Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 7952-7956

  Paumi, Christian M ^b   Ledford, Billy Gene ^b   Smitherman, Pamela K ^b   Townsend, Alan J ^b   Morrow, Charles S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CATALYSIS; CELLS; DETOXIFICATION; DRUG PRODUCTS; DRUG THERAPY; TOXICITY; TUMORS;

CONJUGATE FORMATION; ELECTROPHILIC XENOBIOTICS; PRODUCT INHIBITION;

ENZYMES;

ALKYLATING AGENT; CHLORAMBUCIL; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; MELPHALAN; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; ABC TRANSPORTER; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE ALPHA; ISOENZYME; MULTIDRUG RESISTANCE PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CATALYSIS; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; DRUG CONJUGATION; DRUG CYTOTOXICITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOBIOTIC METABOLISM; CELL CULTURE; DRUG RESISTANCE; FEMALE; KINETICS; METABOLISM; PHYSIOLOGY;

MINK CELL FOCUS-FORMING VIRUS;

ANTINEOPLASTIC AGENTS, ALKYLATING; ATP-BINDING CASSETTE TRANSPORTERS; CHLORAMBUCIL; DRUG RESISTANCE; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; KINETICS; MELPHALAN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TUMOR CELLS, CULTURED;

EID: 0035896509     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009400200     Document Type: Article

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