PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells

Science

Volumn 271, Issue 5250, 1996, Pages 813-815

  Eliasson, Lena ^a   Renström, Erik ^b   Ämmälä, Carina ^a   Berggren, Per Olof ^c   Bertorello, Alejandro M ^c   Bokvist, Krister ^b   Chibalin, Alexander ^c   Deeney, Jude T ^d   Flatt, Peter R ^e   Gäbel, Jakob ^a   Gromada, Jesper ^b   Larsson, Olof ^c   Lindström, Per ^f   Rhodes, Christopher J ^g   Rorsman, Patrik ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b NOVO NORDISK A S   (Denmark)

^c KAROLINSKA INSTITUTE   (Sweden)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ULSTER   (United Kingdom)

^f UMEÅ UNIVERSITY   (Sweden)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; CALCIUM ION; GLIBENCLAMIDE; GLIPIZIDE; INSULIN; POTASSIUM CHANNEL; PROTEIN KINASE C; SULFONYLUREA; TOLBUTAMIDE;

ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; EXOCYTOSIS; HUMAN; HUMAN CELL; INSULIN RELEASE; MEMBRANE DEPOLARIZATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 13344269671     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5250.813     Document Type: Article

References (32)

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14. 2+ abolishes depolarization-evoked capacitance changes [C. Ammalä et al , J Physiol (London) 474, 665 (1993)] and (ii) lowering the temperature from +34°C to room temperature suppresses exocytosis (and capacitance increases) while not much affecting the properties of the voltage-gated currents (E Renström, L Eliasson, P Rorsman. in preparation).
15. 2+ abolishes depolarization-evoked capacitance changes [C. Ammalä et al , J Physiol (London) 474, 665 (1993)] and (ii) lowering the temperature from +34°C to room temperature suppresses exocytosis (and capacitance increases) while not much affecting the properties of the voltage-gated currents (E Renström, L Eliasson, P Rorsman. in preparation).
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32. L E and E R contributed equally to this study and their names appear in alphabetical order. Supported by the Juvenile Diabetes Foundation International, the Swedish Medical Research Council, the Nordic Insulin Foundation Committee, National Institutes of Health, and the Swedish Diabetes Association.