Structural determinants of PIP2 regulation of inward rectifier K(ATP) channels

Journal of General Physiology

Volumn 116, Issue 5, 2000, Pages 599-607

  Shyng, S L ^a   Cukras, C A ^a   Harwood, J ^a   Nichols, C G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP; Kir6.2; PH domain; Phospholipid; Potassium channel

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID; LIGAND; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM; POTASSIUM CHANNEL; RUBIDIUM 86;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; COMPETITION; LIGAND BINDING; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; CELL CULTURE TECHNIQUES; HUMANS; LIGANDS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POINT MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033756604     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.116.5.599     Document Type: Article

References (41)

1. Cloning of the β-cell high affinity sulfonylurea receptor: A regulator of insulin secretion
2. Adenosine 5'-triphosphate-sensitive potassium channels
3. 2 and PIP as determinants for ATP inhibition of K-ATP channels
4. Inward rectification in K(ATP) channels: A pH switch in the pore
5. Cloning and expression of two brain-specific inwardly rectifying potassium channels
6. Association and stoichiometry of K(ATP) channel subunits
7. + channel that is sensitive to ATP
8. K(ATP) channel inhibition by ATP requires distinct functional domains of the cytoplasmic C-terminus of the pore-forming subunit
9. The kinetic and physical basis of K(ATP) channel gating: Towards a unified molecular understanding
10. Anionic phospholipids activate ATP-sensitive potassium channels
11. + channel. A molecular probe for the mechanism of ATP-sensitive inhibition
12. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide
13. 2
14. 2 and its stabilization by G-beta-gamma
15. Reconstitution of IK(ATP): An inward rectifier subunit plus the sulfonylurea receptor
16. + channel
17. ATP inhibition of K(ATP) channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit
18. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
19. Structure and dynamics of the pore of inward rectifier K(ATP) channels
20. Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel
21. + channel (ROMK2)
22. ATP-sensitive potassium channels in the cardiovascular system
23. Adenosine diphosphate as an intracellular regulator of insulin secretion
24. The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells
25. Pleckstrin homology domains: A common fold with diverse functions
26. PHD: Predicting one-dimensional protein structure by profile-based neural networks
27. The pleckstrin homology domain: An intriguing multifunctional protein module
28. Octameric stoichiometry of the K(ATP) channel complex
29. Phosphatidyl inositol phosphates control of nucleotide-sensitivity of K(ATP) channels
30. Control of rectification and gating of cloned K(ATP) channels by the Kir6.2 subunit
31. Regulation of K(ATP) channel activity by diazoxide and MgADP: Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
32. Functional analyses of novel mutations of the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy
33. Modulation of nucleotide sensitivity, of K(ATP) channels by PI-4-P 5-kinase
34. + channel by 8-azido-ATP
35. Molecular analysis of K(ATP) channel gating and implications for channel inhibition by ATP
36. + channels in the absence of the sulphonylurea receptor
37. Molecular determinants of K-ATP channel inhibition by ATP
38. Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism
39. + channel
40. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels
41. + channels by distinct PtdIns (4,5)P-2 interactions