Evolution: Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila

Science

Volumn 309, Issue 5735, 2005, Pages 764-767

  Aminetzach, Yael T ^a   Macpherson, J Michael ^a   Petrov, Dmitri A ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECOLOGY; GENES; GENETIC ENGINEERING; PHOSPHATES; PROTEINS;

FUNCTIONAL PROTEINS; ORGANOPHOSPHATE PESTICIDES; PESTICIDE RESISTANCE; PHENOTYPES;

PESTICIDES;

GENE PRODUCT; ORGANOPHOSPHATE INSECTICIDE; PESTICIDE; PROTEIN; AZINPHOS METHYL; CHOLINE; DROSOPHILA PROTEIN; INSECTICIDE;

ADAPTATION; MUTATION; ORGANOPHOSPHATE; PESTICIDE RESISTANCE;

ADAPTATION; ARTICLE; DNA POLYMORPHISM; DROSOPHILA; DROSOPHILA MELANOGASTER; ECOLOGY; GENE INSERTION; GENE INSERTION SEQUENCE; GENE MUTATION; GENETIC ANALYSIS; GENOMICS; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ALLELE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; CROSS BREEDING; DRUG EFFECT; EXON; FEMALE; GENE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETIC SELECTION; GENETICS; HAPLOTYPE; INSECTICIDE RESISTANCE; INTRON; LONG INTERSPERSED REPEAT; METABOLISM; MOLECULAR EVOLUTION; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TRANSPOSON;

DROSOPHILA MELANOGASTER;

ADAPTATION, PHYSIOLOGICAL; ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; AZINPHOSMETHYL; BASE SEQUENCE; CHOLINE; CROSSES, GENETIC; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; EXONS; FEMALE; GENE EXPRESSION; GENES, INSECT; HAPLOTYPES; INSECTICIDE RESISTANCE; INSECTICIDES; INTRONS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, GENETIC; RECOMBINATION, GENETIC; SELECTION (GENETICS);

EID: 23044509495     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112699     Document Type: Article

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18. This work was supported by NSF grant 0317171 and by the Sloan Fellowship to D.A.P. J.M.M. is a Howard Hughes Medical Institute Predoctoral Fellow. The authors thank M. Feldman, S. Palumbi, P. Batterham, T. Wilson, L. Hadani, and members of D.A.P.'s lab for helpful discussions. We also thank T. Li and P. Carlson for help with experiments and J. Davis and O. Brandman for help with data analysis.