Structure and regulation of voltage-gated Ca2+ channels

Annual Review of Cell and Developmental Biology

Volumn 16, Issue , 2000, Pages 521-555

  Catterall, W A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Contraction; Cyclic AMP; Exocytosis; G proteins; Protein phosphorylation; SNARE proteins; Synaptic transmission

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CALMODULIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C; RYANODINE; SNARE PROTEIN;

CALCIUM CURRENT; CALCIUM TRANSPORT; FEEDBACK SYSTEM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; REGULATORY MECHANISM; REVIEW; SKELETAL MUSCLE; STRUCTURE ANALYSIS; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; ELECTROPHYSIOLOGY; GTP-BINDING PROTEINS; HUMANS; INTRACELLULAR FLUID; PHOSPHORYLATION; PROTEINS;

EID: 0034518423     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.16.1.521     Document Type: Review

References (218)

1. Muscular dysgenesis in mice: A model system for studying excitation-contraction coupling
2. Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina
3. Slow calcium and potassium currents across frog muscle membrane: Measurements with a vaseline-gap technique
4. 2+ current in rabbit ventricular myocytes
5. Twitches in the presence of ethylene glycol bis(-aminoethyl ether)-N,N′-tetracetic acid
6. Enzymatic gating of voltage-activated calcium channels
7. Modulation of calcium channels of twitch skeletal muscle fibres of the frog by adrenaline and cyclic adenosine monophosphate
8. The biochemistry of neurotransmitter secretion
9. Classes of calcium channels in vertebrate cells
10. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence
11. β-adrenergic modulation of cardiac calcium channel gating
12. Beta-adrenergic modulation of calcium channels in frog ventricular heart cells
13. Functional impact of syntaxin on gating of N-type and Q-type calcium channels
14. Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels
15. Facilitation of presynaptic calcium currents in the rat brainstem
16. Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes
17. 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
18. 2 subunit
19. 2+ channel activity by PKA
20. 2+ channel modulation by 8-bromocyclic AMP in cultured heart cells
21. The effects of beta-adrenoceptor activation on contraction in isolated fast and slow-twitch skeletal muscle fibres of the rat
22. Identification of residues in the N terminus of alpha 1B critical for inhibition of the voltage-dependent calcium channel by Gβγ
23. A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones
24. Excitation-contraction coupling in vertebrate skeletal muscle: A tale of two calcium channels
25. Structure and function of voltage-gated ion channels
26. Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different
27. 1A subunit of the P/Q-type calcium channel
28. Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules
29. Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase
30. Facilitation of the presynaptic calcium current at an auditory synapse in rat brainstem
31. 1 and partial amino acid sequence of a phosphorylation site of an independent β subunit
32. 1 subunit of the cardiac L-type calcium channel by cAMP-dependent protein kinase
33. 2 and δ are encoded by the same gene
34. 1 subunit of skeletal muscle L-type calcium channels
35. Direct binding of G-protein βγ complex to voltage-dependent calcium channels
36. 1 subunit gene generates developmentally regulated isoforms in the rat heart
37. Voltage-dependent calcium channels and their modulation by neurotransmitters and G proteins
38. Mechanisms of modulation of voltage-dependent calcium channels by G proteins
39. 1 subunit of an ω-conotoxin-sensitive calcium channel
40. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
41. 2δ subunits of a DHP-sensitive calcium channel
42. Nomenclature of voltage-gated calcium channels
43. Two types of calcium channels in the somatic membrane of new-born rat dorsal root ganglion neurones
44. Silent calcium channels generate excessive tail currents and facilitation of calcium currents in rat skeletal myoballs
45. Acute effects of calcitonin gene-related peptide on the mechanical and electrical responses of the rat hemidiaphragm
46. Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel
47. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events
48. 2+ channels with G-protein α and βγ, subunits II. Evidence for direct binding
49. 2+ channels with G-protein α and βγ subunits I. Molecular determination
50. Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes
51. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits
52. 2+ channels
53. Effects of catecholamines and cyclic AMP on excitation-contraction coupling in isolated skeletal muscle fibres of the frog
54. The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the bi-directional coupling with the ryanodine receptor
55. Primary structure and function of an A kinase anchoring protein associated with calcium channels
56. Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins
57. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels
58. 2δ subunit in current stimulation and subunit interaction
59. 2+molecules
60. Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers
61. In vivo phosphorylation of the cardiac L-type calcium channel betasubunit in response to catecholamines
62. Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish
63. 2+ channels by G protein βγ subunits
64. 1A subunit
65. G-proteins involved in the calcium channnel signalling system
66. Calcium channels in vertebrate cells
67. Differential modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
68. Modulation of ion-channel function by G-protein-coupled receptors
69. 2+ channel diversity
70. Volgate-dependent calcium channels: From structure to function
71. Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels
72. Structure and regulation of L-type calcium channels a current assessment of the properties and roles of channel subunits
73. 1 subunit of the voltage-dependent calcium channel
74. Calcium channel beta subunit heterogeneity: Functional expression of cloned cDNA from heart, aorta and brain
75. Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers
76. Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits
77. Voltage-dependent modulation of N-type calcium channels: Role of G protein subunits
78. Site-specific phosphorylation of the purified receptor for calcium-channel blockers by cAMP- and cGMP-dependent protein kinases, protein kinase C, calmodulin-dependent protein kinase II and casein kinase II
79. Cloned potassium channels from eukaryotes and prokaryotes
80. Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle
81. 2-subunit and the associated δ peptides
82. 2+ channel by anchored cAMP-dependent protein kinase
83. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase
84. G-protein modulation of N-type calcium channel gating current in human embryonic kidney cells (HEK 293)
85. Transmitter modulation of neuronal calcium channels
86. Relation between isometric force and stimulus rate in cat's hindlimb motor units of different twitch contraction time
87. 2+ channels with presynaptic SNARE proteins
88. 2δ subunit
89. Structural characterization of the dihydropyridine receptor-linked calcium channel from porcine heart
90. Inhibition by extracellular ATP of L-type calcium channel currents in guinea-pig single sinoatrial nodal cells: Involvement of protein kinase C
91. 2+ channel
92. 2+ channels
93. 1 subunits of L-type calcium channels in rat skeletal muscle cells
94. 2+ channels
95. 2+/calmodulin binds to and modulates P/Q-type calcium channels
96. Inactivation of calcium channels in mammalian heart cells: Joint dependence on membrane potential and intracellular calcium
97. 2+-channel γ subunit
98. 2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits
99. 2+ channel
100. 2+ channels in the mammalian central nervous system
101. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances
102. Voltage-dependent calcium conductances in mammalian neurons. The P channel
103. 2+ channel currents in rat sensory neurons
104. Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick
105. Interaction of SNARE complexes with P/Q-type calcium channels in rat cerebellar synaptosomes
106. 1A calcium channel subunits in rat brain
107. Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II
108. ω-Conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle
109. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
110. Purified ω-conotoxin GVIA receptor of rat brain resembles a dihydropyridine-sensitive L-type calcium channel
111. Inhibition of cardiac calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain
112. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
113. 2+ stores in neuronal and neuroendocrine cells
114. P-type calcium channels in rat central and peripheral neurons
115. 1 subunits
116. 2+ channels
117. The inotropic actions of adrenaline on frog ventricular muscle: Relaxing versus potentiating effects
118. Primary structure and functional expression from complementary DNA of a brain calcium channel
119. Demonstration of the phosphorylation of dihydropyridinesensitive calcium channels in chick skeletal muscle and the resultant activation of the channels after reconstitution
120. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor
121. Joint voltage and calcium dependent inactivation of Ca channels in frog atrial myocardium
122. Three types of neuronal calcium channel with different calcium agonist sensitivity
123. Activation of purified calcium channels by stoichiometric protein phosphorylation
124. Multiple phosphorylation sites in the 165-kilodalton peptide associated with dihydropyridine-sensitive calcium channels
125. Effects of calcitonin gene-related peptide on neuromuscular transmission in the isolated rat diaphragm
126. 2+ current
127. Decrease in the size of tetanic responses produced by nitrendipine or by extracellular calcium ion removal without blocking twitches or action potentials in skeletal muscle
128. 1E as an essential determinant of G-protein modulation
129. The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G-protein sensitivity to the E-type calcium channel
130. Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels
131. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
132. Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle
133. Molecular biology of calcium channels
134. 2+-dependent inactivation of L-type calcium channels
135. 2+ channels
136. 2+ channel depends on calmodulin
137. 1 subunit is responsible for channel inhibition by G proteincoupled receptors
138. 2+ channel currents in rat cerebellar granule neurons
139. 2+ channel/syntax in interaction
140. 2+ channels with the presynaptic proteins syntaxin and SNAP-25
141. The dependence of slow inward current in Purkinje fibres on the extracellular calcium-concentration
142. Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle
143. Properties of two inward membrane currents in the heart
144. Calcium channel modulation by neurotransmitters, enzymes and drugs
145. The regulation of calcium conductance of cardiac muscle by adrenaline
146. Properties of single calcium channels in cardiac cell culture
147. Voltage sensor of excitation-contraction coupling in skeletal muscle
148. cAMP-dependent protein kinase rapidly phosphorylates serine-687 of the skeletal muscle receptor for calcium channel blockers
149. 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase
150. 1 subunit from intact rabbit skeletal muscle myotubes
151. A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP
152. Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle
153. 1A subunits of brain calcium channels
154. Inward calcium current in twitch muscle fibers of the frog
155. 1 subunits
156. 2+ channel by stimulation of protein kinase C in isolated guinea pig ventricular cardiomyocytes
157. 2+ channels of skeletal muscle
158. The bovine cardiac receptor for calcium channel blockers is a 195-kDa protein
159. Localization of A-kinase through anchoring proteins
160. 1 subunits due to phosphorylation by cAMP-dependent protein kinase
161. 2+ channels due to phosphorylation by cAMP-dependent protein kinase
162. Calcium-dependent interaction of N-type calcium channels with the synaptic corecomplex
163. Identification of a syntaxin-binding site on N-type calcium channels
164. 2+ channels with the C2B domain of synaptotagmin I
165. 2+ channels
166. The roles of the subunits in the function of the calcium channel
167. Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS
168. 2+ channel
169. 1C subunit gene
170. 2+ dependence of inactivation
171. Structure and functional expression of a member of the low voltage-activated calcium channel family
172. Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels
173. Primary structure of a calcium channel that is highly expressed in the rat cerebellum
174. Determinants of PKC-dependent modulation of a family of neuronal calcium channels
175. 1A calcium channel reflect similarities to neuronal Q- and P-type channels
176. Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel
177. An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness
178. + channels
179. The synaptic vesicle cycle: A cascade of protein-protein interactions
180. Fast deactivating calcium channels in chick sensory neurons
181. 2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition
182. 2+ channels and synaptic transmission
183. Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle
184. Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling
185. Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA
186. Primary structure of the receptor for calcium channel blockers from skeletal muscle
187. N-type voltage-sensitive calcium channel interacts with syntaxin, synaptotagmin and SNAP-25 in a multiprotein complex
188. Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons
189. The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells
190. Different effects of intracellular Ca and protein kinase C on cardiac T and L Ca currents
191. Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres
192. Cyclic AMP mediates the effects of adrenaline on cardiac Purkinje fibres
193. Multiple types of neuronal calcium channels and their selective modulation
194. Release of calcitonin gene-related peptide-like immunoreactive substance from neuromuscular junction by nerve excitation and its action on striated muscle
195. Effects of adrenaline on membrane inward currents during the cardiac action potential
196. Ion channel regulation by G proteins
197. Structure and functional expression of an ω-conotoxin-sensitive human N-type calcium channel
198. 2, and β subunits of a novel human neuronal calcium channel subtype
199. 2+ channels
200. Synaptotagmin restores kinetic properties of a syntaxin-associated N-type voltage sensitive calcium channel
201. 2+ channel is functionally coupled to the exocytotic machinery
202. 1 subunit interaction domain
203. 2+ channel complex purified from brain
204. 2+ current in guinea-pig ventricular myocytes
205. 2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx
206. 2+ channels in pancreatic beta cells
207. Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins
208. Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridinesensitive Ca channel
209. Ca-dependent facilitation of cardiac Ca current is due to Cacalmodulin-dependent protein kinase
210. β-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes
211. 1 subunit
212. βγ subunit
213. 2+ channels support their inhibition by G proteins
214. 2+ channels and their possible counterparts in mammalian CNS neurons
215. 2+ channels by SNAP-25, syntaxin, and synaptotagmin
216. On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation
217. Calmodulin supports both inactivation and facilitation of L-type calcium channels
218. 1C subunit