Molecular mechanism of flop selectivity and subsite recognition for an ampa receptor allosteric modulator: Structures of GluA2 and GluA3 in complexes with PEPA

Biochemistry

Volumn 49, Issue 13, 2010, Pages 2843-2850

  Ahmed, Ahmed H ^a   Ptak, Christopher P ^a   Oswald, Robert E ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; AMPA-RECEPTOR; BINDING DOMAIN; BINDING POCKETS; BINDING SURFACE; CENTRAL NERVOUS SYSTEMS; COGNITIVE ENHANCEMENT; CONSERVED RESIDUES; DIMER INTERFACE; GLUTAMATE RECEPTOR; HYDROGEN-BONDING PATTERNS; ISOFORMS; MOLECULAR MECHANISM; POTENTIAL DRUG; RECEPTOR ACTIVATION; SPECIFIC INTERACTION; SPLICED VARIANT; STRUCTURAL INFORMATION; SUBSITES; THERAPEUTIC AGENTS; VARIABLE INTERACTION;

BINDING ENERGY; COMPLEXATION; CRYSTAL STRUCTURE; HYDROGEN BONDS; MODULATION; SULFUR COMPOUNDS;

MODULATORS;

4 [2 (PHENYLSULFONYLAMINO)ETHYLTHIO] 2,6 DIFLUOROPHENOXYACETAMIDE; AMINE; AMPA RECEPTOR; PROTEIN GLUA2; PROTEIN GLUA3; SULFONAMIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DESENSITIZATION; DIMERIZATION; HYDROGEN BOND; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN;

ALLOSTERIC REGULATION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDASES; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; SULFONAMIDES;

VERTEBRATA;

EID: 77950405049     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1000678     Document Type: Article

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