Mechanism of positive allosteric modulators acting on AMPA receptors

Journal of Neuroscience

Volumn 25, Issue 39, 2005, Pages 9027-9036

  Jin, Rongsheng ^a,d   Clark, Suzanne ^b   Weeks, Autumn M ^b   Dudman, Joshua T ^a   Gouaux, Eric ^a,c   Partin, Kathryn M ^b  

^a Howard Hughes Medical Institute   (United States)

^b Department of Ecosystem Science and Sustainability   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Aniracetam; Crystallography; CX614; Cyclothiazide; Deactivation; Desensitization; Glutamate receptor; Kinetics

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; ANIRACETAM; CX 614; CYCLOTHIAZIDE; DIMER; GLUTAMATE RECEPTOR; GLUTAMIC ACID; ION CHANNEL; KAINIC ACID RECEPTOR; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRROLIDINO 1,3 OXAZINO BENZO 1,4 DIOXAN 10 ONE; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEGENERATIVE DISEASE; DEPRESSION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SEDIMENTATION;

ALLOSTERIC REGULATION; BENZOTHIADIAZINES; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY; DIMERIZATION; DRUG SYNERGISM; ELECTRIC CONDUCTIVITY; HUMANS; LIGANDS; MOLECULAR CONFORMATION; OXAZINES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINONES; RECEPTORS, AMPA; TIME FACTORS;

EID: 25644454403     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2567-05.2005     Document Type: Article

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