Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 1, 2002, Pages 298-304

  Hashizume, Takanori ^a   Imaoka, Susumu ^a   Mise, Masashi ^b   Terauchi, Yoshiaki ^a   Fujii, Toshihiko ^c   Miyazaki, Hisashi ^a   Kamataki, Tetsuya ^b   Funae, Yoshihiko ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

17 OCTADECYNOIC ACID; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2A; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2E; CYTOCHROME P450 2J2; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 4F12; EBASTINE; ENZYME ANTIBODY; ENZYME INHIBITOR; ISOENZYME; OXYGENASE; UNCLASSIFIED DRUG;

ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEALKYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROXYLATION; INTESTINE; MICROSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBODIES, BLOCKING; ARACHIDONIC ACID; ARYL HYDROCARBON HYDROXYLASES; BUTYROPHENONES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; ENZYME INHIBITORS; HISTAMINE H1 ANTAGONISTS; HUMANS; INTESTINES; KINETICS; LEUKOTRIENE B4; MICROSOMES; MIXED FUNCTION OXYGENASES; OXYGENASES; PIPERIDINES; RECOMBINANT PROTEINS;

EID: 0036138172     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.1.298     Document Type: Article

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