Possible role of an ischemic preconditioning-like response mechanism in KATP channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Biochemical Pharmacology

Volumn 76, Issue 12, 2008, Pages 1748-1756

  Sandler, Stellan ^a   Andersson, Annika K ^a   Larsson, Jenny ^a   Makeeva, Natalia ^a   Olsen, Therese ^a   Arkhammar, Per O G ^b   Hansen, John Bondo ^b   Karlsson, F Anders ^a   Welsh, Nils ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Ischemic preconditioning; Mitochondria pancreatic islets; Potassium channel opener; Streptozotocin

Indexed keywords

6 CHLORO 3 (1 METHYLCYCLOBUTYL)AMINO 4H THIENO[3,2 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; INSULIN; N CYANO N' [3,5 BIS(TRIFLUOROMETHYL)PHENYL] N' (CYCLOPENTYL)GUANIDINE; NNC 550321; NNC 550462; OXYGEN RADICAL; POTASSIUM CHANNEL STIMULATING AGENT; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; INSULIN RELEASE; ISCHEMIC PRECONDITIONING; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

ANIMALS; DIAZOXIDE; GUANIDINES; INSULIN; INSULIN ANTAGONISTS; ISCHEMIC PRECONDITIONING; ISLETS OF LANGERHANS; KATP CHANNELS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; NITRILES; ONCOGENE PROTEIN V-AKT; PROTECTIVE AGENTS; PROTEIN KINASE C-EPSILON; REACTIVE OXYGEN SPECIES; STREPTOZOCIN;

EID: 56549096271     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.09.004     Document Type: Article

References (47)

1. Eizirik D.L., Sandler S., and Palmer J.P. Repair of pancreatic β-cells. A relevant phenomenon in early IDDM in different glucose concentrations modifies B cell sensitivity to streptozotocin. Diabetes 42 (1993) 1383-1391
2. Pipeleers D., Hoorens A., Marichal-Pipeleers M., van de Casteele M., Bouwens L., and Ling Z. Role of pancreatic β-cells in the process of β-cell death. Diabetes 50 Suppl. 1 (2001) S52-S57
3. Björk E., Berne C., Kämpe O., Wibell L., Oskarsson P., and Karlsson F.A. Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes. Diabetes 45 (1996) 1427-1430
4. Örtqvist E., Björk E., Wallensteen M., Ludvigsson J., Åman J., Johansson C., et al. Temporary preservation of β-cell function by diazoxide treatment in childhood type 1 diabetes. Diabetes Care 27 (2004) 2191-2197
5. Vondra K., Voborska M., Kvapil M., Weber P., Dvorakova H., Stanicka S., et al. Somatostatin: beneficial effects on remission in young adult patients with newly diagnosed diabetes mellitus type 1. Physiol Res 53 (2004) 115-117
6. Eizirik D.L., Strandell E., and Sandler S. Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin. Diabetologia 31 (1988) 168-174
7. Palmer J.P., Helqvist S., Spinas G.A., Mølvig J., Mandrup-Poulsen T., Andersen H.U., et al. Interaction of β-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes 38 (1989) 1211-1216
8. Spinas G.A., Palmer J.P., Mandrup-Poulsen T., Andersen H., Nielsen J.H., and Nerup J. The bimodal effect of interleukin 1 on rat pancreatic β-cells - stimulation followed by inhibition - depends upon dose, duration, and ambient glucose concentration. Acta Endocrinol (Copenh) 119 (1988) 307-311
9. ATP channel openers: structure-activity relationships and therapeutic potential. Med Res Rev 24 (2004) 213-266
10. Nielsen F.E., Bodvarsdottir T.B., Worsaae A., MacKay P., Stidsen C.E., Boonen H.C., et al. 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiazidine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic β-cells. J Med Chem 45 (2002) 4171-4187
11. ATP channels and inhibitors of insulin release. J Med Chem 47 (2004) 3202-3211
12. ATP channel openers protect rat islets against the toxic effect of streptozotocin. Diabetes 49 (2000) 1131-1136
13. ATP channel opener. Diabetes 53 (2004) 1089-1095
14. ATP channel opener preserves β-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 89 (2004) 795-805
15. Rasmussen S.B., Sørensen T.S., Hansen J.B., Mandrup-Poulsen T., Hornum L., and Markholst H. Functional rest through intensive treatment with insulin and potassium channel openers preserves residual β-cell function and mass in acutely diabetic BB rats. Horm Metab Res 32 (2000) 294-300
16. + channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 53 (2004) 1706-1713
17. Kullin M., Li Z., Hansen J.B., Welsh N., Karlsson F.A., and Sandler S. Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1β mediated suppression-possible involvement of the mitochondrial membrane potential. Diabetologia 46 (2003) 80-88
18. Bolli R. The late phase of preconditioning. Circ Res 87 (2000) 972-983
19. Murphy E. Primary and secondary signalling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ Res 94 (2004) 7-16
20. Knaack D., Fiore D.M., and Surana M. Clonal insulinoma cell line that stably maintains correct glucose responsiveness. Diabetes 43 (1994) 1413-1417
21. Salvioli S., Ardizzoni A., Franceschi C., and Cossarizza A. JC-1, but not DiOC6(3) or rhodamine123, is a reliable fluorescent probe to assess Δψ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 411 (1997) 77-82
22. Ericson A., Niklasson F., and de Verdier C.-H. A systematic study of nucleotide analysis of human erythrocytes using an anionic exchanger and HPLC. Clin Chim Acta 127 (1983) 47-59
23. Sellevold O.F.M., Jynge P., and Aarstad K. High performance liquid chromatography of creatine compounds and adenine nucleotides in myocardial tissue. J Mol Cell Cardiol 18 (1986) 517-527
24. Alcazar O., Qiu-yue Z., Gine E., and Tamarit-Rodriguez J. Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. Diabetes 46 (1997) 1153-1158
25. 2 formation is reduced from iNOS deficient murine islets. Mol Cell Endocrinol 220 (2004) 21-29
26. Barbu A., Welsh N., and Saldeen J. Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Δψ) in pancreatic RINm5F cells: prevention by Bcl-2. Mol Cell Endocrinol 190 (2002) 75-82
27. Raval A.P., Dave K.R., Mochly-Rosen D., Sick T.J., and Pérez-Pinzón M.A. εPKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neurosci 23 (2003) 384-391
28. Zhang J., Baines C.P., Zong C., Cardwell E.M., Wang G., Vondriska T.M., et al. Functional proteomic analysis of a three-tier PKCε-Akt-eNOS signaling module in cardiac protection. Am J Physiol Heart Circ Physiol 288 (2005) H954-H961
29. Malaisse W.J. Glucose-sensing by the pancreatic B-cell: the mitochondrial part. Int J Biochem 24 (1992) 693-701
30. Meglasson M.D., and Matschinsky F.M. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2 (1986) 163-214
31. + channels protect the myocardium against ischemia/reperfusion damage. Circ Res 69 (1991) 571-581
32. + channels. Possible mechanism of cardioprotection. Circ Res 81 (1997) 1072-1082
33. + channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity. Brain Res 706 (1996) 328-332
34. Patel M.N., Yim G.K., and Isom G.E. Potentiation of cyanide neurotoxicity by blockade of ATP-sensitive potassium channels. Brain Res 593 (1992) 114-116
35. Liu G.C., Vasquez J.A., Gallagher K.P., and Lucchesi B.R. Myocardial protection with preconditioning. Circulation 82 (1990) 609-619
36. Murry C.E., Jennings R.B., and Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74 (2004) 1124-1136
37. Yellon D. ATP-dependent potassium channel openers and preconditioning. Cardiovasc Res 27 (1993) 1882-1883
38. + channels in mitochondrial inner membrane. Nature 352 (1991) 244-247
39. Aguilar-Bryan L., Nichols C.G., Wechsler S., Clement IV J.P., Boyd III A.E., Gonzales G., et al. Cloning of the β-cell high-affinity receptor: a regulator of insulin secretion. Science 268 (1995) 423-426
40. ATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270 (1995) 1166-1170
41. ATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 291 (2006) H2067-H2074
42. ATP channels. Am J Physiol Heart Circ Physiol 291 (2006) H2041-H2043
43. ATP channel independent pharmacological preconditioning. Mol Cell Biochem 294 (2007) 11-18
44. Soujorn M.C., and Mochly-Rosen D. Peptide modulators of protein-protein interaction in intracellular signaling. Nat Biotechnol 16 (1998) 19-24
45. Okhrimenko H., Lu W., Xiang C., Hamburger N., Kazimirsky G., and Brodie C. Protein kinase C-ε regulates the apoptosis and survival of glioma cells. Cancer Res 65 (2005) 7301-7309
46. Lu D., Huang J., and Basu A. Protein kinase Cε activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-α-induced cell death. J Biol Chem 281 (2006) 22799-22807
47. Eizirik D.L., Flodström M., Karlsen A.E., and Welsh N. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39 (1996) 875-890