Hyperinsulinism of infancy: The regulated release of insulin by KATP channel-independent pathways

Diabetes

Volumn 50, Issue 2, 2001, Pages 329-339

  Straub, Susanne G ^d   Cosgrove, Karen E ^a   Ämmälä, Carina ^e   Shepherd, Ruth M ^a   O'Brien, Rachel E ^a   Barnes, Philippa D ^a   Kuchinski, Na'ama ^c   Chapman, Joanna C ^a   Schaeppi, Michela ^b   Glaser, Benjamin ^c   Lindley, Keith J ^b   Sharp, Geoffrey W G ^d   Aynsley Green, Albert ^b   Dunne, Mark J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HEBREW UNIVERSITY   (Israel)

^d Department of Obstetrics Gynecology   (United States)

^e GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIAZOXIDE; GLUCOSE; POTASSIUM CHANNEL; PROTEIN KINASE C; SOMATOSTATIN; TOLBUTAMIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM CURRENT; CASE REPORT; CAUCASIAN; CELL ISOLATION; EXOCYTOSIS; GENE MUTATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERINSULINISM; INFANT; INSULIN RELEASE; LANGERHANS CELL; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL; STIMULUS SECRETION COUPLING; UNITED KINGDOM;

EID: 0035145905     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2.329     Document Type: Article

References (42)

1. The practical management of hyperinsulinism in infancy
2. The genetics of neonatal hyperinsulinism
3. Familial hyperinsulinism caused by an activating glucokinase mutation
4. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
5. Adenosine diphosphate as an intracellular regulator of insulin secretion
6. Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor
7. Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy
8. A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
9. ATP channels in β-cells causes persistent hyperinsulinaemic hypoglycaemia of infancy
10. Therapy for persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI): Understanding the responsiveness of β-cells to diazoxide and somatostatin
11. Neonatal hypoglycaemia: Towards understanding the unregulated release of insulin
12. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
13. Voltage-activated calcium and potassium currents in human pancreatic β-cells
14. 2+ currents in human pancreatic islet beta-cells: Evidence for roles in the generation of action potentials and insulin secretion
15. Ions, genes and insulin release: From basic science to clinical disease
16. 2+ influx in rat pancreatic β-cell
17. + channels in mouse B-cells
18. + permeability
19. 2+ in rat pancreatic islets
20. 2+
21. 2+: New insights into stimulus-secretion coupling
22. Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human islets
23. ATP channel-independent signaling pathways in human islets
24. + channel-independent glucose action
25. Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations
26. Coated charcoal immunoassay of insulin
27. Improved patchclamp techniques for high-resolution current recording from cells and cell-free membrane patches
28. Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI)
29. Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells
30. Calcium- and delayed potassium currents in mouse β-cells under voltage-clamp conditions
31. 2+ indicators with greatly improved properties
32. Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium
33. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells
34. Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y
35. + channels in the absence of the sulphonylurea receptor
36. Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia
37. Clinical features of 52 neonates with hyperinsulinism
38. ATP channel
39. ATP channel-deficient mice
40. ATP channel-independent regulation of insulin secretion
41. 2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells