Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition

Neuron

Volumn 57, Issue 1, 2008, Pages 80-93

  Gielen, Marc ^a   Le Goff, Anne ^a   Stroebel, David ^a   Johnson, Jon W ^b   Neyton, Jacques ^a   Paoletti, Pierre ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

CELLBIO; SIGNALING; SYSBIO

Indexed keywords

AMPA RECEPTOR; DIMER; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; ZINC ION;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; OLIGOMERIZATION; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; STRUCTURE ANALYSIS; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGENTS; LARVA; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MOLECULAR BIOLOGY; MUTATION; OOCYTES; OXIDATION-REDUCTION; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTONS; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS; ZINC;

EID: 37549045649     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.11.021     Document Type: Article

References (40)

1. Armstrong N., Jasti J., Beich-Frandsen M., and Gouaux E. Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell 127 (2006) 85-97
2. Ayalon G., Segev E., Elgavish S., and Stern-Bach Y. Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly. J. Biol. Chem. 280 (2005) 15053-15060
3. 2+ inhibition of the NMDA receptor. Neuron 23 (1999) 171-180
4. DeLano W.L. The PyMOL Molecular Graphics System (2002), DeLano Scientific, San Carlos, CA
5. Dingledine R.J., Borges K., Bowie D., and Traynelis S.F. The glutamate receptor ion channel. Pharmacol. Rev. 51 (1999) 1-61
6. Erreger K., and Traynelis S.F. Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. J. Physiol. 569 (2005) 381-393
7. 2+ binding to NMDA receptors. Neuron 25 (2000) 683-694
8. Fersht A.R. Structure and Mechanism in Protein Science: Guide to Enzyme Catalysis and Protein Folding (1999), W.H. Freeman and Company, New York
9. Furukawa H., Singh S.K., Mancusso R., and Gouaux E. Subunit arrangement and function in NMDA receptors. Nature 438 (2005) 185-192
10. Hatton C.J., and Paoletti P. Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 46 (2005) 261-274
11. Horning M.S., and Mayer M.L. Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41 (2004) 379-388
12. Ihle E.C., and Patneau D.K. Modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor desensitization by extracellular protons. Mol. Pharmacol. 58 (2000) 1204-1212
13. Jin R., Banke T.G., Mayer M.L., Traynelis S.F., and Gouaux E. Structural basis for partial agonist action at ionotropic glutamate receptors. Nat. Neurosci. 6 (2003) 803-810
14. Jingami H., Nakanishi S., and Morikawa K. Structure of the metabotropic glutamate receptor. Curr. Opin. Neurobiol. 13 (2003) 271-278
15. Kew J.N., Trube G., and Kemp J.A. A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J. Physiol. 497 (1996) 761-772
16. Kuusinen A., Abele R., Madden D.R., and Keinanen K. Oligomerization and ligand-binding properties of the ectodomain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD. J. Biol. Chem. 274 (1999) 28937-28943
17. Lei S., Orser B.A., Thatcher G.R., Reynolds J.N., and MacDonald J.F. Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. J. Neurophysiol. 85 (2001) 2030-2038
18. Low C.M., Zheng F., Lyuboslavsky P., and Traynelis S.F. Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA 97 (2000) 11062-11067
19. Low C.M., Lyuboslavsky P., French A., Le P., Wyatte K., Thiel W.H., Marchan E.M., Igarashi K., Kashiwagi K., Gernert K., et al. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol. Pharmacol. 63 (2003) 1212-1222
20. Madry C., Mesic I., Betz H., and Laube B. The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of NMDA receptors. Mol. Pharmacol. 72 (2007) 1535-1544
21. Mayer M.L. Glutamate receptors at atomic resolution. Nature 440 (2006) 456-462
22. Meddows E., Le Bourdelles B., Grimwood S., Wafford K., Sandhu S., Whiting P., and McIlhinney R.A. Identification of molecular determinants that are important in the assembly of N-methyl-D-aspartate receptors. J. Biol. Chem. 276 (2001) 18795-18803
23. O'Neil K.T., and DeGrado W.F. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science 250 (1990) 646-651
24. Paoletti P., and Neyton J. NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol. 7 (2007) 39-47
25. 2+. Neuron 15 (1995) 1109-1120
26. Paoletti P., Ascher P., and Neyton J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J. Neurosci. 17 (1997) 5711-5725
27. Paoletti P., Perin-Dureau F., Fayyazuddin A., Le Goff A., Callebaut I., and Neyton J. Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit. Neuron 28 (2000) 911-925
28. Plested A.J., and Mayer M.L. Structure and mechanism of kainate receptor modulation by anions. Neuron 53 (2007) 829-841
29. Perin-Dureau F., Rachline J., Neyton J., and Paoletti P. Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. J. Neurosci. 22 (2002) 5955-5965
30. Priel A., Selak S., Lerma J., and Stern-Bach Y. Block of kainate receptor desensitization uncovers a key trafficking checkpoint. Neuron 52 (2006) 1037-1046
31. Rachline J., Perin-Dureau F., Le Goff A., Neyton J., and Paoletti P. The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J. Neurosci. 25 (2005) 308-317
32. Sine S.M., and Engel A.G. Recent advances in Cys-loop receptor structure and function. Nature 440 (2006) 448-455
33. 2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 10 (2004) 432-442
34. Sun Y., Olson R., Horning M., Armstrong N., Mayer M., and Gouaux E. Mechanism of glutamate receptor desensitization. Nature 417 (2002) 245-253
35. Traynelis S.F., and Cull-Candy S.G. Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. J. Physiol. 433 (1991) 727-763
36. Traynelis S.F., and Chesler M. Proton release as a modulator of presynaptic function. Neuron 32 (2001) 960-962
37. Vogt K., Mellor J., Tong G., and Nicoll R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron 26 (2000) 187-196
38. Westbrook G.L., and Mayer M.L. Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 328 (1987) 640-643
39. Weston M.C., Schuck P., Ghosal A., Rosenmund C., and Mayer M.L. Conformational restriction blocks glutamate receptor desensitization. Nat. Struct. Mol. Biol. 13 (2006) 1120-1127
40. Zheng F., Erreger K., Low C.M., Banke T., Lee C.J., Conn P.J., and Traynelis S.F. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat. Neurosci. 4 (2001) 894-901