Octameric stoichiometry of the K(ATP) channel complex

Journal of General Physiology

Volumn 110, Issue 6, 1997, Pages 655-664

  Shyng, S L ^a   Nichols, C G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine triphosphate binding cassette protein; Inward rectifier; Potassium channel; Sulfonylurea receptor

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN SUBUNIT; RECEPTOR PROTEIN; SULFONYLUREA; DRUG RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CHANNEL GATING; CONTROLLED STUDY; MONKEY; NONHUMAN; PROTEIN FAMILY; PROTEIN POLYMORPHISM; PROTEIN QUATERNARY STRUCTURE; ANIMAL; CELL STRAIN COS1; CHEMISTRY; METABOLISM; PATCH CLAMP; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; COS CELLS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS;

EID: 0030609143     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.110.6.655     Document Type: Article

References (31)

1. Aguilar-Bryan, L., C.G. Nichols, S.W. Wechsler, J.P. Clement IV, A.E. Boyd III, G. Gonzalez, H. Herrera Sosa, K. Nguy, J. Bryan, and D.A. Nelson. 1995. Cloning of the β-cell high affinity sulfonyl-urea receptor: a regulator of insulin secretion. Science. 268:423-426.
2. Ammala, C., A. Moorhouse, F. Gribble, R. Ashfield, P. Proks, P.A. Smith, H. Sakura, B. Coles, S.J. Ashcroft, and F.M. Ashcroft. 1996. Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature. 379:545-548.
3. Ashcroft, F.M. 1988. Adenosine 5′-triphosphate-sensitive potassium channels. Annu. Rev. Neurosci. 11:97-118.
4. 2+. J. Membr. Biol. 103:171-180.
5. ATP channel subunits. Neuron. 18:827-838.
6. + channels to intracellular spermine. FEBS Lett. 356:199-203.
7. Ficker, E., M. Taglialatela, B.A. Wible, C.M. Henley, and A.M. Brown. 1994. Spermine and spermidine as gating molecules for inward rectifier K channels. Science. 266:1068-1072.
8. + channels. Proc. R. Soc. Lond. Ser. B Biol. Sci. 261:251-261.
9. Gribble, F.M., S.J. Tucker, and F.M. Ashcroft. 1997. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO (Eur. Mol. Biol. Organ.) J. 16: 1145-1152.
10. Higgins, C.F. 1995. The ABC of channel regulation. Cell. 82:693-696.
11. Ho, K., C.G. Nichols, W.J. Lederer, J. Lytton, P.M. Vassilev, M.V. Kanazirska, and S.C. Herbert. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 362:31-38.
12. + channels. Neuron. 16:1011-1017.
13. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166-1170.
14. + channel. FEBS Lett. 409: 232-236.
15. Inagaki, N.T., Y. Tsuura, N. Namba, K. Masuda, T. Gonoi, M. Morie, Y. Seino, M. Mizuta, and S. Seino. 1995b. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle and heart. J. Biol. Chem. 270:5691-5694.
16. Lederer, W.J., and C.G. Nichols. 1989. Nucleotide modulation of the activity of rat heart KATP channels in isolated membrane patches. J. Physiol. (Camb. ). 419:193-211.
17. Liman, E.R., J. Tytgat, and P. Hess. 1992. Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs. Neuron. 9:861-871.
18. Lopatin, A.N., E.N. Makhina, and C.G. Nichols. 1994. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 372:366-369.
19. + channel. Nature 371:243-246.
20. MacKinnon, R. 1991. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350:232-235.
21. Noma, A. 1983. ATP-regulated K+ channels in cardiac muscle. Nature. 305:147-148.
22. ATP channel kinetics in isolated membrane patches from rat ventricle. Biophys. J. 60:1164-1177.
23. Nichols, C.G., and A.N. Lopatin. 1997. Inward rectifier potassium channels. Annu. Rev. Physiol. 59:171-191.
24. Nichols, C.G., S.-L. Shyng, A. Nestorowicz, B. Glaser, J.P. Clement IV, G. Gonzales, L. Aguilar-Bryan, A.M. Permutt, and J. Bryan. 1996. Adenosine diphosphate as an intracellular regulator of insulin secretion. Science. 272:1785-1787.
25. Parra-Lopez, C., R. Lin, A. Aspedon, and E.A. Groisman. 1994. A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium. EMBO (Eur. Mol. Biol. Organ.) J. 13:3964-3972.
26. Shyng, S.-L., J.P. Clement IV, J. Bryan, and C.G. Nichols. 1997. Stoichiometry of the KATP channel complex. Biophys. J. 72:A251.
27. Shyng, S.-L., T. Ferrigni, and C.G. Nichols. 1997a. Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. J. Gen. Physiol. 110:141-153.
28. ATP channel activity by diazoxide and MgADP: distinct functions of the two nucleoticle binding folds of the sulfonylurea receptor. J. Gen. Phys. 110:643-654.
29. 2+ of the inward rectifier, IRK1. J. Physiol. (Camb.). 478:1-6.
30. + channels in the absence of the sulfonylurea receptor. Nature. 387:179-183.
31. Yang, J., Y.N. Jan, and L.Y. Jan. 1995. Determination of the subunit stoichiometry of an inwardly rectifying potassium channel. Neuron. 15:1441-1447.