Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 2, 2008, Pages

  Bao, Shunzhong ^a   Jacobson, David A ^b   Wohltmann, Mary ^a   Bohrer, Alan ^a   Jin, Wu ^a   Philipson, Louis H ^b   Turk, John ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Glucose tolerance; Insulin tolerance; Transgenic mice

Indexed keywords

ARACHIDONIC ACID; CYCLIC AMP; DELAYED RECTIFIER POTASSIUM CHANNEL; GLUCOSE; INSULIN; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 BETA; SHAB POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL LINE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; INSULIN RELEASE; INSULINOMA; LIPID COMPOSITION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHOLIPID METABOLISM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ANIMALS; ARACHIDONIC ACID; BLOOD GLUCOSE; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; DNA, COMPLEMENTARY; FASTING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; GLUCOSE TOLERANCE TEST; GROUP IV PHOSPHOLIPASES A2; HOMEODOMAIN PROTEINS; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; ISLETS OF LANGERHANS; KV1.2 POTASSIUM CHANNEL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; PANCREATIC NEOPLASMS; PATCH-CLAMP TECHNIQUES; PHOSPHOLIPIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANS-ACTIVATORS;

EID: 38949151226     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00474.2007     Document Type: Article

References (77)

1. 2+ concentration in pancreatic beta cells. J Biol Chem 262: 5448-5454, 1987.
2. Baburina I, Jackowski S. Cellular responses to excess phospholipid. J Biol Chem 274: 9400-9408, 1999.
3. 2 enzymes from P388D1 macrophages and Chinese hamster ovary cells. J Biol Chem 272: 8576-8580, 1997.
4. 2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem 272: 29317-29321, 1997.
5. 2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells. J Biol Chem 281: 187-198, 2006.
6. 2β movements in response to stimulation with insulin secretagogues in INS-1 cells. Diabetes 53: S186-S189, 2004.
7. 2. J Biol Chem 282: 27100-27114, 2007.
8. 2 produce spermatozoa with impaired motility and have greatly reduced fertility. J Biol Chem 279: 38194-38200, 2004.
9. 2 and effects of metabolic stress on glucose homeostasis. J Biol Chem 281: 20958-20973, 2006.
10. Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 114: 928-936, 2004.
11. Brash AR. Arachidonic acid as a bioactive molecule. J Clin Invest 107: 1339-1345, 2001.
12. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003.
13. Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF. "New" hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1: 309-322, 2005.
14. + channels in pancreatic β-cells. Nature 311: 271-273, 1984.
15. Devendra D, Liu E, Eisenbarth GS. Type I diabetes: recent developments. Br Med J 328: 750-754, 2004.
16. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Intensive treatment and cardiovascular disease in patients with type I diabetes. N Engl J Med 353: 2643-2653, 2005.
17. 2+ stores and plasma membrane ion channels. Curr Opin Endocrinol Diabetes 4: 262-271, 1997.
18. 2 action in the insulin-secreting HIT cell line. Am J Physiol Cell Physiol 268: C181-C190, 1995.
19. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283: 981-985, 1999.
20. Garvey WT. Glucose transport and NIDDM. Diabetes Care 15: 396-417, 1992.
21. Ghosh A, Ronner P, Cheong E, Khalid P, Matschinsky FM. The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet β-cells in isolated perfused rat pancreas. J Biol Chem 266: 22887-22892, 1991.
22. 2. J Cell Biol 145: 1219-1232, 1999.
23. 2+ influx in electrically excitable pancreatic beta cells. J Biol Chem 274: 20197-20205, 1999.
24. Hohmeier HE, BeltrandelRio H, Clark SA, Henkel-Tieger R, Normington K, Newgard CB. Regulation of insulin secretion from novel engineered insulinoma cell lines. Diabetes 46: 968-977, 1997.
25. Hsu FF, Bohrer A, Turk J. Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry. J Am Soc Mass Spectrom 9: 516-526, 1998.
26. Hsu FF, Turk J, Thukkani AK, Messner MC, Wildsmith KR, Ford DA. Characterization of alkylacyl-, alk-1-enylacyl, and lyso subclasses of glycerophosphocholine lipids by tandem quadrupole mass spectrometry with electrospray ionization. J Mass Spectrom 38: 752-763, 2003.
27. 2-deficient mice. Am J Physiol Endocrinol Metab 283: E994-E1001, 2002.
28. Jacobson DA, Kuznetsov A, James Lopez JP P, Kash S, Ämmälä CE, Louis H, Philipson LH. Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab 6: 229-235, 2007.
29. Jacobson DA, Webber C, Bao S, Turk J, Philipson LH. Modulation of the pancreatic islet beta cell delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem 282: 7442-7449, 2007.
30. 2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-48975, 2004.
31. 2 and insulin secretion in pancreatic islets. Biochim Biophys Acta 1135: 215-220, 1992.
32. 2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia. Diabetes 55: 935-941, 2006.
33. Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 281: 2649-53, 2006.
34. 2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin. J Biol Chem 272: 11118-11127, 1997.
35. 2β. J Biol Chem 276: 13198-13208, 2001.
36. 2+-independent phospholipase. Prog Nucleic Acid Res Mol Biol 67: 1-33, 2001.
37. 2 gene on chromosome 22q13.1. J Biol Chem 274: 9607-9616, 1999.
38. 2β in INS-1 insulinoma cells. Am J Physiol Endocrinol Metab 282: E820-E833, 2002.
39. Matschinsky FM. Glucokinase, glucose homeostasis, and diabetes mellitus. Curr Diab Rep 5: 171-176, 2005.
40. Meglasson MD, Matschinsky FM. Pancreatic islet glucose metabolism and the regulation of insulin secretion. Diabetes Metab Rev 2: 163-214, 1986.
41. Metz SA. The pancreatic islet as Rubik's cube. Is phospholipid hydrolysis a piece of the puzzle?. Diabetes 40: 1565-1573, 1991.
42. Miles PDG, Barak Y, He W, Evans RM, Olefsky JM. Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency. J Clin Invest 105: 287-292, 2000.
43. Murphy RC, Barkley RM, Berry KZ, Hankin J, Harrison K, Johnson C, Krank J, McAnoy A, Uhlson C, Zarini S. Electrospray ionization and tandem mass spectrometry of eicosanoids. Anal Biochem 346: 1-42, 2005.
44. Narushima M, Kobayashi Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Tajeu K, Gutierrez AG, Rivas-Carillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JRT, Leboulch P, Tanaka N, Yoon JW. A human beta cell line for transplantation therapy to control type I diabetes. Nat Biotechnol 23: 1274-1282, 2005.
45. Newgard CB. While tinkering with the β-cell. Metabolic regulatory mechanisms and new therapeutic strategies. Diabetes 51: 3141-3150, 2002.
46. Newgard CB, Hohmeier HE, Lu D, Jensen MC, Tran VV, Chen G, Gasa R, Burgess S, Sherry AD. Understanding basic mechanisms of β-cell function and survival: prelude to new diabetes therapies. Cell Biochem Biophys 40: 159-168, 2004.
47. 2β. J Biol Chem 280: 24576-24583, 2005.
48. 2 and protein kinase C-dependent phosphorylation of the α-subunit. J Biol Chem 274: 2000-2008, 1999.
49. Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF. Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion. J Biol Chem 280: 9023-9029, 2005.
50. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67: 1185-1248, 1987.
51. Radu CG, Yang LV, Riedinger M, Au M, Witte ON. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci USA 101: 245-250, 2004.
52. Rae J, Cooper K, Gates P, Watsky M. Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods 37: 15-26, 1991.
53. 2+ concentration. Biochemistry 32: 337-346, 1993.
54. Ramanadham S, Gross R, Turk J. Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cells. Biochem Biophys Res Commun 184: 647-653, 1992.
55. 2) in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells. J Biol Chem 274: 13915-13927, 1999.
56. Ramanadham S, Hsu FF, Bohrer A, Nowatzke W, Ma Z, Turk J. Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes. Comparison to other tissues and implications for membrane fusion in insulin exocytosis. Biochemistry 37: 4553-4567, 1998.
57. 2 is contained in the insulin secretory granules of pancreatic islet beta cells and is co-secreted with insulin upon stimulation of islets with glucose. Biochim Biophys Acta 1390: 301-312, 1998.
58. Ravier MA, Eto K, Jonkers FC, Nenquin M, Kadowaki T, Henquin JC. The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout. J Biol Chem 275: 1587-1593, 2000.
59. Robertson RP. Islet transplantation as a treatment for diabetes. A work in progress. N Engl J Med 350: 694-705, 2004.
60. +-ATP channel-independent pathway of regulation of insulin secretion by glucose. In search of the underlying mechanism. Diabetes 47: 1713-1721, 1998.
61. Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev 85: 1303-1342, 2005.
62. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343: 230-238, 2000.
63. 2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets. Dissociation from the mechanism of carbachol. Diabetes 47: 1436-1443, 1998.
64. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488: 1-19, 2000.
65. Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, Bolotina VM. A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol 6: 113-120, 2004.
66. 2 results in insufficient insulin secretion and impaired glucose tolerance. Mol Endocrinol 19: 504-515, 2005.
67. 2 contains eight ankyrin motifs. J Biol Chem 272: 8567-8575, 1997.
68. + permeability without diminution by exogenous arachidonic acid. Biochem Pharmacol 53: 1077-1086, 1997.
69. Tran VV, Chen G, Newgard CB, Hohmeier HE. Discrete and complementary mechanisms of protection of β-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. Diabetes 52: 1423-1432, 2003.
70. Turk J, Gross R, Ramanadham S. Amplification of insulin secretion by lipid messengers. Diabetes 42: 367-374, 1993.
71. 2. J Biol Chem 273: 21926-21932, 1998.
72. 3 pituitary cells. Am J Physiol Endocrinol Metab 257: E203-E211, 1989.
73. van Tienhoven M, Atkins J, Li Y, Glynn P. Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem 277: 20942-20948, 2002.
74. 2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets. J Biol Chem 261: 3501-3511, 1986.
75. Wolf BA, Pasquale SM, Turk J. Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion. Biochemistry 30: 6372-6379, 1991.
76. Wollheim CB. Beta cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes. Diabetologia 43: 265-277, 2000.
77. + channel-independent pathway of glucose signaling in rat pancreatic islets. Diabetes 48: 1006-1012, 1999.