Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

Journal of Biological Chemistry

Volumn 284, Issue 21, 2009, Pages 14219-14229

  Frydenvang, Karla ^a   Lash, L Leanne ^b   Naur, Peter ^a   Postila, Pekka A ^c   Pickering, Darryl S ^a   Smith, Caleb M ^b   Gajhede, Michael ^a   Sasaki, Makoto ^d   Sakai, Ryuichi ^e   Pentikänen, Olli T ^c   Swanson, Geoffrey T ^b   Kastrup, Jette S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^d TOHOKU UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL OPENING; CONCANAVALIN A; CORE STRUCTURE; ELECTROPHYSIOLOGICAL RECORDINGS; HEK293 CELLS; HIGH AFFINITY; HIGH CONCENTRATION; INTER-DOMAIN; IONOTROPIC GLUTAMATE RECEPTORS; L-GLUTAMATE; LIGAND BINDING; LOW POTENCY; MOLECULAR DYNAMICS SIMULATIONS; PARALLEL RECORDING; PATCH CLAMP RECORDING; PHARMACOLOGICAL ACTIVITY; RECEPTOR MUTANTS; STEADY-STATE CURRENTS; STRUCTURAL MODELS;

DYNAMICS; ELECTRIC CONDUCTIVITY MEASUREMENT; HYDROGEN; HYDROGEN BONDS; MODEL STRUCTURES; MOLECULAR DYNAMICS;

LIGANDS;

8,9 DIDEOXYNEODYSIHERBAINE; CONCANAVALIN A; DYSIHERBAINE; GLUTAMATE RECEPTOR 5; GLUTAMIC ACID; IONOTROPIC RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; SERINE; UNCLASSIFIED DRUG; 2 (2 AMINO 2 CARBOXYETHYL) HEXAHYDROFURO(3,2 B)PYRAN 2 CARBOXYLIC ACID; 2-(2-AMINO-2-CARBOXYETHYL)-HEXAHYDROFURO(3,2-B)PYRAN-2-CARBOXYLIC ACID; ALANINE; AMINO ACID; DRUG DERIVATIVE; FUSED HETEROCYCLIC RINGS; GLUR5 KAINATE RECEPTOR; LIGAND; PROTEIN SUBUNIT;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; STEADY STATE; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACIDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CELL LINE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, KAINIC ACID;

EID: 67649771372     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808547200     Document Type: Article

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