Competitive antagonism of AMPA receptors by ligands of different classes: Crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 214-221

  Hogner, Anders ^a   Greenwood, Jeremy R ^a   Liljefors, Tommy ^a   Lunn, Marie Louise ^a   Egebjerg, Jan ^b   Larsen, Ingrid K ^a   Gouaux, Eric ^c   Kastrup, Jette S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 [5 TERT BUTYL 3 (PHOSPHONOMETHOXY) 4 ISOXAZOLYL]PROPIONIC ACID; 6,7 DINITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR ANTAGONIST; ISOXAZOLE DERIVATIVE; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; EXCITATORY AMINO ACID ANTAGONISTS; ISOXAZOLES; LIGANDS; MODELS, MOLECULAR; PHOSPHONIC ACIDS; QUINOXALINES; RECEPTORS, AMPA;

EID: 0037448433     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020989v     Document Type: Article

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