Structure and function of AMPA receptors

Journal of Physiology

Volumn 554, Issue 2, 2004, Pages 249-253

  Gouaux, Eric ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; ION CHANNEL; IONOTROPIC RECEPTOR; RECEPTOR SUBUNIT; 6,7 DINITRO 2,3 QUINOXALINEDIONE; GLUTAMATE RECEPTOR 4;

CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HUMAN; LIGAND BINDING; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REVIEW; X RAY DIFFRACTION; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; DISULFIDE BOND; HYDROPHOBICITY; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE;

ANIMALS; HUMANS; ION CHANNEL GATING; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0442279279     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.054320     Document Type: Review

References (12)

1. Armstrong N & Gouaux E (2000). Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28, 165-181.
2. Armstrong N, Sun Y, Chen G-Q & Gouaux E (1998). Structure of a glutamate receptor ligand binding core in complex with kainate. Nature 395, 913-917.
3. Chen G-Q, Sun Y, Jin R & Gouaux E (1998). Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct. Protein Sci 7, 2623-2630.
4. Dingledine R, Borges K, Bowie D & Traynelis SF (1999). The glutamate receptor ion channels. Pharmacol Rev 51, 7-61.
5. Kuusinen A, Arvola M & Keinänen K (1995). Molecular dissection of the agonist binding site of an AMPA receptor. EMBO J 14, 6327-6332.
6. Lees GJ (2000). Pharmacology of AMPA/Kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders. Drugs 59, 33-78.
7. Madden DR (2002). The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3, 91-101.
8. Nakanishi N, Shneider NA & Axel R (1990). A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 5, 569-581.
9. Paas Y (1998). The macro- and microarchitectures of the ligand-binding domain of glutamate receptors. Trends Neurosci 21, 117-125.
10. Stern-Bach Y, Bettler B, Hartley M, Sheppard PO, O'Hara PJ & Heinemann SF (1994). Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 13, 1345-1357.
11. Stern-Bach Y, Russo S, Neuman M & Rosenmund C (1998). A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron 21, 907-918.
12. Sun Y, Olson RA, Horning M, Armstrong N, Mayer ML & Gouaux E (2002). Mechanism of glutamate receptor desensitization. Nature 417, 245-253.