Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1): Requirement for glutathione or a non-sulfur-containing analog

Journal of Biological Chemistry

Volumn 276, Issue 30, 2001, Pages 27846-27854

  Leslie, Elaine M ^a   Ito, Ken Ichi ^a   Upadhyaya, Pramod ^b   Hecht, Stephen S ^b   Deeley, Roger G ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CARCINOGENS; DETOXIFICATION; ENZYME INHIBITION; SUBSTRATES; TUMORS;

XENOBIOTICS;

PROTEINS;

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ABC TRANSPORTER; ANION; CARCINOGEN; ESTRADIOL 17 GLUCURONIDE; GLUCURONIDE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLYCINE DERIVATIVE; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 1; SULFATE; SULFUR; XENOBIOTIC AGENT; 4 (METHYLNITROSOAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4-(METHYLNITROSOAMINO)-1--(3-PYRIDYL)-1-BUTANOL; ESTRADIOL; MITOCHONDRIAL PROTEIN; MRP2 PROTEIN, S CEREVISIAE; MULTIDRUG RESISTANCE PROTEIN; NITROSAMINE; RIBOSOME PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CONJUGATION; CONTROLLED STUDY; DETOXIFICATION; EMBRYO; GENETIC TRANSFECTION; GLUCURONIDATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LUNG CANCER; LUNG CARCINOGENESIS; MEMBRANE TRANSPORT; MEMBRANE VESICLE; METABOLITE; PRIORITY JOURNAL; TOBACCO; TRANSPORT KINETICS; XENOBIOTIC METABOLISM; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMICAL MODEL; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; GENETICS; HELA CELL; KINETICS; LUNG TUMOR; METABOLISM; RAT; TRANSPORT AT THE CELLULAR LEVEL;

NICOTIANA TABACUM;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CARCINOGENS; CELL LINE; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; GLUTATHIONE; HELA CELLS; HUMANS; KINETICS; LEUKOTRIENE C4; LUNG NEOPLASMS; MITOCHONDRIAL PROTEINS; MODELS, CHEMICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NITROSAMINES; RATS; RIBOSOMAL PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSFECTION;

EID: 0035958862     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102453200     Document Type: Article

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