The glutamate receptor GluR5 agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro- 6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: Synthesis, molecular pharmacology, and biostructural characterization

Journal of Medicinal Chemistry

Volumn 52, Issue 15, 2009, Pages 4911-4922

  Clausen, Rasmus P ^a   Naur, Peter ^a   Kristensen, Anders S ^a   Greenwood, Jeremy R ^a   Strange, Mette ^a   Brauner Osborne, Hans ^a   Jensen, Anders A ^a   Nielsen, Anne Sophie T ^a   Geneser, Ulla ^a   Ringgaard, Lone M ^a   Nielsen, Birgitte ^a   Pickering, Darryl S ^a   Brehm, Lotte ^a   Gajhede, Michael ^a   Krogsgaard Larsen, Povl ^a   Kastrup, Jette S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (3 HYDROXY 7,8 DIHYDRO 6H CYCLOHEPTA[D]ISOXAZOL 4 YL)PROPIONIC ACID; 2 AMINO 3 (3 HYDROXY 8 METHYL 7,8 DIHYDRO 6H CYCLOHEPTA[D]ISOXAZOL 4 YL)PROPIONIC ACID; ALPHA AMINO 5 TERT BUTYL 3 HYDROXY 4 ISOXAZOLEPROPIONIC ACID; AMINE; AMPA RECEPTOR; CALCIUM; CYCLOHEPTANE DERIVATIVE; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; GLUTAMATE RECEPTOR 4; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR 7; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR; ISOXAZOLE DERIVATIVE; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; STEREOCHEMISTRY; VOLTAGE CLAMP; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EXCITATORY AMINO ACID AGONISTS; HUMANS; MODELS, MOLECULAR; PROPIONIC ACIDS; RECEPTORS, KAINIC ACID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 68649122921     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900565c     Document Type: Article

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