Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis

Molecular and Cellular Biology

Volumn 21, Issue 18, 2001, Pages 6322-6331

  Chen, Jian Kang ^a   Capdevila, Jorge ^a   Harris, Raymond C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 17 OCTADECYNOIC ACID; 2 MORPHOLINO 8 PHENYLCHROMONE; CERAMIDE; CYTOCHROME P450; ETOPOSIDE; FUMONISIN B1; HYDROGEN PEROXIDE; OXYGENASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; CELL LINE; CERAMIDES; CYTOCHROME P-450 ENZYME SYSTEM;

ANIMALIA; BACTERIA (MICROORGANISMS); SUS SCROFA;

EID: 0035725998     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.18.6322-6331.2001     Document Type: Article

References (61)

1. Development of Na+-dependent hexose transport in a cultured line of porcine kidney cells
2. Cyclooxygenase and lipoxygenase inhibitors in cancer therapy
3. Segmental synthesis and actions of prostaglandins along the nephron
4. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells
5. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
6. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule
7. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
8. Oxidant-induced arachidonic acid release and impairment of fatty acid acylation in vascular smooth muscle cells
9. Intracellular unesterified arachidonic acid signals apoptosis
10. Cytochrome P450 arachidonic acid epoxygenase: Stereochemical characterization of epoxyeicosatrienoic acids
11. Cytochrome P-450 arachidonate oxygenase
12. Cytochrome P450 and the arachidonate cascade
13. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension
14. Down-regulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells
15. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
16. Overexpression of C-terminal Src kinase blocks 14,15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis
17. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells
18. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor
19. Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels
20. Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells
21. Cytochrome P-450 monooxygenase system in the rabbit kidney: Its intranephron localization and its induction
22. Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells
23. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
24. Structure, regulation and function of phosphoinositide 3-kinases
25. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
26. Specificity of expression and effects of eicosanoid mediators in normal physiology, and human diseases
27. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli
28. An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase
29. Cytochrome P450 monooxygenase-regulated signalling of Ca2+ entry in human and bovine endothelial cells
30. Ceramide in the eukaryotic stress response
31. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone
32. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells
33. Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid
34. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells
35. Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell dif- ferentiation
36. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase
37. Regulation of ceramide production and apoptosis
38. Cytochrome P450, the arachidonic acid cascade, and hypertension: New vistas for an old enzyme system
39. Lipopolysaccharide, tumor necrosis factor-alpha, and IL-1 beta prevent programmed cell death (apoptosis) in human peripheral blood monocytes
40. A potential second messenger role for unsaturated fatty acids: Activation of Ca2+-dependent protein kinase
41. Apoptosis and APC in colorectal tumorigenesis
42. Scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima: Taxonomy of the producing organism, fermentation, isolation, and physico-chemical properties
43. Biological activities of scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima
44. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma
45. Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: A c-Myc-dependent and Bcl-2-independent associated pathway
46. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
47. The role of phosphoinositide 3-kinase lipid products in cell function
48. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
49. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
50. Nonsteroidal anti-inflammatory drugs and colorectal cancer: Evolving concepts of their chemopreventive actions
51. Cytochrome P450BM-3 (CYP102): Regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation
52. Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells
53. Cytochrome P-450 arachidonate metabolites in rat kidney: Characterization and hemodynamic responses
54. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis
55. Signalling through the lipid products of phosphoinositide-3-OH kinase
56. Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo
57. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells
58. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
59. Apoptosis in human primary brain tumours: Actions of arachidonic acid
60. Characterization of arachidonic acid-induced apoptosis
61. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor