Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic β-cells

Journal of Physiology

Volumn 567, Issue 1, 2005, Pages 159-175

  Herrington, James ^a   Sanchez, Manuel ^b   Wunderler, Denize ^a   Yan, Lizhen ^a   Bugianesi, Randal M ^a   Dick, Ivy E ^a   Clark, Sam A ^c   Brochu, Richard M ^a   Priest, Birgit T ^a   Kohler, Martin G ^a   McManus, Owen B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSIDAD DE OVIEDO   (Spain)

^c BetaGene Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYL 4 [3 (2 METHOXYPHENYL) 3 OXO 2 AZAPROP 1 YL]CYCLOHEXANONE; AGITOXIN 2; CYCLOHEXANONE DERIVATIVE; GLUCOSE; HANATOXIN; INSULIN; KALIOTOXIN; MARGATOXIN; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; ARTHROPOD VENOM; DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL KV3.12; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; STEADY STATE; ACTION POTENTIAL AMPLITUDE; ACTIVATION TIME CONSTANT; CELL DENSITY; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; DEACTIVATION TIME CONSTANT; IC50; INACTIVATION TIME CONSTANT; MEMBRANE CURRENT; PROTEIN FUNCTION; RECOVERY TIME CONSTANT;

BIOPHYSICS; CELLS, CULTURED; CYCLOHEXANONES; DELAYED RECTIFIER POTASSIUM CHANNELS; HUMANS; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; SCORPION VENOMS; TETRAETHYLAMMONIUM;

EID: 23844541276     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.089375     Document Type: Article

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