Kir6.2 polymorphisms sensitize β-cell ATP-sensitive potassium channels to activation by acyl CoAs: A possible cellular mechanism for increased susceptibility to type 2 diabetes?

Diabetes

Volumn 52, Issue 10, 2003, Pages 2630-2635

  Riedel, Michael J ^a   Boora, Parveen ^a   Steckley, Diana ^a   De Vries, Gerda ^a   Light, Peter E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; ADENOSINE TRIPHOSPHATE; CELL PROTEIN; FATTY ACID; GLUCAGON; INSULIN; LONG CHAIN FATTY ACID; PALMITOYL COENZYME A; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KIR6.2; UNCLASSIFIED DRUG;

ARTICLE; CAUCASIAN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DISEASE PREDISPOSITION; DNA POLYMORPHISM; EMBRYO; FATTY ACID BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; PATCH CLAMP; PATHOGENESIS; PRIORITY JOURNAL; WILD TYPE;

ACYL COENZYME A; ADENOSINE TRIPHOSPHATE; CELL LINE; DIABETES MELLITUS, TYPE 2; ELECTROPHYSIOLOGY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ISLETS OF LANGERHANS; PATCH-CLAMP TECHNIQUES; POLYMORPHISM, GENETIC; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; TRANSFECTION;

EID: 0141643279     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.10.2630     Document Type: Article

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