Modulation of L-type Ca2+ channels by distinct domains within SNAP-25

Diabetes

Volumn 51, Issue 5, 2002, Pages 1425-1436

  Ji, Junzhi ^a   Yang, Shao Nian ^b   Huang, Xiaohang ^a   Li, Xidan ^b   Sheu, Laura ^a   Diamant, Nicholas ^a   Berggren, Per Olof ^b   Gaisano, Herbert Y ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; CALCIUM CHANNEL L TYPE; CALCIUM ION; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; EXOCYTOSIS; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INSULINOMA; NEUROSECRETORY CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SECRETORY VESICLE;

EID: 0036319045     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.5.1425     Document Type: Article

References (36)

1. 2+ channels exposed to serum from patients with type 1 diabetes
2. Glucose and tolbutanude induce apoptosis in pancreatic beta-cells: A process dependent on intracellular calcium concentration
3. 2+ current mediates cytokine-induced pancreatic b-cell death
4. 2+ channels
5. Functional impact of syntaxin on gating of N-type and Q-type calcium channels
6. Calcium-dependent interaction of N-type calcium channels with the synaptic core complex
7. Co-localization of L-type calcium channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic β cells
8. 2+ channel is functionally coupled to the exocytotic machinery
9. The synaptic vesicle cycle: A cascade of protein-protein interactions
10. Clostridial neurotoxins: New tools for dissecting exocytosis
11. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
12. Characterization of SNARE protein expression in β cell lines and pancreatic islets
13. SNAP-25 is expressed in islets of Langerhans and is involved in insulin release
14. Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal βcells
15. Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity
16. Truncated SNAP-25 (1-197), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T 15 insulinoma cells
17. 2+ indicators with greatly improved fluorescence properties
18. Calcium and delayed potassium currents in mouse pancreatic β-cells under voltage-clamp conditions
19. Evidence for two calcium currents in insulin-secreting cells
20. Rates of diffusional exchange between small cells and a measuring patch pipette
21. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
22. Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
23. Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion
24. Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis
25. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
26. Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion
27. Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells
28. 2+ channels in pancreatic βcells
29. Voltage-dependent calcium channels and their modulation by neurotransmitters and G proteins
30. 2+ sensitivity
31. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic βcells
32. Time course of calcium concentration triggering exocytosis in neuroendocrine cells
33. 2+-induced exocytosis in mouse pancreatic B-cells
34. β-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression
35. Decreased expression of t-SNARE syntaxin 1 and SNAP25 in pancreatic beta cells is involved in impaired insulin secretion from diabetic GK rat islets: Restoration of decreased t-SNARE proteins improves impaired insulin secretion
36. 2+-induced insulin release from electrically permeabilized pancreatic islets of diabetic GK rats and its defective augmentation by glucose