Mechanisms and physiological significance of the cholinergic control of pancreatic β-cell function

Endocrine Reviews

Volumn 22, Issue 5, 2001, Pages 565-604

  Gilon, P ^a   Henquin, J C ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARACHIDONIC ACID; CALCIUM CHANNEL; DIACYLGLYCEROL; GLUCOSE; INSULIN; LYSOPHOSPHATIDYLCHOLINE; MUSCARINIC M3 RECEPTOR; NEUROTRANSMITTER; PHOSPHOLIPASE A2; RECEPTOR SUBTYPE;

CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL FUNCTION; CELL ORGANELLE; CHOLINERGIC SYSTEM; ENDOPLASMIC RETICULUM; EXOCYTOSIS; FEEDING; GLUCOSE METABOLISM; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MEMBRANE DEPOLARIZATION; NERVE ENDING; NEUROTRANSMISSION; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW;

ACETYLCHOLINE; ANIMALS; CHOLINERGIC FIBERS; HUMANS; INSULIN; ISLETS OF LANGERHANS; PARASYMPATHETIC NERVOUS SYSTEM; SYMPATHETIC NERVOUS SYSTEM;

EID: 0034786750     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.22.5.565     Document Type: Review

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268. Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic β cell in rats
269. Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice
270. Potentiated β-cell response to nonglucose stimuli in insulin-resistant C57BL/6Jmice
271. Cholinergic enhancement by pyridostigmine increases the insulin response to glucose load in obese patients but not in normal subjects
272. Peripheral insulin in response to the sight and smell of food
273. Influence of external and covert food stimuli on insulin secretion in obese and normal persons
274. Cephalic-phase insulin in obese and normal-weight men: Relation to postprandial insulin
275. Cephalic phase of insulin secretion in obese women
276. The pathogenesis of non-insulin-dependent diabetes: An update
277. Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes
278. Modulation of the effect of acetylcholine on insulin release by the membrane potential of B cells
279. Triggering and amplifying pathways of regulation of insulin secretion by glucose
280. Extracellular calcium and acetylcholine-stimulated insulin secretion
281. Extracellular calcium and adrenergic and cholinergic effects on islet β-cell function
282. The influence of calcium on the basal and acetylcholine-stimulated secretion of pancreatic polypeptide
283. 2+ uptake by rat pancreatic islets
284. Distinct effects of acetylcholine and glucose on 45-calcium and 86-rubidium efflux from mouse pancreatic islets
285. Cholinergic stimulation of ion fluxes in pancreatic islets
286. 2+ for acetylcholine stimulation of insulin release in mouse islets
287. 3 muscarinic receptors
288. 2+ as evidenced in single pancreatic islets
289. The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse
290. Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans
291. Regulation of inositol phospholipid-specific phospholipase C isozymes
292. Function of phospholipases in signal transduction
293. Mammalian phosphoinositide-specific phospholipase C
294. 2 in canine myocardium
295. Multiple pathways for signal transduction through the muscarinic cholinergic receptor
296. Is arachidonic acid a second messenger in signal transduction?
297. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
298. Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans
299. Characteristics of phosphoinositide-specific phospholipase C activity from mouse pancreatic islets
300. Glucose-induced desensitization of the pancreatic β-cell is species dependent
301. Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets: Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation
302. Stimulation of phosphoinositide breakdown in rat pancreatic islets by glucose and carbamylcholine
303. Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans
304. 2+ regulates the inositol tris/ tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells
305. Phosphoinositide phosphorylation and hydrolysis in pancreatic islet cell membrane
306. Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets
307. Differential effects of purinergic and cholinergic activation on the hydrolysis of membrane polyphosphoinositides in rat pancreatic islets
308. 2+ requirements for glucose- and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin-permeabilized islets: Evidence for a glucose recognition site in insulin secretion
309. Possible role of a GTP-binding protein in the activation of phospholipase C by carbamylcholine in tumoral insulin-producing cells
310. 2+, and insulin release in carbamylcholine-stimulated RINm5F cells
311. Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr)
312. Calmodulin antagonist W7 increases inositol phosphates in insulin secreting RINm5F cells
313. Muscarinic receptors-characterization, coupling and function
314. 3 receptor coupling and regulation
315. Synergistic interaction of glucose and neurohumoral agonists to stimulate islet phosphoinositide hydrolysis
316. Regulation of insulin release by phospholipase C activation in mouse islets: Differential effects of glucose and neurohumoral stimulation
317. Roles of phospholipids and phospholipase activation in B-cell function
318. 11α and isoforms of phospholipase C in islet β-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion
319. Insulin secretion, inositol phosphate levels, and phospholipase C isozymes in rodent pancreatic islets
320. Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes
321. Carbamoylcholine regulation of polyphosphoinositide synthesis and hydrolysis in cultured, dispersed, digitonin-permeabilized mouse pancreatic islet cells
322. Involvement of G proteins in the effect of carbachol and cholecystokinin in rat pancreatic islets
323. Signal transduction in insulin secretion: Comparison between fuel stimuli and receptor agonists
324. 2+ and insulin secretion
325. 2+-independent insulin secretion from permeabilized RINm5F cells
326. Arachidonic acid metabolism in isolated pancreatic islets. VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release
327. G-protein specificity in signaling pathways that mobilize calcium in insulin-secreting β-TC3 cells
328. Activation of the β 1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
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330. Heterotrimeric G proteins: Organizers of transmembrane signals
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332. Membrane potential and cytosolic free calcium levels modulate acetylcholine-induced inositol phosphate production in insulin-secreting BTC3 cells
333. Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans
334. Stimulation by glucose and carbamylcholine of phospholipase C in pancreatic islets
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336. Calmodulin and calbindin in pancreatic islet cells
337. Glucose stimulates voltage- and calcium-dependent inositol trisphosphate production and intracellular calcium mobilization in insulin-secreting βTC3 cells
338. Regulation by membrane potential of phosphatidylinositol hydrolysis in pancreatic islets
339. + channel independent mechanisms: Role of phospholipase C
340. Regulation of insulin secretion by phosphoinositide-specific phospholipase C and protein kinase C activation
341. Regulation of insulin secretion by phospholipase C
342. 2+ on phosphoinositide breakdown in exocrine pancreas
343. Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes: Roles of guanine nucleotides and calcium
344. 2+ for kinase C insertion into membranes
345. Role of phosphoinositides in transmembrane signaling
346. Crosstalk between the cAMP and inositol trisphosphate-signalling pathways in pancreatic β-cells
347. Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine: Kinetic analysis of inositol polyphosphate metabolism
348. Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells
349. Back in the water: The return of the inositol phosphates
350. 2+ from permeabilized insulin-secreting cells
351. Regulation of inositol 1,4,5-trisphosphate metabolism in insulin-secreting RINm5F cells
352. The versatility of inositol phosphates as cellular signals
353. 2+ cycle of a rat insulinoma cell line
354. Unresponsiveness of phospholipase C to the regulatory proteins Ns and Ni in pancreatic islets
355. A possible role for glucose metabolites in the regulation of inositol-1,4,5-trisphosphate 5-phosphomonoesterase activity in pancreatic islets
356. Potentiation by glucose metabolites of inositol trisphosphate-induced calcium mobilization in permeabilized rat pancreatic islets
357. Stimulation by D-glucose of the synthesis of polyphosphoinositides in pancreatic islets
358. Glycolytic metabolites and intracellular signaling in the pancreatic β cell
359. Enhanced de novo synthesis of phosphatidic acid and
360. Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism
361. Rapid glucose-dependent increases in phosphatidic acid and phosphoinositides in rat pancreatic islets
362. Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets
363. Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans
364. Protein kinase C in insulin releasing cells. Putative role in stimulus secretion coupling
365. 2+, cAMP and diacylglycerol
366. Inositol trisphosphate, a novel second messenger in cellular signal transduction
367. The metabolism of phosphoinositide derived messenger molecules
368. Inositol phosphates and cell signalling
369. Enzymes of phospholipid metabolism in rat pancreatic islets: Subcellular distribution and the effect of glucose and calcium
370. Phosphatidylinositol kinase in rat pancreatic islets: Subcellular distribution and sensitivity to calcium
371. Phosphatidylinositol and phosphatidic acid metabolism in rat pancreatic islets in response to neurotransmitter and hormonal stimuli
372. Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets
373. Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate
374. Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets
375. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic β-cells
376. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
377. Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: Sequential actions of diacylglycerol and monoacylglycerol lipases
378. Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers?
379. Amplification of insulin secretion by lipid messengers
380. Protein kinases: Protein kinase C and lipid signaling for sustained cellular responses
381. 2+, diacylglycerol, and protein kinase C activity
382. Protein kinase C-a question of specificity
383. Anchoring proteins for protein kinase C: A means for isozyme selectivity
384. The extended protein kinase C superfamily
385. Protein kinase C isoenzymes: A review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis
386. Localization of β II subspecies of protein kinase C in β-cells
387. Different expression of protein kinase C isozymes in pancreatic islet cells
388. Glucose-induced translocation of protein kinase C in rat pancreatic islets
389. Age-dependent expression of protein kinase C isoforms in rat islets
390. Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets
391. Molecular cloning and characterization of PKC, an atypical isoform of protein kinase C derived from insulin-secreting cells
392. 2+ channels
393. Identification and subcellular characterization of protein kinase-C isoforms in insulinoma β-cells and whole islets
394. 2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets
395. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells
396. Potentiation of stimulus-induced insulin secretion in protein kinase C-deficient RINm5F cells
397. Regulation of distinct pools of protein kinase C δ in β cells
398. Protein kinase C in β-cells: Expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion
399. Atypical protein kinase C isozyme mediates carbachol-stimulated insulin secretion in RINm5F cells
400. Translocation of protein kinase C in rat islets of Langerhans: Effects of a phorbol ester, carbachol and glucose
401. Localization of protein kinases by anchoring proteins: A theme in signal transduction
402. Protein kinase C isoenzymes: Divergence in signal transduction
403. The MARCKS family of cellular protein kinase C substrates
404. MARCKS, membranes, and calmodulin: Kinetics of their interaction
405. 2+-calmodulin and protein kinase Cs: A hypothetical synthesis of their conflicting convergences on shared substrate domains
406. Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic β-cells
407. Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets
408. Activation of protein kinase C partially alleviates noradrenaline inhibition of insulin secretion
409. 2-adrenergic signalling in rat pancreatic islets
410. 2+ rise induced by the activation of muscarinic receptors in PC12 cells
411. Studies of inositol phospholipid-specific phospholipase C
412. 2+and ATP-dependent reversible inactivation of pancreatic islet phosphoinositide-specific phospholipase C activity
413. Guanosine 5′-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C
414. Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters
415. Diversity of structure, signaling and regulation within the family of muscarinic cholinergic receptors
416. Identification of a novel receptor kinase that phosphorylates a phospholipase C-linked muscarinic receptor
417. Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells
418. Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists
419. 2 and arachidonic acid release in signal transduction
420. 2 superfamily of signal transduction enzymes
421. 2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet β-cells
422. 2
423. 2 in pancreatic β cells: Regulation of mRNA levels by starvation or glucose excess
424. 2 isoforms in human and rat pancreatic islets and insulin secreting β-cell lines
425. 2 expression in human and rodent insulin-secreting cells
426. 2 is contained in insulin secretory granules of pancreatic islet β-cells and is co-secreted with insulin from glucose-stimulated islets
427. 2 activity in pancreatic islets?
428. 2 in rat pancreatic β-cells
429. 2 enzyme in clonal insulinoma cell lines
430. 2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin
431. 2
432. 2 in pancreatic islets
433. 2 and insulin secretion in pancreatic islets
434. +-ATP channel-independent pathway of regulation of insulin secretion by glucose: In search of the underlying mechanism
435. 2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: Dissociation from the mechanism of carbachol
436. Glucose and carbachol synergistically stimulate phosphatidic acid accumulation in pancreatic islets
437. Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in β-cell cytosolic calcium ion concentration
438. 2 by insulin secretagogues in isolated pancreatic islets
439. Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion
440. 2+ concentration
441. 2 is phosphorylated and activated by MAP kinase
442. 2+ mobilization by arachidonic acid: Comparison with myoinositol 1,4,5-trisphosphate in isolated pancreatic islets
443. 2+ in islets
444. Unmasking of arachidonate-induced insulin release by removal of extracellular calcium: Arachidonic acid mobilizes cellular calcium in rat islets of Langerhans
445. 2+ mobilization and protein kinase C
446. 2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion
447. Mechanisms involved in intracellular calcium mobilization in isolated rat islets of Langerhans
448. Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet β cells
449. + channels in insulinoma cells are activated by nonesterified fatty acids
450. Parallel effects of arachidonic acid on insulin secretion, calmodulin-dependent protein kinase activity and protein kinase C activity in pancreatic islets
451. Activation of protein kinase C by lipoxin A and other eicosanoids: Intracellular action of oxygenation products of arachidonic acid
452. Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: Its possible implications
453. Arachidonic acid metabolite regulation of insulin secretion
454. The pancreatic islet as Rubik's cube: Is phospholipid hydrolysis a piece of the puzzle?
455. 2 activation on hormone release
456. Putative roles for lysophospholipids as mediators and lipoxygenase-mediated metabolites of arachidonic acid as potentiators of stimulus-secretion coupling: Dual mechanisms of p-hydroxymercuribenzoic acid-induced insulin release
457. 2, and lysophospholipids on insulin secretion
458. Phasic effects of glucose, p-hydroxymercuribenzoate, and lysophosphatidylcholine on insulin secretion from HIT cells
459. Regulation of phospholipase D by protein kinase C
460. Phospholipase D: A novel major player in signal transduction
461. Effects of starvation on phospholipid metabolism of pancreatic islets
462. Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: Quantitative effects on the phospholipid content of arachidonate and other fatty acids
463. Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: Prominence of plasmenylethanolamine molecular species
464. Phospholipase D: Regulation by GTPases and protein kinase C and physiological relevance
465. Regulation of phospholipase D
466. 3H-labelled phosphatidylcholine in mouse pancreatic islets
467. A phospholipase D-like mechanism in pancreatic islet cells: Stimulation by calcium ionophore, phorbol ester and sodium fluoride
468. Phosphatidic acid directly activates endothelial cell protein kinase C
469. 2+, and adenylate cyclase
470. Stimulation of insulin release by phospholipase D: A potential role for endogenous phosphatidic acid in pancreatic islet function
471. Phospholipase D: Enzymology, mechanisms of regulation, and function
472. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells
473. Is GLUT2 required for glucose sensing?
474. Are there kinetic advantages of GLUT2 in pancreatic glucose sensing?
475. Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release: Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets
476. Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells
477. Electrophysiology of the pancreatic β-cell
478. + channels may control glucose-induced electrical activity in pancreatic B-cells
479. Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx
480. Analysis of the acetylcholine action on the electrical activities of pancreatic islet B-cells in mice
481. Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists
482. + permeabilities by oxotremorine-m (Oxo-m) in rodent pancreatic B-cells
483. Glucose and acetylcholine have different effects on the plateau pacemaker of pancreatic islet cells
484. Muscarinic receptors and the control of glucose-induced electrical activity in the pancreatic β-cell
485. Muscarinic receptor modulation of glucose-induced electrical activity in mouse pancreatic B-cells
486. A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic β-cells
487. Muscarinic inhibition of pancreatic B-cells
488. ATP channels
489. Membrane phospholipid control of nucleotide sensitivity of KATP channels
490. --selective channels in mouse pancreatic B-cells
491. Effects of chloride deficiency on the pancreatic B-cell response to acetylcholine
492. Effects of acetylcholine on ion fluxes and chlorotetracycline fluorescence in pancreatic islets
493. + current by acetylcholine in mouse pancreatic β-cells
494. Carbachol has opposite effects to glucose in raising the sodium content of pancreatic islets
495. + in mouse pancreatic B-cells
496. + currents in cultured mouse pancreatic B-cells
497. Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assay
498. The nicotinic acetylcholine receptor and its ion channel
499. Acetylcholine increases intracellular sodium activity in sheep cardiac Purkinje fibers
500. + current by means of a phosphatase and a diffusible messenger
501. 2+ influx: How many mechanisms for how many channels?
502. TRP is cracked but is CRAC TRP?
503. 2+ entry
504. Depletion of intracellular calcium stores activates an outward potassium current in mast and RBL-1 cells that is correlated with CRAC channel activation
505. Identification of four trp1 gene variants murine pancreatic β-cells
506. 2+-permeable cation channel activated by calcium store depletion
507. 2+ influx by a tyrosine kinase-dependent pathway
508. i increase activates sodium influx in human platelets
509. 2+ pools
510. Sodium-dependent membrane current induced by carbachol in single guinea-pig ventricular myocytes
511. 2 muscarinic receptors
512. Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides
513. Acetylcholine activates single sodium channels in smooth muscle cells
514. Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein
515. Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle
516. Muscarinic receptors controlling the carbachol-activated non-selective cationic current in guinea pig gastric smooth muscle cells
517. Acetylcholine activates an inward current in single mammalian smooth muscle cells
518. Cholinergic stimulation activates a non-selective cation current in canine pyloric circular muscle cells
519. 2+-dependent currents, but not non-selective cation currents, by muscarine in chromaffin cells
520. The m3 muscarinic acetylcholine receptor differentially regulates calcium influx and release through modulation of monovalent cation channels
521. 2+ entry in mouse pancreatic β-cells by both direct and indirect mechanisms
522. 2+ influx in the electrically excitable pancreatic B-cell
523. Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry
524. i in the pancreatic B-cell
525. Electrophysiology of the pancreas
526. + conductance in glucose-stimulated pancreatic β-cells
527. + currents in pancreatic β-cells
528. 2+ oscillations induced by carbachol and guanosine 5′-O-(3-thiotriphosphate) in hyperpolarized pancreatic β-cells
529. + current in insulin-secreting murine βTC-3 cells
530. 86Rb efflux in mouse pancreatic B-cells
531. Acetylcholine stimulates glucose metabolism by pancreatic islets
532. Effects of glucose and acetylcholine on islet tissue NADH and insulin release
533. A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets
534. Changes in 2′,7′-bis(carboxyethyl) 5′(6′-carboxyfluorescein-, fura-2 and autofluorescence in intact rat pancreatic islets in response to nutrients and non-nutrients
535. Calcium and the control of insulin secretion
536. Adenylyl cyclases and the interaction between calcium and cAMP signalling
537. 2+ entry in rat pancreatic acinar cells
538. Structure and regulation of muscarinic receptors
539. Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans
540. Effect of intracellular alkalinization on pancreatic islet calcium uptake and insulin secretion
541. Regulation of pH in individual pancreatic β-cells as evaluated by fluorescence ratio microscopy
542. + exchange, an effect not dependent on protein kinase C
543. 2+ in subpopulations of individual rat pancreatic β-cells
544. 2+ in the electrically excitable pancreatic B-cell
545. 2+ origin
546. Inositol 1,4,5-trisphosphate mobilizes glucose-incorporated calcium from pancreatic islets
547. Mobilization of different intracellular calcium pools after activation of muscarinic receptors in pancreatic β-cells
548. 2+ in pancreatic β-cells without participation of the thapsigargin-sensitive store
549. 2+ entry in insulin-releasing pancreatic β-cells
550. 2+ by isolated organelles from a rat insulinoma
551. 2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate
552. 2+ fluxes in insulin-secreting tumor cells
553. 2+ mobilization
554. Calcium mobilization by inositol 1,4,5-trisphosphate during activation of islet, pituitary, and myeloid cells
555. 2+ release in pancreatic β-cells
556. 2+ release in permeabilized pancreatic β-cells
557. 2+ sequestration in permeabilised insulin-secreting cells
558. 2+ pool
559. 2+ stores in insulin-secreting cells: Lack of effect of cADP ribose
560. 2+ stores in individual pancreatic β-cells permeabilized or not with digitonin or α-toxin
561. 2+ in mouse pancreatic β-cells
562. 2+ in insulin secreting cells and its regulation by isolated organelles
563. 2+ responses in rat pancreatic β-cells
564. 2+ in the endoplasmic reticulum of mouse pancreatic β cells
565. 2+ in pancreatic β-cells stimulated by glucose, carbachol, and ATP
566. 2+ in carbamylcholine-stimulated insulinoma cells
567. 2+ oscillations in pancreatic β-cells
568. The role of calcium in stimulus-secretion coupling in excitable and non-excitable cells
569. 2+ oscillations in clusters of pancreatic β-cells exposed to glucose
570. Homologous and heterologous asynchronicity between identified α-, β- and δ-cells within intact islets of Langerhans in the mouse
571. 2+ oscillations in clusters of mouse pancreatic islet cells
572. 2+ and protein kinase C in acetylcholine-induced insulin release in the clonal β-cell line, HIT-T15
573. 2+ in hyperpolarized pancreatic β cells
574. 2+ release at the endoplasmic reticulum in rat pancreatic β-cells
575. 2+ channels
576. Inositol 1,4,5-trisphosphate receptors in endocrine cells: Localization and association in hetero- and homotetramers
577. 3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues
578. Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and βHC9 cells
579. Glucose regulates expression of inositol 1,4,5-trisphosphate receptor isoforms in isolated rat pancreatic islets
580. Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction
581. Inositol 1,4,5-trisphosphate receptor isoform expression in mouse pancreatic islets: Effects of carbachol
582. 3 receptor in 16HBE14o-bronchial mucosal cells
583. 3 receptor subtypes
584. 3
585. 2+ release from inositol trisphosphate-sensitive calcium stores
586. Differences among type I, II, and III inositol-1,4,5-trisphosphate receptors in ligand-binding affinity influence the sensitivity of calcium stores to inositol-1,4,5-trisphosphate
587. Phosphorylation of the inositol trisphosphate receptor in isolated rat hepatocytes
588. 2+ flux in reconstituted lipid vesicles
589. 2+/calmodulin
590. 2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci
591. 3- and calcium-gated channels from endoplasmic reticulum of cerebellum
592. Calcium as coagonist of inositol 1,4,5-trisphosphate-induced calcium release
593. 3 receptor channel stays open in the presence of increased calcium
594. 2+ store in secretory granules of insulin-producing cells
595. Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells
596. Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited
597. 2+ concentration by rat insulinoma mitochondria
598. 2+ transport by isolated organelles of a rat insulinoma: Studies with endoplasmic reticulum and secretory granules
599. 2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells
600. Calcium and organelles: A two-sided story
601. 2+ in the vicinity of secretory granules
602. Low-molecular-weight constituents of isolated insulin-secretory granules: Bivalent cations, adenine nucleotides and inorganic phosphate
603. 2+ stores and arachidonic acid metabolism
604. 2+ store, with functional properties distinct from those of the endoplasmic reticulum
605. Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells
606. Unusual carbachol responses in RINm5F cells: Evidence for a "distal" site of action in stimulus-secretion coupling
607. 2+ stores in individual pancreatic β-cells
608. 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells
609. 2+ gradients in pancreatic islet-cells stimulated by glucose and carbachol
610. 3-sensitive channels that are sensed by neighboring mitochondria
611. 2+ responses
612. 2+ to supramicromolar levels in a pancreatic β-cell line: Possible role in glucose and agonist-induced insulin secretion
613. A model for receptor-regulated calcium entry
614. Capacitative calcium entry
615. Capacitative calcium entry channels
616. 2+ signaling and insulin secretion in β-cells
617. Store depletion and calcium influx
618. Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F
619. 2+ in pancreatic β-cells occur without involvement of intracellular mobilization
620. Control of cytosolic free calcium in cultured human pancreatic β-cells occurs by external calcium-dependent and independent mechanisms
621. 2+ signaling in single mouse β-cells
622. 2+ concentration and insulin release reflects the β-cell being deprived of fuel
623. The electrical activity of mouse pancreatic β-cells recorded in vivo shows glucose-dependent oscillations
624. The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: Studies with a phorbol ester
625. 2+ efflux
626. 2+-ATPase from human erythrocytes
627. 2+ exchanger isoforms NCX1 and NCX3 does not require their direct phosphorylation
628. 2+)-ATPase activity in islets of Langerhans
629. 2+ currents by acetylcholine in mouse pancreatic B-cells
630. 2+) channel currents in the insulin-secreting cell line RINm5F
631. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β cells
632. 2+ channels by basal and stimulated protein kinase C activation in insulin-secreting RINm5F cells
633. 2+ channels in insulin-secreting HIT-T15 cells
634. Inhibition of L-type calcium channels by internal GTP- γS in mouse pancreatic β cells
635. 2+ current by isoprenaline, carbachol and phorbol ester in cultured rat aortic vascular smooth muscle (A7r5) cells
636. Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons
637. 2+ current and M current in rat sympathetic neurons
638. 2+ currents in rat striatal neurons through parallel pathways
639. Modulation of ion-channel function by G-protein-coupled receptors
640. 2+ channels by using knockout mice
641. 2+ and G-proteins
642. Calcium sensors in regulated exocytosis
643. Mechanism of insulin exocytosis
644. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
645. 2+/calmodulin and cyclic 3,5′ adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic β-cell
646. 2+
647. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells
648. + channels in mouse B cells
649. 2+ in β-cells
650. Oscillations de l'activité des protéine kinases A et C dans les cellules β et oscillations de la sécrétion d'insuline
651. 2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge
652. 2+ by forskolin and phorbol ester
653. 2+ concentration
654. 2+ sensitivity in rat pancreatic islets
655. Inhibition by 1-(5-isoquinolinesulfonyl)2-methylpiperazine (H-7) of protein kinase C activity and insulin release in pancreatic islets
656. Protein kinase C and the regulation of insulin secretion from pancreatic B cells
657. Species differences in the induction of time-dependent potentiation of insulin secretion
658. 2+ and cyclic AMP in addition to inhibiting protein kinase C in rat islets of Langerhans
659. A myristoylated pseudosubstrate peptide inhibitor of protein kinase C: Effects on glucose- and carbachol-induced insulin secretion
660. Phorbol-ester-induced down-regulation of protein kinase C in mouse pancreatic islets: Potentiation of phase 1 and inhibition of phase 2 of glucose-induced insulin secretion
661. Activation of protein kinase C is essential for sustained insulin secretion in response to cholinergic stimulation
662. The role of protein kinase C in the desensitization of rat pancreatic islets to cholinergic stimulation
663. Comparative inhibitory effects of pirenzepine and atropine on cholinergic stimulation of exocrine and endocrine rat pancreas
664. Time-dependent effects of cholinergic stimulation on β cell responsiveness
665. Insulin secretion without the participation of arachidonic acid
666. Arachidonic acid as a second messenger in glucose-induced insulin secretion from pancreatic β-cells
667. Arachidonic acid-induced insulin secretion from rat islets of Langerhans
668. 3, inhibits glucose-induced insulin secretion from isolated rat islets
669. The mechanism of arachidonic acid-induced insulin secretion from rat islets of Langerhans
670. Arachidonic acid-induced insulin secretion from rat islets of Langerhans is not mediated by protein phosphorylation
671. Exogenous arachidonic acid inactivates protein kinase C in mouse pancreatic islets
672. Neurotransmitters partially restore glucose sensitivity of insulin and glucagon secretion from perfused streptozotocin-induced diabetic rat pancreas
673. Interactions between cholinergic agonists and enteric factors in the regulation of insulin secretion from isolated perifused rat islets
674. Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas
675. 2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell
676. Effects of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on islet-cell responsiveness
677. Islet priming by phorbol ester
678. Nutrient and hormonal regulation of the threshold of glucose-stimulated insulin secretion in isolated rat pancreases
679. Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol
680. Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathway
681. Pancreatic B-cell lines: Their roles in B-cell research and diabetes therapy
682. + channels
683. 2+ concentration
684. Cholinergic stimulation of insulin release from cloned B-cell lines HIT-T15 and RINm5F
685. Effects of cholinergic agonists on diacylglycerol and intracellular calcium levels in pancreatic β-cells
686. Participation of nicotinic receptor in hormone release from isolated rat islets of Langerhans
687. Possible involvement of cholinergic nicotinic receptor in insulin release from isolated rat islets
688. Cholinergic modification of glucose-induced biphasic insulin release in vitro
689. 2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation
690. The structural and functional interrelationships of muscarinic acetylcholine receptor subtypes
691. Muscarinic receptor subtypes. Physiology and clinical implications
692. Agonist activation of muscarinic acetylcholine receptors
693. Muscarinic acetylcholine receptors: Signal transduction through multiple effectors
694. Muscarinic receptor subtypes: Modulation of ion channels
695. +-channel proteins
696. 1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover
697. Pharmacology and second messenger interactions of cloned muscarinic receptors
698. The muscarinic receptor subtype in mouse pancreatic B-cells
699. Muscarinic receptor subtypes in rat pancreatic islets: Binding and functional studies
700. Structural basis of muscarinic acetylcholine receptor subtype diversity
701. Identification of a family of muscarinic acetylcholine receptor genes
702. Pharmacological muscarinic receptor subtypes
703. Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing
704. Muscarinic receptor subtypes in carbachol-stimulated insulin and glucagon secretion in the mouse
705. Muscarinic receptors in pancreatic islets of the rat. Demonstration and dependence on long-term glucose environment
706. Influence of thiol groups, calcium, and glucose metabolism on cholinergic-induced insulin release and on methylscopolamine binding to muscarinic receptors in pancreatic islets of the rat
707. 3H)-methylscopolamine to rat pancreatic islets
708. Evidence that hyperglycemia increases muscarinic binding in pancreatic islets of the rat
709. Glucose exerts opposite effects on muscarinic receptor binding to A and B cells of the endocrine pancreas
710. Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets
711. 2+
712. 2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover
713. Inhibition of the L-type calcium channel by the five muscarinic receptors (m1-m5) expressed in NIH 3T3 cells
714. Established, unsuspected and novel pharmacological insulin secretagogues
715. Delineating muscarinic receptor functions