A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2: A mutagenic, kinetic, and crystallographic study

Journal of Biological Chemistry

Volumn 280, Issue 42, 2005, Pages 35469-35476

  Holm, Mai Marie ^a,b   Naur, Peter ^c   Vestergaard, Bente ^c   Geballe, Matthew T ^d   Gajhede, Michael ^c   Kastrup, Jette S ^c   Traynelis, Stephen F ^b   Egebjerg, Jan ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(S)-GLUTAMATE; DESENSITIZATION KINETICS; GENETIC MANIPULATIONS; TRYPTOPHAN MUTANT;

BINDING ENERGY; CRYSTALLOGRAPHY; ELECTROPHYSIOLOGY; ORGANIC ACIDS; REACTION KINETICS; SENSITIVITY ANALYSIS;

BIOCHEMISTRY;

AMPA RECEPTOR; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; ION CHANNEL; KAINIC ACID; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CRYSTALLIZATION; CRYSTALLOGRAPHY; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALANINE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GLUTAMIC ACID; IONS; KAINIC ACID; KINETICS; LIGANDS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, AMPA; RNA, COMPLEMENTARY; TRYPTOPHAN; TYROSINE; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 27444434374     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507800200     Document Type: Article

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