Kir6.2-dependent high-affinity repaglinide binding to β-cell K ATP channels

British Journal of Pharmacology

Volumn 144, Issue 4, 2005, Pages 551-557

  Hansen, Ann Maria K ^a   Hansen, John Bondo ^a   Carr, Richard D ^a   Ashcroft, Frances M ^b   Wahl, Philip ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Binding; Co expression; Coupling; Glibenclamide; Kir6.2; Repaglinide; SUR1

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; NATEGLINIDE; REPAGLINIDE; SULFONYLUREA; SULFONYLUREA RECEPTOR; TOLBUTAMIDE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING, COMPETITIVE; CARBAMATES; CELL LINE; CELL MEMBRANE; DRUG INTERACTIONS; HUMANS; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; MICE; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG;

EID: 14844292137     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706082     Document Type: Article

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