Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15635-15643

  Jin, Rongsheng ^a   Horning, Michelle ^b   Mayer, Mark L ^b   Gouaux, Eric ^a  

^a Columbia University ^*  (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

CRYSTALLOGRAPHY; ELECTROPHYSIOLOGY; IONS; NEGATIVE IONS; NEUROLOGY;

BIOCHEMISTRY;

2 AMINO 3 (3 HYDROXY 5 METHYL 4 ISOXAZOLE)PROPIONIC ACID; AMPA RECEPTOR AGONIST; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; PROPIONIC ACID DERIVATIVE; QUISQUALIC ACID; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN FUNCTION; CHANNEL GATING; DRUG SELECTIVITY; HYDROPHOBICITY; ION TRANSPORT; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; ION CHANNEL GATING; LIGANDS; METHIONINE; OOCYTES; PATCH-CLAMP TECHNIQUES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUISQUALIC ACID; RATS; RECEPTORS, AMPA; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

MAMMALIA;

EID: 0037207136     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020583k     Document Type: Article

References (54)

1. Chen, G.-Q., Cui, C., Mayer, M., and Gouaux, E. (1999) Nature 402, 817-821.
2. Mayer, M. L., Olson, R. A., and Gouaux, E. (2001) J. Mol. Biol. 311, 815-836.
3. Dingledine, R., Borges, K., Bowie, D., and Traynelis, S. F. (1999) Pharmacol. Rev. 51, 7-61.
4. Hollmann, M., and Heinemann, S. (1994) Annu. Rev. Neurosci. 17, 31-108.
5. Seeburg, P. H. (1993) Trends Neurosci. 16, 359-365.
6. Rosenmund, C., Stern-Bach, Y., and Stevens, C. F. (1998) Science 280, 1596-1599.
7. Armstrong, N., and Gouaux, E. (2000) Neuron 28, 165-181.
8. Robert, A., Irizarry, S. N., Hughes, T. E., and Howe, J. R. (2001) J. Neurosci. 21, 5574-5586.
9. Ayalon, G., and Stern-Bach, Y. (2001) Neuron 31, 103-113.
10. Madden, D. R. (2002) Nat. Rev. Neurosci. 3, 91-101.
11. Hollmann, M., Maron, C., and Heinemann, S. (1994) Neuron 13, 1331-1343.
12. Stern-Bach, Y., Bettler, B., Hartley, M., Sheppard, P. O., O'Hara, P. J., and Heinemann, S. F. (1994) Neuron 13, 1345-1357.
13. Kuusinen, A., Arvola, M., and Keinänen, K. (1995) EMBO J. 14, 6327-6332.
14. Wo, Z. G., and Oswald, R. E. (1995) Trends Neurosci. 18, 161-168.
15. Paas, Y. (1998) Trends Neurosci. 21, 117-125.
16. Chen, G. Q., and Gouaux, E. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 13431-13436.
17. Chen, G.-Q., Sun, Y., Jin, R., and Gouaux, E. (1998) Protein Sci. 7, 2623-2630.
18. Armstrong, N., Sun, Y., Chen, G.-Q., and Gouaux, E. (1998) Nature 395, 913-917.
19. McFeeters, R. L., and Oswald, R. E. (2002) Biochemistry 41, 10472-10481.
20. Sun, Y., Olson, R. A., Homing, M., Armstrong, N., Mayer, M. L., and Gouaux, E. (2002) Nature 417, 245-253.
21. Takemoto, T. (1978) in Kainic Acid as a Tool in Neurobiology (McGeer, E. G., Olney, J. W., and McGeer, P. L., Eds.) pp 1-15, Raven, New York.
22. Johnston, G. A. R., Curtis, D. R., Davies, J., and McCulloch, R. M. (1974) Nature 248, 804-805.
23. Davies, J., and Watkins, J. C. (1981) Brain Res. 206, 172-177.
24. Monaghan, D. T., Bridges, R. J., and Cotman, C. W. (1989) Annu. Rev. Pharmacol. Toxicol. 29, 365-402.
25. Sugiyama, H., Ito, I., and Hirono, C. (1987) Nature 325, 531-533.
26. Krogsgaard-Larsen, P., Honore, T., Hansen, J. J., Curtis, D. R., and Lodge, D. (1980) Nature 284, 64-66.
27. Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., and Heinemann, S. (1989) Nature 342, 643-648.
28. Chen, G.-Q., and Gouaux, E. (2000) Tetrahedron 56, 9409-9419.
29. Otwinowsky, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326.
30. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
31. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L, M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
32. Jones, T. A., and Kjeldgaard, M. (1997) Methods Enzymol. 277, 173-208.
33. Jones, T. A., Zou, J.-Y., and Cowan, S. W. (1991) Acta Crystallogr. A47, 110-119.
34. Briinger, A. T. (1992) Nature 355, 472-475.
35. Kleywegt, G. J. (1999) Acta Crystallogr. D55, 1878-1884.
36. Lu, G. (2001) http://bioinfol.mbfys.lu.se/guoguang/fit.html.
37. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
38. Esnouf, R. M. (1999) Acta Crystallogr. D55, 938-940.
39. Merritt, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. D50, 869-873.
40. Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., Sakmann, B., and Seeburg, P. H. (1990) Science 249, 556-560.
41. Schreibmayer, W., Lester, H. A., and Dascal, N. (1994) Pfluegers Arch. 426, 453-458.
42. Arvola, M., and Keinänen, K. (1996) J. Biol. Chem. 271, 15527-15532.
43. Keinänen, K., Köhr, G., Seeburg, P. H., Laukkanen, M.-L., and Oker-Blom, C. (1994) Bio/Technology 12, 802-806.
44. Stern-Bach, Y., Russo, S., Neuman, M., and Rosenmund, C. (1998) Neuron 21, 907-918.
45. Kiskin, N. I., Krishtal, O. A., and Tsyndrenko, A. Y. (1986) Neurosci. Lett. 63, 225-230.
46. Patneau, D. K., and Mayer, M. L. (1991) Neuron 6, 785-798.
47. Fersht, A. (1999) Structure and Mechanism in Protein Science, W. H. Freeman and Co., New York.
48. Patneau, D. K., Mayer, M. L., Jane, D. E., and Watkins, J. C. (1992) J. Neurosci. 12, 595-606.
49. Wong, L. A., Mayer, M. L., Jane, D. E., and Watkins, J. C. (1994) J. Neurosci. 14, 3881-3897.
50. Bettler, B., Egebjerg, J., Sharma, G., Pecht, G., Hermans-Borgmeyer, I., Moll, C., Stevens, C. F., and Heinemann, S. (1992) Neuron 8, 257-265.
51. Egebjerg, J., Bettler, B., Hermans-Borgmeyer, I., and Heinemann, S. (1991) Nature 351, 745-748.
52. Bettler, B., Boulter, J., Hermans-Borgmeyer, I., O'Shea-Greenfield, A., Deneris, E. S., Moll, C., Borgmeyer, U., Hollmann, M., and Heinemann, S. (1990) Neuron 5, 583-595.
53. Swanson, G. T., Gereau, R. W., Green, T., and Heinemann, S. F. (1997) Neuron 19, 913-926.
54. Swanson, G. T., Green, T., and Heinemann, S. F. (1998) Mol. Pharmacol. 53, 942-949.