Long-Chain CoA esters activate human pancreatic beta-cell KATP channels: Potential role in Type 2 diabetes

Diabetologia

Volumn 47, Issue 2, 2004, Pages 277-283

  Branstrom R ^a   Aspinwall, C A ^a   Valimaki S ^a   Ostensson C G ^b   Tibell, A ^a   Eckhard, M ^c   Brandhorst, H ^c   Corkey, B E ^d   Berggren, P O ^a   Larsson, O ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Fatty acids; Human; Ion channel; Pancreas

Indexed keywords

9 MONOUNSATURATED OLEOYL COENZYME A; ACYL COENZYME A; ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBON; LAUROYL COENZYME A; MAGNESIUM; MALONYL COENZYME A; MYRISTOYL COENZYME A; OCTANOYL COENZYME A; PALMITOYL COENZYME A; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CONCENTRATION (PARAMETERS); CONDUCTANCE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATCH CLAMP; PATHOPHYSIOLOGY; PIPETTE; PRIORITY JOURNAL; RECORDING; STIMULATION;

ACYL COENZYME A; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DIABETES MELLITUS, TYPE 2; DIAZOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMANS; ISLETS OF LANGERHANS; KINETICS; MAGNESIUM CHLORIDE; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; OLEIC ACID; PALMITOYL COENZYME A; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS;

EID: 12144287604     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1299-x     Document Type: Article

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