SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic b-cells

Journal of General Physiology

Volumn 121, Issue 3, 2003, Pages 181-197

  Eliasson, Lena ^a   Ma, Xiaosong ^a   Renström, Erik ^a   Barg, Sebastian ^a   Berggren, Per Olof ^b   Galvanovskis, Juris ^a   Gromada, Jesper ^c   Jing, Xingjun ^a   Lundquist, Ingmar ^a   Salehi, Albert ^a   Sewing, Sabine ^c   Rorsman, Patrik ^a  

^a Institute of Physiological Sciences   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Lilly Research Laboratories   (Germany)

Author keywords

Ca2+; CAMP; CAMP GEFII; Insulin; SUR1

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC PHOSPHATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CYCLIC AMP; CYCLIC AMP BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; FORSKOLIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL KINETICS; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; EXOCYTOSIS; GRANULE CELL; INSULIN RELEASE; MEMBRANE TRANSPORT; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; REGULATORY MECHANISM; TRANSPORT KINETICS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRIC CAPACITANCE; ELECTROPHYSIOLOGY; EXOCYTOSIS; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN PRECURSORS; RECEPTORS, DRUG; SECRETORY VESICLES; TIME FACTORS;

EID: 0037337832     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028707     Document Type: Article

References (46)

1. Ämmälä, C., F.M. Ashcroft, and P. Rorsman. 1993. Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells. Nature. 363:356-358.
2. + channels. Trends Neurosci. 21:288-294.
3. Ashcroft, F.M., and P. Rorsman. 1989. Electrophysiology of the pancreatic B-cell. Prog. Biophys. Mol. Biol. 54:87-143.
4. Ashcroft, S.J. C.J. Hedeskov, and P.J. Randle. 1970. Glucose metabolism in mouse pancreatic islets. Biochem. J. 118:143-154.
5. 2+dependent exocytosis in pancreatic β cells is mediated by a 65kDa mdr-like P-glycoprotein. Proc. Natl. Acad. Sci. USA. 96:5539-5544.
6. - uptake and acidification. J. Cell Sci. 114:2145-2154.
7. 2+ channels in insulin-secreting mouse pancreatic B cells. Biophys. J. 81:3308-3323.
8. 2+-channels accounts for first-phase insulin secretion in mouse β-cells. Diabetes. 51:S74-S82.
9. 2+dependent exocytosis of synaptic -like microvesicles, Diabetologia. 45:A163.
10. Eddlestone, G.T., S.B. Oldham, L.G. Lipson, F.H. Premdas, and P.M. Beigelman. 1985. Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans. Am. J. Physiol. 248:C145-C153.
11. Eliasson, L., E. Renström, C. Ämmälä, P.O. Berggren, A.M. Bertorello, K. Bokvist, A. Chibalin, J.T. Deeney, P.R. Flatt, J. Gäbel, et al. 1996. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells. Science. 271:813-815.
12. Enserink, J.M., A.E. Christensen, J. de Rooij, M. van Triest, F. Schwede, H.G. Genieser, S.O. Doskeland, J.L. Blank, and J.L. Bos. 2002. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat. Cell Biol. 4:901-906.
13. Flatt, P.R., O. Shibier, J. Szecowka, and P.O. Berggren. 1994. New perspectives on the action of sulfonylureas and hypoglycemic sulfonamides on the pancreatic β-cell. Diabete Metab. 20:157-162.
14. Gillis, K.D. 1995. Techniques for membrane capacitance measurements. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 155-198.
15. Gromada, J., S. Dissing, K. Bokvist, E. Renström, J. Frökjaer-Jensen, B.S. Wulff, and P. Rorsman. 1995. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting βTC3-cells by enhancement of intracellular calcium mobilization, Diabetes. 44: 767-774.
16. Gromada, J., W.G. Ding, S. Barg, E. Renström, and P. Rorsman, 1997. Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Arch. 434:515-524.
17. Gromada, J., J.J. Holst, and P. Rorsman. 1998. Cellular regulation of islet hormon secretion by the incretin hormon glucagon-like peptide 1. Pflugers Arch. 435:583-594.
18. 2+. Biophys. J. 67:2546-2557.
19. Henquin,J.C. 2000. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 49:1751-1760.
20. Henquin, J.C. N. Ishiyama, M. Nenquin, M.A. Ravier, and J.C. Jonas. 2002. Signals and pools underlying biphasic insulin secretion. Diabetes. 51:S60-S67.
21. Holz, G.G. IV, W.M. Kuhtreiber, and J.F. Habener. 1993. Pancreatic β-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature. 361:362-365.
22. Jacobsson, G., A.J. Bean, R.H. Scheller, L. Juntti-Berggren, J.T. Deeney, P.O. Berggren, and B. Meister. 1994. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc. Natl. Acad. Sci. USA. 91: 12487-12491.
23. 2+, cyclic AMP, a phorbol ester and noradrenaline. Biochem. J. 254:397-403.
24. 2+ release in INS-1 pancreatic β-cells. J. Physiol. 536: 375-385.
25. 2+ channels in rat islet β-cells. Pflugers Arch. 435:578-580.
26. Kashima, Y. T. Miki, T. Shibasaki, N. Ozaki, M. Miyazaki, H. Yano, and S. Seino. 2001. Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 276:46046-46053.
27. Leech, C.A., and J.F. Habener. 1997. Insnlinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin. J. Biol. Chem. 272: 17987-17993.
28. Lin, R.C., and R.H. Scheller. 2000. Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol. 16:19-49.
29. Martell, A.E., and R.M. Smith. 1974. Critically stability constants. Plenum Press, New York.
30. Miyazaki, J., K. Araki, E. Yamato, H. Ikegami, T. Asano, Y. Shibasaki, Y. Oka, and K. Yamamura. 1990. Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology. 127:126-132.
31. Nakazaki, M., A. Crane, M. Hu, V. Seghers, S. Ullrich, L. AguilarBryan, and J. Bryan. 2002. cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes. 51:3440-3449.
32. Nesher, R., E. Anteby, M. Ydovizky, N. Warwar, N. Kaiser, and E. Cerasi. 2002. β-Cell protein kinases and the dynamics of the insulin response to glucose. Diabetes. 51:S68-S73.
33. Ozaki, N., T. Shibasaki, Y. Kashima, T. Miki, K. Takahashi, H. Ueno, Y. Sunuga, H. Yano, Y. Matsuura, T. Iwanaga, et al. 2000. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat. Cell Biol. 2:805-811.
34. Renström, E., L. Eliasson, K. Bokvist, and P. Rorsman. 1996. Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J. Physiol. 494:41-52.
35. Renström, E., L. Eliasson, and P. Rorsman. 1997. PKA-dependent and PKA-independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J. Physiol. 502:105-118.
36. Renström, E., S. Barg, F. Thévenod, and P. Rorsman. 2002a. Sulphonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action. Diabetes. 51:S33-S36.
37. Renström, E., R. Ivarsson, and S. Shears. 2002b. Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential. J. Biol. Chem. 277:26717-26720.
38. Satin, L.S., and T.A. Kinard. 1998. Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit? Endocrine. 8:213-223.
39. 2+-dependent insulin secretion from the islets of Langerhans. Endocrine. 13:251-262.
40. Schoch, S., P.E. Castillo, T. Jo, K. Mukherjee, M. Geppert, Y. Wang, F. Schmitz, R.C. Malenka, and T.C. Südhof. 2002. RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature. 415:321-326.
41. Shiota, C., O. Larsson, K.D. Shelton, M. Shiota, A.M. Efanov, M. Hoy, J. Lindner, S. Kooptiwut, L. Juntti-Berggren, J. Gromada, et al. 2002. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J. Biol. Chem. 277:37176-37183.
42. Takahashi, N., T. Kadowaki, Y. Yazaki, Y. Miyashita, and H. Kasai. 1997. Multiple exocytotic pathways in pancreatic β-cells. J. Cell Biol. 138:55-64.
43. 2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs. Neuron. 11:93-104.
44. Tian, Y.A., G. Johnson, and S.J. Ashcroft. 1998. Sulfonylureas enhance exocytosis from pancreatic β-cells by a mechanism that does not involve direct activation of protein kinase C. Diabetes. 47:1722-1726.
45. Wang, Y., M. Okamoto, F. Schmitz, K. Hofmann, and T.C. Südhof. 1997. Rim is a putative Rab3 effector in regulating synaptic-vesi cle fusion. Nature. 388:593-598.
46. Wollheim, C.B., and G.W. Sharp. 1981. Regulation of insulin release by calcium. Physiol. Rev. 61:914-973.