GluR2 ligand-binding core complexes: Importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

FEBS Letters

Volumn 531, Issue 2, 2002, Pages 173-178

  Kasper, C ^a   Lunn, M L ^a,b   Liljefors, T ^a   Gouaux, E ^c   Egebjerg, J ^b   Kastrup, J S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Agonist; AMPA analogue; Ionotropic glutamate receptor; Ligand binding core; X ray crystallography

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CHEMICAL COMPOUND; CORE PROTEIN; GLUTAMATE RECEPTOR; ISOXAZOLE DERIVATIVE; ZINC ION;

AGONIST; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; HYDROPHOBICITY; ISOXAZOLES; LIGANDS; MACROMOLECULAR SUBSTANCES; METHIONINE; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; RECEPTORS, AMPA; SULFATES; ZINC;

EID: 0037032411     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03496-8     Document Type: Article

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