECTRICITY; EMBRYO; HUMAN; HUMAN CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR BLOCKING;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; ELECTROSTATICS; EXCITATORY AMINO ACID AGONISTS; HUMANS; ION CHANNEL GATING; LIGANDS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 2442675355     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0757-04.2004     Document Type: Article

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