Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

Diabetes

Volumn 52, Issue 2, 2003, Pages 568-572

  Gloyn, Anna L ^a   Weedon, Michael N ^a   Owen, Katharine R ^a   Turner, Martina J ^a   Knight, Bridget A ^a   Hitman, Graham ^b   Walker, Mark ^c   Levy, Jonathan C ^d   Sampson, Mike ^e   Halford, Stephanie ^f   McCarthy, Mark I ^f,g   Hattersley, Andrew T ^a   Frayling, Timothy M ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e University Hospital   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INWARDLY RECTIFYING POTASSIUM CHANNEL; MEMBRANE PROTEIN; POTASSIUM CHANNEL; PROTEIN KIR6.2; PROTEIN SUBUNIT; SULFONYLUREA RECEPTOR 1; UNCLASSIFIED DRUG;

ABCC8 GENE; ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DATA ANALYSIS; DISEASE PREDISPOSITION; EVALUATION; EXON; FAMILIAL DISEASE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RELEASE; KCNJ11 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROGENY; PROTEIN VARIANT; RISK FACTOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; UNITED KINGDOM;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; ATP-BINDING CASSETTE TRANSPORTERS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; EXONS; FEMALE; GENOTYPE; HUMANS; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; VARIATION (GENETICS);

EID: 0037317981     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.568     Document Type: Article

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