메뉴 건너뛰기




Volumn 120, Issue 3, 2007, Pages 694-701

The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil

Author keywords

Chemotherapy, adjuvant; Colonic neoplasms; Dihydrouracil dehydrogenase (NADP); Disease free survival; Fluorouracil; Immunohistochemistry; Predictive value of tests; Survival rate; Thymidylate synthase; Treatment outcome; Tumour markers, biological

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINATE CALCIUM; THYMIDYLATE SYNTHASE; TUMOR MARKER;

EID: 33845691987     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22318     Document Type: Article
Times cited : (39)

References (47)
  • 3
    • 0036534108 scopus 로고    scopus 로고
    • Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
    • Edler D, Glimelius B, Hallstrom M, Jakobsen A, Johnston PG, Magnusson I, Ragnhammar P, Blomgren H. Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 2002;20:1721-8.
    • (2002) J Clin Oncol , vol.20 , pp. 1721-1728
    • Edler, D.1    Glimelius, B.2    Hallstrom, M.3    Jakobsen, A.4    Johnston, P.G.5    Magnusson, I.6    Ragnhammar, P.7    Blomgren, H.8
  • 6
    • 9144264837 scopus 로고    scopus 로고
    • Tumor dihydropyrimidine dehydrogenase in stage II and III colorectal cancer: Low level expression is a beneficial marker in oral-adjuvant chemotherapy, but is also a predictor for poor prognosis in patients treated with curative surgery alone
    • Tsuji T, Sawai T, Takeshita H, Nakagoe T, Hidaka S, Atsushi N, Yamaguchi H, Yasutake T, Nagayasu T, Tagawa Y. Tumor dihydropyrimidine dehydrogenase in stage II and III colorectal cancer: low level expression is a beneficial marker in oral-adjuvant chemotherapy, but is also a predictor for poor prognosis in patients treated with curative surgery alone. Cancer Lett 2004;204:97-104.
    • (2004) Cancer Lett , vol.204 , pp. 97-104
    • Tsuji, T.1    Sawai, T.2    Takeshita, H.3    Nakagoe, T.4    Hidaka, S.5    Atsushi, N.6    Yamaguchi, H.7    Yasutake, T.8    Nagayasu, T.9    Tagawa, Y.10
  • 7
    • 24944441382 scopus 로고    scopus 로고
    • Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information
    • Ohrling K, Edler D, Hallstrom M, Ragnhammar P, Blomgren H. Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information. J Clin Oncol 2005;23:5628-34.
    • (2005) J Clin Oncol , vol.23 , pp. 5628-5634
    • Ohrling, K.1    Edler, D.2    Hallstrom, M.3    Ragnhammar, P.4    Blomgren, H.5
  • 8
    • 33244468377 scopus 로고    scopus 로고
    • Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up
    • Lassmann S, Hennig M, Rosenberg R, Nahrig J, Schreglmann J, Krause F, Poignee-Heger M, Nekarda H, Hofler H, Werner M. Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up. Int J Colorectal Dis 2005;21:238-47.
    • (2005) Int J Colorectal Dis , vol.21 , pp. 238-247
    • Lassmann, S.1    Hennig, M.2    Rosenberg, R.3    Nahrig, J.4    Schreglmann, J.5    Krause, F.6    Poignee-Heger, M.7    Nekarda, H.8    Hofler, H.9    Werner, M.10
  • 9
    • 11144303556 scopus 로고    scopus 로고
    • Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer
    • Tsuji T, Sawai T, Takeshita H, Nakagoe T, Hidaka S, Yamaguchi H, Yasutake T, Nagayasu T, Tagawa Y. Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer. Cancer Chemother Pharmacol 2004;54:531-6.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 531-536
    • Tsuji, T.1    Sawai, T.2    Takeshita, H.3    Nakagoe, T.4    Hidaka, S.5    Yamaguchi, H.6    Yasutake, T.7    Nagayasu, T.8    Tagawa, Y.9
  • 10
    • 1442277085 scopus 로고    scopus 로고
    • Immunohistochemical dihydropyrimidine dehydrogenase expression is a good prognostic indicator for patients with Dukes' C colorectal cancer
    • Oi K, Makino M, Ozaki M, Takemoto H, Yamane N, Nakamura S, Ikeguchi M, Kaibara N. Immunohistochemical dihydropyrimidine dehydrogenase expression is a good prognostic indicator for patients with Dukes' C colorectal cancer. Anticancer Res 2004;24:273-9.
    • (2004) Anticancer Res , vol.24 , pp. 273-279
    • Oi, K.1    Makino, M.2    Ozaki, M.3    Takemoto, H.4    Yamane, N.5    Nakamura, S.6    Ikeguchi, M.7    Kaibara, N.8
  • 11
    • 12444302837 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer
    • Tsuji T, Hidaka S, Sawai T, Nakagoe T, Yano H, Haseba M, Komatsu H, Shindou H, Fukuoka H, Yoshinaga M, Shibasaki S, Nanashima A, et al. Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer. Clin Cancer Res 2003;9:3700-4.
    • (2003) Clin Cancer Res , vol.9 , pp. 3700-3704
    • Tsuji, T.1    Hidaka, S.2    Sawai, T.3    Nakagoe, T.4    Yano, H.5    Haseba, M.6    Komatsu, H.7    Shindou, H.8    Fukuoka, H.9    Yoshinaga, M.10    Shibasaki, S.11    Nanashima, A.12
  • 14
    • 0036582566 scopus 로고    scopus 로고
    • Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5′-deoxy-5-fluorouridine as adjuvant chemotherapy
    • Nishimura G, Terada I, Kobayashi T, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Kayahara M, Shimizu K, Ohta T, Miwa K. Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5′-deoxy-5-fluorouridine as adjuvant chemotherapy. Oncol Rep 2002;9:479-82.
    • (2002) Oncol Rep , vol.9 , pp. 479-482
    • Nishimura, G.1    Terada, I.2    Kobayashi, T.3    Ninomiya, I.4    Kitagawa, H.5    Fushida, S.6    Fujimura, T.7    Kayahara, M.8    Shimizu, K.9    Ohta, T.10    Miwa, K.11
  • 15
    • 0033995850 scopus 로고    scopus 로고
    • Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method
    • Takenoue T, Nagawa H, Matsuda K, Fujii S, Nita ME, Hatano K, Kitayama J, Tsuruo T, Muto T. Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. Ann Surg Oncol 2000;7:193-8.
    • (2000) Ann Surg Oncol , vol.7 , pp. 193-198
    • Takenoue, T.1    Nagawa, H.2    Matsuda, K.3    Fujii, S.4    Nita, M.E.5    Hatano, K.6    Kitayama, J.7    Tsuruo, T.8    Muto, T.9
  • 16
    • 0037862137 scopus 로고    scopus 로고
    • Prognostic effects of dihydropyrimidine dehydrogenase in advanced colorectal cancer after surgery: Immunohistochemistry using a new monoclonal antibody
    • Tokunaga Y, Nakagami M, Tokuka A, Ohsumi K. Prognostic effects of dihydropyrimidine dehydrogenase in advanced colorectal cancer after surgery: immunohistochemistry using a new monoclonal antibody. Anticancer Res 2003;23:1763-8.
    • (2003) Anticancer Res , vol.23 , pp. 1763-1768
    • Tokunaga, Y.1    Nakagami, M.2    Tokuka, A.3    Ohsumi, K.4
  • 17
    • 0036942196 scopus 로고    scopus 로고
    • Thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in colorectal carcinoma and patients prognosis
    • Ikeguchi M, Makino M, Kaibara N. Thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in colorectal carcinoma and patients prognosis. Langenbecks Arch Surg 2002;387:240-5.
    • (2002) Langenbecks Arch Surg , vol.387 , pp. 240-245
    • Ikeguchi, M.1    Makino, M.2    Kaibara, N.3
  • 19
    • 0035860142 scopus 로고    scopus 로고
    • A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
    • Iacopetta B, Grieu F, Joseph D, Elsaleh H. A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 2001;85:827-30.
    • (2001) Br J Cancer , vol.85 , pp. 827-830
    • Iacopetta, B.1    Grieu, F.2    Joseph, D.3    Elsaleh, H.4
  • 21
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
    • Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2004;22:529-36.
    • (2004) J Clin Oncol , vol.22 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 22
    • 10944243586 scopus 로고    scopus 로고
    • Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil
    • Hosokawa A, Yamada Y, Shimada Y, Muro K, Hamaguchi T, Morita H, Araake M, Orita H, Shirao K. Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil. Int J Clin Oncol 2004;9:388-92.
    • (2004) Int J Clin Oncol , vol.9 , pp. 388-392
    • Hosokawa, A.1    Yamada, Y.2    Shimada, Y.3    Muro, K.4    Hamaguchi, T.5    Morita, H.6    Araake, M.7    Orita, H.8    Shirao, K.9
  • 23
    • 0036928518 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil
    • Aschele C, Debernardis D, Bandelloni R, Cascinu S, Catalano V, Giordani P, Barni S, Turci D, Drudi G, Lonardi S, Gallo L, Maley F, et al. Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil. Ann Oncol 2002;13:1882-92.
    • (2002) Ann Oncol , vol.13 , pp. 1882-1892
    • Aschele, C.1    Debernardis, D.2    Bandelloni, R.3    Cascinu, S.4    Catalano, V.5    Giordani, P.6    Barni, S.7    Turci, D.8    Drudi, G.9    Lonardi, S.10    Gallo, L.11    Maley, F.12
  • 24
    • 0033637476 scopus 로고    scopus 로고
    • Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma
    • Tachikawa D, Arima S, Futami K. Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma. Anticancer Res 2000;20:4103-7.
    • (2000) Anticancer Res , vol.20 , pp. 4103-4107
    • Tachikawa, D.1    Arima, S.2    Futami, K.3
  • 26
    • 0032997572 scopus 로고    scopus 로고
    • Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy
    • Aschele C, Debernardis D, Casazza S, Antonelli G, Tunesi G, Baldo C, Lionetto R, Maley F, Sobrero A. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy. J Clin Oncol 1999;17:1760-70.
    • (1999) J Clin Oncol , vol.17 , pp. 1760-1770
    • Aschele, C.1    Debernardis, D.2    Casazza, S.3    Antonelli, G.4    Tunesi, G.5    Baldo, C.6    Lionetto, R.7    Maley, F.8    Sobrero, A.9
  • 28
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • Marcuello E, Altes A, del Rio E, Cesar A, Menoyo A, Baiget M. Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004;112:733-7.
    • (2004) Int J Cancer , vol.112 , pp. 733-737
    • Marcuello, E.1    Altes, A.2    Del Rio, E.3    Cesar, A.4    Menoyo, A.5    Baiget, M.6
  • 29
    • 3843130823 scopus 로고    scopus 로고
    • A multivariate analysis of genomic polymorphisms: Prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
    • Stoehlmacher J, Park DJ, Zhang W, Yang D, Groshen S, Zahedy S, Lenz HJ. A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer 2004;91:344-54.
    • (2004) Br J Cancer , vol.91 , pp. 344-354
    • Stoehlmacher, J.1    Park, D.J.2    Zhang, W.3    Yang, D.4    Groshen, S.5    Zahedy, S.6    Lenz, H.J.7
  • 32
    • 3142660249 scopus 로고    scopus 로고
    • Topoisomerase-1, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients
    • Paradiso A, Xu J, Mangia A, Chiriatti A, Simone G, Zito A, Montemurro S, Giuliani F, Maiello E, Colucci G. Topoisomerase-1, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004;111:252-8.
    • (2004) Int J Cancer , vol.111 , pp. 252-258
    • Paradiso, A.1    Xu, J.2    Mangia, A.3    Chiriatti, A.4    Simone, G.5    Zito, A.6    Montemurro, S.7    Giuliani, F.8    Maiello, E.9    Colucci, G.10
  • 33
    • 0037364351 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer: Lack of correlation with outcome and response to fluorouracil in metastatic disease sites
    • Johnston PG, Benson AB, Catalano P, Rao MS, O'Dwyer PJ, Allegra CJ. Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. J Clin Oncol 2003;21:815-19.
    • (2003) J Clin Oncol , vol.21 , pp. 815-819
    • Johnston, P.G.1    Benson, A.B.2    Catalano, P.3    Rao, M.S.4    O'Dwyer, P.J.5    Allegra, C.J.6
  • 34
    • 0036875104 scopus 로고    scopus 로고
    • Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma
    • Berglund A, Edler D, Molin D, Nordlinder H, Graf W, Glimelius B. Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma. Anticancer Res 2002;22:3653-9.
    • (2002) Anticancer Res , vol.22 , pp. 3653-3659
    • Berglund, A.1    Edler, D.2    Molin, D.3    Nordlinder, H.4    Graf, W.5    Glimelius, B.6
  • 35
    • 0031053520 scopus 로고    scopus 로고
    • Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy
    • Findlay MP, Cunningham D, Morgan G, Clinton S, Hardcastle A, Aherne GW. Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy. Br J Cancer 1997;75:903-9.
    • (1997) Br J Cancer , vol.75 , pp. 903-909
    • Findlay, M.P.1    Cunningham, D.2    Morgan, G.3    Clinton, S.4    Hardcastle, A.5    Aherne, G.W.6
  • 36
    • 0035344101 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine
    • Ikeguchi M, Hirooka Y, Makino M, Kaibara N. Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine. Oncol Rep 2001;8:621-5.
    • (2001) Oncol Rep , vol.8 , pp. 621-625
    • Ikeguchi, M.1    Hirooka, Y.2    Makino, M.3    Kaibara, N.4
  • 38
    • 0037440051 scopus 로고    scopus 로고
    • Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
    • Allegra CJ, Paik S, Colangelo LH, Parr AL, Kirsch I, Kim G, Klein P, Johnston PG, Wolmark N. Wicand HS. Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 2003;21:241-50.
    • (2003) J Clin Oncol , vol.21 , pp. 241-250
    • Allegra, C.J.1    Paik, S.2    Colangelo, L.H.3    Parr, A.L.4    Kirsch, I.5    Kim, G.6    Klein, P.7    Johnston, P.G.8    Wolmark, N.9    Wicand, H.S.10
  • 41
    • 0034486207 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil
    • Aschele C, Debernardis D, Tunesi G, Maley F, Sobrero A. Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil. Clin Cancer Res 2000;6:4797-802.
    • (2000) Clin Cancer Res , vol.6 , pp. 4797-4802
    • Aschele, C.1    Debernardis, D.2    Tunesi, G.3    Maley, F.4    Sobrero, A.5
  • 42
    • 0035430619 scopus 로고    scopus 로고
    • Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion
    • Uchida K, Hayashi K, Kuramochi H, Takasaki K. Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. Int J Oncol 2001;19:341-6.
    • (2001) Int J Oncol , vol.19 , pp. 341-346
    • Uchida, K.1    Hayashi, K.2    Kuramochi, H.3    Takasaki, K.4
  • 43
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • Jakobsen A, Nielsen JN, Gyldenkerne N, Lindeberg J. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005;23:1365-9.
    • (2005) J Clin Oncol , vol.23 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3    Lindeberg, J.4
  • 44
    • 0037144354 scopus 로고    scopus 로고
    • Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation
    • van Kuilenburg AB, Meinsma R, Zoetekouw L, van Gennip AH. Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation. Int J Cancer 2002;101:253-8.
    • (2002) Int J Cancer , vol.101 , pp. 253-258
    • Van Kuilenburg, A.B.1    Meinsma, R.2    Zoetekouw, L.3    Van Gennip, A.H.4
  • 45
    • 9744250225 scopus 로고    scopus 로고
    • Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer
    • Jakob C, Aust DE, Meyer W, Baretton GB, Schwabe W, Hausler P, Becker H, Liersch T. Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer. J Pathol 2004;204:562-8.
    • (2004) J Pathol , vol.204 , pp. 562-568
    • Jakob, C.1    Aust, D.E.2    Meyer, W.3    Baretton, G.B.4    Schwabe, W.5    Hausler, P.6    Becker, H.7    Liersch, T.8
  • 46
    • 8344245563 scopus 로고    scopus 로고
    • Thymidylate synthase expression in normal colonic mucosa: A predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy
    • Santini D, Vincenzi B, Perrone G, Rabitti C, Borzomati D, Caricato M, La Cesa A, Grilli C, Verzi A, Coppola R, Tonini G. Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy. Oncology 2004;67:135-42.
    • (2004) Oncology , vol.67 , pp. 135-142
    • Santini, D.1    Vincenzi, B.2    Perrone, G.3    Rabitti, C.4    Borzomati, D.5    Caricato, M.6    La Cesa, A.7    Grilli, C.8    Verzi, A.9    Coppola, R.10    Tonini, G.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.