Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia

Biochemical and Biophysical Research Communications

Volumn 323, Issue 3, 2004, Pages 728-730

  Sorel, N ^a   Bonnet, M L ^a   Guillier, M ^a   Guilhot, F ^b   Brizard, A ^a   Turhan, A G ^a,b  

^a POITIERS UNIVERSITY HOSPITAL   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

ABL kinase domain mutations; BCR ABL; Chronic myelogenous leukemia; Imatinib mesylate; Stem cells; Tyrosine kinase

Indexed keywords

ABELSON KINASE; CD34 ANTIGEN; CD38 ANTIGEN; IMATINIB;

ARTICLE; BLOOD CELL; CELL POPULATION; CELL SELECTION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGENY; PROTEIN DOMAIN; PURIFICATION; STEM CELL;

ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELLS, CULTURED; DRUG RESISTANCE; ENZYME INHIBITORS; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MUTATION; PHOSPHOTRANSFERASES; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; SEQUENCE ANALYSIS, PROTEIN; STEM CELLS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 4544312606     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.169     Document Type: Article

References (8)

1. S.G. O'Brien, F. Guilhot, R.A. Larson, I. Gathmann, M. Baccarani, F. Cervantes, J.J. Cornelissen, T. Fischer, A. Hochhaus, T. Hughes, K. Lechner, J.L. Nielsen, P. Rousselot, J. Reiffers, G. Saglio, J. Shepherd, B. Simonsson, A. Gratwohl, J.M. Goldman, H. Kantarjian, K. Taylor, G. Verhoef, A.E. Bolton, R. Capdeville, and B.J. Druker IRIS investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia N. Engl. J. Med. 348 2003 994 1004
2. M.E. Gorre, M. Mohammed, K. Ellwood, N. Hsu, R. Paquette, P.N. Rao, and C.L. Sawyers Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification Science 293 2001 876 880
3. S. Branford, Z. Rudzki, S. Walsh, A. Grigg, C. Arthur, K. Taylor, R. Herrmann, K.P. Lynch, and T.P. Hughes High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop Imatinib (STI571) resistance Blood 99 2002 3472 3475
4. A. Hochhaus, S. Kreil, A.S. Corbin, P. La Rosee, M.C. Muller, T. Lahaye, B. Hanfstein, C. Schoch, N.C. Cross, U. Berger, H. Gschaidmeier, B.J. Druker, and R. Hehlmann Molecular and chromosomal mechanisms of resistance to Imatinib (STI571) therapy Leukemia 16 2002 2190 2196
5. S.M. Graham, H.G. Jorgensen, E. Allan, C. Pearson, M.J. Alcorn, L. Richmond, and T.L. Holyoake Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro Blood 99 2002 319 325
6. C. Tourino, F. Pflumio, S. Novault, A. Masse, M. Guiller, M.L. Bonnet, D. Valteau-Couanet, O. Hartmann, W. Vainchenker, F. Beaujean, L. Coulombel, and A.G. Turhan Efficient ex vivo expansion of NOD/SCID-repopulating cells with lympho-myeloid potential in hematopoietic grafts of children with solid tumors Hematol. J. 2 2001 108 116
7. N.C. Cross, J.V. Melo, L. Feng, and J.M. Goldman An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders Leukemia 8 1994 186 189
8. C. Roche-Lestienne, V. Soenen-Cornu, N. Grardel-Duflos, J.L. Lai, N. Philippe, T. Facon, P. Fenaux, and C. Preudhomme Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment Blood 100 2002 1014 1018