NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines

Neuron

Volumn 22, Issue 3, 1999, Pages 559-570

  Beck, C ^a   Wollmuth, L P ^b,c   Seeburg, P H ^a   Sakmann, B ^b   Kuner, T ^a,d  

^a Abteilung Molekulare Genetik   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c STONY BROOK UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYSTEINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; ION PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; XENOPUS;

EID: 0033103522     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80710-2     Document Type: Article

References (43)

1. Akabas, M.H., Kaufmann, C., Archdeacon, P., and Karlin, A. (1994). Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron 13, 919-927.
2. Bennett, J.A., and Dingledine, R. (1995). Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop. Neuron 14, 373-384.
3. Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J.P., Günther, W., Seeburg, P.H., and Sakmann, B. (1992). Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257, 1415-1419.
4. Burnashev, N., Zhou, Z., Neher, E., and Sakmann, B. (1995). Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. (Lond) 485, 403-418.
5. Collingridge, G.L., and Lester, R.A. (1989). Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40, 143-210.
6. Dani, J.A. (1986). Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations. Biophys. J. 49, 607-618.
7. Ferrer-Montiel, A.V., Sun, W., and Montal, M. (1995). Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine. Proc. Natl. Acad. Sci. USA 92, 8021-8025.
8. Gasic, G.P., and Hollmann, M. (1992). Molecular neurobiology of glutamate receptors. Annu. Rev. Physiol. 54, 507-536.
9. Hille, B. (1992). Ionic Channels of Excitable Membranes, Vol. 2. Sunderland, MA: Sinauer Assiociates).
10. Hollmann, M. (1996). The topology of glutamate receptors. In The Lonotropic Glutamate Receptors, D.T. Monaghan and R.J. Wenthold, eds. (Totowa, NJ: Humana Press Inc.).
11. Hollmann, M., Maron, C., and Heinemann, S. (1994). N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13, 1331-1343.
12. Holmgren, M., Liu, Y., Xu, Y., and Yellon, G. (1996). On the use of thiol-modifying agents to determine channel topology. Neuropharmacology 35, 797-804.
13. Javitch, J.A., Fu, D., Chen, J., and Karlin, A. (1995). Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method. Neuron 14, 825-831.
14. Karlin, A., and Akabas, M. H. (1998). Substituted-cysteine-accessibility method. Methods Enzymol. 293, 123-136.
15. Kashiwagi, K., Pahk, A.J., Masuko, T., Igarashi, K., and Williams, K. (1997). Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: Role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol. Pharmacol. 52, 701-713.
16. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing. Neuron 10, 491-500.
17. Krupp, J.J.,Vissel, B., Heinemann, S.F., and Westbrook, G.L. (1998). N-terminal domains in the NR2 subunit control desensitization of NMDA receptors. Neuron 20, 317-327.
18. 2+ block in NMDA receptor channels. J. Neurosci. 16, 3549-3558.
19. Kuner, T., Wollmuth, L.P., Karlin, A., Seeburg, P.H., and Sakmann, B. (1996). Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron 17, 343-352.
20. Leonard, J.P., and Kelso, S.R. (1990). Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 4, 53-60.
21. Monaghan, D.T., Bridges, R.J., and Cotman, C.W. (1989). The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29, 365-402.
22. 2+-block site of the NMDA receptor channel. Nature 358, 673-675.
23. Paas, Y. (1998). The macro- and microarchitectures of the ligand-binding domain of glutamate receptors. Trends Neurosci. 21, 117-125. Erratum: Trends Neurosci. 21, 175, 1998.
24. Paas, Y. (1998). The macro- and microarchitectures of the ligand-binding domain of glutamate receptors. Trends Neurosci. 21, 117-125. Erratum: Trends Neurosci. 21, 175, 1998.
25. Pascual, J.M., and Karlin, A. (1998). State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the m2 segment of the alpha subunit. J. Gen. Physiol. 111, 717-739.
26. Pascual, J.M., Shieh, C.-C., Kirsch, G.E., and Brown, A.M. (1995). K+ pore structure revealed by reporter cysteines at inner and outer surfaces. Neuron 14, 1055-1063.
27. Premkumar, L.S., and Auerbach, A. (1996). Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel. Neuron 16, 869-880.
28. Schneggenburger, R., Zhou, Z., Konnerth, A., and Neher, E. (1993). Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron 11, 133-143.
29. Sommer, B., Keinänen, K., Verdoorn, T.A., Wisden, W., Burnashev, N., Herb, A., Kohler, M., Takagi, T., Sakmann, B., and Seeburg, P.H. (1990). Flip and flop: A cell-specific functional switch in glutamate-operated channels of the CNS. Science 249, 1580-1585.
30. Sprengel, R., and Seeburg, P.H. (1995). Lonotropic glutamate receptors. In Ligand and Voltage-Gated Ion Channels. R.A. North, ed. (Boca Raton, FL: CRC Press), 213-263.
31. Stauffer, D.A., and Karlin, A. (1994). Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates. Biochemistry 33, 6840-6849.
32. Villarroel, A., Burnashev, N., and Sakmann, B. (1995). Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys. J. 68, 866-875.
33. Villarroel, A., Regalado, M.P., and Lerma, J. (1998). Glycine-independent NMDA receptor desensitization: Localization of structural determinants. Neuron 20, 329-339.
34. Watkins, J.C. (1984). Excitatory amino acids and central synaptic transmission. Trends Pharmacol. Sci. 5, 373-376.
35. Wilson, G.G., and Karlin, A. (1998). The location of the gate in the acetylcholine receptor channel. Neuron 20, 1269-1281.
36. Wo, Z.G., and Oswald, R.E. (1994). Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation. Proc. Natl. Acad. Sci. USA 91, 7154-7158.
37. 2+-permeable AMPA glutamate receptor channels. J. Gen. Physiol. 112, 623-636.
38. Wollmuth, L.P., Kuner, T., Seeburg, P.H., and Sakmann, B. (1996). Differential contribution of the NR1-and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. J. Physiol. (Lond) 491, 779-797.
39. 2+. J. Physiol. (Lond) 506, 13-32.
40. Wood, M.W., VanDongen, H.M., and VanDongen, A.M. (1995). Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc. Natl. Acad. Sci. USA 92, 4882-4886.
41. Zarei, M.M., and Dani, J.A. (1995). Structural basis for explaining open-channel blockade of the NMDA receptor. J. Neurosci. 15, 1446-1454.
42. Zhang, H., and Karlin, A. (1998). Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor. Biochemistry 37, 7952-7964.
43. Zuo, J., De, J.P., Takahashi, K.A., Jiang, W., Linden, D.J., and Heintz, N. (1997). Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature 388, 769-773.