메뉴 건너뛰기




Volumn 22, Issue 15, 2003, Pages 3844-3854

Impaired insulin secretion and glucose tolerance in β cell-selective Cav1.2 Ca2+ channel null mice

Author keywords

Ca2+ channels; Diabetes; Exocytosis; Insulin secretion; Pancreatic cells

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM CHANNEL R TYPE; GLUCOSE;

EID: 0043076321     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg389     Document Type: Article
Times cited : (200)

References (43)
  • 1
    • 0024917106 scopus 로고
    • Electrophysiology of the pancreatic β-cell
    • Ashcroft, F.M. and Rorsman, P. (1989) Electrophysiology of the pancreatic β-cell. Prog. Biophys. Mol. Biol., 54, 87-143.
    • (1989) Prog. Biophys. Mol. Biol. , vol.54 , pp. 87-143
    • Ashcroft, F.M.1    Rorsman, P.2
  • 2
    • 0018657067 scopus 로고
    • Potassium permeability activated by intracellular calcium ion concentration in the pancreatic β cell
    • Atwater, I., Dawson, C.M., Ribalet, B. and Rojas, E. (1979) Potassium permeability activated by intracellular calcium ion concentration in the pancreatic β cell. J. Physiol., 288, 575-588.
    • (1979) J. Physiol. , vol.288 , pp. 575-588
    • Atwater, I.1    Dawson, C.M.2    Ribalet, B.3    Rojas, E.4
  • 3
    • 0033850226 scopus 로고    scopus 로고
    • Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting α-cells
    • Barg, S., Galvanovskis, J., Göpel, S., Rorsman, P. and Eliasson, L. (2000) Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting α-cells. Diabetes, 49, 1500-1510.
    • (2000) Diabetes , vol.49 , pp. 1500-1510
    • Barg, S.1    Galvanovskis, J.2    Göpel, S.3    Rorsman, P.4    Eliasson, L.5
  • 4
    • 0035201145 scopus 로고    scopus 로고
    • 2+ channels in insulin-secreting mouse pancreatic B cells
    • 2+ channels in insulin-secreting mouse pancreatic B cells. Biophys. J., 81, 3308-3323.
    • (2001) Biophys. J. , vol.81 , pp. 3308-3323
    • Barg, S.1
  • 6
    • 0028984692 scopus 로고
    • 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells
    • 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells. EMBO J., 14, 50-57.
    • (1995) EMBO J. , vol.14 , pp. 50-57
    • Bokvist, K.1    Eliasson, L.2    Ämmälä, C.3    Renström, E.4    Rorsman, P.5
  • 7
    • 0036310679 scopus 로고    scopus 로고
    • Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion
    • Bratanova-Tochkova, T.K. et al. (2002) Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes, 51, S83-S90.
    • (2002) Diabetes , vol.51
    • Bratanova-Tochkova, T.K.1
  • 8
    • 0014336473 scopus 로고
    • Dynamics of insulin secretion by the perfused rat pancreas
    • Curry, D.L., Bennett, L.L. and Grodsky, G.M. (1968) Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology, 83, 572-584.
    • (1968) Endocrinology , vol.83 , pp. 572-584
    • Curry, D.L.1    Bennett, L.L.2    Grodsky, G.M.3
  • 11
    • 17344371519 scopus 로고    scopus 로고
    • A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
    • Hager, J. et al. (1998) A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat. Genet., 20, 304-308.
    • (1998) Nat. Genet. , vol.20 , pp. 304-308
    • Hager, J.1
  • 12
    • 0021679735 scopus 로고
    • Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic β-cells
    • Henquin, J.C. and Meissner, H.P. (1984) Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic β-cells. Experientia, 40, 1043-1052.
    • (1984) Experientia , vol.40 , pp. 1043-1052
    • Henquin, J.C.1    Meissner, H.P.2
  • 13
    • 0031942841 scopus 로고    scopus 로고
    • Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes
    • Pima Diabetes Genes Group
    • Imperatore, G., Hanson, R.L., Pettitt, D.J., Kobes, S., Bennett, P.H. and Knowler, W.C. (1998) Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group. Diabetes, 47, 821-830.
    • (1998) Diabetes , vol.47 , pp. 821-830
    • Imperatore, G.1    Hanson, R.L.2    Pettitt, D.J.3    Kobes, S.4    Bennett, P.H.5    Knowler, W.C.6
  • 16
    • 0036319126 scopus 로고    scopus 로고
    • Contribution of known and unknown susceptibility genes to early-onset diabetes in Scandinavia: Evidence for heterogeneity
    • Lindgren, C.M. et al. (2002) Contribution of known and unknown susceptibility genes to early-onset diabetes in Scandinavia: evidence for heterogeneity. Diabetes, 51, 1609-1617.
    • (2002) Diabetes , vol.51 , pp. 1609-1617
    • Lindgren, C.M.1
  • 17
    • 0035856942 scopus 로고    scopus 로고
    • Mitochondrial funtion in normal and diabetic β-cells
    • Maechler, P. and Wollheim, C.B. (2001) Mitochondrial funtion in normal and diabetic β-cells Nature, 414, 807-812.
    • (2001) Nature , vol.414 , pp. 807-812
    • Maechler, P.1    Wollheim, C.B.2
  • 18
    • 0036311083 scopus 로고    scopus 로고
    • Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas
    • Maechler, P., Gjinovci, A. and Wollheim, C.B. (2002) Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas. Diabetes, 51, (Suppl. 1), S99-S102.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Maechler, P.1    Gjinovci, A.2    Wollheim, C.B.3
  • 19
    • 0036325596 scopus 로고    scopus 로고
    • Genetic approaches to the molecular understanding of type 2 diabetes
    • McCarthy, M.I. and Froguel, P. (2002) Genetic approaches to the molecular understanding of type 2 diabetes. Am. J. Physiol. Endocrinol. Metab., 283, E217-E225.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • McCarthy, M.I.1    Froguel, P.2
  • 20
    • 0033513495 scopus 로고    scopus 로고
    • Decreased expression of T-SNARE, syntaxin 1, and SNAP-25 in pancreatic β-cells is involved in impaired insulin secretion from diabetic GK rat islets: Restoration of decreased T-SNARE proteins improves impaired insulin secretion
    • Nagamatsu, S., Nakamichi, Y., Yamamura, C., Matsushima, S., Watanabe, T., Ozawa, S., Furukawa, H. and Ishida, H. (1999) Decreased expression of T-SNARE, syntaxin 1, and SNAP-25 in pancreatic β-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased T-SNARE proteins improves impaired insulin secretion. Diabetes, 48, 2367-2373.
    • (1999) Diabetes , vol.48 , pp. 2367-2373
    • Nagamatsu, S.1    Nakamichi, Y.2    Yamamura, C.3    Matsushima, S.4    Watanabe, T.5    Ozawa, S.6    Furukawa, H.7    Ishida, H.8
  • 21
    • 0034794289 scopus 로고    scopus 로고
    • D subunit in postnatal pancreatic β cell generation
    • D subunit in postnatal pancreatic β cell generation. J. Clin. Invest., 108, 1015-1022.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1015-1022
    • Namkung, Y.1
  • 22
    • 0032008553 scopus 로고    scopus 로고
    • 2+ microdomains: New tools for understanding their roles in neurotransmitter release
    • 2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron, 20, 389-399.
    • (1998) Neuron , vol.20 , pp. 389-399
    • Neher, E.1
  • 23
    • 17344373951 scopus 로고    scopus 로고
    • Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians
    • Norman, R.A. et al. (1998) Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians Am. J. Hum. Genet., 62, 659-668.
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 659-668
    • Norman, R.A.1
  • 25
    • 0035120347 scopus 로고    scopus 로고
    • A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
    • Parker, A. et al. (2001) A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11. Diabetes, 50, 675-680.
    • (2001) Diabetes , vol.50 , pp. 675-680
    • Parker, A.1
  • 27
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knockouts using Cre recombinase
    • Postic, C. et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knockouts using Cre recombinase. J. Biol. Chem., 274, 305-315.
    • (1999) J. Biol. Chem. , vol.274 , pp. 305-315
    • Postic, C.1
  • 28
    • 0032522927 scopus 로고    scopus 로고
    • An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
    • Pratley, R.E. et al. (1998) An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J. Clin. Invest., 101, 1757-1764.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1757-1764
    • Pratley, R.E.1
  • 29
    • 0025875235 scopus 로고
    • GABA and pancreatic β cells: Colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion
    • Reetz, A., Solimena, M., Matteoli, M., Folli, F., Takei, K. and De Camilli, P. (1991) GABA and pancreatic β cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J., 10, 1275-1284,
    • (1991) EMBO J. , vol.10 , pp. 1275-1284
    • Reetz, A.1    Solimena, M.2    Matteoli, M.3    Folli, F.4    Takei, K.5    De Camilli, P.6
  • 30
    • 11944258877 scopus 로고
    • 2+-but not for GTPγS-induced insulin secretion
    • 2+-but not for GTPγS-induced insulin secretion. EMBO J., 14, 2723-2730.
    • (1995) EMBO J. , vol.14 , pp. 2723-2730
    • Regazzi, R.1
  • 31
    • 0030004317 scopus 로고    scopus 로고
    • Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization
    • Renström, E., Eliasson, L., Bokvist, K. and Rorsman, P. (1996) Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J. Physiol., 494, 41-52.
    • (1996) J. Physiol. , vol.494 , pp. 41-52
    • Renström, E.1    Eliasson, L.2    Bokvist, K.3    Rorsman, P.4
  • 32
    • 0019417953 scopus 로고
    • Effects of divalent cations on β-cell electrical activity
    • Ribalet, B. and Beigelman, P.M. (1981) Effects of divalent cations on β-cell electrical activity. Am. J. Physiol., 241, 59-67.
    • (1981) Am. J. Physiol. , vol.241 , pp. 59-67
    • Ribalet, B.1    Beigelman, P.M.2
  • 34
    • 0033555490 scopus 로고    scopus 로고
    • Gastrectomy induces impaired insulin and glucagon secretion: Evidence for a gastro-insular axis in mice
    • Salehi, A., Chen, D., Håkansson, R., Nordin, G. and Lundquist, I. (1999) Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. J. Physiol., 514, 579-593.
    • (1999) J. Physiol. , vol.514 , pp. 579-593
    • Salehi, A.1    Chen, D.2    Håkansson, R.3    Nordin, G.4    Lundquist, I.5
  • 35
    • 0034671896 scopus 로고    scopus 로고
    • v1.2) calcium channel gene in the mouse
    • v1.2) calcium channel gene in the mouse. J. Biol. Chem., 275, 39193-3999.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39193-3999
    • Seisenberger, C.1
  • 37
    • 0035200172 scopus 로고    scopus 로고
    • Single nucleotide polymorphism (D68D, T to C) in the syntaxin 1A gene correlates to age at onset and insulin requirement in Type II diabetic patients
    • Tsunoda, K., Sanke, T., Nakagawa, T., Furuta, H. and Nanjo, K. (2001) Single nucleotide polymorphism (D68D, T to C) in the syntaxin 1A gene correlates to age at onset and insulin requirement in Type II diabetic patients. Diabetologia, 44, 2092-2097.
    • (2001) Diabetologia , vol.44 , pp. 2092-2097
    • Tsunoda, K.1    Sanke, T.2    Nakagawa, T.3    Furuta, H.4    Nanjo, K.5
  • 38
    • 0028817815 scopus 로고
    • Overview of 6 years therapy of type II diabetes: A progressive disease (UKPDS16)
    • UKPDS16 (United Kingdom Prospective Diabetes Study Group) (1995) Overview of 6 years therapy of type II diabetes: a progressive disease (UKPDS16). Diabetes, 44, 1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 39
    • 0035059731 scopus 로고    scopus 로고
    • 2+ channels and insulin secretion in the insulinoma cell line INS-1
    • 2+ channels and insulin secretion in the insulinoma cell line INS-1. Eur. J. Biochem., 268, 1066-1075.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 1066-1075
    • Vajna, R.1
  • 40
    • 0043227515 scopus 로고    scopus 로고
    • 2+ influx regulates growth plate chondrocyte maturation and apoptosis
    • in press
    • 2+ influx regulates growth plate chondrocyte maturation and apoptosis. J. Biol. Chem., in press.
    • (2002) J. Biol. Chem.
    • Wang, W.1    Xu, J.2    Kirsch, T.3
  • 42
    • 0033621137 scopus 로고    scopus 로고
    • 2+ channels in pancreatic β cells
    • 2+ channels in pancreatic β cells. Proc. Natl Acad. Sci. USA, 96, 10164-10169.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10164-10169
    • Yang, S.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.