Mechanisms of antagonism of the GluR2 AMPA receptor: Structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain

Biochemistry

Volumn 48, Issue 18, 2009, Pages 3894-3903

  Ahmed, Ahmed H ^a   Thompson, Melissa D ^a   Fenwick, Michael K ^a   Romero, Bethsabe ^a   Loh, Adrienne P ^b   Jane, David E ^c   Sondermann, Holger ^a   Oswald, Robert E ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b UNIVERSITY OF WISCONSIN LA CROSSE   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA-RECEPTOR; APO-STATE; BINDING DOMAIN; GLUTAMATE RECEPTOR; INTERNAL DYNAMICS; IONOTROPIC GLUTAMATE RECEPTORS; NATURAL PRODUCTS; NEUROLOGICAL DISORDERS; SPECIFIC INTERACTION; STRUCTURE AND DYNAMICS; SYNAPTIC TRANSMISSION; THERMAL STABILITY;

DYNAMICS;

CRYSTAL STRUCTURE;

3 (2 CARBOXYBENZYL)WILLARDIINE; 3 (2 CARBOXYETHYL)WILLARDIINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; GLUTAMIC ACID; IONOTROPIC RECEPTOR; UBP 277; UBP 282; UNCLASSIFIED DRUG; URACIL; WILLARDIINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BLOCKING; THERMOSTABILITY;

ALANINE; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECEPTORS, AMPA; URACIL;

VERTEBRATA;

EID: 66149128065     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900107m     Document Type: Article

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