Stargazin modulates AMPA receptor antagonism

Neuropharmacology

Volumn 54, Issue 7, 2008, Pages 1062-1070

  Cokić, Barbara ^a   Stein, Valentin ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

AMPA receptor; CNQX; GYKI; Partial agonist; Stargazin; TARP

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CALCIUM CHANNEL; CP 465022; GLUTAMATE RECEPTOR 1; GLUTAMIC ACID; PROTEIN STARGAZIN; PROTEIN TARP; REGULATOR PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BENZODIAZEPINES; BINDING SITES; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RECEPTORS, AMPA; SYNAPTIC TRANSMISSION; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 42749086916     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.02.012     Document Type: Article

References (37)

1. Balannik V., Menniti F.S., Paternain A.V., Lerma J., and Stern-Bach Y. Molecular mechanism of AMPA receptor noncompetitive antagonism. Neuron 48 (2005) 279-288
2. Chen L., Chetkovich D.M., Petralia R.S., Sweeney N.T., Kawasaki Y., Wenthold R.J., Bredt D.S., and Nicoll R.A. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408 (2000) 936-943
3. Chen L., El-Husseini A., Tomita S., Bredt D.S., and Nicoll R.A. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Mol. Pharmacol. 64 (2003) 703-706
4. Donevan S.D., and Rogawski M.A. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron 10 (1993) 51-59
5. Donevan S.D., Yamaguchi S., and Rogawski M.A. Non-N-methyl-d-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: relationship to anticonvulsant activity. J. Pharmacol. Exp. Ther. 271 (1994) 25-29
6. El-Husseini A.E., Schnell E., Chetkovich D.M., Nicoll R.A., and Bredt D.S. PSD-95 involvement in maturation of excitatory synapses. Science 290 (2000) 1364-1368
7. Elias G.M., Funke L., Stein V., Grant S.G., Bredt D.S., and Nicoll R.A. Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron 52 (2006) 307-320
8. Greger I.H., Khatri L., and Ziff E.B. RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum. Neuron 34 (2002) 759-772
9. Greger I.H., Akamine P., Khatri L., and Ziff E.B. Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis. Neuron 51 (2006) 85-97
10. Hollmann M., and Heinemann S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17 (1994) 31-108
11. Kato A.S., Zhou W., Milstein A.D., Knierman M.D., Siuda E.R., Dotzlaf J.E., Yu H., Hale J.E., Nisenbaum E.S., Nicoll R.A., and Bredt D.S. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J. Neurosci. 27 (2007) 4969-4977
12. Kew J.N., and Kemp J.A. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179 (2005) 4-29
13. Lazzaro J.T., Paternain A.V., Lerma J., Chenard B.L., Ewing F.E., Huang J., Welch W.M., Ganong A.H., and Menniti F.S. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 (2002) 143-153
14. Lorenz C., Pusch M., and Jentsch T.J. Heteromultimeric CLC chloride channels with novel properties. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 13362-13366
15. Menuz K., Stroud R.M., Nicoll R.A., and Hays F.A. TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science 318 (2007) 815-817
16. Mitchell N.A., and Fleck M.W. Targeting AMPA receptor gating processes with allosteric modulators and mutations. Biophys. J. 92 (2007) 2392-2402
17. Nicoll R.A., Tomita S., and Bredt D.S. Auxiliary subunits assist AMPA-type glutamate receptors. Science 311 (2006) 1253-1256
18. Noebels J.L., Qiao X., Bronson R.T., Spencer C., and Davisson M.T. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 7 (1990) 129-135
19. Partin K.M., and Mayer M.L. Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI 53655. Mol. Pharmacol. 49 (1996) 142-148
20. Priel A., Kolleker A., Ayalon G., Gillor M., Osten P., and Stern-Bach Y. Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci. 25 (2005) 2682-2686
21. Priel A., Selak S., Lerma J., and Stern-Bach Y. Block of kainate receptor desensitization uncovers a key trafficking checkpoint. Neuron 52 (2006) 1037-1046
22. Schnell E., Sizemore M., Karimzadegan S., Chen L., Bredt D.S., and Nicoll R.A. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. PNAS 99 (2002) 13902-13907
23. Seeburg P.H. The TiPS/TINS lecture: the molecular biology of mammalian glutamate receptor channels. Trends Pharmacol. Sci. 14 (1993) 297-303
24. Stern-Bach Y., Russo S., Neuman M., and Rosenmund C. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron 21 (1998) 907-918
25. Tomita S., Chen L., Kawasaki Y., Petralia R.S., Wenthold R.J., Nicoll R.A., and Bredt D.S. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J. Cell Biol. 161 (2003) 805-816
26. Tomita S., Fukata M., Nicoll R.A., and Bredt D.S. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303 (2004) 1508-1511
27. Tomita S., Adesnik H., Sekiguchi M., Zhang W., Wada K., Howe J.R., Nicoll R.A., and Bredt D.S. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435 (2005) 1052-1058
28. Tomita S., Stein V., Stocker T.J., Nicoll R.A., and Bredt D.S. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron 45 (2005) 269-277
29. Tomita S., Sekiguchi M., Wada K., Nicoll R.A., and Bredt D.S. Stargazin controls the pharmacology of AMPA receptor potentiators. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 10064-10067
30. Tomita S., Shenoy A., Fukata Y., Nicoll R.A., and Bredt D.S. Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology 52 (2007) 87-91
31. Turetsky D., Garringer E., and Patneau D.K. Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms. J. Neurosci. 25 (2005) 7438-7448
32. Vandenberghe W., Nicoll R.A., and Bredt D.S. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. J. Neurosci. 25 (2005) 1095-1102
33. Welch W.M., Ewing F.E., Huang J., Menniti F.S., Pagnozzi M.J., Kelly K., Seymour P.A., Guanowsky V., Guhan S., Guinn M.R., Critchett D., Lazzaro J., Ganong A.H., DeVries K.M., Staigers T.L., and Chenard B.L. Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists. Bioorg. Med. Chem. Lett. 11 (2001) 177-181
34. Yamada K.A., and Tang C.M. Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. J. Neurosci. 13 (1993) 3904-3915
35. Zappala M., Grasso S., Micale N., Polimeni S., and De Micheli C. Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists. Mini Rev. Med. Chem. 1 (2001) 243-253
36. Zerangue N., Schwappach B., Jan Y.N., and Jan L.Y. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22 (1999) 537-548
37. Zorumski C.F., Yamada K.A., Price M.T., and Olney J.W. A benzodiazepine recognition site associated with the non-NMDA glutamate receptor. Neuron 10 (1993) 61-67