Selective inhibition of glucose-stimulated β-cell activity by an anion channel inhibitor

Journal of Membrane Biology

Volumn 177, Issue 2, 2000, Pages 169-175

  Best, L ^a   Brown, P D ^a   Sheader, E A ^a   Yates, A P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Chloride channel; Cytosolic Ca2+ ; Electrical activity; Insulin release; Islet; Pancreatic cell

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ANION; CALCIUM ION; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; GLUCOSE; HYPERTONIC SOLUTION; INSULIN; POTASSIUM ION; POTASSIUM PUMP; RUBIDIUM 86; TOLBUTAMIDE;

ANIMAL CELL; ANION CHANNEL; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVITY; CELL MEMBRANE CONDUCTANCE; CELL PH; CELL STIMULATION; CELL VOLUME; CHLORIDE CHANNEL; CHLORIDE TRANSPORT; CONTROLLED STUDY; ELECTRIC ACTIVITY; INSULIN RELEASE; ION PERMEABILITY; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; REPOLARIZATION;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMAL; CALCIUM; GLUCOSE; HYDROGEN-ION CONCENTRATION; IN VITRO; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; KINETICS; MEMBRANE POTENTIALS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; TOLBUTAMIDE;

ANIMALIA;

EID: 0034665379     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320001110     Document Type: Article

References (30)

1. The role of chloride-bicarbonate exchange in the regulation of intracellular chloride in guinea-pig vas deferens
2. + channels
3. Electrophysiology of the pancreatic β-cell
4. Glucose and 2-ketoisocaproate induce transient inward currents in rat pancreatic beta cells
5. Cell-attached recordings of the volume-sensitive anion channel in rat pancreatic β-cells
6. Effects of sulfonylureas on the volume-sensitive anion channel in rat pancreatic beta-cells
7. Changes in 2'7'-bis(carboxyethyl) 5'(6')-carboxy-fluorescein, fura-2 and autofluorescence in intact rat pancreatic islets in response to nutrients and non-nutrients
8. Activation of an anion conductance and β-cell depolarization during hypotonically induced insulin release
9. A volume-activated anion conductance in insulin-secreting cells
10. Modulation by cytosolic pH of calcium and rubidium fluxes in rat pancreatic islets
11. + channels as a common pathway for both stimuli
12. Pancreatic β-cells are bursting, but how?
13. Pancreatic β-cell electrical activity: The role of anions and the control of pH
14. Stimulation of HIT-T15 insulinoma cells by glyceraldehyde does not require its metabolism
15. + channels in guinea pig ventricular myocytes
16. Interaction of sulfonylurea with the pancreatic β-cell
17. Tolbutamide stimulation and inhibition of insulin release: Studies of the underlying ionic mechanisms in isolated rat islets
18. + channels may control glucose-induced electrical activity in pancreatic beta-cells
19. A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic beta-cells
20. - channel current that is activated by cell swelling, cAMP and glyburide in insulin-secreting cells
21. Method for the isolation of intact islets of Langerhans from the rat pancreas
22. 2+](ι) changes in single rat pancreatic islets and correlation with simultaneously measured insulin release
23. Regulatory volume increase in rat pancreatic β-cells
24. Glucose-induced swelling in rat pancreatic beta-cells
25. 3/Cl anti-porters
26. Low access resistance perforated patch recordings using amphotericin B
27. + channels in pancreatic beta-cells are regulated by intracellular ATP
28. Interrelationships between chloride fluxes in pancreatic islets and insulin release
29. + currents in isolated mouse pancreatic β-cells
30. The sulfonylurea receptor may be an ATP-sensitive potassium channel