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Volumn 276, Issue 6 45-6, 1999, Pages

Kinetic profile of the rat CYP4A isoforms: Arachidonic acid metabolism and isoform-specific inhibitors

Author keywords

12 epoxyeicosatrienoic acid; 20 hydroxyeicosatetraenoic acid 11; Fatty acid hydroxylation

Indexed keywords

ARACHIDONIC ACID; CYTOCHROME P450; HYDROXYICOSATETRAENOIC ACID; ICOSATRIENOIC ACID; LAURIC ACID; LINOLEIC ACID;

EID: 0032997280     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.6.r1691     Document Type: Article
Times cited : (160)

References (41)
  • 1
    • 0029041015 scopus 로고
    • Fatty acid discrimination and ω-hydroxylation by cytochrome P450 4A1 and cytochrome P4504A1/NADPH-P450 reductase fusion protein
    • Alterman, M. A., C. S. Chaurasia, P. Lu, J. P. Hardwick, and R. P. Hanzlik. Fatty acid discrimination and ω-hydroxylation by cytochrome P450 4A1 and cytochrome P4504A1/NADPH-P450 reductase fusion protein. Arch. Biochem. Biophys. 320: 289-296, 1995.
    • (1995) Arch. Biochem. Biophys. , vol.320 , pp. 289-296
    • Alterman, M.A.1    Chaurasia, C.S.2    Lu, P.3    Hardwick, J.P.4    Hanzlik, R.P.5
  • 3
    • 0029983833 scopus 로고    scopus 로고
    • Active site structure and substrate specificity of cytochrome P4504A1: Steric control of ligand approach perpendicular to heme plane
    • Bambal, R. B., and R. P. Hanzlik. Active site structure and substrate specificity of cytochrome P4504A1: steric control of ligand approach perpendicular to heme plane. Biochem. Biophys. Res. Commun. 219: 445-449, 1996.
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 445-449
    • Bambal, R.B.1    Hanzlik, R.P.2
  • 4
    • 0030269976 scopus 로고    scopus 로고
    • Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein
    • Bambal, R. B., and R. P. Hanzlik. Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein. Arch. Biochem. Biophys. 334: 59-66, 1996.
    • (1996) Arch. Biochem. Biophys. , vol.334 , pp. 59-66
    • Bambal, R.B.1    Hanzlik, R.P.2
  • 5
    • 0030914663 scopus 로고    scopus 로고
    • Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue
    • Lung Cell. Mol. Physiol. 16
    • Birks, E. K., M. Bousamara, K. Presberg, J. A. Marsh, R. M. Effros, and E. R. Jacobs. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16): L823-L829, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Birks, E.K.1    Bousamara, M.2    Presberg, K.3    Marsh, J.A.4    Effros, R.M.5    Jacobs, E.R.6
  • 7
    • 0028918432 scopus 로고
    • Biochemical characterization of lauric acid ω-hydroxylation by a CYP4A1/NADPH-cytochrome p450 reductase fusion protein
    • Chaurasia, C. S., M. A. Alterman, P. Lu, and R. P. Hanzelik. Biochemical characterization of lauric acid ω-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. Arch. Biochem. Biophys. 317: 161-169, 1995.
    • (1995) Arch. Biochem. Biophys. , vol.317 , pp. 161-169
    • Chaurasia, C.S.1    Alterman, M.A.2    Lu, P.3    Hanzelik, R.P.4
  • 8
    • 0031049745 scopus 로고    scopus 로고
    • The cytochrome P450 4 (CYP4) family
    • Claire, A. E., and M. Simpson. The cytochrome P450 4 (CYP4) family. Gen. Pharmacol. 28: 351-359, 1997.
    • (1997) Gen. Pharmacol. , vol.28 , pp. 351-359
    • Claire, A.E.1    Simpson, M.2
  • 10
    • 0024417435 scopus 로고
    • Comparative aspects of the mammalian cytochrome P450 IV gene family
    • Gibson, G. G. Comparative aspects of the mammalian cytochrome P450 IV gene family. Xenobiotica 19: 1123-1148, 1989.
    • (1989) Xenobiotica , vol.19 , pp. 1123-1148
    • Gibson, G.G.1
  • 11
    • 0028155755 scopus 로고
    • Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels
    • Heart Circ. Physiol. 35
    • Harder, D. R., D. Gebremedhin, J. Narayanari, C. Jefcote, J. R. Falck, W. B. Campbell, and R. Roman. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2098-H2107, 1994.
    • (1994) Am. J. Physiol. , vol.266
    • Harder, D.R.1    Gebremedhin, D.2    Narayanari, J.3    Jefcote, C.4    Falck, J.R.5    Campbell, W.B.6    Roman, R.7
  • 12
    • 0026356150 scopus 로고
    • CYP 4A subfamily: Functional analysis by immunocytochemistry and in situ hybridization
    • Hardwick, J. P. CYP 4A subfamily: functional analysis by immunocytochemistry and in situ hybridization. Methods Enzymol. 206: 273-283, 1991.
    • (1991) Methods Enzymol. , vol.206 , pp. 273-283
    • Hardwick, J.P.1
  • 13
    • 0032497411 scopus 로고    scopus 로고
    • Molecular, enzymatic and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3
    • Helvig, C., E. Dishman, and J. H. Capdevila. Molecular, enzymatic and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3. Biochemistry 37: 12546-12558, 1998.
    • (1998) Biochemistry , vol.37 , pp. 12546-12558
    • Helvig, C.1    Dishman, E.2    Capdevila, J.H.3
  • 14
    • 0025843587 scopus 로고
    • Hepatic and renal cytochrome P450s in spontaneously hypertensive rats
    • Imaoka, S., and Y. Funae. Hepatic and renal cytochrome P450s in spontaneously hypertensive rats. Biochim. Biophys. Acta 1074: 209-213, 1991.
    • (1991) Biochim. Biophys. Acta , vol.1074 , pp. 209-213
    • Imaoka, S.1    Funae, Y.2
  • 15
    • 0025139362 scopus 로고
    • Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal microsomes
    • Imaoka, S., K. Nagashima, and Y. Funae. Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal microsomes. Arch. Biochem. Biophys. 276: 473-480, 1990.
    • (1990) Arch. Biochem. Biophys. , vol.276 , pp. 473-480
    • Imaoka, S.1    Nagashima, K.2    Funae, Y.3
  • 16
    • 0026440364 scopus 로고
    • Hormonal regulation of rat cytochrome P450s by androgen and pituitary
    • Imaoka, S., Y. Yamazoe, R. Kato, and Y. Funae. Hormonal regulation of rat cytochrome P450s by androgen and pituitary. Arch. Biochem. Biophys. 299: 179-184, 1992.
    • (1992) Arch. Biochem. Biophys. , vol.299 , pp. 179-184
    • Imaoka, S.1    Yamazoe, Y.2    Kato, R.3    Funae, Y.4
  • 17
    • 0030028233 scopus 로고    scopus 로고
    • Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles
    • Regulatory Integrative Comp. Physiol. 39
    • Imig, J. D., A.-P. Zou, D. E. Stec, D. R. Harder, J. R. Falck, and R. J. Roman. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am. J. Physiol. 270 (Regulatory Integrative Comp. Physiol. 39): R217-R227, 1996.
    • (1996) Am. J. Physiol. , vol.270
    • Imig, J.D.1    Zou, A.-P.2    Stec, D.E.3    Harder, D.R.4    Falck, J.R.5    Roman, R.J.6
  • 18
    • 0025963568 scopus 로고
    • Isolation of preferentially expressed genes in the kidneys of hypertensive rats
    • Iwai, N., and T. Inagami. Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension 17: 161-169, 1991.
    • (1991) Hypertension , vol.17 , pp. 161-169
    • Iwai, N.1    Inagami, T.2
  • 19
    • 0024350111 scopus 로고
    • The rat clofibrate-inducible CYP4A gene subfamily I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element
    • Kimura, S., N. Hanioka, E. Matsunaga, and F. J. Gonzalez. The rat clofibrate-inducible CYP4A gene subfamily I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. DNA 8: 503-516, 1989.
    • (1989) DNA , vol.8 , pp. 503-516
    • Kimura, S.1    Hanioka, N.2    Matsunaga, E.3    Gonzalez, F.J.4
  • 20
    • 0024385160 scopus 로고
    • The rat clofibrate-inducible CYP4A gene subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes
    • Kimura, S., J. P. Hardwick, C. A. Kozak, and F. J. Gonzalez. The rat clofibrate-inducible CYP4A gene subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. DNA 8: 517-525, 1989.
    • (1989) DNA , vol.8 , pp. 517-525
    • Kimura, S.1    Hardwick, J.P.2    Kozak, C.A.3    Gonzalez, F.J.4
  • 21
    • 0030755144 scopus 로고    scopus 로고
    • Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney
    • Kroetz, D. L., L. M. Huse, A. Thuresson, and M. P. Grillo. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol. Pharmacol. 52: 362-372, 1997.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 362-372
    • Kroetz, D.L.1    Huse, L.M.2    Thuresson, A.3    Grillo, M.P.4
  • 22
    • 0029756792 scopus 로고    scopus 로고
    • Cytochrome P450 4A expression and arachidonic acid co-hydroxylation in the kidney of the spontaneously hypertensive rat
    • Laniado-Schwartzman, M., J.-L. Da Silva, F. Lin, M. Nishimura and N. G. Abraham. Cytochrome P450 4A expression and arachidonic acid co-hydroxylation in the kidney of the spontaneously hypertensive rat. Nephron 73: 652-663, 1996.
    • (1996) Nephron , vol.73 , pp. 652-663
    • Laniado-Schwartzman, M.1    Silva, J.-L.D.2    Lin, F.3    Nishimura, M.4    Abraham, N.G.5
  • 23
    • 0029177711 scopus 로고
    • 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule
    • Renal Fluid Electrolyte Physiol. 38
    • Lin, F., A. Rios, J. R. Falck, Y. Belosludtsev, and M. L. Schwartzman. 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F806-F816, 1995.
    • (1995) Am. J. Physiol. , vol.269
    • Lin, F.1    Rios, A.2    Falck, J.R.3    Belosludtsev, Y.4    Schwartzman, M.L.5
  • 25
    • 0024501044 scopus 로고
    • Prostaglandin and fatty acid ω- and (ω-1)-oxidation in rabbit lung. Acetylenic fatty acid mechanism-based inactivators as specific inhibitors
    • Muerhoff, A. S., D. E. Williams, N. O. Reich, C. A. CaJacob, P. R. Ortiz de Montellano, and B. S. S. Masters. Prostaglandin and fatty acid ω- and (ω-1)-oxidation in rabbit lung. Acetylenic fatty acid mechanism-based inactivators as specific inhibitors. J. Biol. Chem. 264: 749-756, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 749-756
    • Muerhoff, A.S.1    Williams, D.E.2    Reich, N.O.3    CaJacob, C.A.4    Ortiz De Montellano, P.R.5    Masters, B.S.S.6
  • 26
    • 0026557626 scopus 로고
    • Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats
    • Renal Fluid Electrolyte Physiol. 31
    • Omata, K., N. G. Abraham, B. Escalante, and M. L. Schwartzman. Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol. 31): F8-F16, 1992.
    • (1992) Am. J. Physiol. , vol.262
    • Omata, K.1    Abraham, N.G.2    Escalante, B.3    Schwartzman, M.L.4
  • 27
    • 0026596934 scopus 로고
    • Renal cytochrome P-450-arachidonic acid metabolism: Localization and hormonal regulation in SHR
    • Renal Fluid Electrolyte Physiol. 31
    • Omata, K., N. G. Abraham, and M. L. Schwartzman. Renal cytochrome P-450-arachidonic acid metabolism: localization and hormonal regulation in SHR. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol. 31): F591-F599, 1992.
    • (1992) Am. J. Physiol. , vol.262
    • Omata, K.1    Abraham, N.G.2    Schwartzman, M.L.3
  • 28
    • 50449100139 scopus 로고
    • The carbon monoxide binding pigment of liver microsomes
    • Omura, T., and R. Sato. The carbon monoxide binding pigment of liver microsomes. J. Biol. Chem. 239: 2370-2379, 1964.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2379
    • Omura, T.1    Sato, R.2
  • 29
    • 0030875147 scopus 로고    scopus 로고
    • Improved separation and immunodetection of rat cytochrome P450 4A forms in liver and kidney
    • Rice-Okita, J., S. B. Johnson, P. J. Castle, S. C. Dezellem, and R. T. Okita. Improved separation and immunodetection of rat cytochrome P450 4A forms in liver and kidney. Drug Metab. Dispos. 25: 1008-1012, 1997.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1008-1012
    • Rice-Okita, J.1    Johnson, S.B.2    Castle, P.J.3    Dezellem, S.C.4    Okita, R.T.5
  • 30
    • 0024416301 scopus 로고
    • Differential induction of peroxisomal and microsomal fatty-acid-oxidizing enzymes by peroxisome proliferators in rat liver and kidney
    • Sharma, R. K., B. G. Lake, R. Kakowski, T. Bradshaw, D. Earnshaw, J. W. Dale, and G. G. Gibson. Differential induction of peroxisomal and microsomal fatty-acid-oxidizing enzymes by peroxisome proliferators in rat liver and kidney. Eur. J. Pharmacol. 184: 69-78, 1989.
    • (1989) Eur. J. Pharmacol. , vol.184 , pp. 69-78
    • Sharma, R.K.1    Lake, B.G.2    Kakowski, R.3    Bradshaw, T.4    Earnshaw, D.5    Dale, J.W.6    Gibson, G.G.7
  • 31
    • 0030007897 scopus 로고    scopus 로고
    • Cytochrome P4504A genotype cosegregates with hypertension in Dahl S rats
    • Stec, D. E., A. Y. Deng, J. P. Rapp, and R. J. Roman. Cytochrome P4504A genotype cosegregates with hypertension in Dahl S rats. Hypertension 27: 564-568, 1996.
    • (1996) Hypertension , vol.27 , pp. 564-568
    • Stec, D.E.1    Deng, A.Y.2    Rapp, J.P.3    Roman, R.J.4
  • 32
    • 0029889569 scopus 로고    scopus 로고
    • Cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats
    • Stec, D. E., M. R. Trolleit, J. E. Krieger, H. J. Jacob, and R. J. Roman. Cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension 27: 1329-1336, 1996.
    • (1996) Hypertension , vol.27 , pp. 1329-1336
    • Stec, D.E.1    Trolleit, M.R.2    Krieger, J.E.3    Jacob, H.J.4    Roman, R.J.5
  • 33
    • 0025027879 scopus 로고
    • Cloning and characterization of a novel member of the cytochrome P450 subfamily IVA in rat prostate
    • Stromstedt, M., S. I. Hayashi, P. G. Zaphiropoulos, and J. A. Gustafsson. Cloning and characterization of a novel member of the cytochrome P450 subfamily IVA in rat prostate. DNA 9: 567-577, 1990.
    • (1990) DNA , vol.9 , pp. 567-577
    • Stromstedt, M.1    Hayashi, S.I.2    Zaphiropoulos, P.G.3    Gustafsson, J.A.4
  • 34
    • 0026671184 scopus 로고
    • Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid ω-hydroxylases
    • Sundseth, S. S., and D. J. Waxman. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid ω-hydroxylases. J. Biol. Chem. 267: 3915-3921, 1993.
    • (1993) J. Biol. Chem. , vol.267 , pp. 3915-3921
    • Sundseth, S.S.1    Waxman, D.J.2
  • 37
    • 0032995361 scopus 로고    scopus 로고
    • Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in the rat kidney
    • Renal Physiol. 45
    • Wang, M.-H., H. Guan, X. Nguyen, B. Zand, A. Nasjletti, and M. L. Schwartzman. Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in the rat kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F246-F253, 1999.
    • (1999) Am. J. Physiol. , vol.276
    • Wang, M.-H.1    Guan, H.2    Nguyen, X.3    Zand, B.4    Nasjletti, A.5    Schwartzman, M.L.6
  • 38
    • 0030589540 scopus 로고    scopus 로고
    • Cloning, sequencing and cDNA-directed expression of the rat renal CYp4A2: Arachidonic acid ω-hydroxylation and 11,12-epoxidation by CYp4A2 protein
    • Wang, M.-H., D. E. Stec, M. Balazy, V. Mastyugin, C. S. Yang, R. J. Roman, and M. Laniado-Schwartzman. Cloning, sequencing and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid ω-hydroxylation and 11,12-epoxidation by CYP4A2 protein. Arch. Biochem. Biophys. 336: 240-250, 1996.
    • (1996) Arch. Biochem. Biophys. , vol.336 , pp. 240-250
    • Wang, M.-H.1    Stec, D.E.2    Balazy, M.3    Mastyugin, V.4    Yang, C.S.5    Roman, R.J.6    Laniado-Schwartzman, M.7
  • 39
    • 0029888211 scopus 로고    scopus 로고
    • Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K-channel activity
    • Renal Fluid Electrolyte Physiol. 39
    • Zou, A.-P., J. T. Fleming, J. R. Falck, E. R. Jacobs, D. Gebremedhin, D. R. Harder, and R. J. Roman. Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K-channel activity. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F822-F832, 1996.
    • (1996) Am. J. Physiol. , vol.270
    • Zou, A.-P.1    Fleming, J.T.2    Falck, J.R.3    Jacobs, E.R.4    Gebremedhin, D.5    Harder, D.R.6    Roman, R.J.7
  • 40
    • 0028296987 scopus 로고
    • Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow
    • Renal Fluid Electrolyte Physiol. 35
    • Zou, A.-P., J. D. Imig, M. Kaldunski, P. R. Ortiz de Montellano, Z. Sui, and R. J. Roman. Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35): F275-F282, 1994.
    • (1994) Am. J. Physiol. , vol.266
    • Zou, A.-P.1    Imig, J.D.2    Kaldunski, M.3    Ortiz De Montellano, P.R.4    Sui, Z.5    Roman, R.J.6
  • 41


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