Disruption of pancreatic β-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 24685-24691

  Xia, Fuzhen ^a   Gao, Xiaodong ^a   Kwan, Edwin ^a   Lam, Patrick P L ^a   Chan, Lillian ^a   Sy, Keiyan ^a   Sheu, Laura ^a   Wheeler, Michael B ^a   Gaisano, Herbert Y ^a   Tsushima, Robert G ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CELL MEMBRANES; CHOLESTEROL; INSULIN; PROTEINS;

MEMBRANE COMPARTMENTALIZATION; SPATIAL COORDINATION;

LIPIDS;

CALCIUM CHANNEL; CHOLESTEROL; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LIPID; METHYL BETA CYCLODEXTRIN; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN 1A; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; EXOCYTOSIS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VOLTAGE GATED POTASSIUM CHANNEL 2.1;

ANIMALS; BETA-CYCLODEXTRINS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CHOLESTEROL; CRICETINAE; CYCLODEXTRINS; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTROPHYSIOLOGY; EXOCYTOSIS; INSULIN; IONS; ISLETS OF LANGERHANS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; RATS; SHAB POTASSIUM CHANNELS; SNARE PROTEINS; SYNTAXIN 1; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 2642585010     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M314314200     Document Type: Article

References (39)

1. Rorsman, P. & Renström, E. (2003) Diabetologia 46, 1029-1045
2. MacDonald, P. E., Ha, X. F., Wang, J., Smukler, S. R., Sun, A. M., Gaisano, H. Y., Salapatek, A. M. F., Backx, P. H. & Wheeler, M. B. (2001) Mol. Endocrinol. 15, 1423-1435
3. Dukes, I. D. & Philipson, L. H. (1996) Diabetes 45, 845-853
4. Yan, L., Figueroa, D. J., Austin, C. P., Liu, Y., Bugianesi, R. M., Slaughter, R. S., Kaczorowski, G. J. & Kohler, M. G. (2004) Diabetes 53, 597-607
5. MacDonald, P. E., Sewing, S., Wang, J., Joseph, J. W., Smukler, S. R., Sakellaropoulos, G., Wang, J., Saleh, M. C., Chan, C. B., Tsushima, R. G., Salapatek, A. M. F. & Wheeler, M. B. (2002) J. Biol. Chem. 277, 44938-44945
6. Namkung, Y., Shrypnyk, N., Jeong, M.-J., Lee, T., Lee, M.-S., Kim, H.-L., Chin, H., Suh, P.-G., Kim, S.-S. & Shin, H.-S. (2001) J. Clin. Invest. 108, 1015-1022
7. Schulla, V., Renström, E., Feil, R., Feil, S., Franklin, I., Gjinovci, A., Jing, X. J., Laux, D., Lundquist, I., Magnuson, M. A., Obermuller, S., Olofsson, C. S., Salehi, A., Wendt, A., Klugbauer, N., Wollheim, C. B., Rorsman, P. & Hofmann, F. (2003) EMBO J. 22, 3844-3854
8. Malaisse-Lagae, F., Mathias, P. C. F. & Malaisse, W. J. (1984) Biochem. Biophys. Res. Commun. 123, 1062-1068
9. Morgan, N. G., Short, C. D., Rumford, G. M. & Montague, W. (1985) Biochem. J. 231, 629-634
10. Platzer, J., Engel, J., Schrott-Fisher, A., Stephan, K., Bova, S., Chen, H., Zhen, H. & Striessnig, J. (2000) Cell 102, 89-97
11. Galbiati, F., Razani, B. & Lisanti, M. P. (2001) Cell 106, 403-411
12. Simons, K. & Ehehalt, R. (2002) J. Clin. Invest. 110, 597-603
13. Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T. & Lisanti, M. P. (1999) Mol. Cell. Biol. 19, 7289-7304
14. Wheeler, M. B., Sheu, L., Ghai, M., Bouquillon, A., Grondin, G., Weller, U., Beaudoin, A. R., Bennett, M. K., Trimble, W. S. & Gaisano, H. Y. (1996) Endocrinology 137, 1340-1348
15. Leung, Y. M., Kang, Y., Gao, X., Xia, F., Xie, H., Sheu, L., Tsuk, S., Lotan, I., Tsushima, R. G. & Gaisano, H. Y. (2003) J. Biol. Chem. 278, 17532-17538
16. Sheu, L., Pasyk, E. A., Ji, J., Huang, X., Gao, X., Varoqueaux, F., Brose, N. & Gaisano, H. Y. (2003) J. Biol. Chem. 278, 27556-27563
17. Lindau, M. & Neher, E. (1988) Pfluegers Arch. Eur. J. Physiol. 411, 137-146
18. Liu, P., Li, W. P., Machleidt, T. & Anderson, R. G. W. (1999) Nat. Cell Biol. 1, 369-375
19. Chamberlain, L. H., Burgoyne, R. D. & Gould, G. W. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5619-5624
20. Lang, T., Bruns, D., Wenzel, D., Riedel, D., Holroyd, P., Thiele, C. & Jahn, R. (2001) EMBO J. 20, 2202-2213
21. Olofsson, C. S., Göpel, S. O., Barg, S., Galvanovskis, J., Ma, X., Salehi, A., Rorsman, P. & Eliasson, L. (2002) Pfluegers Arch. Eur. J. Physiol. 444, 43-51
22. Martens, J. R., Navarro-Polanco, R., Coppock, E. A., Nishiyama, A., Parshley, L., Grobaski, T. D. & Tamkun, M. M. (2000) J. Biol. Chem. 275, 7443-7448
23. MacDonald, P. E., Wang, G., Tsuk, S., Dodo, C., Kang, Y., Tang, L., Wheeler, M. B., Cattral, M. S., Lakey, J. R., Salapatek, A. M., Lotan, I. & Gaisano, H. Y. (2002) Mol. Endocrinol. 16, 2452-2461
24. Kang, Y., Huang, X., Pasyk, E. A., Ji, J., Holz, G. G., Wheeler, M. B., Tsushima, R. G., Gaisano, H. Y. (2002) Diabetologia 45, 231-241
25. Wiser, O., Bennett, M. K. & Atlas, D. (1996) EMBO J. 15, 4100-4110
26. Wiser, O., Trus, M., Hernández, A., Renström, E., Barg, S., Rorsman, P. & Atlas, D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 248-253
27. Barg, S., Ma, X., Eliasson, L., Galvanovskis, J., Gopel, S. O., Obermuller, S., Platzer, J., Renström, E., Trus, M., Atlas, D., Striessing, J. & Rorsman, P. (2001) Biophys. J. 81, 3308-3323
28. Racine, C., Belanger, M., Hirabayashi, H., Boucher, M., Chakir, J. & Couet, J. (1999) Biochem. Biophys. Res. Commun. 255, 580-586
29. Wiechen, K., Diatchenko, L., Agoulnik, A., Scharff, K. M., Schober, H., Arlt, K., Zhumabayeva, B., Siebert, P. D., Dietel, M., Schafer, R. & Sers, C. (2001) Am. J. Pathol. 159, 1635-1643
30. Galbiati, F., Volonte, D., Gil, O., Zanazzi, G., Salzer, J. L., Sargiacomo, M., Scherer, P. E., Engelman, J. A., Schlegel, A., Parenti, M., Okamoto, T. & Lisanti, M. P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 10257-10262
31. Orci, L., Amherdt, M., Montesano, R., Vassalli, P. & Perrelet, A. (1981) Philos. Trans. R. Soc. Lond. B Biol. Sci. 296, 47-54
32. Smart, E. J., Ying, Y., Donzell, W. C. & Anderson, R. G. (1996) J. Biol. Chem. 271, 29427-29435
33. Löhn, M., Furstenau, M., Sagach, V., Elger, M., Schulze, W., Luft, F. C., Haller, H. & Gollasch, M. (2000) Circ. Res. 87, 1034-1039
34. Geng, X., Li, L., Watkins, S., Robbins, P. D. & Drain, P. (2003) Diabetes 52, 767-777
35. Bokvist, K., Eliasson, L., Ämmälä, C., Renström, E. & Rorsman, P. (1995) EMBO J. 14, 50-57
36. McGarry, J. D. & Dobbins, R. L. (1999) Diabetologia 42, 128-138
37. Iwashima, Y., Pugh, W., Depaoli, A. M., Takeda, J., Seino, S., Bell, G. I. & Polonsky, K. S. (1993) Diabetes 42, 948-955
38. Roe, M. W., Worley, J. F. 3rd, Tokuyama, Y., Philipson, L. H., Sturis, J., Tang, J., Dukes, I. D., Bell, G. I. & Polonsky, K. S. (1996) Am. J. Physiol. 270, E133-E140
39. Iwashima, Y., Abiko, A., Ushikubi, F., Hata, A., Kaku, K., Sano, H. & Eto, M. (2001) Biochem. Biophys. Res. Commun. 280, 923-932