High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib

Hematology Journal

Volumn 5, Issue 1, 2004, Pages 55-60

  Al Ali, Haifa Kathrin ^a   Heinrich, Michael Charles ^b   Lange, Thoralf ^a   Krahl, Rainer ^a   Mueller, Matthias ^a   Müller, Christel ^a   Niederwieser, Dietger ^a   Druker, Brian James ^b   Deininger, Michael Werner Nikolaus ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chronic myeloid leukemia; Drug resistance; Imatinib; Kinase domain mutations

Indexed keywords

BCR ABL PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEIN TYROSINE KINASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER RECURRENCE; CANCER SCREENING; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DRUG EFFICACY; FEMALE; GENE AMPLIFICATION; GENE MUTATION; HUMAN; IN VIVO STUDY; MALE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; WILD TYPE;

CLONE CELLS; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; GENE FREQUENCY; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MUTATION; NEOPLASM PROTEINS; ONCOGENE PROTEINS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECURRENCE;

EID: 1342287959     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200319     Document Type: Article

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