Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15635-15643

  Jin, Rongsheng ^a   Horning, Michelle ^b   Mayer, Mark L ^b   Gouaux, Eric ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

CRYSTALLOGRAPHY; ELECTROPHYSIOLOGY; IONS; NEGATIVE IONS; NEUROLOGY;

BIOCHEMISTRY;

2 AMINO 3 (3 HYDROXY 5 METHYL 4 ISOXAZOLE)PROPIONIC ACID; AMPA RECEPTOR AGONIST; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; PROPIONIC ACID DERIVATIVE; QUISQUALIC ACID; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN FUNCTION; CHANNEL GATING; DRUG SELECTIVITY; HYDROPHOBICITY; ION TRANSPORT; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; ION CHANNEL GATING; LIGANDS; METHIONINE; OOCYTES; PATCH-CLAMP TECHNIQUES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUISQUALIC ACID; RATS; RECEPTORS, AMPA; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

MAMMALIA;

EID: 0037207136     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020583k     Document Type: Article

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