메뉴 건너뛰기




Volumn 9, Issue 5, 2009, Pages 652-674

Importance of influx and efflux systems and xenobiotic metabolizing enzymes in intratumoral disposition of anticancer agents

Author keywords

ABC; Cancer; CYP; Drug disposition; Efflux; Metabolism; Resistance; SLC

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL)BENZOTHIAZOLE; 2 (4 AMINO 3 METHYLPHENYL)BENZOTHIAZOLE DERIVATIVE; ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; BENZOTHIAZOLE DERIVATIVE; CELL ENZYME; CELL PROTEIN; CYCLOPHOSPHAMIDE; CYTOCHROME P450 ISOENZYME; DASATINIB; DNA TOPOISOMERASE INHIBITOR; ENZYME INHIBITOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; GLYCOPROTEIN P; ICRF 505; IMATINIB; IRINOTECAN; LAPATINIB; METHOTREXATE; MICRORNA; MULTIDRUG RESISTANCE PROTEIN 1; NILOTINIB; PACLITAXEL; PROTEIN KINASE INHIBITOR; SOLUTE CARRIER FAMILY PROTEIN; TUMOR EXPRESSED METABOLIZING ENZYME INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC METABOLIZING ENZYME;

EID: 69249222758     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800909789056999     Document Type: Review
Times cited : (45)

References (398)
  • 1
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • Assaraf, Y. G. Molecular basis of antifolate resistance. Cancer Metastasis Rev. 2007, 26, 153-181
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 153-181
    • Assaraf, Y.G.1
  • 2
    • 33845691987 scopus 로고    scopus 로고
    • The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil
    • DOI 10.1002/ijc.22318
    • Jensen, S. A.; Vainer, B.; Sorensen, J. B. The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil. Int. J. Cancer 2007, 120, 694-701. (Pubitemid 44969043)
    • (2007) International Journal of Cancer , vol.120 , Issue.3 , pp. 694-701
    • Jensen, S.A.1    Vainer, B.2    Sorensen, J.B.3
  • 4
    • 0035057872 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer agents: Lessons from amonafide and irinotecan
    • Innocenti, F.; Iyer, L.; Ratain, M. J. Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan. Drug Metab. Dispos. 2001, 29, 596-600.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 596-600
    • Innocenti, F.1    Iyer, L.2    Ratain, M.J.3
  • 5
    • 33847244929 scopus 로고    scopus 로고
    • Drug resistance, predictive markers and pharmacogenomics in colorectal cancer
    • DOI 10.1016/j.bbcan.2006.08.001, PII S0304419X06000503
    • Longley, D. B.; Allen, W. L.; Johnston, P. G. Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim. Biophys. Acta. 2006, 1766, 184-196. (Pubitemid 46321456)
    • (2006) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1766 , Issue.2 , pp. 184-196
    • Longley, D.B.1    Allen, W.L.2    Johnston, P.G.3
  • 7
    • 39749098413 scopus 로고    scopus 로고
    • Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells
    • DOI 10.1080/10428190701824569, PII 790365665
    • Fotoohi, A. K.; Albertioni, F. Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk. Lymphoma. 2008, 49, 410-426. (Pubitemid 351298325)
    • (2008) Leukemia and Lymphoma , vol.49 , Issue.3 , pp. 410-426
    • Fotoohi, A.K.1    Albertioni, F.2
  • 8
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • DOI 10.1016/S1470-2045(07)70342-X, PII S147020450770342X
    • Apperley, J. F. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007, 8, 1018-1029. (Pubitemid 47629897)
    • (2007) Lancet Oncology , vol.8 , Issue.11 , pp. 1018-1029
    • Apperley, J.F.1
  • 10
    • 18644380835 scopus 로고    scopus 로고
    • Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: Focus on tamoxifen, paclitaxel and imatinib metabolism
    • DOI 10.2165/00003088-200544040-00002
    • Rochat, B. Role of cytochrome p450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, Paclitaxel and imatinib metabolism. Clin. Pharmacokinet. 2005, 44, 349-366. (Pubitemid 40663682)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.4 , pp. 349-366
    • Rochat, B.1
  • 11
    • 0037238805 scopus 로고    scopus 로고
    • Lessons learned from the irinotecan metabolic pathway
    • Ma, M. K.; McLeod, H. L. Lessons learned from the irinotecan metabolic pathway. Curr. Med. Chem. 2003, 10, 41-49
    • (2003) Curr. Med. Chem. , vol.10 , pp. 41-49
    • Ma, M.K.1    McLeod, H.L.2
  • 12
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571, diverse mechanisms of resistance
    • Mahon, F. X.; Deininger, M. W.; Schultheis, B.; Chabrol, J.; Reiffers, J.; Goldman, J. M.; Melo, J. V. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571, diverse mechanisms of resistance. Blood 2000, 96, 1070-1079.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3    Chabrol, J.4    Reiffers, J.5    Goldman, J.M.6    Melo, J.V.7
  • 14
    • 1542713480 scopus 로고    scopus 로고
    • P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    • DOI 10.1038/sj.leu.2403257
    • Illmer, T.; Schaich, M.; Platzbecker, U.; Freiberg-Richter, J.; Oelschlagel, U.; von Bonin, M.; Pursche, S.; Bergemann, T.; Ehninger, G.; Schleyer, E. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004, 18, 401-408. (Pubitemid 38425851)
    • (2004) Leukemia , vol.18 , Issue.3 , pp. 401-408
    • Illmer, T.1    Schaich, M.2    Platzbecker, U.3    Freiberg-Richter, J.4    Oelschlagel, U.5    Von Bonin, M.6    Pursche, S.7    Bergemann, T.8    Ehninger, G.9    Schleyer, E.10
  • 16
    • 18344396578 scopus 로고    scopus 로고
    • Determination of alpha-1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571
    • Le Coutre, P.; Kreuzer, K. A.; Il-Kang, N. A. Determination of alpha-1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571. Blood Cell Mol. 2002, 28, 75-85.
    • (2002) Blood Cell Mol. , vol.28 , pp. 75-85
    • Le Coutre, P.1    Kreuzer, K.A.2    Il-Kang, N.A.3
  • 19
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah, N. P.; Nicoll, J. M.; Nagar, B.; Gorre, M. E.; Paquette, R. L.; Kuriyan, J.; Sawyers, C. L. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002, 2, 117-125.
    • (2002) Cancer Cell. , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6    Sawyers, C.L.7
  • 20
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
    • Roumiantsev, S.; Shah, N. P.; Gorre, M. E.; Nicoll, J.; Brasher, B. B.; Sawyers, C. L.; Van Etten, R. A. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc. Natl. Acad. Sci. USA 2002, 99, 10700-10705.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10700-10705
    • Roumiantsev, S.1    Shah, N.P.2    Gorre, M.E.3    Nicoll, J.4    Brasher, B.B.5    Sawyers, C.L.6    Van Etten, R.A.7
  • 21
    • 0036493544 scopus 로고    scopus 로고
    • + acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • DOI 10.1182/blood.V99.5.1860
    • Hofmann, W. K.; Jones, L. C.; Lemp, N. A.; de Vos, S.; Gschaidmeier, H.; Hoelzer, D.; Ottmann, O. G.; Koeffler, H. P. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 2002, 99, 1860-1862. (Pubitemid 34533064)
    • (2002) Blood , vol.99 , Issue.5 , pp. 1860-1862
    • Hofmann, W.-K.1    Jones, L.C.2    Lemp, N.A.3    De Vos, S.4    Gschaidmeier, H.5    Hoelzer, D.6    Ottmann, O.G.7    Phillip Koeffler, H.8
  • 22
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre, M. E.; Mohammed, M.; Ellwood, K.; Hsu, N.; Paquette, R.; Rao, P. N.; Sawyers, C. L. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001, 293, 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 23
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
    • DOI 10.1016/S0140-6736(02)07679-1
    • von Bubnoff, N.; Schneller, F.; Peschel, C.; Duyster, J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 2002, 359, 487-491. (Pubitemid 34164296)
    • (2002) Lancet , vol.359 , Issue.9305 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 24
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • DOI 10.1182/blood.V99.9.3472
    • Branford, S.; Rudzki, Z.; Walsh, S.; Grigg, A.; Arthur, C.; Taylor, K.; Herrmann, R.; Lynch, K. P.; Hughes, T. P. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002, 99, 3472-3475. (Pubitemid 34525335)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6    Herrmann, R.7    Lynch, K.P.8    Hughes, T.P.9
  • 25
    • 33750344192 scopus 로고    scopus 로고
    • A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib [10]
    • DOI 10.1038/sj.leu.2404400, PII 2404400
    • Gruber, F. X.; Hjorth-Hansen, H.; Mikkola, I.; Stenke, L.; Johansen, T. A novel BCR-ABL splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib. Leukemia 2006, 20, 2057-2060. (Pubitemid 44614904)
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 2057-2060
    • Gruber, F.X.1    Hjorth-Hansen, H.2    Mikkola, I.3    Stenke, L.4    Johansen, T.5
  • 27
    • 34548830437 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia [28] Burchert, A. Roots of imatinib resistance: A question of selfrenewal?
    • Donato, N. J.; Wu, J. Y.; Stapley, J.; Gallick, G.; Lin, H.; Arlinghaus, R.; Talpaz, M. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia [28] Burchert, A. Roots of imatinib resistance: A question of selfrenewal? Drug Resist. Updat. 2007, 10, 152-161.
    • (2007) Drug Resist. Updat. , vol.10 , pp. 152-161
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 28
    • 0035949485 scopus 로고    scopus 로고
    • Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy
    • DOI 10.1073/pnas.201398998
    • Duesberg, P.; Stindl, R.; Hehlmann, R. Origin of multidrug resistance in cells with and without multidrug resistance genes: chromosome reassortments catalyzed by aneuploidy. Proc. Natl. Acad. Sci. USA 2001, 98, 11283-11288. (Pubitemid 32928720)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.20 , pp. 11283-11288
    • Duesberg, P.1    Stindl, R.2    Hehlmann, R.3
  • 31
    • 2442551051 scopus 로고    scopus 로고
    • Chromosomal instability
    • Gollin, S. M. Chromosomal instability. Curr. Opin. Oncol. 2004, 16, 25-31.
    • (2004) Curr. Opin. Oncol. , vol.16 , pp. 25-31
    • Gollin, S.M.1
  • 32
    • 43049183136 scopus 로고    scopus 로고
    • Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia
    • DOI 10.1016/j.cancergencyto.2008.01.024, PII S0165460808001404
    • Yamamoto, K.; Yakushijin, K.; Nishikawa, S.; Minagawa, K.; Katayama, Y.; Shimoyama, M.; Matsui, T. Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia. Cancer Genet. Cytogenet. 2008, 183, 77-81. (Pubitemid 351636130)
    • (2008) Cancer Genetics and Cytogenetics , vol.183 , Issue.1 , pp. 77-81
    • Yamamoto, K.1    Yakushijin, K.2    Nishikawa, S.3    Minagawa, K.4    Katayama, Y.5    Shimoyama, M.6    Matsui, T.7
  • 33
    • 35648999534 scopus 로고    scopus 로고
    • Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies
    • Mimeault, M.; Hauke, R.; Batra, S. K. Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin. Pharmacol. Ther. 2007, 11, 981-1011.
    • (2007) Clin. Pharmacol. Ther. , vol.11 , pp. 981-1011
    • Mimeault, M.1    Hauke, R.2    Batra, S.K.3
  • 34
    • 35748981505 scopus 로고    scopus 로고
    • Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells
    • DOI 10.1080/10245330701384179, PII 779749476
    • Baran, Y.; Ural, A. U.; Gunduz, U. Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells. Hematology 2007, 12, 497-503. (Pubitemid 350048059)
    • (2007) Hematology , vol.12 , Issue.6 , pp. 497-503
    • Baran, Y.1    Ural, A.U.2    Gunduz, U.3
  • 35
    • 43749123266 scopus 로고    scopus 로고
    • Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells
    • DOI 10.1038/leu.2008.95, PII LEU200895
    • Bonhoure, E.; Lauret, A.; Barnes, D. J.; Martin, C.; Malavaud, B.; Kohama, T.; Melo, J. V.; Cuvillier O. Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. Leukemia 2008, 2, 971-979. (Pubitemid 351689879)
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 971-979
    • Bonhoure, E.1    Lauret, A.2    Barnes, D.J.3    Martin, C.4    Malavaud, B.5    Kohama, T.6    Melo, J.V.7    Cuvillier, O.8
  • 37
    • 34248166041 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
    • Nam, S.; Williams, A.; Vultur, A.; List, A.; Bhalla, K.; Smith, D.; Lee, F. Y.; Jove, R. Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol. Cancer Ther. 2007, 6, 1400-1405.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1400-1405
    • Nam, S.1    Williams, A.2    Vultur, A.3    List, A.4    Bhalla, K.5    Smith, D.6    Lee, F.Y.7    Jove, R.8
  • 38
    • 34548412863 scopus 로고    scopus 로고
    • + human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
    • DOI 10.1124/mol.106.033308
    • Rahmani, M.; Nguyen, T. K.; Dent, P.; Grant, S. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol. Pharmacol. 2007, 72, 788-795. (Pubitemid 47351213)
    • (2007) Molecular Pharmacology , vol.72 , Issue.3 , pp. 788-795
    • Rahmani, M.1    Nguyen, T.K.2    Dent, P.3    Grant, S.4
  • 41
    • 0142227047 scopus 로고    scopus 로고
    • Comparative gene expression profile of chronic myeloid leukemia cells innately resistant to imatinib mesylate
    • Tipping, A. J.; Deininger, M. W.; Goldman, J. M.; Melo, J. V. Comparative gene expression profile of chronic myeloid leukemia cells innately resistant to imatinib mesylate. Exp. Hematol. 2003, 31, 1073-1080.
    • (2003) Exp. Hematol. , vol.31 , pp. 1073-1080
    • Tipping, A.J.1    Deininger, M.W.2    Goldman, J.M.3    Melo, J.V.4
  • 42
    • 34249737950 scopus 로고    scopus 로고
    • Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
    • DOI 10.1074/jbc.M610157200
    • Baran, Y.; Salas, A.; Senkal, C. E.; Gunduz, U.; Bielawski, J.; Obeid, L. M.; Ogretmen, B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J. Biol. Chem. 2007, 282, 10922-10934. (Pubitemid 47100788)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 10922-10934
    • Baran, Y.1    Salas, A.2    Senkal, C.E.3    Gunduz, U.4    Bielawski, J.5    Obeid, L.M.6    Ogretmen, B.7
  • 43
    • 40849126769 scopus 로고    scopus 로고
    • HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells
    • Sugimoto, Y.; Nakamura, S.; Okinaka, K.; Hirano, I.; Ono, T.; Shigeno, K.; Shinjo, K.; Ohnishi, K. HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells. Leuk. Res. 2008, 32, 962-971
    • (2008) Leuk. Res. , vol.32 , pp. 962-971
    • Sugimoto, Y.1    Nakamura, S.2    Okinaka, K.3    Hirano, I.4    Ono, T.5    Shigeno, K.6    Shinjo, K.7    Ohnishi, K.8
  • 44
    • 4344715880 scopus 로고    scopus 로고
    • Prognostic and predictive markers in cancer
    • Conley, B. A.; Taube, S. E. Prognostic and predictive markers in cancer. Dis. Markers. 2004, 20, 35-43. (Pubitemid 39149913)
    • (2004) Disease Markers , vol.20 , Issue.2 , pp. 35-43
    • Conley, B.A.1    Taube, S.E.2
  • 45
    • 12144289310 scopus 로고    scopus 로고
    • Changes Associated with the Development of Resistance to Imatinib (STI571) in Two Leukemia Cell Lines Expressing p210 Bcr/Abl Protein
    • DOI 10.1002/cncr.20131
    • Scappini, B.; Gatto, S.; Onida, F.; Ricci, C.; Divoky, V.; Wierda, W. G.; Andreeff, M.; Dong, L.; Hayes, K.; Verstovsek, S.; Kantarjian, H. M.; Beran, M. Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein. Cancer 2004, 100, 1459-1471. (Pubitemid 38366849)
    • (2004) Cancer , vol.100 , Issue.7 , pp. 1459-1471
    • Scappini, B.1    Gatto, S.2    Onida, F.3    Ricci, C.4    Divoky, V.5    Wierda, W.G.6    Andreeff, M.7    Dong, L.8    Hayes, K.9    Verstovsek, S.10    Kantarjian, H.M.11    Beran, M.12
  • 47
    • 0037108879 scopus 로고    scopus 로고
    • Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin
    • Nimmanapalli, R.; O'Bryan, E.; Huang, M.; Bali, P.; Burnette, P. K.; Loughran, T.; Tepperberg, J.; Jove, R.; Bhalla, K. Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin. Cancer Res. 2002, 60, 5761-5769. (Pubitemid 35204733)
    • (2002) Cancer Research , vol.62 , Issue.20 , pp. 5761-5769
    • Nimmanapalli, R.1    O'Bryan, E.2    Huang, M.3    Bali, P.4    Burnette, P.K.5    Loughran, T.6    Tepperberg, J.7    Jove, R.8    Bhalla, K.9
  • 51
    • 34247387973 scopus 로고    scopus 로고
    • Cancer drug resistance: The central role of the karyotype
    • DOI 10.1016/j.drup.2007.02.003, PII S1368764607000076
    • Duesberg, P.; Li, R.; Sachs, R.; Fabarius, A.; Upender, M. B.; Hehlmann, R. Cancer drug resistance, the central role of the karyotype. Drug Resist. Updat. 2007, 10, 51-58. (Pubitemid 46636382)
    • (2007) Drug Resistance Updates , vol.10 , Issue.1-2 , pp. 51-58
    • Duesberg, P.1    Li, R.2    Sachs, R.3    Fabarius, A.4    Upender, M.B.5    Hehlmann, R.6
  • 52
    • 34247391483 scopus 로고    scopus 로고
    • Multiple paths to a drug resistance phenotype: Mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs
    • DOI 10.1016/j.drup.2007.02.002, PII S1368764607000064
    • Fojo, T. Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs. Drug Resist. Updat. 2007, 10, 59-67. (Pubitemid 46656478)
    • (2007) Drug Resistance Updates , vol.10 , Issue.1-2 , pp. 59-67
    • Fojo, T.1
  • 54
    • 33748122556 scopus 로고    scopus 로고
    • Cancer-linked DNA hypomethylation and its relationship to hypermethylation
    • DNA Methylation: Development, Genetic Disease and Cancer
    • Ehrlich, M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr. Top. Microbiol. Immunol. 2006, 310, 251-274. (Pubitemid 47400293)
    • (2006) Current Topics in Microbiology and Immunology , vol.310 , pp. 251-274
    • Ehrlich, M.1
  • 55
    • 33845237644 scopus 로고    scopus 로고
    • RNAi, microRNAs, and human disease
    • Hammond, S. M. RNAi, microRNAs, and human disease. Cancer Chemother. Pharmacol. 2006, 58, 63-68.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 63-68
    • Hammond, S.M.1
  • 56
    • 33749487425 scopus 로고    scopus 로고
    • MicroRNA regulates the expression of human cytochrome P450 1B1
    • DOI 10.1158/0008-5472.CAN-06-1403
    • Tsuchiya, Y.; Nakajima, M.; Takagi, S.; Taniya, T.; Yokoi T. MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 2006, 66, 9090-9098. (Pubitemid 44521128)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9090-9098
    • Tsuchiya, Y.1    Nakajima, M.2    Takagi, S.3    Taniya, T.4    Yokoi, T.5
  • 57
    • 35348992096 scopus 로고    scopus 로고
    • Investigation of MicroRNA Alterations in Leukemias and Lymphomas
    • Calin, G. A.; Croce, C. M. Investigation of MicroRNA Alterations in Leukemias and Lymphomas. Methods Enzymol. 2007, 427, 191-213.
    • (2007) Methods Enzymol. , vol.427 , pp. 191-213
    • Calin, G.A.1    Croce, C.M.2
  • 59
    • 33846401539 scopus 로고    scopus 로고
    • Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics
    • Li, X.; Schuler, M. A.; Berenbaum, M. R. Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics. Annu. Rev. Entomol. 2007, 52, 231-253.
    • (2007) Annu. Rev. Entomol. , vol.52 , pp. 231-253
    • Li, X.1    Schuler, M.A.2    Berenbaum, M.R.3
  • 60
    • 21344453004 scopus 로고    scopus 로고
    • Pharmacogenetics for individualized cancer chemotherapy
    • Efferth, T.; Volm, M. Pharmacogenetics for individualized cancer chemotherapy. Pharmacol. Ther. 2005, 107, 155-176.
    • (2005) Pharmacol. Ther. , vol.107 , pp. 155-176
    • Efferth, T.1    Volm, M.2
  • 61
    • 18844409128 scopus 로고    scopus 로고
    • Predicting drug response and toxicity based on gene polymorphisms
    • DOI 10.1016/j.critrevonc.2005.01.005, PII S1040842805000314
    • Robert, J.; Morvan, V. L.; Smith, D.; Pourquier, P.; Bonnet, J. Predicting drug response and toxicity based on gene polymorphisms. Crit. Rev. Oncol. Hematol. 2005, 54, 171-196 (Pubitemid 40693684)
    • (2005) Critical Reviews in Oncology/Hematology , vol.54 , Issue.3 , pp. 171-196
    • Robert, J.1    Le Morvan, V.2    Smith, D.3    Pourquier, P.4    Bonnet, J.5
  • 62
    • 20144388183 scopus 로고    scopus 로고
    • Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5-year follow-up
    • Lahaye, T.; Riehm, B.; Berger, U.; Paschka, P.; Muller, M. C.; Kreil, S.; Merx, K.; Schwindel, U.; Schoch, C.; Hehlmann, R.; Hochhaus, A. Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up. Cancer 2005, 103, 1659-1669.
    • (2005) Cancer , vol.103 , pp. 1659-1669
    • Lahaye, T.1    Riehm, B.2    Berger, U.3    Paschka, P.4    Muller, M.C.5    Kreil, S.6    Merx, K.7    Schwindel, U.8    Schoch, C.9    Hehlmann, R.10    Hochhaus, A.11
  • 63
    • 42049122204 scopus 로고    scopus 로고
    • New therapeutic approaches and prognostic factors in chronic myeloid leukaemia
    • Saglio, G.; Ulisciani, S.; Bosa, M.; Cilloni, D.; Rege-Cambrin, G. New therapeutic approaches and prognostic factors in chronic myeloid leukaemia. Leuk. Lymphoma 2008, 49, 625-628.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 625-628
    • Saglio, G.1    Ulisciani, S.2    Bosa, M.3    Cilloni, D.4    Rege-Cambrin, G.5
  • 64
    • 42049086836 scopus 로고    scopus 로고
    • BCR/ABL, DNA damage and DNA repair: Implications for new treatment concepts
    • Skorski, T. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk. Lymphoma 2008, 49, 610-614.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 610-614
    • Skorski, T.1
  • 66
    • 0345688603 scopus 로고    scopus 로고
    • Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias
    • DOI 10.1038/sj.onc.1206942, Drug Resistance
    • Shah, N. P.; Sawyers, C. L. Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias. Oncogene 2003, 22, 7389-7395. (Pubitemid 37487164)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISS. 6 , pp. 7389-7395
    • Shah, N.P.1    Sawyers, C.L.2
  • 67
    • 33750613947 scopus 로고    scopus 로고
    • Varying response to escalating the dose of imatinib in patients with CML who "acquire" a BCR-ABL M244V mutant allele
    • Anand, M.; Khorashad, J.; Marin, D.; Apperley, J. F.; Goldman, J. M.; Kaeda, J. S. Varying response to escalating the dose of imatinib in patients with CML who "acquire" a BCR-ABL M244V mutant allele. Blood 2006, 108, 2881-2882.
    • (2006) Blood , vol.108 , pp. 2881-2882
    • Anand, M.1    Khorashad, J.2    Marin, D.3    Apperley, J.F.4    Goldman, J.M.5    Kaeda, J.S.6
  • 69
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • DOI 10.1182/blood-2002-09-2896
    • Branford, S.; Rudzki, Z.; Walsh, S.; Parkinson, I.; Grigg, A.; Szer, J.; Taylor, K.; Herrmann, R.; Seymour, J.F.; Arthur, C.; Joske, D.; Lynch, K.; Hughes, T. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance.; and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003, 102, 276-283. (Pubitemid 36759665)
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6    Taylor, K.7    Herrmann, R.8    Seymour, J.F.9    Arthur, C.10    Joske, D.11    Lynch, K.12    Hughes, T.13
  • 70
    • 1342287959 scopus 로고    scopus 로고
    • High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib
    • Al-Ali, H. K.; Heinrich, M. C.; Lange, T.; Krahl, R.; Mueller, M.; Muller, C.; Niederwieser, D.; Druker, B. J.; Deininger, M. W. High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. Hematol. J. 2004, 5, 55-60.
    • (2004) Hematol. J. , vol.5 , pp. 55-60
    • Al-Ali, H.K.1    Heinrich, M.C.2    Lange, T.3    Krahl, R.4    Mueller, M.5    Muller, C.6    Niederwieser, D.7    Druker, B.J.8    Deininger, M.W.9
  • 73
    • 24644523246 scopus 로고    scopus 로고
    • Resistance to tyrosine kinase inhibitors: Calling on extra forces
    • DOI 10.1016/j.drup.2005.04.005, PII S1368764605000312
    • Cools, J.; Maertens, C.; Marynen, P. Resistance to tyrosine kinase inhibitors: calling on extra forces. Drug Resist. Updat. 2005, 8, 119-129. (Pubitemid 41267063)
    • (2005) Drug Resistance Updates , vol.8 , Issue.3 , pp. 119-129
    • Cools, J.1    Maertens, C.2    Marynen, P.3
  • 75
    • 29244436704 scopus 로고    scopus 로고
    • BCR-ABL kinase domain mutations in chronic myeloid leukemia: Not quite enough to cause resistance to imatinib therapy?
    • Lange, T.; Park, B.; Willis, S. G.; Deininger, M. W. BCR-ABL kinase domain mutations in chronic myeloid leukemia: not quite enough to cause resistance to imatinib therapy? Cell Cycle 2005, 4, 1761-1766.
    • (2005) Cell Cycle , vol.4 , pp. 1761-1766
    • Lange, T.1    Park, B.2    Willis, S.G.3    Deininger, M.W.4
  • 78
    • 39749189452 scopus 로고    scopus 로고
    • Sustained remissions and low rate of BCR-ABL resistance mutations with imatinib treatment chronic myelogenous leukemia in patients treated in late chronic phase: A 5-year follow up
    • DOI 10.1002/ajh.21055
    • Hess, G.; Meyer, R. G.; Schuch, B.; Bechthold, K.; El-Kholy, I.; Huber C. Sustained remissions and low rate of BCR-ABL resistance mutations with imatinib treatment chronic myelogenous leukemia in patients treated in late chronic phase: A 5-year follow up. Am. J. Hematol. 2008, 83, 178-184. (Pubitemid 351303939)
    • (2008) American Journal of Hematology , vol.83 , Issue.3 , pp. 178-184
    • Hess, G.1    Meyer, R.G.2    Schuch, B.3    Bechthold, K.4    El-Kholy, I.5    Huber, C.6
  • 79
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour, E.; Kantarjian, H.; Jones, D.; Breeden, M.; Garcia-Manero, G.; O'Brien, S.; Ravandi, F.; Borthakur, G.; Cortes, J. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 2008, 112, 53-55.
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Breeden, M.4    Garcia-Manero, G.5    O'Brien, S.6    Ravandi, F.7    Borthakur, G.8    Cortes, J.9
  • 80
    • 0038375012 scopus 로고    scopus 로고
    • Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • DOI 10.1182/blood-2002-12-3659
    • Corbin, A. S.; La Rosée, P.; Stoffregen, E. P.; Druker, B. J.; Deininger, M. W. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood 2003, 101, 4611-4614. (Pubitemid 36857835)
    • (2003) Blood , vol.101 , Issue.11 , pp. 4611-4614
    • Corbin, A.S.1    La Rosee, P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 83
  • 84
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham, S. M.; Jorgensen, H. G.; Allan, E.; Pearson, C.; Alcorn, M. J.; Richmond, L.; Holyoake, T. L. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99, 319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6    Holyoake, T.L.7
  • 85
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia, R.; Holtz, M.; Niu, N.; Gray, R.; Snyder, D. S.; Sawyers, C. L.; Arber, D. A.; Slovak, M. L.; Forman, S. J. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003, 101, 4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3    Gray, R.4    Snyder, D.S.5    Sawyers, C.L.6    Arber, D.A.7    Slovak, M.L.8    Forman, S.J.9
  • 86
    • 4544312606 scopus 로고    scopus 로고
    • Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia
    • Sorel, N.; Bonnet, M. L.; Guillier, M.; Guilhot, F.; Brizard, A.; Turhan, A. G. Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia. Biochem. Biophys. Res Commun. 2004, 323, 728-730.
    • (2004) Biochem. Biophys. Res Commun. , vol.323 , pp. 728-730
    • Sorel, N.1    Bonnet, M.L.2    Guillier, M.3    Guilhot, F.4    Brizard, A.5    Turhan, A.G.6
  • 87
    • 0842322903 scopus 로고    scopus 로고
    • Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells
    • DOI 10.1080/1042819031000151905
    • Holtz, M. S.; Bhatia R. Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells. Leuk. Lymphoma 2004, 45, 237-245. (Pubitemid 38181424)
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.2 , pp. 237-245
    • Holtz, M.S.1    Bhatia, R.2
  • 88
    • 38349168416 scopus 로고    scopus 로고
    • Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
    • Li, S.; Li, D. Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors. J. Cell.Mol. Med.2007, 11, 1251-1262.
    • (2007) J. Cell.Mol. Med. , vol.11 , pp. 1251-1262
    • Li, S.1    Li, D.2
  • 89
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary, P. M.; Roninson, I. B. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991, 66, 85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 90
    • 2942590202 scopus 로고    scopus 로고
    • ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status
    • DOI 10.1182/blood-2003-11-3989
    • Uchida, N.; Dykstra, B.; Lyons, K.; Leung, F.; Kristiansen, M.; Eaves, C. ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status. Blood 2004, 103, 4487-4495 (Pubitemid 38745974)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4487-4495
    • Uchida, N.1    Dykstra, B.2    Lyons, K.3    Leung, F.4    Kristiansen, M.5    Eaves, C.J.6
  • 91
    • 27144512265 scopus 로고    scopus 로고
    • + hematopoietic stem and progenitor cells
    • DOI 10.1634/stemcells.2005-0066
    • Soucek, P.; Anzenbacher, P.; Skoumalova, I.; Dvorak, M. Expression of cytochrome P450 genes in CD34+ hematopoietic stem and progenitor cells. Stem Cells. 2005, 23, 1417-1422. (Pubitemid 41504929)
    • (2005) Stem Cells , vol.23 , Issue.9 , pp. 1417-1422
    • Soucek, P.1    Anzenbacher, P.2    Skoumalova, I.3    Dvorak, M.4
  • 93
    • 44649098271 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: DNA genotyping and gene expression profiling to identify molecular determinants of chemosensitivity
    • Auman, J. T. ; McLeod, H. L. Cancer pharmacogenomics: DNA genotyping and gene expression profiling to identify molecular determinants of chemosensitivity. Drug Metab. Rev. 2008, 40, 303-315.
    • (2008) Drug Metab. Rev. , vol.40 , pp. 303-315
    • Auman, J.T.1    McLeod, H.L.2
  • 94
    • 46749141730 scopus 로고    scopus 로고
    • Imatinib metabolite profiling in parallel to imatinib quantification in plasma of treated patients using liquid chromatography-mass spectrometry
    • DOI 10.1002/jms.1369
    • Rochat, B.; Fayet, A.; Widmer, N.; Lahrichi, S. L.; Pesse, B.; Décosterd, L. A.; Biollaz, J. Imatinib metabolite profiling in parallel to imatinib quantification in plasma of treated patients using liquid chromatography-mass spectrometry. J. Mass Spectrom. 2008, 43, 43736-43752. (Pubitemid 351954808)
    • (2008) Journal of Mass Spectrometry , vol.43 , Issue.6 , pp. 736-752
    • Rochat, B.1    Fayet, A.2    Widmer, N.3    Lahrichi, S.L.4    Pesse, B.5    Decosterd, L.A.6    Biollaz, J.7
  • 96
    • 0037438467 scopus 로고    scopus 로고
    • Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
    • DOI 10.1182/blood-2002-05-1451
    • Kantarjian, H. M.; Talpaz, M.; O'Brien, S.; Giles, F.; Garcia-Manero, G.; Faderl, S.; Thomas, D.; Shan, J.; Rios, M. B.; Cortes, J. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood 2003, 101, 473-475. (Pubitemid 36077567)
    • (2003) Blood , vol.101 , Issue.2 , pp. 473-475
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3    Giles, F.4    Garcia-Manero, G.5    Faded, S.6    Thomas, D.7    Shan, J.8    Rios, M.B.9    Cortes, J.10
  • 97
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • Van Glabbeke, M.; Verweij, J.; Casali, P. G.; Le Cesne, A.; Hohenberger, P.; Ray-Coquard, I.; Schlemmer, M.; van Oosterom, A. T.; Goldstein, D.; Sciot, R.; Hogendoorn, P. C.; Brown, M.; Bertulli, R.; Judson, I. R. Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J. Clin. Oncol. 2005, 23, 5795-5804.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3    Le Cesne, A.4    Hohenberger, P.5    Ray-Coquard, I.6    Schlemmer, M.7    Van Oosterom, A.T.8    Goldstein, D.9    Sciot, R.10    Hogendoorn, P.C.11    Brown, M.12    Bertulli, R.13    Judson, I.R.14
  • 98
    • 23644452642 scopus 로고    scopus 로고
    • Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg
    • EORTC Soft Tissue and Bone Sarcoma Group; the Italian Sarcoma Group; Australasian Gastrointestinal Trials Group.
    • Zalcberg, J. R.; Verweij, J.; Casali, P. G.; Le Cesne, A.; Reichardt, P.; Blay, J. Y.; Schlemmer, M.; Van Glabbeke, M.; Brown, M.; Judson, I. R.; EORTC Soft Tissue and Bone Sarcoma Group; the Italian Sarcoma Group; Australasian Gastrointestinal Trials Group. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur. J. Cancer 2005, 41, 1751-1757.
    • (2005) Eur. J. Cancer , vol.41 , pp. 1751-1757
    • Zalcberg, J.R.1    Verweij, J.2    Casali, P.G.3    Le Cesne, A.4    Reichardt, P.5    Blay, J.Y.6    Schlemmer, M.7    Van Glabbeke, M.8    Brown, M.9    Judson, I.R.10
  • 100
    • 1042289341 scopus 로고    scopus 로고
    • Differences and similarities in kinetics of BCR-ABL transcript levels in CML patients treated with imatinib mesylate for chronic or accelerated disease phase
    • Moravcova, J.; Zmekova, V.; Klamova, H.; Voglova, J.; Faber, E.; Michalova, K.; Rabasova, J.; Jarosova, M. Differences and similarities in kinetics of BCR-ABL transcript levels in CML patients treated with imatinib mesylate for chronic or accelerated disease phase. Leuk. Res. 2004, 28, 415-419.
    • (2004) Leuk. Res. , vol.28 , pp. 415-419
    • Moravcova, J.1    Zmekova, V.2    Klamova, H.3    Voglova, J.4    Faber, E.5    Michalova, K.6    Rabasova, J.7    Jarosova, M.8
  • 102
    • 31344441164 scopus 로고    scopus 로고
    • Looking beyond imatinib: Next line of targeted drugs for CML shows promise
    • DOI 10.1001/jama.295.4.369
    • Hampton, T. Looking beyond imatinib: next line of targeted drugs for CML shows promise. JAMA 2006, 295, 369-370. (Pubitemid 43144964)
    • (2006) Journal of the American Medical Association , vol.295 , Issue.4 , pp. 369-370
    • Hampton, T.1
  • 106
    • 34247570352 scopus 로고    scopus 로고
    • Dasatinib is effective in imatinib-resistant CML
    • Cannell, E. Dasatinib is effective in imatinib-resistant CML. Lancet Oncol. 2007, 8, 286.
    • (2007) Lancet Oncol. , vol.8 , pp. 286
    • Cannell, E.1
  • 108
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • DOI 10.1182/blood-2007-02-073528
    • Ottmann, O.; Dombret, H.; Martinelli, G.; Simonsson, B.; Guilhot, F.; Larson, R. A.; Rege-Cambrin, G.; Radich, J.; Hochhaus, A.; Apanovitch, A. M.; Gollerkeri, A.; Coutre, S. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007, 110, 2309-2315. (Pubitemid 47523149)
    • (2007) Blood , vol.110 , Issue.7 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3    Simonsson, B.4    Guilhot, F.5    Larson, R.A.6    Rege-Cambrin, G.7    Radich, J.8    Hochhaus, A.9    Apanovitch, A.M.10    Gollerkeri, A.11    Coutre, S.12
  • 110
    • 42049123098 scopus 로고    scopus 로고
    • Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib
    • Hantschel, O.; Rix, U.; Superti-Furga, G. Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib. Leuk. Lymphoma 2008, 49, 615-619.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 615-619
    • Hantschel, O.1    Rix, U.2    Superti-Furga, G.3
  • 111
    • 33745069351 scopus 로고    scopus 로고
    • Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)
    • DOI 10.1182/blood-2005-12-010132
    • von Bubnoff, N.; Manley, P. W.; Mestan, J.; Sanger, J.; Peschel, C.; Duyster, J. Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107). Blood 2006, 108, 1328-1333. (Pubitemid 44232032)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1328-1333
    • Von Bubnoff, N.1    Manley, P.W.2    Mestan, J.3    Sanger, J.4    Peschel, C.5    Duyster, J.6
  • 113
    • 33847164409 scopus 로고    scopus 로고
    • Second-line treatment with dasatinib in patients resistant to imatinib can select novel inhibitor-specific BCR-ABL mutants in Ph+ ALL
    • DOI 10.1016/S1470-2045(07)70078-5, PII S1470204507700785
    • Soverini, S.; Martinelli, G.; Colarossi, S.; Gnani, A.; Rondoni, M.; Castagnetti, F.; Paolini, S.; Rosti, G.; Baccarani, M. Second-line treatment with dasatinib in patients resistant to imatinib can select novel inhibitor-specific BCR-ABL mutants in Ph+ ALL. Lancet Oncol. 2007, 8, 273-274. (Pubitemid 46291717)
    • (2007) Lancet Oncology , vol.8 , Issue.3 , pp. 273-274
    • Soverini, S.1    Martinelli, G.2    Colarossi, S.3    Gnani, A.4    Rondoni, M.5    Castagnetti, F.6    Paolini, S.7    Rosti, G.8    Baccarani, M.9
  • 115
    • 33846200681 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure
    • Quintas-Cardama, A.; Kantarjian, H.; Jones, D.; Nicaise, C.; O'Brien, S.; Giles, F.; Talpaz, M.; Cortes, J. Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure. Blood 2007, 109, 497-1479
    • (2007) Blood , vol.109 , pp. 497-1479
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3    Nicaise, C.4    O'Brien, S.5    Giles, F.6    Talpaz, M.7    Cortes, J.8
  • 116
    • 35548930789 scopus 로고    scopus 로고
    • Nilotinib can override dasatinib resistance in chronic myeloid leukemia patients with secondary resistance to imatinib first-line therapy
    • DOI 10.1159/000108639
    • Breccia, M.; Cannella, L.; Nanni, M.; Stefanizzi, C.; Alimena, G. Nilotinib can override dasatinib resistance in chronic myeloid leukemia patients with secondary resistance to imatinib first-line therapy. Acta Haematol. 2007, 118, 162-164. (Pubitemid 350014906)
    • (2007) Acta Haematologica , vol.118 , Issue.3 , pp. 162-164
    • Breccia, M.1    Cannella, L.2    Nanni, M.3    Stefanizzi, C.4    Alimena, G.5
  • 119
    • 33846849302 scopus 로고    scopus 로고
    • New Targeted Therapies for Chronic Myelogenous Leukemia: Opportunities to
    • DOI 10.1053/j.seminhematol.2006.12.003, PII S0037196306002563, Integrating the New Generation of Targeted Therapies for Chronic Myelogenous Leukemia
    • Jabbour, E.; Cortes, J.; O'Brien, S.; Giles, F.; Kantarjian, H. New targeted therapies for chronic myelogenous leukemia: opportunities to overcome imatinib resistance. Semin. Hematol. 2007, 44, 25-31. (Pubitemid 46209244)
    • (2007) Seminars in Hematology , vol.44 , Issue.SUPPL. 1 , pp. 25-31
    • Jabbour, E.1    Cortes, J.2    O'Brien, S.3    Giles, F.4    Kantarjian, H.5
  • 120
    • 34548799800 scopus 로고    scopus 로고
    • Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib
    • Cortes, J.; Jabbour, E.; Daley, G. Q.; O'brien, S.; Verstovsek, S.; Ferrajoli, A.; Koller, C.; Zhu, Y.; Statkevich, P.; Kantarjian, H. Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib. Cancer 2007, 110, 1295-1302.
    • (2007) Cancer , vol.110 , pp. 1295-1302
    • Cortes, J.1    Jabbour, E.2    Daley, G.Q.3    O'Brien, S.4    Verstovsek, S.5    Ferrajoli, A.6    Koller, C.7    Zhu, Y.8    Statkevich, P.9    Kantarjian, H.10
  • 121
    • 33947216149 scopus 로고    scopus 로고
    • Important therapeutic targets in chronic myelogenous leukemia
    • DOI 10.1158/1078-0432.CCR-06-2147
    • Kantarjian, H. M.; Giles, F.; Quintas-Cardama, A.; Cortes, J. Important therapeutic targets in chronic myelogenous leukemia. Clin. Cancer Res. 2007, 13, 1089-1097. (Pubitemid 46424047)
    • (2007) Clinical Cancer Research , vol.13 , Issue.4 , pp. 1089-1097
    • Kantarjian, H.M.1    Giles, F.2    Quintas-Cardama, A.3    Cortes, J.4
  • 124
  • 125
    • 0030010301 scopus 로고    scopus 로고
    • Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient
    • Conus, P.; Bondolfi, G.; Eap, C. B.; Macciardi, F.; Baumann, P. Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient. Pharmacopsychiatry. 1996, 29, 108-110.
    • (1996) Pharmacopsychiatry , vol.29 , pp. 108-110
    • Conus, P.1    Bondolfi, G.2    Eap, C.B.3    Macciardi, F.4    Baumann, P.5
  • 126
    • 0031945353 scopus 로고    scopus 로고
    • Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping
    • Baumann, P.; Broly, F.; Kosel, M.; Eap, C. B. Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping. Pharmacopsychiatry 1998, 31, 72.
    • (1998) Pharmacopsychiatry , vol.31 , pp. 72
    • Baumann, P.1    Broly, F.2    Kosel, M.3    Eap, C.B.4
  • 127
    • 34147107091 scopus 로고    scopus 로고
    • Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs
    • White, D. L.; Saunders, V. A.; Quinn, S. R.; Manley, P. W.; Hughes, T. P. Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs. Blood 2007, 109, 3609-3610.
    • (2007) Blood , vol.109 , pp. 3609-3610
    • White, D.L.1    Saunders, V.A.2    Quinn, S.R.3    Manley, P.W.4    Hughes, T.P.5
  • 130
    • 0043245793 scopus 로고    scopus 로고
    • Functional consequence of MDR1 expression on imatinib intracellular concentrations
    • Widmer, N.; Colombo, S.; Buclin, T.; Decosterd, L. A. Functional consequence of MDR1 expression on imatinib intracellular concentrations. Blood 2003, 102, 1142.
    • (2003) Blood , vol.102 , pp. 1142
    • Widmer, N.1    Colombo, S.2    Buclin, T.3    Decosterd, L.A.4
  • 131
    • 33750355434 scopus 로고    scopus 로고
    • Extracellular concentration of anticancer drugs that regulates their intracellular distribution and binding to DNA in cells with multidrug resistant phenotype
    • Bogush, T. A.; Ravcheeva, A. B.; Bogush, E. A.; Konukhova, A. V.; Kuz'mina, K. E.; Baryshnikov, A. Y.; Davydov, M. I. Extracellular concentration of anticancer drugs that regulates their intracellular distribution and binding to DNA in cells with multidrug resistant phenotype. Dokl. Biochem. Biophys. 2006, 410, 273-277.
    • (2006) Dokl. Biochem. Biophys. , vol.410 , pp. 273-277
    • Bogush, T.A.1    Ravcheeva, A.B.2    Bogush, E.A.3    Konukhova, A.V.4    Kuz'Mina, K.E.5    Baryshnikov, A.Y.6    Davydov, M.I.7
  • 132
    • 0041766239 scopus 로고    scopus 로고
    • An automated HPLC method to determine intracellular vincristine concentrations in mononuclear cells of children with acute lymphoblastic leukemia
    • DOI 10.1097/00007691-200308000-00004
    • Groninger, E.; Koopmans, P.; Kamps, W.; de Graaf, S.; Uges, D. An automated HPLC method to determine intracellular vincristine concentrations in mononuclear cells of children with acute lymphoblastic leukemia. Ther. Drug Monit. 2003, 25, 441-446. (Pubitemid 36927974)
    • (2003) Therapeutic Drug Monitoring , vol.25 , Issue.4 , pp. 441-446
    • Groninger, E.1    Koopmans, P.2    Kamps, W.3    De Graaf, S.4    Uges, D.5
  • 134
    • 33748163469 scopus 로고    scopus 로고
    • Are plasma levels valid surrogates for cellular concentrations of antiretroviral drugs in HIV-infected patients?
    • Swiss HIV Cohort Study
    • Colombo, S.; Telenti, A.; Buclin, T.; Furrer, H.; Lee, B. L.; Biollaz, J.; Decosterd, L. A.; Swiss HIV Cohort Study. Are plasma levels valid surrogates for cellular concentrations of antiretroviral drugs in HIV-infected patients? Ther. Drug Monit. 2006, 28, 332-338.
    • (2006) Ther. Drug Monit. , vol.28 , pp. 332-338
    • Colombo, S.1    Telenti, A.2    Buclin, T.3    Furrer, H.4    Lee, B.L.5    Biollaz, J.6    Decosterd, L.A.7
  • 135
    • 36749068990 scopus 로고    scopus 로고
    • Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment
    • Ma, J.; Waxman, D. J. Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment. Mol. Cancer Ther. 2007, 6, 2879-2890.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2879-2890
    • Ma, J.1    Waxman, D.J.2
  • 136
    • 36148937068 scopus 로고    scopus 로고
    • Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model
    • Chen, C. S.; Jounaidi, Y.; Su, T.; Waxman, D. J. Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model. Cancer Gene Ther. 2007, 14, 935-944.
    • (2007) Cancer Gene Ther. , vol.14 , pp. 935-944
    • Chen, C.S.1    Jounaidi, Y.2    Su, T.3    Waxman, D.J.4
  • 137
    • 33645466808 scopus 로고    scopus 로고
    • Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11
    • Jounaidi, Y.; Chen, C. S.; Veal, G. J.; Waxman, D. J. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Mol. Cancer Ther. 2006, 5, 541-555.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 541-555
    • Jounaidi, Y.1    Chen, C.S.2    Veal, G.J.3    Waxman, D.J.4
  • 138
    • 0033828231 scopus 로고    scopus 로고
    • The evolution of drug metabolism
    • Nebert, D. W.; Dieter, M. Z. The evolution of drug metabolism. Pharmacology 2000, 61, 124-135.
    • (2000) Pharmacology , vol.61 , pp. 124-135
    • Nebert, D.W.1    Dieter, M.Z.2
  • 139
    • 0041930641 scopus 로고    scopus 로고
    • Vertebrate UDP-glucuronosyltransferases: Functional and evolutionary aspects
    • DOI 10.1016/S0006-2952(03)00296-X
    • Bock, K. W. Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochem. Pharmacol. 2003, 66, 691-696. (Pubitemid 37011407)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.5 , pp. 691-696
    • Bock, K.W.1
  • 140
    • 25844487733 scopus 로고    scopus 로고
    • Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates
    • DOI 10.1146/annurev.genom.6.080604.162122
    • Dean, M.; Annilo, T. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Annu. Rev. Genomics Hum. Genet. 2005, 6, 123-142. (Pubitemid 41397078)
    • (2005) Annual Review of Genomics and Human Genetics , vol.6 , pp. 123-142
    • Dean, M.1    Annilo, T.2
  • 141
    • 0025333289 scopus 로고
    • Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
    • Gonzalez, F. J.; Nebert, D. W. Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet. 1990, 6, 182-186.
    • (1990) Trends Genet. , vol.6 , pp. 182-186
    • Gonzalez, F.J.1    Nebert, D.W.2
  • 142
    • 0032102916 scopus 로고    scopus 로고
    • Evolution of the cytochrome P450 superfamily: Sequence alignments and pharmacogenetics
    • Lewis, D. F.; Watson, E.; Lake, B. G. Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics. Mutat. Res. 1998, 410, 245-270.
    • (1998) Mutat. Res. , vol.410 , pp. 245-270
    • Lewis, D.F.1    Watson, E.2    Lake, B.G.3
  • 143
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
    • Hediger, M. A.; Romero, M. F.; Peng, J. B.; Rolfs, A.; Takanaga, H.; Bruford, E. A. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch. 2004, 447, 465-468.
    • (2004) Pflugers Arch. , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 144
    • 65249139907 scopus 로고    scopus 로고
    • Analysis and update of the human solute carrier (SLC) gene superfamily
    • He, L.; Vasiliou, K.; Nebert, D. W. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum. Genomics 2009, 3, 195-206.
    • (2009) Hum. Genomics , vol.3 , pp. 195-206
    • He, L.1    Vasiliou, K.2    Nebert, D.W.3
  • 146
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • Deeley, R. G.; Westlake, C.; Cole, S. P. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol. Rev. 2006, 86, 849-899.
    • (2006) Physiol. Rev. , vol.86 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.3
  • 147
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system
    • DOI 10.1152/physrev.00037.2005
    • Sarkadi, B.; Homolya, L.; Szakács, G.; Váradi, A. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol. Rev. 2006, 86, 1179-1236. (Pubitemid 44521651)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakacs, G.3    Varadi, A.4
  • 149
    • 6344250770 scopus 로고    scopus 로고
    • 57 varieties: The human cytochromes P450
    • Lewis, D. F. 57 varieties: the human cytochromes P450. Pharmacogenomics 2004, 5, 305-318.
    • (2004) Pharmacogenomics , vol.5 , pp. 305-318
    • Lewis, D.F.1
  • 150
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T.; Yamazaki, H.; Mimura, M.; Inui, Y.; Guengerich, F. P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 1994, 270, 414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 151
    • 34548381638 scopus 로고    scopus 로고
    • Characterization of orphan human cytochromes P450
    • DOI 10.1080/03602530701467708, PII 781832530
    • Stark, K.; Guengerich, F. P. Characterization of orphan human cytochromes P450. Drug. Metab. Rev. 2007, 39, 627-637. (Pubitemid 47355742)
    • (2007) Drug Metabolism Reviews , vol.39 , Issue.2-3 , pp. 627-637
    • Stark, K.1    Guengerich, F.P.2
  • 153
    • 33847092271 scopus 로고    scopus 로고
    • The biochemistry of drug metabolism - An introduction part 2. Redox reactions and their enzymes
    • DOI 10.1002/cbdv.200790032
    • Testa, B.; Kramer, S. D. The biochemistry of drug metabolism - an introduction: part 2. Redox reactions and their enzymes. Chem. Biodivers. 2007, 4, 257-405. (Pubitemid 46937873)
    • (2007) Chemistry and Biodiversity , vol.4 , Issue.3 , pp. 257-405
    • Testa, B.1    Kramer, S.D.2
  • 155
    • 33747871144 scopus 로고    scopus 로고
    • ABC drug transporter at the blood-brain barrier: Effects on drug metabolism and drug response
    • DOI 10.1007/s00406-006-0664-4
    • Ebinger, M.; Uhr, M. ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response. Eur Arch. Psychiatr. Clin. Neurosci. 2006, 256, 294-298. (Pubitemid 44285053)
    • (2006) European Archives of Psychiatry and Clinical Neuroscience , vol.256 , Issue.5 , pp. 294-298
    • Ebinger, M.1    Uhr, M.2
  • 156
    • 0011099824 scopus 로고    scopus 로고
    • Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain
    • El-Bacha, R. S.; Minn, A. Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain. Cell. Mol. Biol. 1999, 45, 15-23.
    • (1999) Cell. Mol. Biol. , vol.45 , pp. 15-23
    • El-Bacha, R.S.1    Minn, A.2
  • 159
    • 21644475953 scopus 로고    scopus 로고
    • Analysis of the glutathione S-transferase (GST) gene family
    • Nebert, D. W.; Vasiliou, V. Analysis of the glutathione S-transferase (GST) gene family. Hum. Genomics 2004, 1, 460-464.
    • (2004) Hum. Genomics , vol.1 , pp. 460-464
    • Nebert, D.W.1    Vasiliou, V.2
  • 160
    • 33847021147 scopus 로고    scopus 로고
    • Aldo-keto reductases and bioactivation/detoxication
    • Jin, Y.; Penning, T. M. Aldo-keto reductases and bioactivation/ detoxication. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 263-292.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 263-292
    • Jin, Y.1    Penning, T.M.2
  • 161
    • 0033988708 scopus 로고    scopus 로고
    • Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction
    • DOI 10.1016/S0006-2952(99)00322-6, PII S0006295299003226
    • Ax, W.; Soldan, M.; Koch, L.; Maser, E. Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction. Biochem. Pharmacol. 2000, 59, 293-300. (Pubitemid 30001756)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.3 , pp. 293-300
    • Ax, W.1    Soldan, M.2    Koch, L.3    Maser, E.4
  • 162
    • 34547679864 scopus 로고    scopus 로고
    • Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes
    • DOI 10.1016/j.canlet.2007.03.018, PII S0304383507001565
    • Plebuch, M.; Soldan, M.; Hungerer, C.; Koch, L.; Maser, E. Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes. Cancer Lett. 2007, 255, 49-56. (Pubitemid 47212606)
    • (2007) Cancer Letters , vol.255 , Issue.1 , pp. 49-56
    • Plebuch, M.1    Soldan, M.2    Hungerer, C.3    Koch, L.4    Maser, E.5
  • 164
    • 0035097039 scopus 로고    scopus 로고
    • Overexpression of aldose reductase in liver cancers may contribute to drug resistance
    • Lee, K. W.; Ko, B. C.; Jiang, Z.; Cao, D.; Chung, S. S. Overexpression of aldose reductase in liver cancers may contribute to drug resistance. Anticancer Drugs 2001, 12, 129-132.
    • (2001) Anticancer Drugs , vol.12 , pp. 129-132
    • Lee, K.W.1    Ko, B.C.2    Jiang, Z.3    Cao, D.4    Chung, S.S.5
  • 165
    • 33847083503 scopus 로고    scopus 로고
    • Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily
    • DOI 10.1080/03602530600969440, PII 770753014
    • Hoffmann, F.; Maser, E. Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily. Drug Metab. Rev. 2007, 39, 87-144. (Pubitemid 46263532)
    • (2007) Drug Metabolism Reviews , vol.39 , Issue.1 , pp. 87-144
    • Hoffmann, F.1    Maser, E.2
  • 167
    • 0028678077 scopus 로고
    • Alcohol dehydrogenase: Enzymology and metabolism
    • Yin, S. J. Alcohol dehydrogenase: enzymology and metabolism. Alcohol. Alcohol. Suppl. 1994, 2, 113-119.
    • (1994) Alcohol. Alcohol. Suppl. , vol.2 , pp. 113-119
    • Yin, S.J.1
  • 168
    • 32444448861 scopus 로고    scopus 로고
    • Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
    • Vasiliou, V.; Nebert, D. W. Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum. Genomics 2005, 2, 138-143.
    • (2005) Hum. Genomics , vol.2 , pp. 138-143
    • Vasiliou, V.1    Nebert, D.W.2
  • 169
    • 0030772328 scopus 로고    scopus 로고
    • The role of non-P450 enzymes in drug oxidation
    • DOI 10.1023/A:1008668913093
    • Beedham, C. The role of non-P450 enzymes in drug oxidation. Pharm. World Sci. 1997, 19, 255-263. (Pubitemid 27511692)
    • (1997) Pharmacy World and Science , vol.19 , Issue.6 , pp. 255-263
    • Beedham, C.1
  • 170
    • 6344270255 scopus 로고    scopus 로고
    • Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes
    • DOI 10.1021/tx030059u
    • Panoutsopoulos, G. I.; Kouretas, D.; Beedham, C. Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes. Chem. Res.Toxicol. 2004, 17, 1368-1376. (Pubitemid 39403051)
    • (2004) Chemical Research in Toxicology , vol.17 , Issue.10 , pp. 1368-1376
    • Panoutsopoulos, G.I.1    Kouretas, D.2    Beedham, C.3
  • 171
    • 33645221836 scopus 로고    scopus 로고
    • Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    • Vasiliou, V.; Ross, D.; Nebert, D. W. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum. Genomics 2006, 2, 329-335.
    • (2006) Hum. Genomics , vol.2 , pp. 329-335
    • Vasiliou, V.1    Ross, D.2    Nebert, D.W.3
  • 172
    • 45249103473 scopus 로고    scopus 로고
    • Flavin mono-oxygenase (FMO) - The 'other' oxidase
    • Mitchell, S. C. Flavin mono-oxygenase (FMO) - the 'other' oxidase. Curr. Drug Metab. 2008, 9, 280-284.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 280-284
    • Mitchell, S.C.1
  • 173
    • 0742321737 scopus 로고    scopus 로고
    • Pharmacogenetics of soluble sulfotransferases (SULTs)
    • Glatt, H.; Meinl, W. Pharmacogenetics of soluble sulfotransferases (SULTs). Naunyn Schmiedebergs Arch. Pharmacol. 2004, 369, 55-68.
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol. , vol.369 , pp. 55-68
    • Glatt, H.1    Meinl, W.2
  • 176
    • 30144442042 scopus 로고    scopus 로고
    • Epoxide hydrolases: Structure, function, mechanism, and assay
    • DOI 10.1016/S0076-6879(05)00032-7, PII S0076687905000327, 32, Phase II Conjugation Enzymes and Transport Systems
    • Arand, M.; Cronin, A.; Adamska, M.; Oesch, F. Epoxide hydrolases: structure, function, mechanism, and assay. Methods Enzymol. 2005, 400, 569-588. (Pubitemid 43052441)
    • (2005) Methods in Enzymology , vol.400 , pp. 569-588
    • Arand, M.1    Cronin, A.2    Adamska, M.3    Oesch, F.4
  • 177
    • 34547899883 scopus 로고    scopus 로고
    • Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
    • DOI 10.1097/FPC.0b013e32810f2e58, PII 0121301120070900000006
    • Bièche, I.; Narjoz, C.; Asselah, T.; Vacher, S.; Marcellin, P.; Lidereau, R.; Beaune, P.; de Waziers, I. Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet. Genomics 2007, 17, 731-742. (Pubitemid 47263068)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.9 , pp. 731-742
    • Bieche, I.1    Narjoz, C.2    Asselah, T.3    Vacher, S.4    Marcellin, P.5    Lidereau, R.6    Beaune, P.7    De Waziers, I.8
  • 178
    • 0037478407 scopus 로고    scopus 로고
    • Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts
    • Ding, X.; Kaminsky, L. S. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu. Rev. Pharmacol. Toxicol. 2003, 43, 149-173.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 149-173
    • Ding, X.1    Kaminsky, L.S.2
  • 179
    • 33845348869 scopus 로고    scopus 로고
    • Xenobiotic-metabolizing enzymes in human lung
    • Zhang, J. Y.; Wang, Y.; Prakash, C. Xenobiotic-metabolizing enzymes in human lung. Curr. Drug Metab. 2006, 7, 939-948.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 939-948
    • Zhang, J.Y.1    Wang, Y.2    Prakash, C.3
  • 180
    • 44249098959 scopus 로고    scopus 로고
    • Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
    • Hardwick, J. P. Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem. Pharmacol. 2008, 75, 2263-2275.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2263-2275
    • Hardwick, J.P.1
  • 181
    • 34548390084 scopus 로고    scopus 로고
    • Human cytochrome p450 family 4 enzymes: Function, genetic variation and regulation
    • Hsu, M. H.; Savas, U.; Griffin, K. J.; Johnson, E. F. Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation. Drug Metab. Rev. 2007, 39, 515-538.
    • (2007) Drug Metab. Rev. , vol.39 , pp. 515-538
    • Hsu, M.H.1    Savas, U.2    Griffin, K.J.3    Johnson, E.F.4
  • 182
    • 27744454598 scopus 로고    scopus 로고
    • Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
    • DOI 10.1016/j.bcp.2005.09.011, PII S0006295205005885
    • Müller, J.; Lips, K. S.; Metzner, L.; Neubert, R. H.; Koepsell, H.; Brandsch M. Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem. Pharmacol. 2005, 70, 1851-1860. (Pubitemid 41612016)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.12 , pp. 1851-1860
    • Muller, J.1    Lips, K.S.2    Metzner, L.3    Neubert, R.H.H.4    Koepsell, H.5    Brandsch, M.6
  • 185
    • 33644841714 scopus 로고    scopus 로고
    • Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells
    • DOI 10.1016/j.ejps.2005.09.008, PII S0928098705002812, Drug Transporters: Integration in Understanding ADME
    • Zhou, F.; Illsley, N. P.; You, G. Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. Eur. J. Pharm. Sci. 2006, 27, 518-523. (Pubitemid 43363342)
    • (2006) European Journal of Pharmaceutical Sciences , vol.27 , Issue.5 , pp. 518-523
    • Zhou, F.1    Illsley, N.P.2    You, G.3
  • 186
    • 16844384592 scopus 로고    scopus 로고
    • Metformin transport by renal basolateral organic cation transporter hOCT2
    • DOI 10.1007/s11095-004-1193-3
    • Kimura, N.; Okuda, M.; Inui, K. Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm. Res. 2005, 22, 255-259. (Pubitemid 40487209)
    • (2005) Pharmaceutical Research , vol.22 , Issue.2 , pp. 255-259
    • Kimura, N.1    Okuda, M.2    Inui, K.-I.3
  • 189
    • 10644270827 scopus 로고    scopus 로고
    • Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population
    • DOI 10.1002/jps.20190
    • Kawasaki, Y.; Kato, Y.; Sai, Y.; Tsuji, A. Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population. J. Pharm. Sci. 2004, 93, 2920-2926. (Pubitemid 39657796)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.12 , pp. 2920-2926
    • Kawasaki, Y.1    Kato, Y.2    Sai, Y.3    Tsuji, A.4
  • 191
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui, Y.; König, J.; Keppler, D. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol. Pharmacol. 2001, 60, 934-943. (Pubitemid 33027428)
    • (2001) Molecular Pharmacology , vol.60 , Issue.5 , pp. 934-943
    • Cui, Y.1    Konig, J.2    Keppler, D.3
  • 192
    • 34447339394 scopus 로고    scopus 로고
    • Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity
    • DOI 10.1021/bi700020m
    • Chloupková, M.; Pickert, A.; Lee, J.Y.; Souza, S.; Trinh, Y.T.; Connelly, S.M.; Dumont. M.E.; Dean, M.; Urbatsch, I.L. Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity. Biochemistry 2007, 46, 7992-8003. (Pubitemid 47051635)
    • (2007) Biochemistry , vol.46 , Issue.27 , pp. 7992-8003
    • Chloupkova, M.1    Pickert, A.2    Lee, J.-Y.3    Souza, S.4    Trinh, Y.T.5    Connelly, S.M.6    Dumont, M.E.7    Dean, M.8    Urbatsch, I.L.9
  • 193
    • 0035958862 scopus 로고    scopus 로고
    • Transport of the beta-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1): Requirement for glutathione or a non-sulfur-containing analog
    • DOI 10.1074/jbc.M102453200
    • Leslie, E. M.; Ito, K.; Upadhyaya, P.; Hecht, S. S.; Deeley, R. G.; Cole, S. P. Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. J. Biol. Chem. 2001, 276, 27846-27854. (Pubitemid 37391478)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.30 , pp. 27846-27854
    • Leslie, E.M.1    Ito, K.-I.2    Upadhyaya, P.3    Hecht, S.S.4    Deeley, R.G.5    Cole, S.P.C.6
  • 194
    • 0034282991 scopus 로고    scopus 로고
    • Transport of amphipathic anions by human multidrug resistance protein 3
    • Zeng, H.; Liu, G.; Rea, P. A.; Kruh, G. D. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 2000, 60, 4779-4784. (Pubitemid 30701488)
    • (2000) Cancer Research , vol.60 , Issue.17 , pp. 4779-4784
    • Zeng, H.1    Liu, G.2    Rea, P.A.3    Kruh, G.D.4
  • 195
    • 33646798056 scopus 로고    scopus 로고
    • Comparison of drug efflux transport kinetics in various blood-brain barrier models
    • Bachmeier, C. J.; Trickler, W. J.; Miller, D. W. Comparison of drug efflux transport kinetics in various blood-brain barrier models. Drug Metab. Dispos. 2006, 34, 998-1003.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 998-1003
    • Bachmeier, C.J.1    Trickler, W.J.2    Miller, D.W.3
  • 197
    • 0030070072 scopus 로고    scopus 로고
    • Transport mechanism of anthracycline derivatives in human leukemia cell lines: Uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells
    • DOI 10.1007/s002800050389
    • Nagasawa, K.; Natazuka, T.; Chihara, K.; Kitazawa, F.; Tsumura, A.; Takara, K.; Nomiyama, M.; Ohnishi, N.; Yokoyama ,T. Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells. Cancer Chemother. Pharmacol. 1996, 37, 297-304. (Pubitemid 26031009)
    • (1996) Cancer Chemotherapy and Pharmacology , vol.37 , Issue.4 , pp. 297-304
    • Nagasawa, K.1    Natazuka, T.2    Chihara, K.3    Kitazawa, F.4    Tsumura, A.5    Takara, K.6    Nomiyama, M.7    Ohnishi, N.8    Yokoyama, T.9
  • 198
    • 0242585000 scopus 로고    scopus 로고
    • Midazolam exhibits characteristics of a highly permeable Pglycoprotein substrate
    • Tolle-Sander, S.; Rautio, J.; Wring, S.; Polli, J. W.; Polli, J. E. Midazolam exhibits characteristics of a highly permeable Pglycoprotein substrate. Pharm. Res. 2003, 20, 757-764
    • (2003) Pharm. Res. , vol.20 , pp. 757-764
    • Tolle-Sander, S.1    Rautio, J.2    Wring, S.3    Polli, J.W.4    Polli, J.E.5
  • 199
    • 0029781372 scopus 로고    scopus 로고
    • Inhibitors of P-glycoprotein-mediated daunomycin transport in rat liver canalicular membrane vesicles
    • DOI 10.1021/js9600540
    • Kwon, Y.; Kamath, A. V.; Morris, M. E. Inhibitors of P-glycoprotein- mediated daunomycin transport in rat liver canalicular membrane vesicles. J. Pharm. Sci. 1996, 85, 935-939. (Pubitemid 26300219)
    • (1996) Journal of Pharmaceutical Sciences , vol.85 , Issue.9 , pp. 935-939
    • Kwon, Y.1    Kamath, A.V.2    Morris, M.E.3
  • 200
    • 0035686183 scopus 로고    scopus 로고
    • Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes
    • Guns, E. S.; Bullock, P. L.; Reimer, M. L.; Dixon, R.; Bally, M.; Mayer, L. D. Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes. Eur. J. Drug Metab. Pharmacokinet. 2001, 26, 273-282.
    • (2001) Eur. J. Drug Metab. Pharmacokinet. , vol.26 , pp. 273-282
    • Guns, E.S.1    Bullock, P.L.2    Reimer, M.L.3    Dixon, R.4    Bally, M.5    Mayer, L.D.6
  • 201
    • 18444395839 scopus 로고    scopus 로고
    • Identification of cytochrome P450 enzymes involved in the metabolism of FK228, a potent histone deacetylase inhibitor, in human liver microsomes
    • DOI 10.1248/bpb.28.124
    • Shiraga, T.; Tozuka, Z.; Ishimura, R.; Kawamura, A.; Kagayama, A. Identification of cytochrome P450 enzymes involved in the metabolism of FK228, a potent histone deacetylase inhibitor, in human liver microsomes. Biol. Pharm. Bull. 2005, 28, 124-129. (Pubitemid 40879796)
    • (2005) Biological and Pharmaceutical Bulletin , vol.28 , Issue.1 , pp. 124-129
    • Shiraga, T.1    Tozuka, Z.2    Ishimura, R.3    Kawamura, A.4    Kagayama, A.5
  • 202
    • 0037636423 scopus 로고    scopus 로고
    • Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones
    • Hu, M.; Krausz, K.; Chen, J.; Ge, X.; Li, J.; Gelboin, H. L.; Gonzalez, F. J. Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab. Dispos. 2003, 31, 924-931.
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 924-931
    • Hu, M.1    Krausz, K.2    Chen, J.3    Ge, X.4    Li, J.5    Gelboin, H.L.6    Gonzalez, F.J.7
  • 204
    • 24944464940 scopus 로고    scopus 로고
    • Contribution of human hepatic cytochrome P450 isoforms to the metabolism of psychotropic drugs
    • DOI 10.1248/bpb.28.1711
    • Niwa, T.; Shiraga, T.; Ishii, I.; Kagayama, A.; Takagi, A. Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol. Pharm. Bull. 2005, 28, 1711-1716. (Pubitemid 41324138)
    • (2005) Biological and Pharmaceutical Bulletin , vol.28 , Issue.9 , pp. 1711-1716
    • Niwa, T.1    Shiraga, T.2    Ishii, I.3    Kagayama, A.4    Takagi, A.5
  • 206
    • 0032797632 scopus 로고    scopus 로고
    • Hepatic metabolism of diclofenac: Role of human CYP in the minor oxidative pathways
    • DOI 10.1016/S0006-2952(99)00167-7, PII S0006295299001677
    • Bort, R.; Macé, K.; Boobis, A.; Gómez-Lechón, M. J.; Pfeifer, A.; Castell J. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem. Pharmacol. 1999, 58, 787-796. (Pubitemid 29329528)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.5 , pp. 787-796
    • Bort, R.1    MacE, K.2    Boobis, A.3    Gomez-Lechon, M.-J.4    Pfeifer, A.5    Castell, J.6
  • 207
    • 37249048453 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL
    • Kamath, A. V.; Wang, J.; Lee, F. Y.; Marathe, P. H. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother. Pharmacol. 2008, 61, 365-376.
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 365-376
    • Kamath, A.V.1    Wang, J.2    Lee, F.Y.3    Marathe, P.H.4
  • 208
    • 34250694236 scopus 로고    scopus 로고
    • Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
    • DOI 10.1158/1078-0432.CCR-07-0088
    • Li, J.; Zhao, M.; He, P.; Hidalgo, M.; Baker, S. D. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin. Cancer Res. 2007, 13, 3731-3737. (Pubitemid 46955138)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3731-3737
    • Li, J.1    Zhao, M.2    He, P.3    Hidalgo, M.4    Baker, S.D.5
  • 209
    • 0037185964 scopus 로고    scopus 로고
    • FT-IR spectroscopic investigations of single cells on the subcellular level
    • DOI 10.1016/S0924-2031(01)00153-9, PII S0924203101001539
    • Lasch, P.; Boese, M.; Pacifico, A.; Diem, M. FT-IR spectroscopic investigations of single cells on the subcellular level. Vibrational Spectrosc., 2002, 28, 147-157. (Pubitemid 34291406)
    • (2002) Vibrational Spectroscopy , vol.28 , Issue.1 , pp. 147-157
    • Lasch, P.1    Boese, M.2    Pacifico, A.3    Diem, M.4
  • 210
    • 0023689651 scopus 로고
    • Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics
    • Burt, R. K.; Thorgeirsson, S. S. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. J. Natl. Cancer Inst. 1988, 80, 1383-1386.
    • (1988) J. Natl. Cancer Inst. , vol.80 , pp. 1383-1386
    • Burt, R.K.1    Thorgeirsson, S.S.2
  • 211
    • 0028004345 scopus 로고
    • Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells
    • Schrenk, D.; Gant, T. W.; Michalke, A.; Orzechowski, A.; Silverman, J. A.; Battula, N.; Thorgeirsson, S. S. Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells. Carcinogenesis 1994, 15, 2541-2546.
    • (1994) Carcinogenesis , vol.15 , pp. 2541-2546
    • Schrenk, D.1    Gant, T.W.2    Michalke, A.3    Orzechowski, A.4    Silverman, J.A.5    Battula, N.6    Thorgeirsson, S.S.7
  • 213
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • Xu, C.; Li, C. Y.; Kong, A. N. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res. 2005, 28, 249-268.
    • (2005) Arch Pharm Res. , vol.28 , pp. 249-268
    • Xu, C.1    Li, C.Y.2    Kong, A.N.3
  • 214
    • 23144456286 scopus 로고    scopus 로고
    • Regulation of hepatic transporters by xenobiotic receptors
    • DOI 10.2174/1389200054633826
    • Klaassen, C. D.; Slitt, A. L. Regulation of hepatic transporters by xenobiotic receptors. Curr. Drug Metab. 2005, 6, 309-328. (Pubitemid 41086765)
    • (2005) Current Drug Metabolism , vol.6 , Issue.4 , pp. 309-328
    • Klaassen, C.D.1    Slitt, A.L.2
  • 215
    • 23944438892 scopus 로고    scopus 로고
    • Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways
    • Cheng, X.; Maher, J.; Dieter, M. Z.; Klaassen, C. D. Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab. Dispos. 2005, 33, 1276-1282.
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1276-1282
    • Cheng, X.1    Maher, J.2    Dieter, M.Z.3    Klaassen, C.D.4
  • 216
    • 33751092279 scopus 로고    scopus 로고
    • Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine
    • Oscarson, M.; Zanger, U. M.; Rifki, O. F.; Klein, K.; Eichelbaum, M.; Meyer, U. A. Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin. Pharmacol. Ther. 2006, 80, 440-456.
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 440-456
    • Oscarson, M.1    Zanger, U.M.2    Rifki, O.F.3    Klein, K.4    Eichelbaum, M.5    Meyer, U.A.6
  • 217
    • 34247603065 scopus 로고    scopus 로고
    • Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2
    • Kohle, C.; Bock, K. W. Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem. Pharmacol. 2007, 73, 1853-1862.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1853-1862
    • Kohle, C.1    Bock, K.W.2
  • 218
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold, T. W.; Dussault, I.; Forman, B. M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med. 2001, 7, 584-590.
    • (2001) Nat. Med. , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 221
    • 33751345817 scopus 로고    scopus 로고
    • In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice
    • Hu, R.; Shen, G.; Yerramilli, U. R.; Lin, W.; Xu, C.; Nair, S.; Kong, A. N. In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice. Arch. Pharm. Res. 2006, 29, 911-920.
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 911-920
    • Hu, R.1    Shen, G.2    Yerramilli, U.R.3    Lin, W.4    Xu, C.5    Nair, S.6    Kong, A.N.7
  • 223
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher, V. J.; Wu, C. Y.; Benet, L. Z. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol. Carcinog. 1995, 13, 129-134.
    • (1995) Mol. Carcinog. , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 224
    • 24944529235 scopus 로고    scopus 로고
    • Coupling of conjugating enzymes and efflux transporters: Impact on bioavailability and drug interactions
    • DOI 10.2174/138920005774330657
    • Jeong, E. J.; Liu, X.; Jia, X.; Chen, J.; Hu, M. Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions. Curr. Drug Metab. 2005, 6, 455-468. (Pubitemid 41300790)
    • (2005) Current Drug Metabolism , vol.6 , Issue.5 , pp. 455-468
    • Jeong, E.J.1    Liu, X.2    Jia, X.3    Chen, J.4    Hu, M.5
  • 225
    • 0024592166 scopus 로고
    • Pharmacokinetics of daunorubicin and doxorubicin in plasma and leukemic cells from patients with acute nonlymphoblastic leukemia
    • Paul, C.; Liliemark, J.; Tidefelt, U.; Gahrton, G.; Peterson, C. Pharmacokinetics of daunorubicin and doxorubicin in plasma and leukemic cells from patients with acute nonlymphoblastic leukemia. Ther. Drug Monit. 1989, 11, 140-148. (Pubitemid 19064837)
    • (1989) Therapeutic Drug Monitoring , vol.11 , Issue.2 , pp. 140-148
    • Paul, C.1    Liliemark, J.2    Tidefelt, U.3    Gahrton, G.4    Peterson, C.5
  • 226
    • 28244485775 scopus 로고    scopus 로고
    • Pharmacogenomics of the human ABC transporter ABCG2: From functional evaluation to drug molecular design
    • DOI 10.1007/s00114-005-0019-4
    • Ishikawa, T.; Tamura, A.; Saito, H.; Wakabayashi, K.; Nakagawa, H. Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design. Naturwissenschaften 2005, 92, 451-463. (Pubitemid 41719161)
    • (2005) Naturwissenschaften , vol.92 , Issue.10 , pp. 451-463
    • Ishikawa, T.1    Tamura, A.2    Saito, H.3    Wakabayashi, K.4    Nakagawa, H.5
  • 227
    • 41549151966 scopus 로고    scopus 로고
    • ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells
    • Decleves, X.; Bihorel, S.; Debray, M.; Yousif, S.; Camenisch, G.; Scherrmann, J. M. ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells. Pharmacol. Res. 2008, 57, 214-222.
    • (2008) Pharmacol. Res. , vol.57 , pp. 214-222
    • Decleves, X.1    Bihorel, S.2    Debray, M.3    Yousif, S.4    Camenisch, G.5    Scherrmann, J.M.6
  • 228
    • 22144442645 scopus 로고    scopus 로고
    • Functional proteinprotein interaction of drug metabolizing enzymes
    • Ishii, Y.; Takeda, S.; Yamada, H.; Oguri, K. Functional proteinprotein interaction of drug metabolizing enzymes. Front. Biosci. 2005, 10, 887-895.
    • (2005) Front. Biosci. , vol.10 , pp. 887-895
    • Ishii, Y.1    Takeda, S.2    Yamada, H.3    Oguri, K.4
  • 229
    • 14944354806 scopus 로고    scopus 로고
    • Modulation of UDP-glucuronosyltransferase function by cytochrome P450: Evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
    • DOI 10.1124/mol.104.007641
    • Takeda, S.; Ishii, Y.; Iwanaga, M.; Mackenzie, P. I.; Nagata, K.; Yamazoe, Y.; Oguri, K.; Yamada, H. Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. Mol. Pharmacol. 2005, 67, 665-672. (Pubitemid 40365314)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 665-672
    • Takeda, S.1    Ishii, Y.2    Iwanaga, M.3    Mackenzie, P.I.4    Nagata, K.5    Yamazoe, Y.6    Oguri, K.7    Yamada, H.8
  • 230
    • 0033745088 scopus 로고    scopus 로고
    • Hepatic secretion of conjugated drugs and endogenous substances
    • Keppler, D.; König, J. Hepatic secretion of conjugated drugs and endogenous substances. Semin. Liver Dis. 2000, 20, 265-272. (Pubitemid 30807964)
    • (2000) Seminars in Liver Disease , vol.20 , Issue.3 , pp. 265-272
    • Keppler, D.1    Konig, J.2
  • 232
    • 0345734082 scopus 로고    scopus 로고
    • Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: Reversal of resistance by food additives
    • Cummings, J.; Ethell, B. T.; Jardine, L.; Boyd, G.; Macpherson, J. S.; Burchell, B.; Smyth, J. F.; Jodrell, D. I. Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. Cancer Res. 2003, 63, 8443-8450.
    • (2003) Cancer Res. , vol.63 , pp. 8443-8450
    • Cummings, J.1    Ethell, B.T.2    Jardine, L.3    Boyd, G.4    Macpherson, J.S.5    Burchell, B.6    Smyth, J.F.7    Jodrell, D.I.8
  • 234
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • Muller, M.; Meijer, C.; Zaman, G. J.; Borst, P.; Scheper, R. J.; Mulder, N. H.; de Vries, E. G.; Jansen, P. L. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA 1994, 91, 13033-13037.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 13033-13037
    • Muller, M.1    Meijer, C.2    Zaman, G.J.3    Borst, P.4    Scheper, R.J.5    Mulder, N.H.6    De Vries, E.G.7    Jansen, P.L.8
  • 235
    • 0031867669 scopus 로고    scopus 로고
    • Multidrug resistance protein and glutathione Stransferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity
    • Morrow, C. S.; Diah, S.; Smitherman, P. K.; Schneider, E.; Townsend, A. J. Multidrug resistance protein and glutathione Stransferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity. Carcinogenesis 1998, 19, 109-115.
    • (1998) Carcinogenesis , vol.19 , pp. 109-115
    • Morrow, C.S.1    Diah, S.2    Smitherman, P.K.3    Schneider, E.4    Townsend, A.J.5
  • 236
    • 0032493638 scopus 로고    scopus 로고
    • Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells
    • Morrow, C. S.; Smitherman, P. K.; Diah, S. K.; Schneider, E.; Townsend, A. J. Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells. J. Biol. Chem. 1998, 273, 20114-20120.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20114-20120
    • Morrow, C.S.1    Smitherman, P.K.2    Diah, S.K.3    Schneider, E.4    Townsend, A.J.5
  • 237
    • 0345267138 scopus 로고    scopus 로고
    • Glutathione metabolism and glutathione S-conjugate export ATPase (MRP1/GS-X pump) activity in cancer. I. Differential expression in human cancer cell lines
    • de Bittencourt Jr, P. I.; Senna, S. M.; Vidor, A. C.; Miyasaka, C. K.; Curi, R.; Williams, J. F. Glutathione metabolism and glutathione S-conjugate export ATPase (MRP1/GS-X pump) activity in cancer. I. Differential expression in human cancer cell lines. Biochem. Mol. Biol. Int. 1998, 45, 1227-1241.
    • (1998) Biochem. Mol. Biol. Int. , vol.45 , pp. 1227-1241
    • De Bittencourt Jr., P.I.1    Senna, S.M.2    Vidor, A.C.3    Miyasaka, C.K.4    Curi, R.5    Williams, J.F.6
  • 238
    • 0034002720 scopus 로고    scopus 로고
    • Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein
    • Benderra, Z.; Trussardi, A.; Morjani, H.; Villa, A. M.; Doglia, S. M.; Manfait, M. Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein. Eur. J. Cancer. 2000, 36, 428-434.
    • (2000) Eur. J. Cancer. , vol.36 , pp. 428-434
    • Benderra, Z.1    Trussardi, A.2    Morjani, H.3    Villa, A.M.4    Doglia, S.M.5    Manfait, M.6
  • 239
    • 0035896509 scopus 로고    scopus 로고
    • Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity
    • DOI 10.1074/jbc.M009400200
    • Paumi, C. M.; Ledford, B. G.; Smitherman, P. K.; Townsend, A. J.; Morrow, C. S. Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. J. Biol. Chem. 2001, 276, 7952-7956. (Pubitemid 37385593)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.11 , pp. 7952-7956
    • Paumi, C.M.1    Ledford, B.G.2    Smitherman, P.K.3    Townsend, A.J.4    Morrow, C.S.5
  • 240
    • 0346497684 scopus 로고    scopus 로고
    • Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione Stransferase A1-1-mediated resistance to chlorambucil cytotoxicity
    • Smitherman, P. K.; Townsend, A. J.; Kute, T. E.; Morrow, C. S. Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione Stransferase A1-1-mediated resistance to chlorambucil cytotoxicity. J. Pharmacol. Exp. Ther. 2004, 308, 260-267.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 260-267
    • Smitherman, P.K.1    Townsend, A.J.2    Kute, T.E.3    Morrow, C.S.4
  • 241
    • 0344845291 scopus 로고    scopus 로고
    • Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimaneglutathione
    • Bai, J.; Lai, L.; Yeo, H. C.; Goh, B. C.; Tan, T. M. Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimaneglutathione. Int. J. Biochem. Cell. Biol. 2004, 36, 247-257.
    • (2004) Int. J. Biochem. Cell. Biol. , vol.36 , pp. 247-257
    • Bai, J.1    Lai, L.2    Yeo, H.C.3    Goh, B.C.4    Tan, T.M.5
  • 242
    • 14944364661 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen
    • DOI 10.1124/mol.104.007393
    • Adachi, Y.; Suzuki, H.; Schinkel, A. H.; Sugiyama, Y. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Mol. Pharmacol. 2005, 67, 923-928. (Pubitemid 40365339)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 923-928
    • Adachi, Y.1    Suzuki, H.2    Schinkel, A.H.3    Sugiyama, Y.4
  • 243
    • 15544376626 scopus 로고    scopus 로고
    • Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: Contributions of glutathione, glutathione S-transferase, and MRP1
    • Peklak-Scott, C.; Townsend, A. J.; Morrow, C. S. Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1. Biochemistry 2005, 44, 4426-4433.
    • (2005) Biochemistry , vol.44 , pp. 4426-4433
    • Peklak-Scott, C.1    Townsend, A.J.2    Morrow, C.S.3
  • 244
    • 0033230779 scopus 로고    scopus 로고
    • Export pumps for glutathione S-conjugates
    • Keppler, D. Export pumps for glutathione S-conjugates. Free Radic. Biol. Med. 1999, 27, 985-991.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 985-991
    • Keppler, D.1
  • 246
    • 23744464363 scopus 로고    scopus 로고
    • Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver
    • Albermann, N.; Schmitz-Winnenthal, F. H.; Z'graggen, K.; Volk, C.; Hoffmann, M. M.; Haefeli, W. E.; Weiss, J. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem. Pharmacol. 2005, 70, 949-958.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 949-958
    • Albermann, N.1    Schmitz-Winnenthal, F.H.2    Z'Graggen, K.3    Volk, C.4    Hoffmann, M.M.5    Haefeli, W.E.6    Weiss, J.7
  • 248
    • 41549114526 scopus 로고    scopus 로고
    • Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues
    • Pavek, P.; Dvorak, Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr. Drug Metab. 2008, 9, 129-143.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 129-143
    • Pavek, P.1    Dvorak, Z.2
  • 253
    • 0037331756 scopus 로고    scopus 로고
    • Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines
    • Nakumura, T.; Sakaeda, T.; Ohmoto, N.; Moriya, Y.; Komoto, C.; Shirakawa, T.; Gotoh, A.; Matsuo, M.; Okmura, K. Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines. Pharm. Res. 2003, 20, 324-347.
    • (2003) Pharm. Res. , vol.20 , pp. 324-347
    • Nakumura, T.1    Sakaeda, T.2    Ohmoto, N.3    Moriya, Y.4    Komoto, C.5    Shirakawa, T.6    Gotoh, A.7    Matsuo, M.8    Okmura, K.9
  • 254
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • DOI 10.1182/blood-2003-12-4276
    • Thomas, J.; Wang, L.; Clark, R. E.; Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004, 104, 3739-3745. (Pubitemid 39564452)
    • (2004) Blood , vol.104 , Issue.12 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3    Pirmohamed, M.4
  • 256
    • 52949095077 scopus 로고    scopus 로고
    • Retrotransposons revisited: The restraint and rehabilitation of parasites
    • Goodier, J. L.; Kazazian, H. H. Jr. Retrotransposons revisited: the restraint and rehabilitation of parasites. Cell 2008, 135, 23-35.
    • (2008) Cell , vol.135 , pp. 23-35
    • Goodier, J.L.1    Kazazian Jr., H.H.2
  • 257
    • 52949110235 scopus 로고    scopus 로고
    • SnapShot: Vertebrate transposons
    • Mandal, P. K.; Kazazian, H. H. Jr. SnapShot: Vertebrate transposons. Cell 2008, 135, 192-192
    • (2008) Cell , vol.135 , pp. 192-192
    • Mandal, P.K.1    Kazazian Jr., H.H.2
  • 258
    • 33645319220 scopus 로고    scopus 로고
    • Retrotransposons
    • Schulz, W. A. Retrotransposons. J. Biomed. Biotechnol. 2006, 2006, 83672-83681.
    • (2006) J. Biomed. Biotechnol. , vol.2006 , pp. 83672-83681
    • Schulz, W.A.1
  • 259
    • 18144383865 scopus 로고    scopus 로고
    • Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: Alternative subcellular enzyme compartmentation may contribute to carcinogenesis
    • Leung, Y. K.; Lau, K. M.; Mobley, J.; Jiang, Z.; Ho, S. M. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005, 65, 3726-3734.
    • (2005) Cancer Res. , vol.65 , pp. 3726-3734
    • Leung, Y.K.1    Lau, K.M.2    Mobley, J.3    Jiang, Z.4    Ho, S.M.5
  • 260
    • 34247253801 scopus 로고    scopus 로고
    • Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes
    • DOI 10.1186/1471-2148-7-46
    • Chen, S.; Li, X. Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. BMC Evol. Biol. 2007, 7, 46-58. (Pubitemid 46623219)
    • (2007) BMC Evolutionary Biology , vol.7 , pp. 46
    • Chen, S.1    Li, X.2
  • 261
    • 33846023369 scopus 로고    scopus 로고
    • Characterization of gene rearrangements leading to activation of MDR-1
    • DOI 10.1074/jbc.M602998200
    • Huff, L. M.; Lee, J. S.; Robey, R. W.; Fojo, T. Characterization of gene rearrangements leading to activation of MDR-1. J. Biol. Chem. 2006, 281, 36501-36509. (Pubitemid 46042117)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.48 , pp. 36501-36509
    • Huff, L.M.1    Lee, J.-S.2    Robey, R.W.3    Fojo, T.4
  • 262
    • 33846576044 scopus 로고    scopus 로고
    • Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance
    • DOI 10.1016/j.cancergencyto.2006.07.020, PII S0165460806005139
    • Yabuki, N.; Sakata, K.; Yamasaki, T.; Terashima, H.; Mio, T.; Miyazaki, Y.; Fujii, T.; Kitada, K. Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance. Cancer Genet. Cytogenet. 2007, 173, 1-9. (Pubitemid 46187292)
    • (2007) Cancer Genetics and Cytogenetics , vol.173 , Issue.1 , pp. 1-9
    • Yabuki, N.1    Sakata, K.2    Yamasaki, T.3    Terashima, H.4    Mio, T.5    Miyazaki, Y.6    Fujii, T.7    Kitada, K.8
  • 263
    • 33846299874 scopus 로고    scopus 로고
    • Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis
    • Pumbwe, L.; Wareham, D. W.; Aduse-Opoku, J.; Brazier, J. S.; Wexler, H. M. Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis. Clin. Microbiol. Infect. 2007, 13, 183-189.
    • (2007) Clin. Microbiol. Infect. , vol.13 , pp. 183-189
    • Pumbwe, L.1    Wareham, D.W.2    Aduse-Opoku, J.3    Brazier, J.S.4    Wexler, H.M.5
  • 265
    • 33947260230 scopus 로고    scopus 로고
    • Molecular Mechanisms of Antibacterial Multidrug Resistance
    • DOI 10.1016/j.cell.2007.03.004, PII S009286740700311X
    • Alekshun, M. N.; Levy, S. B. Molecular mechanisms of antibacterial multidrug resistance. Cell 2007, 128, 1037-1050. (Pubitemid 46427883)
    • (2007) Cell , vol.128 , Issue.6 , pp. 1037-1050
    • Alekshun, M.N.1    Levy, S.B.2
  • 266
    • 34548724460 scopus 로고    scopus 로고
    • Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria
    • Lubelski, J.; Konings, W. N.; Driessen, A. J. Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol. Mol. Biol. Rev. 2007, 71, 463-476.
    • (2007) Microbiol. Mol. Biol. Rev. , vol.71 , pp. 463-476
    • Lubelski, J.1    Konings, W.N.2    Driessen, A.J.3
  • 267
    • 33646251815 scopus 로고    scopus 로고
    • Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
    • Piddock, L. J. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin. Microbiol. Rev. 2006, 19, 382-402.
    • (2006) Clin. Microbiol. Rev. , vol.19 , pp. 382-402
    • Piddock, L.J.1
  • 268
    • 16244406203 scopus 로고    scopus 로고
    • Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: Natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
    • Mussi, M. A.; Limansky, A. S.; Viale, A. M. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob. Agents Chemother. 2005, 49, 1432-1440.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 1432-1440
    • Mussi, M.A.1    Limansky, A.S.2    Viale, A.M.3
  • 269
    • 0037183880 scopus 로고    scopus 로고
    • A single P450 allele associated with insecticide resistance in Drosophila
    • Daborn, P. J.; Yen, J. L.; Bogwitz, M. R.; Le Goff, G.; Feil, E.; Jeffers, S.; Tijet, N.; Perry, T.; Heckel, D.; Batterham, P.; Feyereisen, R.; Wilson, T. G.; Ffrench-Constant, R. H. A single P450 allele associated with insecticide resistance in Drosophila. Science 2002, 297, 2253-2256.
    • (2002) Science , vol.297 , pp. 2253-2256
    • Daborn, P.J.1    Yen, J.L.2    Bogwitz, M.R.3    Le Goff, G.4    Feil, E.5    Jeffers, S.6    Tijet, N.7
  • 270
    • 3242720690 scopus 로고    scopus 로고
    • World-wide survey of an Accord insertion and its association with DDT resistance in Drosophila melanogaster
    • DOI 10.1111/j.1365-294X.2004.02263.x
    • Catania, F.; Kauer, M. O.; Daborn, P. J.; Yen, J. L.; Ffrench-Constant, R.H.; Schlotterer, C. Worldwide survey of an Accord insertion and its association with DDT resistance in Drosophila melanogaster. Mol. Ecol. 2004, 13, 2491-2504. (Pubitemid 38946437)
    • (2004) Molecular Ecology , vol.13 , Issue.8 , pp. 2491-2504
    • Catania, F.1    Kauer, M.O.2    Daborn, P.J.3    Yen, J.L.4    Ffrench-Constant, R.H.5    Schlotterer, C.6
  • 271
    • 23044509495 scopus 로고    scopus 로고
    • Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila
    • Aminetzach, Y. T.; Macpherson, J. M.; Petrov, D. A. Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila. Science 2005, 309, 764-767.
    • (2005) Science , vol.309 , pp. 764-767
    • Aminetzach, Y.T.1    Macpherson, J.M.2    Petrov, D.A.3
  • 272
    • 24744438217 scopus 로고    scopus 로고
    • Evidence for a functional interaction between the Bari1 transposable element and the cytochrome P450 cyp12a4 gene in Drosophila melanogaster
    • DOI 10.1016/j.gene.2005.06.005, PII S0378111905003380
    • Marsano, R. M.; Caizzi, R.; Moschetti, R.; Junakovic, N. Evidence for a functional interaction between the Bari1 transposable element and the cytochrome P450 cyp12a4 gene in Drosophila melanogaster. Gene 2005, 357, 122-128. (Pubitemid 41297578)
    • (2005) Gene , vol.357 , Issue.2 , pp. 122-128
    • Marsano, R.M.1    Caizzi, R.2    Moschetti, R.3    Junakovic, N.4
  • 273
    • 34247854158 scopus 로고    scopus 로고
    • Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1
    • Chung, H.; Bogwitz, M. R.; McCart, C.; Andrianopoulos, A.; Ffrench-Constant, R.H.; Batterham, P.; Daborn, P.J. Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1. Genetics 2007, 175, 1071-1077.
    • (2007) Genetics , vol.175 , pp. 1071-1077
    • Chung, H.1    Bogwitz, M.R.2    McCart, C.3    Andrianopoulos, A.4    Ffrench-Constant, R.H.5    Batterham, P.6    Daborn, P.J.7
  • 274
    • 1542378140 scopus 로고    scopus 로고
    • Genomic structure of the NtPDR1 gene, harboring the two miniature inverted-repeat transposable elements, NtToya1 and NtStowaway101
    • DOI 10.1266/ggs.78.409
    • Schenke, D.; Sasabe, M.; Toyoda, K.; Inagaki, Y. S.; Shiraishi, T.; Ichinose, Y. Genomic structure of the NtPDR1 gene, harboring the two miniature inverted-repeat transposable elements, NtToya1 and NtStowaway101. Genes Genet. Syst. 2003, 78, 409-418. (Pubitemid 38298018)
    • (2003) Genes and Genetic Systems , vol.78 , Issue.6 , pp. 409-418
    • Schenke, D.1    Sasabe, M.2    Toyoda, K.3    Inagaki, Y.-S.4    Shiraishi, T.5    Ichinose, Y.6
  • 275
    • 34247568394 scopus 로고    scopus 로고
    • Efflux pumps as antimicrobial resistance mechanisms
    • DOI 10.1080/07853890701195262, PII 777631811
    • Poole, K. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med. 2007, 39, 162-176. (Pubitemid 46676478)
    • (2007) Annals of Medicine , vol.39 , Issue.3 , pp. 162-176
    • Poole, K.1
  • 276
    • 34447553357 scopus 로고    scopus 로고
    • Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: Role of enhanced efflux pump activity and inactivation
    • DOI 10.1093/jac/dkl380
    • Schumacher, A.; Trittler, R.; Bohnert, J. A.; Kümmerer, K.; Pagès, J. M.; Kern, W. V. Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation. J. Antimicrob. Chemother. 2007, 59, 1261-1264. (Pubitemid 47073344)
    • (2007) Journal of Antimicrobial Chemotherapy , vol.59 , Issue.6 , pp. 1261-1264
    • Schumacher, A.1    Trittler, R.2    Bohnert, J.A.3    Kummerer, K.4    Pages, J.-M.5    Kern, W.V.6
  • 279
    • 39049134890 scopus 로고    scopus 로고
    • Metallo beta lactamases in Pseudomonas aeruginosa and acinetobacter species
    • DOI 10.1517/13543784.17.2.131
    • Gupta, V. Metallo beta lactamases in Pseudomonas aeruginosa and Acinetobacter species. Expert Opin. Investig. Drugs 2008, 17, 131-143. (Pubitemid 351578196)
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , Issue.2 , pp. 131-143
    • Gupta, V.1
  • 280
    • 0035028431 scopus 로고    scopus 로고
    • Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone
    • Jellen-Ritter, A. S.; Kern, W. V. Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone. Antimicrob. Agents Chemother. 2001, 45, 1467-1472.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1467-1472
    • Jellen-Ritter, A.S.1    Kern, W.V.2
  • 281
    • 33646825385 scopus 로고    scopus 로고
    • Mechanisms of antimicrobial resistance in bacteria
    • Tenover, F. C. Mechanisms of antimicrobial resistance in bacteria. Am. J. Med. 2006, 119, 3-10.
    • (2006) Am. J. Med. , vol.119 , pp. 3-10
    • Tenover, F.C.1
  • 282
    • 37249087837 scopus 로고    scopus 로고
    • Genetic support of extended-spectrum beta-lactamases
    • Poirel, L.; Naas, T.; Nordmann, P. Genetic support of extended-spectrum beta-lactamases. Clin. Microbiol. Infect. 2008, 14, 75-81.
    • (2008) Clin. Microbiol. Infect. , vol.14 , pp. 75-81
    • Poirel, L.1    Naas, T.2    Nordmann, P.3
  • 283
    • 34249996213 scopus 로고    scopus 로고
    • Unexpected effect of a Bacteroides conjugative transposon, CTnDOT, on chromosomal gene expression in its bacterial host
    • Moon, K.; Sonnenburg, J.; Salyers, A. A. Unexpected effect of a Bacteroides conjugative transposon, CTnDOT, on chromosomal gene expression in its bacterial host. Mol. Microbiol. 2007, 64, 1562-1571.
    • (2007) Mol. Microbiol. , vol.64 , pp. 1562-1571
    • Moon, K.1    Sonnenburg, J.2    Salyers, A.A.3
  • 284
    • 34250219965 scopus 로고    scopus 로고
    • Chemotherapy-induced resistance by ATP-binding cassette transporter genes
    • DOI 10.1016/j.bbcan.2007.05.002, PII S0304419X07000054
    • Gillet, J. P.; Efferth, T.; Remacle, J. Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim. Biophys. Acta 2007, 1775, 237-262. (Pubitemid 46899341)
    • (2007) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1775 , Issue.2 , pp. 237-262
    • Gillet, J.-P.1    Efferth, T.2    Remacle, J.3
  • 285
    • 33745736603 scopus 로고    scopus 로고
    • Multidrug resistance: Retrospect and prospects in anti-cancer drug treatment
    • Pérez-Tomás, R. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr. Med. Chem. 2006, 13, 1859-1876.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 1859-1876
    • Pérez-Tomás, R.1
  • 286
    • 33745746815 scopus 로고    scopus 로고
    • Pharmacological strategies for overcoming multidrug resistance
    • Nobili, S.; Landini, I.; Giglioni, B.; Mini, E. Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 2006, 7, 861-879.
    • (2006) Curr. Drug Targets , vol.7 , pp. 861-879
    • Nobili, S.1    Landini, I.2    Giglioni, B.3    Mini, E.4
  • 287
    • 32544437036 scopus 로고    scopus 로고
    • Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): A trial of the Eastern Cooperative Oncology Group
    • Friedenberg, W. R.; Rue, M.; Blood, E. A.; Dalton, W. S.; Shustik, C.; Larson, R. A.; Sonneveld, P.; Greipp, P. R. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group. Cancer 2006, 106, 830-838.
    • (2006) Cancer , vol.106 , pp. 830-838
    • Friedenberg, W.R.1    Rue, M.2    Blood, E.A.3    Dalton, W.S.4    Shustik, C.5    Larson, R.A.6    Sonneveld, P.7    Greipp, P.R.8
  • 288
    • 33846209483 scopus 로고    scopus 로고
    • Tumour-specific expression of CYP2W1: Its potential as a drug target in cancer therapy
    • DOI 10.1517/14728222.11.1.61
    • Karlgren, M.; Ingelman-Sundberg, M. Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy. Expert Opin. Ther. Targets 2007, 11, 61-67. (Pubitemid 46099752)
    • (2007) Expert Opinion on Therapeutic Targets , vol.11 , Issue.1 , pp. 61-67
    • Karlgen, M.1    Ingelman-Sundberg, M.2
  • 290
    • 33646463990 scopus 로고    scopus 로고
    • Cytochrome P450 1B1: A novel anticancer therapeutic target
    • McFadyen, M. C.; Murray, G. I. Cytochrome P450 1B1: a novel anticancer therapeutic target. Future Oncol. 2005, 1, 259-263.
    • (2005) Future Oncol. , vol.1 , pp. 259-263
    • McFadyen, M.C.1    Murray, G.I.2
  • 292
    • 0034665390 scopus 로고    scopus 로고
    • Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells
    • Chua, M. S.; Kashiyama, E.; Bradshaw, T. D.; Stinson, S. F.; Brantley, E.; Sausville, E. A.; Stevens, M. F. Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. Cancer Res. 2000, 60, 5196-5203.
    • (2000) Cancer Res. , vol.60 , pp. 5196-5203
    • Chua, M.S.1    Kashiyama, E.2    Bradshaw, T.D.3    Stinson, S.F.4    Brantley, E.5    Sausville, E.A.6    Stevens, M.F.7
  • 293
    • 9444263203 scopus 로고    scopus 로고
    • Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells
    • Brantley, E.; Trapani, V.; Alley, M. C.; Hose, C. D.; Bradshaw, T. D.; Stevens, M. F.; Sausville, E. A.; Stinson, S. F. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells. Drug Metab. Dispos. 2004, 32, 1392-1401.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 1392-1401
    • Brantley, E.1    Trapani, V.2    Alley, M.C.3    Hose, C.D.4    Bradshaw, T.D.5    Stevens, M.F.6    Sausville, E.A.7    Stinson, S.F.8
  • 295
    • 0035181464 scopus 로고    scopus 로고
    • Strategies for enzyme/prodrug cancer therapy
    • Xu, G.; McLeod, H. L. Strategies for enzyme/prodrug cancer therapy. Clin Cancer Res. 2001, 7, 3314-3324.
    • (2001) Clin Cancer Res. , vol.7 , pp. 3314-3324
    • Xu, G.1    McLeod, H.L.2
  • 296
    • 30644478786 scopus 로고    scopus 로고
    • Activation of oxazaphosphorines by cytochrome P450: Application to gene-directed enzyme prodrug therapy for cancer
    • Roy, P.; Waxman, D. J. Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. Toxicol. In Vitro 2006, 20, 176-186.
    • (2006) Toxicol. in Vitro , vol.20 , pp. 176-186
    • Roy, P.1    Waxman, D.J.2
  • 299
    • 42949091356 scopus 로고    scopus 로고
    • Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo
    • DOI 10.1155/2008/683505, PII S1110724308683505
    • Klein, R.; Ruttkowski, B.; Schwab, S.; Peterbauer, T.; Salmons, B.; Günzburg, W. H.; Hohenadl, C. Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for genedirected enzyme prodrug therapy are functional in vitro and in vivo. J. Biomed. Biotechnol. 2008, 2008, 683505-683515. (Pubitemid 352000606)
    • (2008) Journal of Biomedicine and Biotechnology , vol.2008 , Issue.1 , pp. 683505
    • Klein, R.1    Ruttkowski, B.2    Schwab, S.3    Peterbauer, T.4    Salmons, B.5    Gunzburg, W.H.6    Hohenadl, C.7
  • 301
    • 0036080081 scopus 로고    scopus 로고
    • P-450 metabolites of arachidonic acid in the control of cardiovascular function
    • Roman, R. J. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol. Rev. 2002, 82, 131-185.
    • (2002) Physiol. Rev. , vol.82 , pp. 131-185
    • Roman, R.J.1
  • 303
    • 33845291121 scopus 로고    scopus 로고
    • Sphingolipids as modulators of cancer cell death: Potential therapeutic targets
    • DOI 10.1016/j.bbamem.2006.05.024, PII S0005273606002094, Sphingolipids, Apoptosis and Disease
    • Ségui, B.; Andrieu-Abadie, N.; Jaffrézou, J. P.; Benoist, H.; Levade, T. Sphingolipids as modulators of cancer cell death: potential therapeutic targets. Biochim. Biophys. Acta 2006, 1758, 2104-2120. (Pubitemid 44879359)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.12 , pp. 2104-2120
    • Segui, B.1    Andrieu-Abadie, N.2    Jaffrezou, J.-P.3    Benoist, H.4    Levade, T.5
  • 308
    • 0036372506 scopus 로고    scopus 로고
    • Intra-individual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes
    • DOI 10.1038/sj.tpj.6500086
    • Finnstrom, N.; Ask, B.; Dahl, M. L.; Gagg, M.; Rane, A. Intraindividual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes. Pharmacogenomics J. 2002, 2, 111-116. (Pubitemid 34982214)
    • (2002) Pharmacogenomics Journal , vol.2 , Issue.2 , pp. 111-116
    • Finnstrom, N.1    Ask, B.2    Dahl, M.-L.3    Gadd, M.4    Rane, A.5
  • 309
    • 0242418227 scopus 로고    scopus 로고
    • Immunochemical analysis of Cytochrome P450 variability in human leukapheresed samples and its consequences for the risk assessment process
    • DOI 10.1016/S0273-2300(03)00012-6
    • Bernauer, U.; Garritsen, H.; Heinrich-Hirsch, B.; Gundert-Remy, U. Immunochemical analysis of cytochrome P450 variability in human leukapheresed samples and its consequences for the risk assessment process. Regul. Toxicol. Pharmacol. 2003, 37, 318-327. (Pubitemid 36506584)
    • (2003) Regulatory Toxicology and Pharmacology , vol.37 , Issue.2 , pp. 318-327
    • Bernauer, U.1    Garritsen, H.2    Heinrich-Hirsch, B.3    Gundert-Remy, U.4
  • 310
    • 0035142865 scopus 로고    scopus 로고
    • Human CYP1B1 and anticancer agent metabolism: Mechanism for tumor-specific drug inactivation?
    • Rochat, B.; Morsman, J. M.; Murray, G. I.; Figg, W. D.; McLeod, H. L. Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation? J. Pharmacol. Exp. Ther. 2001, 296, 537-541.
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 537-541
    • Rochat, B.1    Morsman, J.M.2    Murray, G.I.3    Figg, W.D.4    McLeod, H.L.5
  • 311
    • 33645509358 scopus 로고    scopus 로고
    • Fragmentation Study of Imatinib and Characterization of New Imatinib Metabolites by Liquid Chromatography - Triple Quadrupole and Linear Ion Trap Mass Spectrometers
    • Marull, M.; Rochat, B. Fragmentation Study of Imatinib and Characterization of New Imatinib Metabolites by Liquid Chromatography - Triple Quadrupole and Linear Ion Trap Mass Spectrometers. J. Mass Spectrom. 2006, 41, 390-404.
    • (2006) J. Mass Spectrom. , vol.41 , pp. 390-404
    • Marull, M.1    Rochat, B.2
  • 312
    • 33845726062 scopus 로고    scopus 로고
    • Identification of a novel co-transcription of P450/1A1 with telomerase in A549
    • DOI 10.1016/j.gene.2006.10.010, PII S0378111906006627
    • Shervington, A.; Mohammed, K.; Patel, R.; Lea, R. Identification of a novel co-transcription of P450/1A1 with telomerase in A549. Gene 2007, 388, 110-116. (Pubitemid 46014019)
    • (2007) Gene , vol.388 , Issue.1-2 , pp. 110-116
    • Shervington, A.1    Mohammed, K.2    Patel, R.3    Lea, R.4
  • 313
    • 51549121877 scopus 로고    scopus 로고
    • Can CYP1A1 siRNA be an effective treatment for lung cancer?
    • Mohammed, K.; Shervington, A. Can CYP1A1 siRNA be an effective treatment for lung cancer? Cell. Mol Biol. Lett. 2008, 13, 240-249.
    • (2008) Cell. Mol Biol. Lett. , vol.13 , pp. 240-249
    • Mohammed, K.1    Shervington, A.2
  • 314
    • 0035965327 scopus 로고    scopus 로고
    • Epoxygenase Pathways of Arachidonic Acid Metabolism
    • DOI 10.1074/jbc.R100030200
    • Zeldin, D. C. Epoxygenase pathways of arachidonic acid metabolism. J. Biol. Chem. 2001, 276, 36059-36062 (Pubitemid 37384204)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.39 , pp. 36059-36062
    • Zeldin, D.C.1
  • 315
    • 33845346159 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids, cell signaling and angiogenesis
    • DOI 10.1016/j.prostaglandins.2006.05.003, PII S1098882306000529, Eicosanoid-Mediated Regulation of Vascular and Renal Function
    • Fleming, I. Epoxyeicosatrienoic acids, cell signaling and angiogenesis. Prostaglandins Other Lipid. Mediat. 2007, 82, 60-67. (Pubitemid 44880162)
    • (2007) Prostaglandins and Other Lipid Mediators , vol.82 , Issue.1-4 , pp. 60-67
    • Fleming, I.1
  • 316
    • 22944448688 scopus 로고    scopus 로고
    • Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways
    • Wang, Y.; Wei, X.; Xiao, X.; Hui, R.; Card, J. W.; Carey, M. A.; Wang, D. W.; Zeldin, D. C. Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways. J. Pharmacol. Exp. Ther. 2005, 314, 522-532.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 522-532
    • Wang, Y.1    Wei, X.2    Xiao, X.3    Hui, R.4    Card, J.W.5    Carey, M.A.6    Wang, D.W.7    Zeldin, D.C.8
  • 317
    • 0035725998 scopus 로고    scopus 로고
    • Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis
    • DOI 10.1128/MCB.21.18.6322-6331.2001
    • Chen, J. K.; Capdevila, J.; Harris R. C. Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol. Cell Biol. 2001, 21, 6322-6331. (Pubitemid 34263530)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.18 , pp. 6322-6331
    • Chen, J.-K.1    Capdevila, J.2    Harris, R.C.3
  • 318
    • 33746716855 scopus 로고    scopus 로고
    • From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling
    • DOI 10.1016/j.pharmthera.2005.11.003, PII S0163725805002676
    • Michaelis, U. R.; Fleming, I. From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling. Pharmacol. Ther. 2006, 111, 584-595. (Pubitemid 44160519)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.3 , pp. 584-595
    • Michaelis, U.R.1    Fleming, I.2
  • 319
    • 33947389882 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation
    • DOI 10.1124/jpet.106.115360
    • Guo, A. M.; Arbab, A. S.; Falck, J. R.; Chen, P.; Edwards, P. A.; Roman, R. J.; Scicli, A. G. Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. J. Pharmacol. Exp. Ther. 2007, 321, 18-27. (Pubitemid 46456964)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.1 , pp. 18-27
    • Guo, A.M.1    Arbab, A.S.2    Falck, J.R.3    Chen, P.4    Edwards, P.A.5    Roman, R.J.6    Scicli, A.G.7
  • 320
    • 33746713687 scopus 로고    scopus 로고
    • CYP4B1: An enigmatic P450 at the interface between xenobiotic and endobiotic metabolism
    • Baer, B. R.; Rettie, A. E. CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism. Drug Metab. Rev. 2006, 38, 451-457.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 451-457
    • Baer, B.R.1    Rettie, A.E.2
  • 321
    • 33750000583 scopus 로고    scopus 로고
    • Cytochrome P450 4F subfamily: At the crossroads of eicosanoid and drug metabolism
    • DOI 10.1016/j.pharmthera.2006.03.008, PII S0163725806001100
    • Kalsotra, A.; Strobel, H. W. Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism. Pharmacol. Ther. 2006, 112, 589-611. (Pubitemid 44573491)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.3 , pp. 589-611
    • Kalsotra, A.1    Strobel, H.W.2
  • 322
    • 0032997280 scopus 로고    scopus 로고
    • Kinetic profile of the rat CYP4A isoforms: Arachidonic acid metabolism and isoform-specific inhibitors
    • Nguyen, X.; Wang, M. H.; Reddy, K. M.; Falck, J. R.; Schwartzman, M. L. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am. J. Physiol. 1999, 276, 1691-1700.
    • (1999) Am. J. Physiol. , vol.276 , pp. 1691-1700
    • Nguyen, X.1    Wang, M.H.2    Reddy, K.M.3    Falck, J.R.4    Schwartzman, M.L.5
  • 323
    • 0032403179 scopus 로고    scopus 로고
    • 2
    • DOI 10.1006/abio.1998.2897
    • Bylund, J.; Ericsson, J.; Oliw, E. H. Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS. Anal. Biochem. 1998, 265, 55-68. (Pubitemid 28541793)
    • (1998) Analytical Biochemistry , vol.265 , Issue.1 , pp. 55-68
    • Bylund, J.1    Ericsson, J.2    Oliw, E.H.3
  • 324
    • 0030063499 scopus 로고    scopus 로고
    • Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    • Wu, S.; Moomaw, C. R.; Tomer, K. B.; Falck, J. R.; Zeldin, D. C. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J. Biol. Chem. 1996, 271, 3460-3468.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3460-3468
    • Wu, S.1    Moomaw, C.R.2    Tomer, K.B.3    Falck, J.R.4    Zeldin, D.C.5
  • 325
    • 33751541195 scopus 로고    scopus 로고
    • Altering the sphingosine-1-phosphate/ceramide balance: A promising approach for tumor therapy
    • DOI 10.2174/138161206779010422
    • Huwiler, A.; Pfeilschifter, J. Altering the sphingosine-1-phosphate/ ceramide balance: a promising approach for tumor therapy. Curr. Pharm. Des. 2006, 12, 4625-4635. (Pubitemid 44835150)
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.35 , pp. 4625-4635
    • Huwiler, A.1    Pfeilschifter, J.2
  • 326
    • 56649118965 scopus 로고    scopus 로고
    • New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development
    • Moreno, J. J. New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development. Biochem. Pharmacol. 2009, 77, 1-10.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1-10
    • Moreno, J.J.1
  • 330
  • 332
    • 32144447613 scopus 로고    scopus 로고
    • Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells
    • Sun, Y. L.; Zhou, G. Y.; Li, K. N.; Gao, P.; Zhang, Q. H.; Zhen, J. H.; Bai, Y. H.; Zhang, X. F. Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells. Neoplasma 2006, 53, 1-8. (Pubitemid 43206931)
    • (2006) Neoplasma , vol.53 , Issue.1 , pp. 1-8
    • Sun, Y.-L.1    Zhou, G.-Y.2    Li, K.-N.3    Gao, P.4    Zhang, Q.-H.5    Zhen, J.-H.6    Bai, Y.-H.7    Zhang, X.-F.8
  • 333
    • 1642453732 scopus 로고    scopus 로고
    • Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib
    • DOI 10.1158/1078-0432.CCR-0784-3
    • McLean, L. A.; Gathmann, I.; Capdeville, R.; Polymeropoulos, M. H.; Dressman, M. Pharmacogenomics analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Clin. Cancer Res. 2004, 10, 155-165. (Pubitemid 38114174)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 I , pp. 155-165
    • McLean, L.A.1    Gathmann, I.2    Capdeville, R.3    Polymeropoulos, M.H.4    Dressman, M.5
  • 334
    • 0037988709 scopus 로고    scopus 로고
    • Pharmacogenomics of ABC transporters and its role in cancer chemotherapy
    • Sparreboom, A.; Danesi, R.; Ando, Y.; Chan, J.; Figg, W. D. Pharmacogenomics of ABC transporters and its role in cancer chemotherapy. Drug Resist. Updat. 2003, 6, 71-84.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 71-84
    • Sparreboom, A.1    Danesi, R.2    Ando, Y.3    Chan, J.4    Figg, W.D.5
  • 335
    • 33745699234 scopus 로고    scopus 로고
    • Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells
    • DOI 10.1016/j.canlet.2005.07.032, PII S0304383505007445
    • Huang, Y.; Sadee, W. Membrane transporters and channels in chemoresistance and sensitivity of tumor cells. Cancer Lett. 2005, 239, 168-182. (Pubitemid 43996825)
    • (2006) Cancer Letters , vol.239 , Issue.2 , pp. 168-182
    • Huang, Y.1    Sadee, W.2
  • 336
    • 16644379769 scopus 로고    scopus 로고
    • Tumoral drug metabolism: Overview and its implications for cancer therapy
    • DOI 10.1200/JCO.2005.02.120
    • Michael, M.; Doherty, M. M. Tumoral drug metabolism: overview and its implications for cancer therapy. J. Clin. Oncol. 2005, 23, 205-229. (Pubitemid 41702640)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.1 , pp. 205-229
    • Michael, M.1    Doherty, M.M.2
  • 337
    • 33947396419 scopus 로고    scopus 로고
    • Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy
    • DOI 10.1007/s10555-007-9050-6, Special Issue on Transporters in Cancer
    • Huang, Y. Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev. 2007, 26, 183-201. (Pubitemid 46452190)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.1 , pp. 183-201
    • Huang, Y.1
  • 338
    • 26444516024 scopus 로고    scopus 로고
    • Modulation of cytochrome P450 activity: Implications for cancer therapy
    • Scripture, C. D.; Sparreboom, A.; Figg, W. D. Modulation of cytochrome P450 activity: implications for cancer therapy. Lancet Oncol. 2005, 6, 780-789.
    • (2005) Lancet Oncol. , vol.6 , pp. 780-789
    • Scripture, C.D.1    Sparreboom, A.2    Figg, W.D.3
  • 339
    • 84934437989 scopus 로고    scopus 로고
    • Pharmacogenetics of membrane transporters: A review of current approaches
    • Sissung, T. M.; Gardner, E. R.; Gao, R.; Figg, W. D. Pharmacogenetics of membrane transporters: a review of current approaches. Methods Mol. Biol. 2008, 448, 41-62.
    • (2008) Methods Mol. Biol. , vol.448 , pp. 41-62
    • Sissung, T.M.1    Gardner, E.R.2    Gao, R.3    Figg, W.D.4
  • 340
    • 23844486685 scopus 로고    scopus 로고
    • Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance
    • DOI 10.1158/0008-5472.CAN-04-4267
    • Huang, Y.; Dai, Z.; Barbacioru, C.; Sadée, W. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005, 65, 7446-17445 (Pubitemid 41161279)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7446-7454
    • Huang, Y.1    Dai, Z.2    Barbacioru, C.3    Sadee, W.4
  • 341
    • 33748922789 scopus 로고    scopus 로고
    • Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin
    • Holzer, A. K.; Manorek, G. H.; Howell, S. B. Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin. Mol. Pharmacol. 2006, 70, 1390-1394.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1390-1394
    • Holzer, A.K.1    Manorek, G.H.2    Howell, S.B.3
  • 344
    • 33645746275 scopus 로고    scopus 로고
    • Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: Transcriptional silencing, inactivating mutations, and allele loss
    • Kaufman, Y.; Ifergan, I.; Rothem, L.; Jansen, G.; Assaraf, Y. G. Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss. Blood 2006, 107, 3288-3294.
    • (2006) Blood , vol.107 , pp. 3288-3294
    • Kaufman, Y.1    Ifergan, I.2    Rothem, L.3    Jansen, G.4    Assaraf, Y.G.5
  • 345
    • 10244250320 scopus 로고    scopus 로고
    • Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: Implications for efficacy of methotrexate therapy
    • DOI 10.1182/blood-2004-04-1493
    • Fotoohi, K.; Jansen, G.; Assaraf, Y. G.; Rothem, L.; Stark, M.; Kathmann, I.; Gregorczyk, J.; Peters, G. J.; Albertioni, F. Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy. Blood 2004, 104, 4194-4201. (Pubitemid 39620174)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4194-4201
    • Fotoohi, K.1    Jansen, G.2    Assaraf, Y.G.3    Rothem, L.4    Stark, M.5    Kathmann, I.6    Gregorczyk, J.7    Peters, G.J.8    Albertioni, F.9
  • 346
    • 3843092833 scopus 로고    scopus 로고
    • Induction and characterization of taxol-resistance phenotypes with a transiently expressed artificial transcriptional activator library
    • Lee, D. K.; Kim, Y. H.; Kim, J. S.; Seol, W. Induction and characterization of taxol-resistance phenotypes with a transiently expressed artificial transcriptional activator library. Nucleic Acids Res. 2004, 32, 116-122.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 116-122
    • Lee, D.K.1    Kim, Y.H.2    Kim, J.S.3    Seol, W.4
  • 347
    • 38349193809 scopus 로고    scopus 로고
    • Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia
    • Wang, L.; Giannoudis, A.; Lane, S.; Williamson, P.; Pirmohamed, M.; Clark, R. E. Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia. Clin. Pharmacol. Ther. 2008, 83, 258-264.
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 258-264
    • Wang, L.1    Giannoudis, A.2    Lane, S.3    Williamson, P.4    Pirmohamed, M.5    Clark, R.E.6
  • 349
    • 33745085275 scopus 로고    scopus 로고
    • OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): Reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
    • White, D. L.; Saunders, V. A.; Dang, P.; Engler, J.; Zannettino, A. C.; Cambareri, A. C.; Quinn, S. R.; Manley, P. W.; Hughes, T. P. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006, 108, 697-704.
    • (2006) Blood , vol.108 , pp. 697-704
    • White, D.L.1    Saunders, V.A.2    Dang, P.3    Engler, J.4    Zannettino, A.C.5    Cambareri, A.C.6    Quinn, S.R.7    Manley, P.W.8    Hughes, T.P.9
  • 351
    • 0036132097 scopus 로고    scopus 로고
    • Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues
    • Miyoshi, Y.; Ando, A.; Takamura, Y.; Taguchi, T.; Tamaki, Y.; Noguchi, S. Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues. Int. J. Cancer 2002, 97, 129-132.
    • (2002) Int. J. Cancer , vol.97 , pp. 129-132
    • Miyoshi, Y.1    Ando, A.2    Takamura, Y.3    Taguchi, T.4    Tamaki, Y.5    Noguchi, S.6
  • 353
    • 0036304753 scopus 로고    scopus 로고
    • Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia
    • Krajinovic, M.; Labuda, D.; Mathonnet, G.; Labuda, M.; Moghrabi, A.; Champagne, J.; Sinnett, D. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. Clin. Cancer Res. 2002, 8, 802-810. (Pubitemid 34742111)
    • (2002) Clinical Cancer Research , vol.8 , Issue.3 , pp. 802-810
    • Krajinovic, M.1    Labuda, D.2    Mathonnet, G.3    Labuda, M.4    Moghrabi, A.5    Champagne, J.6    Sinnett, D.7
  • 354
    • 0038446667 scopus 로고    scopus 로고
    • CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication
    • Bowen, D. T.; Frew, M. E.; Rollinson, S.; Roddam, P. L.; Dring, A.; Smith, M. T.; Langabeer, S. E.; Morgan, G. J. CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication. Blood 2003, 101, 2770-2774.
    • (2003) Blood , vol.101 , pp. 2770-2774
    • Bowen, D.T.1    Frew, M.E.2    Rollinson, S.3    Roddam, P.L.4    Dring, A.5    Smith, M.T.6    Langabeer, S.E.7    Morgan, G.J.8
  • 355
    • 22544431983 scopus 로고    scopus 로고
    • The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia
    • Voso, M. T.; D'Alo', F.; Gumiero, D.; Guidi, F.; Hohaus, S.; Leone, G. The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia. Haematologica 2005, 90, 982-984. (Pubitemid 41020304)
    • (2005) Haematologica , vol.90 , Issue.7 , pp. 982-984
    • Voso, M.T.1    D'Alo, F.2    Gumiero, D.3    Guidi, F.4    Hohaus, S.5    Leone, G.6
  • 358
    • 0036841719 scopus 로고    scopus 로고
    • Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme
    • Bournique, B.; Lemarié, A. Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme. Drug Metab. Dispos. 2002, 30, 1149-1152.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1149-1152
    • Bournique, B.1    Lemarié, A.2
  • 359
    • 34548081331 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer
    • DOI 10.1038/sj.tpj.6500434, PII 6500434
    • Marsh, S.; Somlo, G.; Li, X.; Frankel, P.; King, C. R.; Shannon, W. D.; McLeod, H. L.; Synold, T. W. Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer. Pharmacogenomics J. 2007, 7, 362-365. (Pubitemid 47484774)
    • (2007) Pharmacogenomics Journal , vol.7 , Issue.5 , pp. 362-365
    • Marsh, S.1    Somlo, G.2    Li, X.3    Frankel, P.4    King, C.R.5    Shannon, W.D.6    McLeod, H.L.7    Synold, T.W.8
  • 362
    • 1942532186 scopus 로고    scopus 로고
    • Identification of a Novel Mammary-Restricted Cytochrome P450, CYP4Z1, with Overexpression in Breast Carcinoma
    • DOI 10.1158/0008-5472.CAN-03-0849
    • Rieger, M. A.; Ebner, R.; Bell, D. R.; Kiessling, A.; Rohayem, J.; Schmitz, M.; Temme, A.; Rieber, E. P.; Weigle, B. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. Cancer Res. 2004, 64, 2357-2364. (Pubitemid 38528668)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2357-2364
    • Rieger, M.A.1    Ebner, R.2    Bell, D.R.3    Kiessling, A.4    Rohayem, J.5    Schmitz, M.6    Temme, A.7    Rieber, E.P.8    Weigle, B.9
  • 363
    • 33745576138 scopus 로고    scopus 로고
    • Glucuronidation of SN-38 and NU/ICRF 505 in human colon cancer and adjacent normal colon
    • Cummings, J.; Ethell, B. T.; Jardine, L.; Burchell, B. Glucuronidation of SN-38 and NU/ICRF 505 in human colon cancer and adjacent normal colon. Anticancer Res. 2006, 26, 2189-2196. (Pubitemid 43980170)
    • (2006) Anticancer Research , vol.26 , Issue.3 B , pp. 2189-2196
    • Cummings, J.1    Ethell, B.T.2    Jardine, L.3    Burchell, B.4
  • 368
    • 33751112296 scopus 로고    scopus 로고
    • Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3A
    • Liu, K. H.; Kim, M. G.; Lee, D. J.; Yoon, Y. J.; Kim, M. J.; Shon, J. H.; Choi, C. S.; Choi, Y. K.; Desta, Z.; Shin, J. G. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab. Dispos. 2006, 34, 1793-1797.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1793-1797
    • Liu, K.H.1    Kim, M.G.2    Lee, D.J.3    Yoon, Y.J.4    Kim, M.J.5    Shon, J.H.6    Choi, C.S.7    Choi, Y.K.8    Desta, Z.9    Shin, J.G.10
  • 369
    • 0036842039 scopus 로고    scopus 로고
    • Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole
    • DOI 10.1124/dmd.30.11.1240
    • Matsumoto, S.; Hirama, T.; Matsubara, T.; Nagata, K.; Yamazoe, Y. Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. Drug Metab. Dispos. 2002, 30, 1240-1245. (Pubitemid 35265831)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.11 , pp. 1240-1245
    • Matsumoto, S.1    Hirama, T.2    Matsubara, T.3    Nagata, K.4    Yamazoe, Y.5
  • 371
    • 33751090675 scopus 로고    scopus 로고
    • CYP2J2 and CYP4F12 are active for the metabolism of nonsedating antihistamines: Terfenadine and astemizole
    • Parikh, S.; Gagne, P.; Miller, V.; Crespi, C.; Thummel, K.; Patten, C. CYP2J2 and CYP4F12 are active for the metabolism of nonsedating antihistamines: terfenadine and astemizole. Drug Metab. Rev. 2003, 35, 190-191.
    • (2003) Drug Metab. Rev. , vol.35 , pp. 190-191
    • Parikh, S.1    Gagne, P.2    Miller, V.3    Crespi, C.4    Thummel, K.5    Patten, C.6
  • 373
    • 4444312707 scopus 로고    scopus 로고
    • Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids
    • Kalsotra, A.; Turman, C. M.; Kikuta, Y.; Strobel, H. W. Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol. Appl. Pharmacol. 2004, 199, 295-304.
    • (2004) Toxicol. Appl. Pharmacol. , vol.199 , pp. 295-304
    • Kalsotra, A.1    Turman, C.M.2    Kikuta, Y.3    Strobel, H.W.4
  • 374
    • 34548779111 scopus 로고    scopus 로고
    • Expression of Multidrug Resistance 1 (MDR1), Multidrug Resistance-related Protein 1 (MRP1), Lung Resistance Protein (LRP), and Breast Cancer Resistance Protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia
    • DOI 10.1532/IJH97.E0624
    • Kourti, M.; Vavatsi, N.; Gombakis, N.; Sidi, V.; Tzimagiorgis, G.; Papageorgiou, T.; Koliouskas, D.; Athanassiadou, F. Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia. Int. J. Hematol. 2007, 86, 166-173. (Pubitemid 47425197)
    • (2007) International Journal of Hematology , vol.86 , Issue.2 , pp. 166-173
    • Kourti, M.1    Vavatsi, N.2    Gombakis, N.3    Sidi, V.4    Tzimagiorgis, G.5    Papageorgiou, T.6    Koliouskas, D.7    Athanassiadou, F.8
  • 375
    • 33645747683 scopus 로고    scopus 로고
    • Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma
    • Haber, M.; Smith, J.; Bordow, S. B.; Flemming, C.; Cohn, S. L.; London, W. B.; Marshall, G. M.; Norris, M. D. Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma. J. Clin. Oncol. 2006, 24, 1546-1553.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1546-1553
    • Haber, M.1    Smith, J.2    Bordow, S.B.3    Flemming, C.4    Cohn, S.L.5    London, W.B.6    Marshall, G.M.7    Norris, M.D.8
  • 376
    • 34147156300 scopus 로고    scopus 로고
    • Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
    • DOI 10.1182/blood-2006-09-047621
    • Andreadis, C.; Gimotty, P. A.; Wahl, P.; Hammond, R.; Houldsworth, J.; Schuster, S. J.; Rebbeck, T. R. Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma. Blood 2007, 109, 3409-3416. (Pubitemid 46572530)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3409-3416
    • Andreadis, C.1    Gimotty, P.A.2    Wahl, P.3    Hammond, R.4    Houldsworth, J.5    Schuster, S.J.6    Rebbeck, T.R.7
  • 377
    • 0028242077 scopus 로고
    • Immunocytochemical detection of P-Glycoprotein: Initial expression correlates with survival in renal cell carcinoma patients
    • Duensing, S.; Dallmann, I.; Grosse, J.; Buer, J.; Lopez Hänninen, E.; Deckert, M.; Störkel, S.; Kirchner, H.; Poliwoda, H.; Atzpodien, J. Immunocytochemical detection of P-glycoprotein: initial expression correlates with survival in renal cell carcinoma patients. Oncology 1994, 51, 309-313. (Pubitemid 24185128)
    • (1994) Oncology , vol.51 , Issue.4 , pp. 309-313
    • Duensing, S.1    Dallmann, I.2    Grosse, J.3    Buer, J.4    Hanninen, E.L.5    Deckert, M.6    Storkel, S.7    Kirchner, H.8    Poliwoda, H.9    Atzpodien, J.10
  • 379
    • 23844440902 scopus 로고    scopus 로고
    • Multidrug resistance as a potential prognostic indicator in acute myeloid leukemia with normal karyotypes
    • Kim, D. H.; Lee, N. Y.; Sung, W. J.; Baek, J. H.; Kim, J. G.; Sohn, S. K.; Suh, J. S.; Lee, K. S.; Lee, K. B. Multidrug resistance as a potential prognostic indicator in acute myeloid leukemia with normal karyotypes. Acta Haematol. 2005, 114, 78-83.
    • (2005) Acta Haematol. , vol.114 , pp. 78-83
    • Kim, D.H.1    Lee, N.Y.2    Sung, W.J.3    Baek, J.H.4    Kim, J.G.5    Sohn, S.K.6    Suh, J.S.7    Lee, K.S.8    Lee, K.B.9
  • 380
    • 0031936939 scopus 로고    scopus 로고
    • Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin
    • Mechetner, E.; Kyshtoobayeva, A.; Zonis, S.; Kim, H.; Stroup, R.; Garcia, R.; Parker, R. J.; Fruehauf, J. P. Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin. Clin. Cancer Res. 1998, 4, 389-398.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 389-398
    • Mechetner, E.1    Kyshtoobayeva, A.2    Zonis, S.3    Kim, H.4    Stroup, R.5    Garcia, R.6    Parker, R.J.7    Fruehauf, J.P.8
  • 381
    • 26944497848 scopus 로고    scopus 로고
    • Pharmacogenetics of folate-related drug targets in cancer treatment
    • DOI 10.2217/14622416.6.7.673
    • Robien, K.; Boynton, A.; Ulrich, C. M. Pharmacogenetics of folate-related drug targets in cancer treatment. Pharmacogenomics 2005, 6, 673-689. (Pubitemid 41479413)
    • (2005) Pharmacogenomics , vol.6 , Issue.7 , pp. 673-689
    • Robien, K.1    Boynton, A.2    Ulrich, C.M.3
  • 382
  • 385
    • 0344305459 scopus 로고    scopus 로고
    • Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro
    • Ferrao, P. T.; Frost, M. J.; Siah, S. P.; Ashman, L. K. Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro. Blood 2003, 102, 4499-4503.
    • (2003) Blood , vol.102 , pp. 4499-4503
    • Ferrao, P.T.1    Frost, M.J.2    Siah, S.P.3    Ashman, L.K.4
  • 387
    • 34250708413 scopus 로고    scopus 로고
    • Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels
    • Widmer, N.; Rumpold, H.; Untergasser, G.; Fayet, A.; Buclin, T.; Decosterd, L. A. Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels. Leukemia 2007, 21, 1561-1562.
    • (2007) Leukemia , vol.21 , pp. 1561-1562
    • Widmer, N.1    Rumpold, H.2    Untergasser, G.3    Fayet, A.4    Buclin, T.5    Decosterd, L.A.6
  • 388
    • 34250727018 scopus 로고    scopus 로고
    • Reply to 'Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels' by Widmer et al. [2]
    • DOI 10.1038/sj.leu.2404672, PII 2404672
    • Zong, Y.; Zhou, S.; Sorrentino, B. P. Reply to 'Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels' by Widmer et al. Leukemia 2007, 21, 1562-1563. (Pubitemid 46965299)
    • (2007) Leukemia , vol.21 , Issue.7 , pp. 1562-1563
    • Zong, Y.1    Zhou, S.2    Sorrentino, B.P.3
  • 390
    • 37249061592 scopus 로고    scopus 로고
    • What makes tumors multidrug resistant?
    • Borst, P.; Jonkers, J.; Rottenberg, S. What makes tumors multidrug resistant? Cell Cycle 2007, 6, 2782-2787. (Pubitemid 350277170)
    • (2007) Cell Cycle , vol.6 , Issue.22 , pp. 2782-2787
    • Borst, P.1    Jonkers, J.2    Rottenberg, S.3
  • 393
    • 0037015184 scopus 로고    scopus 로고
    • Guidelines for using antiretroviral agents among HIV-infected adults and adolescents: The panel on clinical practices for treatment of HIV
    • Dybul, M.; Fauci, A. S.; Bartlett, J. G.; Kaplan, J. E.; Pau, A. K.; Panel on Clinical Practices for Treatment of HIV. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann. Intern. Med. 2002, 137, 381-433. (Pubitemid 34982041)
    • (2002) Annals of Internal Medicine , vol.137 , Issue.5 II , pp. 381-433
    • Dybul, M.1    Fauci, A.S.2    Bartlett, J.G.3    Kaplan, J.E.4    Pau, A.K.5
  • 394
    • 12344322578 scopus 로고    scopus 로고
    • The intracellular pharmacology of antiretroviral protease inhibitors
    • Ford, J.; Khoo, S. H.; Back, D. J. The intracellular pharmacology of antiretroviral protease inhibitors. J. Antimicrob. Chemother. 2004, 54, 982-990.
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 982-990
    • Ford, J.1    Khoo, S.H.2    Back, D.J.3
  • 395
    • 33747795961 scopus 로고    scopus 로고
    • What's new in antibiotic resistance? Focus on beta-lactamases
    • DOI 10.1016/j.drup.2006.05.005, PII S1368764606000446
    • Babic, M.; Hujer, A. M.; Bonomo, R. A. What's new in antibiotic resistance? Focus on beta-lactamases. Drug Resist. Updat. 2006, 9, 142-156. (Pubitemid 44279523)
    • (2006) Drug Resistance Updates , vol.9 , Issue.3 , pp. 142-156
    • Babic, M.1    Hujer, A.M.2    Bonomo, R.A.3
  • 396
    • 39049128343 scopus 로고    scopus 로고
    • Extended-spectrum beta-lactamase-producing Enterobacteriaceae: An emerging public-health concern
    • Pitout, J. D; Laupland, K. B. Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 2008, 8, 159-166.
    • (2008) Lancet Infect. Dis. , vol.8 , pp. 159-166
    • Pitout, J.D.1    Laupland, K.B.2
  • 397
    • 37249049746 scopus 로고    scopus 로고
    • Antibiotic policy and prescribing strategies for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae: The role of piperacillin-tazobactam
    • Peterson, L. R. Antibiotic policy and prescribing strategies for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae: the role of piperacillin-tazobactam. Clin. Microbiol. Infect. 2008, 14, 181-184.
    • (2008) Clin. Microbiol. Infect. , vol.14 , pp. 181-184
    • Peterson, L.R.1
  • 398
    • 42049096412 scopus 로고    scopus 로고
    • Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia
    • Clark, R. E.; Davies, A.; Pirmohamed, M.; Giannoudis, A. Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk. Lymphoma 2008, 49, 639-642.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 639-642
    • Clark, R.E.1    Davies, A.2    Pirmohamed, M.3    Giannoudis, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.