Electrophysiology of islet cells

Advances in Experimental Medicine and Biology

Volumn 654, Issue , 2010, Pages 115-163

  Drews, Gisela ^a   Krippeit Drews, Peter ^b   Düfer, Martina ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ANION CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM ION; CREATINE KINASE; CREATINE PHOSPHATE; CYCLIC NUCLEOTIDE GATED CHANNEL; DIAZOXIDE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; NATEGLINIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SODIUM CHANNEL; SULFONYLUREA; SULFONYLUREA RECEPTOR 1; TOLBUTAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT SODIUM CHANNEL; VOLTAGE SENSITIVE ANION CHANNEL; CALCIUM; ION CHANNEL;

ACTION POTENTIAL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CHANNEL GATING; DIABETES MELLITUS; DRUG BINDING SITE; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GENE MUTATION; GLUCAGON RELEASE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HYPERINSULINISM; HYPERPOLARIZATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MEMBRANE POTENTIAL; MEMBRANE POTENTIAL OSCILLATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET DELTA CELL; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; REPOLARIZATION; SODIUM CURRENT; SOMATOSTATIN RELEASE; STIMULUS SECRETION COUPLING; ANIMAL; CELL MEMBRANE; CHEMISTRY; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; OSCILLOMETRY; PANCREAS ISLET; PHYSIOLOGY; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL MEMBRANE; ELECTROPHYSIOLOGY; GLUCOSE; HUMANS; ION CHANNELS; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; OSCILLOMETRY; OXIDATIVE STRESS; POTASSIUM CHANNELS;

EID: 77953945190     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-3271-3_7     Document Type: Article

References (370)

1. ATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 1995;270: 1166-70.
2. ATP channel subunits. Neuron 1997;18:827-38. (Pubitemid 27232792)
3. ATP channels. Physiol Rev 1998;78:227-45. (Pubitemid 28070980)
4. ATP channels. Annu Rev Physiol 1998;60:667-87.
5. + channels. Pflügers Arch 2007;453:703-18. (Pubitemid 46192541)
6. + channel. FEBS Lett 1997;409:232-6.
7. ATP channel complex. J Gen Physiol 1997;110:655-64. (Pubitemid 27524606)
8. Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev 1999;20:101-35. (Pubitemid 29339588)
9. + conduction and selectivity. Science 1998;280:69-77. (Pubitemid 28169082)
10. ATP channels "vingt ans apres": ATG to PDB to Mechanism. J Mol Cell Cardiol 2005;39:79-98. (Pubitemid 40836046)
11. ATP channel openers. J Mol Cell Cardiol 2005;38:951-63. (Pubitemid 40725943)
12. ATP channels. J Biol Chem 1999;274:20628-32.
13. + channels in the absence of the sulphonylurea receptor. Nature 1997;387:179-83. (Pubitemid 27209432)
14. ATP channels. Neuron 1999;22: 537-48. (Pubitemid 29159852)
15. Mikhailov MV, Proks P, Ashcroft FM, Ashcroft SJ. Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus. FEBS Lett 1998;429:390-94. (Pubitemid 28300398)
16. Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K. Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4- azidoanilide. Biochem Biophys Res Commun 2000;272:316-9. (Pubitemid 30444615)
17. + channel by 8-azido-ATP. J Biol Chem 1999;274:3931-3.
18. ATP channels bind nucleotides. J Biol Chem 2002;277: 23260-70. (Pubitemid 34952154)
19. Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM. The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP. J Physiol 1999;520 Pt 3: 661-9. (Pubitemid 29533026)
20. ATP channels. Biochem Biophys Res Commun 1999;255:231-8. (Pubitemid 29292242)
21. ATP pores define a novel gatekeeper. J Biol Chem 2003;278:41577-80. (Pubitemid 37310410)
22. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JPt, Boyd AE, 3rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 1995;268:423-6.
23. Chan KW, Zhang H, Logothetis DE. N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. EMBO J 2003;22: 3833-43. (Pubitemid 36975711)
24. ATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions. J Biol Chem 2002;277: 43997-4004. (Pubitemid 36157825)
25. ATP channel complex Kir6.2-SUR1. EMBO J 2005;24:4166-75. (Pubitemid 41752885)
26. Reimann F, Tucker SJ, Proks P, Ashcroft FM. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor. J Physiol 1999;518 (Pt 2):325-36. (Pubitemid 29366732)
27. ATP channel interaction with adenine nucleotides. J Mol Cell Cardiol 2005;38:907-16. (Pubitemid 40725938)
28. Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J 1997;16:1145-52. (Pubitemid 27136081)
29. 2+- independent ATP binding of the sulfonylurea receptor SUR1. J Biol Chem 1997;272:22983-6. (Pubitemid 27392419)
30. ATP channels. FEBS Lett 1999;445:131-6. (Pubitemid 29101548)
31. de Wet H, Mikhailov MV, Fotinou C, Dreger M, Craig TJ, Venien-Bryan C, Ashcroft FM. Studies of the ATPase activity of the ABC protein SUR1. FEBS J 2007;274:3532-44. (Pubitemid 47052393)
32. ATP channel by interaction with its SUR1 subunit. Proc Natl Acad Sci U S A 1998;95:7185-90.
33. ATP channel-independent regulation of insulin secretion. J Biol Chem 2000;275: 9270-7. (Pubitemid 30185147)
34. ATP channel-deficient mice. Proc Natl Acad Sci U S A 1998;95:10402-6.
35. -/- beta cells. Diabetologia 2004;47:488-98. (Pubitemid 38491245)
36. Eliasson L, Renström E, Ämmälä C, Berggren PO, Bertorello AM, Bokvist K, Chibalin A, Deeney JT, Flatt PR, Gabel J, Gromada J, Larsson O, Lindström P, Rhodes CJ, Rorsman P. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science 1996;271:813-5. (Pubitemid 26058934)
37. Guiot Y, Stevens M, Marhfour I, Stiernet P, Mikhailov M, Ashcroft SJ, Rahier J, Henquin JC, Sempoux C. Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas. Diabetologia 2007;50:1889-99. (Pubitemid 47222851)
38. + channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins. Endocr Rev 2007;28:653-63. (Pubitemid 47606650)
39. Eliasson L, Ma X, Renström E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P. SUR1 regulates PKA-independent cAMPinduced granule priming in mouse pancreatic B-cells. J Gen Physiol 2003;121:181-97. (Pubitemid 36292989)
40. Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol 2000;2:805-11.
41. Nakazaki M, Crane A, Hu M, Seghers V, Ullrich S, Aguilar-Bryan L, Bryan J. cAMPactivated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes 2002;51:3440-9. (Pubitemid 35403448)
42. + channels in pancreatic B-cells. Nature 1984;311:271-3. (Pubitemid 14071146)
43. Ashcroft FM, Harrison DE, Ashcroft SJ. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 1984;312:446-8. (Pubitemid 15217837)
44. Ashcroft FM. Adenosine 5'-triphosphate-sensitive potassium channels. Annu Rev Neurosci 1988;11:97-118. (Pubitemid 18081035)
45. Woll KH, Lönnendonker U, Neumcke B. ATP-sensitive potassium channels in adult mouse skeletal muscle: different modes of blockage by internal cations, ATP and tolbutamide. Pflugers Arch 1989;414:622-8. (Pubitemid 19236282)
46. Trapp S, Proks P, Tucker SJ, Ashcroft FM. Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. J Gen Physiol 1998;112:333-49. (Pubitemid 28421741)
47. ATP channel regulation of mouse pancreatic beta cells. Diabetologia 2007;50:2126-34. (Pubitemid 47373840)
48. + channel in intact and permeabilized pancreatic beta-cells. Diabetes 2006;55:2446-54. (Pubitemid 44871144)
49. Detimary P, Dejonghe S, Ling Z, Pipeleers D, Schuit F, Henquin JC. The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem 1998;273:33905-8. (Pubitemid 29008852)
50. Niki I, Ashcroft FM, Ashcroft SJ. The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells. FEBS Lett 1989;257:361-4.
51. ATP channels: potential role in Type 2 diabetes. Diabetologia 2004;47:277-83. (Pubitemid 38315364)
52. Bränström R, Corkey BE, Berggren PO, Larsson O. Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells. J Biol Chem 1997;272:17390-4. (Pubitemid 27311166)
53. Bränström R, Leibiger IB, Leibiger B, Corkey BE, Berggren PO, Larsson O. Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel. J Biol Chem 1998;273:31395-400. (Pubitemid 28533158)
54. + channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem 1996;271:10623-6. (Pubitemid 26145796)
55. ATP channels. Science 1998;282:1141-4.
56. ATP channels gated by intracellular nucleotides and phospholipids. Eur J Biochem 2000;267:5842-8.
57. ATP channels by the same mechanism. J Physiol 2003;552:357-67. (Pubitemid 37321835)
58. Rapedius M, Soom M, Shumilina E, Schulze D, Schonherr R, Kirsch C, Lang F, Tucker SJ, Baukrowitz T. Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. J Biol Chem 2005;280:30760-67. (Pubitemid 41291805)
59. ATP channels. J Gen Physiol 2000;116:599-608.
60. ATP channels. Science 1998;282:1138-41. (Pubitemid 28516245)
61. rd. Dependence on NADH produced during glycolysis for beta-cell glucose signaling. J Biol Chem 1994;269:10979-82. (Pubitemid 24200295)
62. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 1999;283: 981-5.
63. Lenzen S. Effects of alpha-ketocarboxylic acids and 4-pentenoic acid on insulin secretion from the perfused rat pancreas. Biochem Pharmacol 1978;27:1321-4. (Pubitemid 8401717)
64. Sener A, Kawazu S, Hutton JC, Boschero AC, Devis G, Somers G, Herchuelz A, Malaisse WJ. The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem J 1978;176:217-32. (Pubitemid 9060530)
65. Zawalich WS, Zawalich KC. Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell. J Biol Chem 1997;272:3527-31.
66. 2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates. Biochim Biophys Acta 2000;1523:65-72.
67. ATP channels, and not as a mitochondrial substrate. Biochem J 2002;368:817-25. (Pubitemid 36042684)
68. Bränström R, Efendic S, Berggren PO, Larsson O. Direct inhibition of the pancreatic beta-cell ATP-regulated potassium channel by alpha-ketoisocaproate. J Biol Chem 1998;273:14113-8. (Pubitemid 28319118)
69. Lembert N, Idahl LA. Alpha-ketoisocaproate is not a true substrate for ATP production by pancreatic beta-cell mitochondria. Diabetes 1998;47:339-44. (Pubitemid 28104193)
70. Gerbitz KD, Gempel K, Brdiczka D. Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 1996;45: 113-26. (Pubitemid 26045791)
71. Dzeja PP, Terzic A. Phosphotransfer networks and cellular energetics. J Exp Biol 2003;206:2039-47. (Pubitemid 36761807)
72. ATP channel activity in pancreatic beta-cells. Pflügers Arch 2003;445:556-62. (Pubitemid 36286889)
73. + channel in vivo. FASEB J 2002;16:102-4.
74. Stanojevic V, Habener JF, Holz GG, Leech CA. Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun 2008;368:614-9.
75. Atwater I, Ribalet B, Rojas E. Cyclic changes in potential and resistance of the beta-cell membrane induced by glucose in islets of Langerhans from mouse. J Physiol 1978;278: 117-39. (Pubitemid 8342375)
76. Meissner HP, Henquin JC, Preissler M. Potassium dependence of the membrane potential of pancreatic B-cells. FEBS Lett 1978;94:87-9. (Pubitemid 9037883)
77. Misler S, Falke LC, Gillis K, McDaniel ML. A metabolite-regulated potassium channel in rat pancreatic B cells. Proc Natl Acad Sci U S A 1986;83:7119-23. (Pubitemid 16002380)
78. + permeability in pancreatic beta cells. Nature 1975;253:635-6.
79. Henquin JC. D-glucose inhibits potassium efflux from pancreatic islet cells. Nature 1978;271:271-3. (Pubitemid 8256556)
80. Rorsman P, Trube G. Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP. Pflügers Arch 1985;405:305-9. (Pubitemid 16202499)
81. +-currents in isolated mouse pancreatic beta-cells. FEBS Lett 1990;261:187-90. (Pubitemid 20064803)
82. Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989;54:87-143.
83. Dean PM, Matthews EK. Electrical activity in pancreatic islet cells. Nature 1968;219: 389-90.
84. + channel in mouse pancreatic beta-cells. Pflügers Arch 1986;407:493-9. (Pubitemid 17175041)
85. Henquin JC. A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells. Endocrinology 1998;139: 993-8.
86. + channel in rat pancreatic B-cells. Am J Physiol 1989;257:C1119-27.
87. + channel openers, and ATP. Mol Pharmacol 2001;59: 1086-93. (Pubitemid 32381588)
88. ATP channels. Functional coupling of Kir6.2 and SUR1 subunits. J Gen Physiol 1999;114: 203-13. (Pubitemid 29380150)
89. Klein A, Lichtenberg J, Stephan D, Quast U. Lipids modulate ligand binding to sulphonylurea receptors. Br J Pharmacol 2005;145:907-15. (Pubitemid 41129012)
90. + channels from pancreatic B-cells. FEBS Lett 1988;239:241-4. (Pubitemid 18263455)
91. + channel currents expressed in Xenopus oocytes: a reinterpretation. J Physiol 1997;504 (Pt 1): 35-45. (Pubitemid 27464270)
92. ATP channel closure. FEBS Lett 1999;459:367-76. (Pubitemid 29467370)
93. Dörschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Mol Pharmacol 1999;55:1060-66. (Pubitemid 29252373)
94. + channel in insulin secreting cells. Biochem Biophys Res Commun 1987;146:21-25. (Pubitemid 17102976)
95. rd. Characterization of the sulfonylurea receptor on beta cell membranes. J Biol Chem 1988;263:2589-92. (Pubitemid 18062895)
96. ATP channel. FEBS Lett 2001;499:154-60. (Pubitemid 32539340)
97. ATP channels. J Pharmacol Exp Ther 2003;304:1025-32. (Pubitemid 36254414)
98. Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P. Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes 2002;51:2789-95. (Pubitemid 34970932)
99. Fuhlendorff J, Rorsman P, Kofod H, Brand CL, Rolin B, MacKay P, Shymko R, Carr RD. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes 1998;47: 345-51. (Pubitemid 28104194)
100. ATP channels. Br J Pharmacol 2005;144:551-57. (Pubitemid 40349462)
101. Dabrowski M, Wahl P, Holmes WE, Ashcroft FM. Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels. Diabetologia 2001;44:747-56. (Pubitemid 32846030)
102. + fluxes and membrane potential in pancreatic B cells. Biochem Pharmacol 1982;31:1407-15. (Pubitemid 12141104)
103. + channels in an insulin-secreting cell line. J Membr Biol 1987;99:215-24. (Pubitemid 18046040)
104. + currents recorded from an insulin-secreting cell line. Br J Pharmacol 1989;97:1039-50. (Pubitemid 20051916)
105. ATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells. J Physiol 1993;463:349-65. (Pubitemid 23120590)
106. ATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. J Gen Physiol 1997;110:643-54. (Pubitemid 27524605)
107. + channels. Circ Res 2000;87:873-80.
108. + channel openers. J Biol Chem 2000;275:717-20. (Pubitemid 30051106)
109. Gill GV, Rauf O,MacFarlane IA. Diazoxide treatment for insulinoma: a national UK survey. Postgrad Med J 1997;73:640-1. (Pubitemid 27464460)
110. + channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 2004;53:1706-13. (Pubitemid 38857028)
111. ATP channel openers protect rat islets against the toxic effect of streptozotocin. Diabetes 2000;49:1131-6. (Pubitemid 30439086)
112. ATP channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function. Biochem Pharmacol 2008;76: 1748-56.
113. 2 with stimulus-secretion coupling in mouse pancreatic beta-cells. J Physiol 514 1999; (Pt 2):471-81. (Pubitemid 29055974)
114. 2+ efflux. Endocrine 1999;11:99-107.
115. 2 induced hyperpolarization of pancreatic B-cells. Pflügers Arch 1994;426:552-4.
116. + channels in free radical-mediated inhibition of insulin secretion in rat pancreatic beta-cells. Diabetes 1995;44:878-83.
117. Krippeit-Drews P, Kröncke KD, Welker S, Zempel G, Roenfeldt M, Ammon HP, Lang F, Drews G. The effects of nitric oxide on the membrane potential and ionic currents of mouse pancreatic B cells. Endocrinology 1995;136:5363-9.
118. + channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells. J Gen Physiol 1994;104:1079-98.
119. Drews G, Krämer C, Düfer M, Krippeit-Drews P. Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells. Biochem J 352 Pt 2000;2:389-97. (Pubitemid 32012420)
120. + channel in the pancreatic beta-cell. FEBS Lett 1993;319: 128-32. (Pubitemid 23074284)
121. + channel currents of mouse pancreatic B cells. Endocrinology 1995;136:464-67.
122. + ATP current of mouse pancreatic B-cells: stimulation by deenergizing mitochondria and inhibition by direct interaction with the channel. Biochim Biophys Acta 2000;1464:62-8. (Pubitemid 30110517)
123. + channels in rat pancreatic beta cells. Pflugers Arch 2008;456:573-9.
124. Dunne MJ, Cosgrove KE, Shepherd RM, Aynsley-Green A, Lindley KJ. Hyperinsulinism in infancy: from basic science to clinical disease. Physiol Rev 2004;84:239-75. (Pubitemid 38049881)
125. Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 2005;115:2047-58. (Pubitemid 41134141)
126. ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population. Diabetologia 2003;46:241-9. (Pubitemid 36343888)
127. ATP channel subunits. J Biol Chem 2004;279:9080-90. (Pubitemid 38295972)
128. ATP channels. J Biol Chem 2002;277:17139-46. (Pubitemid 34967746)
129. Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko HL, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. J Clin Invest 2000;106:897-906.
130. ATP channel-independent pathways. Diabetes 2001;50:329-39. (Pubitemid 32127290)
131. Thornton PS, MacMullen C, Ganguly A, Ruchelli E, Steinkrauss L, Crane A, Aguilar-Bryan L, Stanley CA. Clinical and molecular characterization of a dominant form of congenital hyperinsulinism caused by a mutation in the high-affinity sulfonylurea receptor. Diabetes 2003;52:2403-410. (Pubitemid 37059513)
132. Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njolstad PR, Ashcroft FM, Hattersley AT. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838-49. (Pubitemid 38917250)
133. Hattersley AT, Ashcroft FM. Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. Diabetes 2005;54:2503-13. (Pubitemid 41233571)
134. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, Bryan J. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 1995;268:426-29.
135. ATP channel cause transient neonatal diabetes, permanent neonatal diabetes or permanent diabetes diagnosed outside the neonatal period. Diabetes Obes Metab 2007;9 Suppl 2:28-39. (Pubitemid 47543124)
136. Vaxillaire M, Dechaume A, Busiah K, Cave H, Pereira S, Scharfmann R, de Nanclares GP, Castano L, Froguel P, Polak M. New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes 2007;56:1737-41. (Pubitemid 46842623)
137. Klupa T, Kowalska I, Wyka K, Skupien J, Patch AM, Flanagan SE, Noczynska A, Arciszewska M, Ellard S, Hattersley AT, Sieradzki J, Mlynarski W, Malecki MT. Mutations in the ABCC8 gene are associated with a variable clinical phenotype. Clin Endocrinol 2009; 71: 358-62.
138. Riedel MJ, Boora P, Steckley D, de Vries G, Light PE. Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes 2003;52:2630-5. (Pubitemid 37210554)
139. Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT. Relapsing diabetes can result from moderately activating mutations in KCNJ11. Hum Mol Genet 2005;14:925-34. (Pubitemid 40533103)
140. Proks P, Antcliff JF, Lippiat J, Gloyn AL, Hattersley AT, Ashcroft FM. Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proc Natl Acad Sci U S A 2004;101:17539-44. (Pubitemid 39657439)
141. de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM. Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. Proc Natl Acad Sci U S A 2007;104:18988-92.
142. Ellard S, Flanagan SE, Girard CA, Patch AM, Harries LW, Parrish A, Edghill EL, Mackay DJ, Proks P, Shimomura K, Haberland H, Carson DJ, Shield JP, Hattersley AT, Ashcroft FM. Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. Am J Hum Genet 2007;81:375-82. (Pubitemid 47236084)
143. + channels. Diabetes 2002;51:875-9. (Pubitemid 34760205)
144. Tarasov AI, Girard CA, Larkin B, Tammaro P, Flanagan SE, Ellard S, Ashcroft FM. Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes. Diabetes Obes Metab 2007;9 Suppl 2:46-55. (Pubitemid 47543126)
145. Slingerland AS, Hurkx W, Noordam K, Flanagan SE, Jukema JW, Meiners LC, Bruining GJ, Hattersley AT, Hadders-Algra M. Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation. Diabet Med 2008;25:277-81. (Pubitemid 351322710)
146. Pearson ER, Flechtner I, Njolstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Sovik O, Polak M, Hattersley AT. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006;355:467-77. (Pubitemid 44162274)
147. Flechtner I, de Lonlay P, PolakM. Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences. Diabetes Metab 2006;32:569-80. (Pubitemid 46145369)
148. Rafiq M, Flanagan SE, Patch AM, Shields BM, Ellard S, Hattersley AT. Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations. Diabetes Care 2008;31:204-9. (Pubitemid 351213320)
149. ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003;52:568-72. (Pubitemid 36173218)
150. Laukkanen O, Pihlajamaki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M. Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 2004;89:6286-90. (Pubitemid 39628447)
151. Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, ShestakovaMV, Nosikov VV. Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes. Acta Diabetol 2009;46:43-9.
152. Vaxillaire M, Veslot J, Dina C, Proenca C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P. Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes 2008;57:244-54.
153. Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P. The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J Clin Endocrinol Metab 2006;91: 2334-39. (Pubitemid 43855025)
154. Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glumer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O. The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 2003;52:573-7. (Pubitemid 36173219)
155. Tschritter O, Stumvoll M, Machicao F, Holzwarth M, Weisser M, Maerker E, Teigeler A, Häring H, Fritsche A. The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia. Diabetes 2002;51:2854-60. (Pubitemid 34970941)
156. Riedel MJ, Steckley DC, Light PE. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Hum Genet 2005;116:133-45. (Pubitemid 40173997)
157. 2+ channels. J Membr Biol 2004;200:57-66. (Pubitemid 39313753)
158. Yang SN, Berggren PO. Beta-cell CaV channel regulation in physiology and pathophysiology. Am J Physiol Endocrinol Metab 2005;288:E16-28.
159. Yang SN, Berggren PO. The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Endocr Rev 2006;27:621-76.
160. 2+ channels. Annu Rev Cell Dev Biol 2000;16:521-55. (Pubitemid 32037516)
161. 2delta subunits of voltage-gated calcium channels. Trends Pharmacol Sci 2007;28:220-8. (Pubitemid 46661004)
162. Arikkath J, Campbell KP. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 2003;13:298-307. (Pubitemid 36792242)
163. CatterallWA, Perez-Reyes E, Snutch TP, Striessnig J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 2005;57:411-25. (Pubitemid 43036432)
164. 2+ currents by acetylcholine in mouse pancreatic B-cells. J Physiol 1997;499 (Pt 1):65-76. (Pubitemid 27096086)
165. Plant TD. Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells. J Physiol 1988;404:731-47.
166. Satin LS, Tavalin SJ, Kinard TA, Teague J. Contribution of L- and non-L-type calcium channels to voltage-gated calcium current and glucose-dependent insulin secretion in HIT-T15 cells. Endocrinology 1995;136:4589-601.
167. Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes 2008;57:1618-28.
168. 2+ channels in insulin-secreting mouse pancreatic B cells. Biophys J 2001;81:3308-23. (Pubitemid 33111478)
169. Horvath A, Szabadkai G, Varnai P, Aranyi T, Wollheim CB, Spat A, Enyedi P. Voltage dependent calcium channels in adrenal glomerulosa cells and in insulin producing cells. Cell Calcium 1998;23:33-42. (Pubitemid 28159595)
170. Iwashima Y, Pugh W, Depaoli AM, Takeda J, Seino S, Bell GI, Polonsky KS. Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion. Diabetes 1993;42:948-55. (Pubitemid 23182159)
171. 1D subunit in postnatal pancreatic beta cell generation. J Clin Invest 2001;108: 1015-22. (Pubitemid 32946075)
172. 2+ channel null mice. EMBO J 2003;22:3844-54. (Pubitemid 36980594)
173. Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI. Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells. Proc Natl Acad Sci U S A 1992;89:584-8.
174. 2+ channels in pancreatic beta cells. Proc Natl Acad Sci U S A 1999;96:10164-9. (Pubitemid 29422530)
175. Rorsman P, Ashcroft FM, Trube G. Single Ca channel currents in mouse pancreatic B-cells. Pflugers Arch 1988;412:597-603.
176. Ashcroft FM, Rorsman P, Trube G. Single calcium channel activity in mouse pancreatic beta-cells. Ann N Y Acad Sci 1989;560:410-2. (Pubitemid 19226251)
177. Rorsman P, Trube G. Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. J Physiol 1986;374:531-50. (Pubitemid 16062255)
178. Hiriart M, Matteson DR. Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assay. J Gen Physiol 1988;91:617-39.
179. Misler S, Barnett DW, Gillis KD, Pressel DM. Electrophysiology of stimulus-secretion coupling in human beta-cells. Diabetes 1992;41:1221-8.
180. Satin LS, Cook DL. Calcium current inactivation in insulin-secreting cells is mediated by calcium influx and membrane depolarization. Pflügers Arch 1989;414:1-10. (Pubitemid 19140435)
181. 2+ channels. J Biol Chem 1994;269: 2743-49.
182. Ämmälä C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjoholm A, Rorsman P. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells. Proc Natl Acad Sci U S A 1994;91:4343-7. (Pubitemid 24143429)
183. 2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein. Endocrinology 1991;128:958-64.
184. 2+ channels in the beta cell. J Biol Chem 1991;266:837-43. (Pubitemid 21907192)
185. 2+ concentration. J Biol Chem 1989;264:973-80. (Pubitemid 19038080)
186. Aicardi G, Pollo A, Sher E, Carbone E. Noradrenergic inhibition and voltage-dependent facilitation of omega-conotoxin-sensitive Ca channels in insulin-secreting RINm5F cells. FEBS Lett 1991;281:201-4.
187. 2+ current in the RINm5f cell line. Proc Natl Acad Sci U S A 1991;88:8744-8. (Pubitemid 21915433)
188. Ullrich S, Wollheim CB. Galanin inhibits insulin secretion by direct interference with exocytosis. FEBS Lett 1989;247:401-4. (Pubitemid 19129286)
189. + channel in mouse pancreatic B cells. Nature 1991;349: 77-9. (Pubitemid 21912019)
190. + permeability of the B-cell membrane. Endocrinology 1990;126:1646-53. (Pubitemid 20095775)
191. Debuyser A, Drews G, Henquin JC. Adrenaline inhibition of insulin release: role of the repolarization of the B cell membrane. Pflügers Arch 1991;419:131-7.
192. Bokvist K, Ämmälä C, Berggren PO, Rorsman P, Wahlander K. Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells. Biosci Rep 1991;11:147-57.
193. 2+ concentration. Biochem Biophys Res Commun 1986;140:1059-63. (Pubitemid 17207797)
194. 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells. EMBO J 1995;14:50-57.
195. 2+ microdomains and the control of insulin secretion. Cell Calcium 2006;40:539-51. (Pubitemid 44667865)
196. 2+ channel is functionally coupled to the exocytotic machinery. Proc Natl Acad Sci U S A 1999;96:248-53. (Pubitemid 29036085)
197. 2+ channels by distinct domains within SNAP-25. Diabetes 2002;51: 1425-36. (Pubitemid 34826608)
198. Nitert MD, Nagorny CL, Wendt A, Eliasson L, Mulder H. CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells. J Mol Endocrinol 2008;41:1-11.
199. + currents in cultured mouse pancreatic B-cells. Pflügers Arch 1988;411: 429-35.
200. + channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells. J Gen Physiol 1999;114:759-70.
201. 2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion. Pflugers Arch 1995;431:272-82.
202. 2+ influx in the electrically excitable pancreatic B-cell. J Biol Chem 1999;274:20197-205.
203. 2+ channels. Cell 2000;102:89-97.
204. 2+ channels. Mol Endocrinol 2002;16:884-95. (Pubitemid 34297755)
205. Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T. Mice lacking CaV2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun 2001;289:791-95. (Pubitemid 34060072)
206. Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E. CaV2.3 calcium channels control second-phase insulin release. J Clin Invest 2005;115:146-54. (Pubitemid 40385515)
207. Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc Natl Acad Sci U S A 1991;88:53-57. (Pubitemid 21914424)
208. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes 2004;53:597-607. (Pubitemid 38270628)
209. + channels. Role in stimulus-secretion coupling. J Biol Chem 1996;271:32241-6. (Pubitemid 26422260)
210. Göpel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterisation of somatostatinsecreting -cells in intact mouse pancreatic islets. J Physiol 2000;528:497-507.
211. + channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. Diabetologia 2003;46:1046-62. (Pubitemid 37041235)
212. Jacobson DA, Philipson LH. Action potentials and insulin secretion: new insights into the role of KV channels. Diabetes Obes Metab 9 Suppl 2007;2:89-98. (Pubitemid 47543131)
213. Kerschensteiner D, Stocker M. Heteromeric assembly of KV2.1 with KV9.3: effect on the state dependence of inactivation. Biophys J 1999;77:248-57. (Pubitemid 29305225)
214. + channel KV2.1. FEBS Lett 2002;512:230-34. (Pubitemid 34164485)
215. Düfer M, Neye Y, Krippeit-Drews P, Drews G. Direct interference of HIV protease inhibitors with pancreatic beta-cell function. Naunyn Schmiedebergs Arch Pharmacol 2004;369: 583-90. (Pubitemid 38823991)
216. + channel families regulate insulin secretion. Mol Endocrinol 2001;15:1423-35. (Pubitemid 32703488)
217. Smith PA, Bokvist K, Rorsman P. Demonstration of A-currents in pancreatic islet cells. Pflügers Arch 1989;413:441-43. (Pubitemid 19059652)
218. + channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. J Biol Chem 2002;277:44938-45. (Pubitemid 36159091)
219. + channels in the insulin-secreting cell line INS-1. Pflugers Arch 2001;442: 49-56. (Pubitemid 32336825)
220. + channels and their significance for action potential repolarization in mouse pancreatic beta-cells. J Gen Physiol 1990;95:1041-59. (Pubitemid 20217302)
221. Herrington J, Sanchez M, Wunderler D, Yan L, Bugianesi RM, Dick IE, Clark SA, Brochu RM, Priest BT, Kohler MG, McManus OB. Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells. J Physiol 2005;567: 159-75. (Pubitemid 41167313)
222. + channels in the control of glucoseinduced electrical activity in pancreatic B-cells. Pflügers Arch 1990;416:568-72.
223. Xia F, Gao X, Kwan E, Lam PP, Chan L, Sy K, Sheu L, Wheeler MB, Gaisano HY, Tsushima RG. Disruption of pancreatic beta-cell lipid rafts modifies KV2.1 channel gating and insulin exocytosis. J Biol Chem 2004;279: 24685-91. (Pubitemid 38725336)
224. Herrington J. Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon 2007;49:231-38. (Pubitemid 46148996)
225. Kim SJ, Choi WS, Han JS, Warnock G, Fedida D, McIntosh CH. A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. J Biol Chem 2005;280:28692-700. (Pubitemid 41105770)
226. + currents in beta-cells: a possible glucosedependent insulinotropic mechanism. Diabetes 51 Suppl 2002;3:S443-7. (Pubitemid 35403428)
227. V2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem 2007;282:7442-9. (Pubitemid 47093692)
228. 2beta-null mice. Am J Physiol Endocrinol Metab 2008;294: E217-29. (Pubitemid 351231446)
229. V channel in the insulin-secreting RINm5F cell. J Gen Physiol 1988;92:219-37.
230. Satin LS, Hopkins WF, Fatherazi S, Cook DL. Expression of a rapid, low-voltage threshold K current in insulin-secreting cells is dependent on intracellular calcium buffering. J Membr Biol 1989;112:213-22. (Pubitemid 20011369)
231. Ca channel is not involved in glucose-induced electrical activity in pancreatic beta-cells. J Membr Biol 1991;119: 187-95.
232. Ishii TM, Silvia C, Hirschberg B, Bond CT, Adelman JP, Maylie J. A human intermediate conductance calcium-activated potassium channel. Proc Natl Acad Sci U S A 1997;94:11651-56. (Pubitemid 127650718)
233. Düfer M, Gier B, Wolpers D, Ruth P, Krippeit Drews P, Drews G. SK4 channels are involved in the regulation of glucose homeostasis and pancreatic beta-cell function. Diabetes, 2009;58:1835-43.
234. + channels are expressed in pancreatic islets and regulate glucose responses. Diabetes 2003;52: 2000-6. (Pubitemid 36919792)
235. + channel in the cell membrane of mouse intestinal smooth muscle. Biochim Biophys Acta 1998;1371: 309-16. (Pubitemid 28269269)
236. + channel. Am J Physiol 1998;275:C848-56. (Pubitemid 28436048)
237. Ledoux J, Werner ME, Brayden JE, Nelson MT. Calcium-activated potassium channels and the regulation of vascular tone. Physiology 2006;21:69-78.
238. + current in insulin-secreting murine betaTC-3 cells. J Physiol 1998;509 (Pt 2):355-370. (Pubitemid 28286995)
239. slow tail current and modulate insulin secretion. J Gen Physiol 2005;126:353-63. (Pubitemid 41362654)
240. -/- mice. Diabetologia 2005;48:913-21. (Pubitemid 40767985)
241. 2+: experimental and theoretical studies. J Gen Physiol 2002;120:307-22. (Pubitemid 35014731)
242. ATP-channel modulation. J Physiol 2002;545:501-7. (Pubitemid 36004384)
243. Atwater I, Ribalet B, Rojas E. Mouse pancreatic beta-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization. J Physiol 1979;288:561-7.
244. Herrington J, Zhou YP, Bugianesi RM, Dulski PM, Feng Y, Warren VA, Smith MM, Kohler MG, Garsky VM, Sanchez M, Wagner M, Raphaelli K, Banerjee P, Ahaghotu C, Wunderler D, Priest BT, Mehl JT, Garcia ML, McManus OB, Kaczorowski GJ, Slaughter RS. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes 2006;55:1034-42. (Pubitemid 44100179)
245. V2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab 2007;6:229-35. (Pubitemid 47324137)
246. Ribalet B, Beigelman PM. Calcium action potentials and potassium permeability activation in pancreatic beta-cells. Am J Physiol 1980;239:C124-33. (Pubitemid 10004718)
247. + conductance in glucose-stimulated pancreatic beta-cells. Nature 1991;353:849-52. (Pubitemid 21912639)
248. Atwater I, Dawson CM, Scott A, Eddlestone G, Rojas E. The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell. Horm Metab Res Suppl Suppl 1980;10:100-7.
249. 2+ contributes to oscillations of the membrane potential in pancreatic beta-cells. Diabetes 2002;51:376-84. (Pubitemid 34764792)
250. Krippeit-Drews P, Düfer M, Drews G. Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells. Biochem Biophys Res Commun 2000;267:179-83. (Pubitemid 30072527)
251. 2+ channels. Pflugers Arch 1993;424:439-47. (Pubitemid 23279906)
252. Pressel DM, Misler S. Role of voltage-dependent ionic currents in coupling glucose stimulation to insulin secretion in canine pancreatic islet B-cells. J Membr Biol 1991;124: 239-53.
253. Pressel DM, Misler S. Sodium channels contribute to action potential generation in canine and human pancreatic islet B cells. J Membr Biol 1990;116:273-80. (Pubitemid 20222704)
254. Britsch S, Krippeit-Drews P, Gregor M, Lang F, Drews G. Effects of osmotic changes in extracellular solution on electrical activity of mouse pancreatic B-cells. Biochem Biophys Res Commun 1994;204:641-5.
255. - channel current that is activated by cell swelling, cAMP, and glyburide in insulin-secreting cells. Diabetes 1995;44: 1461-6.
256. Best L, Miley HE, Yates AP. Activation of an anion conductance and beta-cell depolarization during hypotonically induced insulin release. Exp Physiol 1996;81: 927-33. (Pubitemid 26401773)
257. Drews G, Zempel G, Krippeit-Drews P, Britsch S, Busch GL, Kaba NK, Lang F. Ion channels involved in insulin release are activated by osmotic swelling of pancreatic B-cells. Biochim Biophys Acta 1998;1370:8-16. (Pubitemid 28164187)
258. Best L. Cell-attached recordings of the volume-sensitive anion channel in rat pancreatic beta-cells. Biochim Biophys Acta 1999;1419:248-56. (Pubitemid 29322714)
259. Best L. Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells. Pflügers Arch 2002;445:97-104. (Pubitemid 35370420)
260. Best L, Benington S. Effects of sulphonylureas on the volume-sensitive anion channel in rat pancreatic beta-cells. Br J Pharmacol 1998;125:874-8. (Pubitemid 28482632)
261. Best L, Brown PD, Sheader EA, Yates AP. Selective inhibition of glucose-stimulated betacell activity by an anion channel inhibitor. J Membr Biol 2000;177:169-75.
262. Best L, Brown PD, Tomlinson S. Anion fluxes, volume regulation and electrical activity in the mammalian pancreatic beta-cell. Exp Physiol 1997;82:957-66. (Pubitemid 27503431)
263. Best L, Davies S, Brown PD. Tolbutamide potentiates the volume-regulated anion channel current in rat pancreatic beta cells. Diabetologia 2004;47:1990-7. (Pubitemid 40110211)
264. Best L, Miley HE, Brown PD, Cook LJ. Methylglyoxal causes swelling and activation of a volume-sensitive anion conductance in rat pancreatic beta-cells. J Membr Biol 1999;167: 65-71. (Pubitemid 29031726)
265. Best L, Sheader EA, Brown PD. A volume-activated anion conductance in insulin-secreting cells. Pflügers Arch 1996;431:363-70.
266. Best L, Speake T, Brown P. Functional characterisation of the volume-sensitive anion channel in rat pancreatic beta-cells. Exp Physiol 2001;86:145-50. (Pubitemid 32266446)
267. Best L, Yates AP, Decher N, Steinmeyer K, Nilius B. Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur J Pharmacol 2004;489:13-9. (Pubitemid 38520066)
268. Miley HE, Brown PD, Best L. Regulation of a volume-sensitive anion channel in rat pancreatic beta-cells by intracellular adenine nucleotides. J Physiol 1999;515 (Pt 2):413-7. (Pubitemid 29129212)
269. Jakab M, Grundbichler M, Benicky J, Ravasio A, Chwatal S, Schmidt S, Strbak V, Furst J, Paulmichl M, Ritter M. Glucose induces anion conductance and cytosol-to-membrane transposition of ICln in INS-1E rat insulinoma cells. Cell Physiol Biochem 2006;18:21-34.
270. Jacobson DA, Philipson LH. TRP channels of the pancreatic beta cell. Handb Exp Pharmacol:409-24.
271. Sakura H, Ashcroft FM. Identification of four trp1 gene variants murine pancreatic betacells. Diabetologia 1997;40:528-32. (Pubitemid 27186788)
272. 2+]i oscillations in transgenically derived beta-cells. J Biol Chem 1998;273:10402-10. (Pubitemid 28227649)
273. Qian F, Huang P,Ma L, Kuznetsov A, Tamarina N, Philipson LH. TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes 2002;51 Suppl 1:S183-9. (Pubitemid 34761515)
274. 2+ signaling events in pancreatic beta-cells. FASEB J 2005;19:301-3. (Pubitemid 40189289)
275. 2+ in pancreatic beta-cells exhibits graded dependence on the filling of the endoplasmic reticulum. J Cell Sci 2001;114: 2179-86. (Pubitemid 32586642)
276. 2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells. J Biol Chem 1994;269:32055-8.
277. Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, Fleig A, Penner R. TRPM4 controls insulin secretion in pancreatic beta-cells. Cell Calcium 2007;41:51-61. (Pubitemid 44872619)
278. 2+]i. Proc Natl Acad Sci U S A 2003;100: 15166-71. (Pubitemid 37518034)
279. + current by muscarinic receptors in mouse pancreatic beta-cells. J Biol Chem 2002;277:38373-80. (Pubitemid 35154693)
280. Leech CA, Habener JF. Insulinotropic glucagon-like peptide-1-mediated activation of nonselective cation currents in insulinoma cells is mimicked by maitotoxin. J Biol Chem 1997;272:17987-93. (Pubitemid 27306376)
281. i associated with insulin secretion in pancreatic beta-cells. Am J Physiol Endocrinol Metab 2003;285:E1001-9. (Pubitemid 37296321)
282. + ATP current in intact mouse pancreatic B-cells. Biochem Biophys Res Commun 1995;207: 33-39.
283. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J. Transient receptor potentialM3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 2008;10:1421-30.
284. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 2006;25:1804-15.
285. Akiba Y, Kato S, Katsube K, Nakamura M, Takeuchi K, Ishii H, Hibi T. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 2004;321:219-25. (Pubitemid 39055627)
286. Noma A, Yanagihara K, Irisawa H. Inward current of the rabbit sinoatrial node cell. Pflügers Arch 1977;372:43-51. (Pubitemid 8226018)
287. Yanagihara K, Irisawa H. Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflügers Arch 1980;385:11-9. (Pubitemid 10102676)
288. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarizationactivated mammalian cation channels. Nature 1998;393:587-91. (Pubitemid 28319249)
289. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 1998;93:717-29. (Pubitemid 28257579)
290. Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB. Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A 1999;96:9391-6. (Pubitemid 29374765)
291. Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003;65:453-80. (Pubitemid 38249163)
292. Debuyser A, Drews G, Henquin JC. Adrenaline inhibition of insulin release: role of cyclic AMP. Mol Cell Endocrinol 1991;78:179-86.
293. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol 2007;21:753-64.
294. m glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. J Biol Chem 1990;265:6548-51.
295. Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000;49:1751-60.
296. Aizawa T, Sato Y, Komatsu M. Importance of nonionic signals for glucose-induced biphasic insulin secretion. Diabetes 51 Suppl 2002;1:S96-98. (Pubitemid 34761501)
297. + channels: a link between B-cell metabolism and insulin secretion. Biochem Soc Trans 1990;18:109-11. (Pubitemid 20048498)
298. Kennedy ED, Wollheim CB. Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release. Diabetes Metab 1998;24: 15-24. (Pubitemid 28097881)
299. Kennedy RT, Kauri LM, Dahlgren GM, Jung SK. Metabolic oscillations in beta-cells. Diabetes 2002;51 Suppl 1:S152-61.
300. 2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets. Biochem J 1998;333 (Pt 2):269-74.
301. 2+ concentration in the pancreatic beta cell. Proc Natl Acad Sci U S A 1996;93:5161-65.
302. 2+ concentration precede oscillations in mitochondrial membrane potential in the pancreatic beta-cell. J Biol Chem 2001;276:34530-36.
303. 2+ controls slow NAD(P)H oscillations in glucosestimulated mouse pancreatic islets. J Physiol 2006;572:379-92.
304. Chay TR, Keizer J. Minimal model for membrane oscillations in the pancreatic beta-cell. Biophys J 1983;42: 181-90.
305. Magnus G, Keizer J. Model of beta-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables. Am J Physiol 1998;274:C1158-73.
306. Bertram R, Sherman A. A calcium-based phantom bursting model for pancreatic islets. Bull Math Biol 2004;66:1313-44. (Pubitemid 39033608)
307. + channels in beta cells. Endocrinology 1999;140: 2252-57. (Pubitemid 30636466)
308. ATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic beta-cell. Endocr J 2001;48: 275-88. (Pubitemid 32625879)
309. + channels owing to a knockout of the pore-forming subunit Kir6.2. Endocrinology 2009;150:33-45.
310. +-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells. Pflügers Arch 2009;457:1351-60.
311. Holz GGt, Kuhtreiber WM, Habener JF. Pancreatic beta-cells are rendered glucosecompetent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993;361:362-5. (Pubitemid 23041630)
312. Gromada J, Bokvist K, Ding WG, Holst JJ, Nielsen JH, Rorsman P. Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling. Diabetes 1998;47:57-65. (Pubitemid 28030808)
313. Light PE, Manning Fox JE, Riedel MJ, Wheeler MB. Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Mol Endocrinol 2002;16:2135-44. (Pubitemid 35013461)
314. 2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes 1998;47: 1066-73. (Pubitemid 28294549)
315. +- dependent manner. Regul Pept 1996;62:23-7. (Pubitemid 26146195)
316. 2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner. Diabetes 1997;46:1755-60. (Pubitemid 27456407)
317. Gromada J, Dissing S, Bokvist K, Renstrom E, Frokjaer-Jensen J, Wulff BS, Rorsman P. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization. Diabetes 1995;44:767-74.
318. Gilon P, Henquin JC. Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev 2001;22:565-604. (Pubitemid 32958576)
319. Ullrich S, Wollheim CB. GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels. J Biol Chem 1988;263:8615-20.
320. + channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO J 1989;8:413-20. (Pubitemid 19274958)
321. ATP channel. J Biol Chem 2008;283:5306-16.
322. ATP channels. Am J Physiol Endocrinol Metab 2004;286:E463-71. (Pubitemid 38292698)
323. 2+ pools. Biochem Biophys Res Commun 1996;224:67-73. (Pubitemid 26252412)
324. 2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms. J Physiol 1997;503 (Pt 2):387-98. (Pubitemid 27423363)
325. 2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells. J Membr Biol 2004;197:59-70. (Pubitemid 38221963)
326. Leibiger IB, Berggren PO. Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr 2008;28:233-51.
327. + channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway. Diabetes 2001;50:2192-8. (Pubitemid 33641900)
328. Persaud SJ, Asare-Anane H, Jones PM. Insulin receptor activation inhibits insulin secretion from human islets of Langerhans. FEBS Lett 2002;510:225-8. (Pubitemid 34093830)
329. 2+ channels. J Gen Physiol 1997;110:217-28. (Pubitemid 27388115)
330. Barg S, Galvanovskis J, Göpel SO, Rorsman P, Eliasson L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 2000;49:1500-10.
331. + channels. J Physiol 2000;528:509-20.
332. Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, Ostenson CG, Smith PA. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 1989;341:233-6. (Pubitemid 19231723)
333. Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler MB, Wang Q. Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells. Diabetologia 2008;51:2290-8.
334. Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Köhler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metab 2008;7:545-54. (Pubitemid 351729201)
335. + channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors. J Biol Chem 1993;268:15221-8. (Pubitemid 23206678)
336. + channels in alpha-TC glucagonoma and beta-TC insulinoma cells. Diabetes 1993;42: 1760-72. (Pubitemid 23346413)
337. + channels in rat pancreatic A-cells. Pflugers Arch 1999;438: 428-36. (Pubitemid 29419895)
338. Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, Gaisano HY. Electrophysiological characterization of pancreatic islet cells in the mouse insulin promotergreen fluorescent protein mouse. Endocrinology 2005;146:4766-75. (Pubitemid 41446614)
339. Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007;28:84-116. (Pubitemid 46220851)
340. Ravier MA, Rutter GA. Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 2005;54:1789-97. (Pubitemid 40770769)
341. ATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology 2006;147:2155-62.
342. Zhou H, Zhang T, Harmon JS, Bryan J, Robertson RP. Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Diabetes 2007;56:1107-12. (Pubitemid 46525066)
343. Göpel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterisation of somatostatinsecreting d-cells in intact mouse pancreatic islets. J Physiol 2000;528:497-507.
344. + channel. FEBS Lett 1999;444:265-69. (Pubitemid 29092815)
345. 2+-dependent action potentials. J Gen Physiol 1988;91: 223-42. (Pubitemid 18073678)
346. Vignali S, Leiss V, Karl R, Hofmann F, Welling A. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J Physiol 2006;572: 691-706.
347. Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J. Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulussecretion coupling in beta-cells. Endocrinology 2005;146:4861-70. (Pubitemid 41446624)
348. Bailey SJ, Ravier MA, Rutter GA. Glucose-dependent regulation of gamma-aminobutyric acid (GABAA) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 2007;56: 320-27.
349. Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, Sewing S, Rorsman P, Braun M. Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes 2004;53:1038-45. (Pubitemid 38436616)
350. Xu E, Kumar M, Zhang Y, Ju W, Obata T, Zhang N, Liu S, Wendt A, Deng S, Ebina Y, Wheeler MB, Braun M, Wang Q. Intra-islet insulin suppresses glucagon release via GABAGABAA receptor system. Cell Metab 2006;3:47-58.
351. Gaskins HR, Baldeon ME, Selassie L, Beverly JL. Glucose modulates gamma-aminobutyric acid release from the pancreatic beta TC6 cell line. J Biol Chem 1995;270:30286-9.
352. 2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells. Acta Physiol Scand 1987;131:230-4. (Pubitemid 18058417)
353. -/- mouse alpha-cells. Diabetes 53 Suppl 2004;3:S181-9. (Pubitemid 39564542)
354. Hjortoe GM, Hagel GM, Terry BR, Thastrup O, Arkhammar PO. Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans. Acta Diabetol 2004;41:185-93. (Pubitemid 40174995)
355. Manning Fox JE, Gyulkhandanyan AV, Satin LS,Wheeler MB. Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology 2006; 147:4655-63. (Pubitemid 44402171)
356. Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005;54:1808-15. (Pubitemid 40770771)
357. 2+]c by different mechanisms in isolated mouse alpha-cells. Diabetes 2009;58:412-21.
358. ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007;5:e143.
359. Kanno T, Göpel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet. Neurosci Res 2002;42:79-90. (Pubitemid 34155365)
360. 2+-induced insulin secretion in permeabilized HIT-T15 cells. Biochem J 1990;270:273-6. (Pubitemid 20275609)
361. Wollheim CB, Winiger BP, Ullrich S, Wuarin F, Schlegel W. Somatostatin inhibition of hormone release: effects on cytosolic Ca++ and interference with distal secretory events. Metabolism 1990;39:101-4. (Pubitemid 20286346)
362. Schuit FC, Derde MP, Pipeleers DG. Sensitivity of rat pancreatic A and B cells to somatostatin. Diabetologia 1989;32:207-12. (Pubitemid 19117103)
363. 2+ signaling. Endocrinology 1996;137:693-7.
364. + channel subunit Kir6.2 in mouse pancreas. Diabetes 1997;46:1440-4. (Pubitemid 27369081)
365. Suzuki M, Fujikura K, Kotake K, Inagaki N, Seino S, Takata K. Immuno-localization of sulphonylurea receptor 1 in rat pancreas. Diabetologia 1999;42:1204-11. (Pubitemid 29459817)
366. + channels and capability to secrete insulin under conditions where it no longer secretes somatostatin. FEBS Lett 1997;411:301-7. (Pubitemid 27301474)
367. Efendic S, Enzmann F, Nylen A, Uvnas-Wallensten K, Luft R. Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas. Proc Natl Acad Sci U S A 1979;76:5901-4. (Pubitemid 10216684)
368. Nadal A, Quesada I, Soria B. Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse. J Physiol 1999;517 (Pt 1):85-93. (Pubitemid 29243473)
369. Quesada I, Nadal A, Soria B. Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans. Diabetes 1999;48:2390-7. (Pubitemid 30395431)
370. 2+-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat Cell Biol 2007;9:453-60. (Pubitemid 46511079)