Identification of cytochrome P450 enzymes involved in the metabolism of FK228, a potent histone deacetylase inhibitor, in human liver microsomes

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 1, 2005, Pages 124-129

  Shiraga, Toshifumi ^a   Tozuka, Zenzaburo ^a   Ishimura, Rika ^a   Kawamura, Akio ^a   Kagayama, Akira ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

CYP3A4; Depsipeptide; FK228; FR901228; Histone deacetylase inhibitor; Human P450

Indexed keywords

CARBON 14; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 4A; FR 901228; HISTONE DEACETYLASE INHIBITOR; KETOCONAZOLE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; DEPSIPEPTIDE; HISTONE DEACETYLASE; PROTEINASE INHIBITOR;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; RADIOACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

CYTOCHROME P-450 ENZYME SYSTEM; DEPSIPEPTIDES; HISTONE DEACETYLASES; HUMANS; MICROSOMES, LIVER; PROTEASE INHIBITORS;

EID: 18444395839     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.124     Document Type: Article

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