CYP4B1: An enigmatic P450 at the interface between xenobiotic and endobiotic metabolism

Drug Metabolism Reviews

Volumn 38, Issue 3, 2006, Pages 451-476

  Baer, Brian ^a   Rettie, Allan ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Bioactivation; Cytochrome P450; Gene regulation; Heme; Pharmacogenetics; Structure

Indexed keywords

1 AMINOBENZOTRIAZOLE; 2 AMINOANTHRACENE; 2 FLUORENYLAMINE; 3,3' DICHLOROBENZIDINE; 4 AMINO 3 METHOXYAZOBENZENE; 4 IPOMEANOL; ANTICONVULSIVE AGENT; AROMATIC AMINE; CYTOCHROME P450; CYTOCHROME P450 4B1; CYTOCHROME P450 INHIBITOR; HEME; N (2 FLUORENYL)ACETAMIDE; PROADIFEN; PRODRUG; SKATOLE; VALPROIC ACID; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; BLADDER CANCER; CANCER CELL CULTURE; CARCINOGENICITY; CELL DEATH; COVALENT BOND; CYTOCHROME P450 4B1 GENE; CYTOTOXICITY; DNA FLANKING REGION; DRUG ACTIVATION; DRUG DNA BINDING; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; GENE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VIVO STUDY; KIDNEY MICROSOME; LIVER MICROSOME; LIVER TOXICITY; LUNG CANCER; LUNG TOXICITY; NONHUMAN; NONVIRAL GENE THERAPY; PROMOTER REGION; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SEX DIFFERENCE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; TRANSGENE; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ENZYME ACTIVATION; HEME; HUMANS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; XENOBIOTICS;

EID: 33746713687     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530600688503     Document Type: Review

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