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Volumn 6, Issue 4, 2000, Pages 1322-1327

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 0034048729     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (848)

References (25)
  • 1
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel, C. G. Chemotherapy for colorectal cancer. N. Engl. J. Med., 330: 1136-1142, 1994.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 2
    • 0027980010 scopus 로고
    • Preclinical and clinical aspects of biomodulation of 5-fluorouracil
    • Soros, G. A., Grogan, L. M., and Allegra, C. J. Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat. Rev., 20: 11-49, 1994.
    • (1994) Cancer Treat. Rev. , vol.20 , pp. 11-49
    • Soros, G.A.1    Grogan, L.M.2    Allegra, C.J.3
  • 3
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted infusion 5-fluorouracil and weekly leucovorin
    • Leichman, C. G., Lenz, H-J., Leichman, L., Danenberg, K., Baranda, J., Groshen, S., Boswell, W., Metzger, R., Tan, M., and Danenberg, P. V. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted infusion 5-fluorouracil and weekly leucovorin. J. Clin. Oncol., 15: 3223-3229, 1997.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.-J.2    Leichman, L.3    Danenberg, K.4    Baranda, J.5    Groshen, S.6    Boswell, W.7    Metzger, R.8    Tan, M.9    Danenberg, P.V.10
  • 4
    • 0031722179 scopus 로고    scopus 로고
    • High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with non-response to 5-fluorouracil
    • Metzger, R., Danenberg, K. D., Leichman, C. G., Salonga, D., Schwartz. E. L., Wadler, S. Lenz, H-J., Groshen, S., Leichman, L., and Danenberg, P. V. High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with non-response to 5-fluorouracil. Clin. Cancer Res., 4: 2371-2376, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2371-2376
    • Metzger, R.1    Danenberg, K.D.2    Leichman, C.G.3    Salonga, D.4    Schwartz E, L.5    Wadler, S.6    Lenz, H.-J.7    Groshen, S.8    Leichman, L.9    Danenberg, P.V.10
  • 5
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib, F. N. M., El Kouni, A. M., and Cha, S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res., 45: 5405-5412, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 5405-5412
    • Naguib, F.N.M.1    El Kouni, A.M.2    Cha, S.3
  • 6
    • 0026793052 scopus 로고
    • Purification and characterization of dihydropyrimidine dehydrogenase from human liver
    • Lu, Z., Zhang, R., and Diasio, R. B. Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J. Biol. Chem., 267: 17102-17109, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17102-17109
    • Lu, Z.1    Zhang, R.2    Diasio, R.B.3
  • 7
    • 0030981029 scopus 로고    scopus 로고
    • Structural organization of the human dihydropyrimidine dehydrogenase gene
    • Johnson, M. R., Wang, K., Tillmanns, S., Albin, N., and Diasio, R. B. Structural organization of the human dihydropyrimidine dehydrogenase gene. Cancer Res., 57: 1660-1663, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 1660-1663
    • Johnson, M.R.1    Wang, K.2    Tillmanns, S.3    Albin, N.4    Diasio, R.B.5
  • 8
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie, D., Sommadossi, J. P., Cross, D. S., Huster, W. J., and Diasio, R. B. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res., 47: 2203-2206, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 2203-2206
    • Heggie, D.1    Sommadossi, J.P.2    Cross, D.S.3    Huster, W.J.4    Diasio, R.B.5
  • 9
    • 0031010583 scopus 로고    scopus 로고
    • Inter-and intra-individual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells
    • Grem, J. L., Yee, L. K., Venzon, D. J., Takimoto, C. H., and Allegra, C. J. Inter-and intra-individual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells. Cancer Chemother. Pharmacol., 40: 117-125, 1997.
    • (1997) Cancer Chemother. Pharmacol. , vol.40 , pp. 117-125
    • Grem, J.L.1    Yee, L.K.2    Venzon, D.J.3    Takimoto, C.H.4    Allegra, C.J.5
  • 10
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris, B. E., Song, R., He, Y. J., Soong, S. J., and Diasio, R. B. Relationship between dihydropyrimidine dehydrogenase activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res., 50: 197-201, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    He, Y.J.3    Soong, S.J.4    Diasio, R.B.5
  • 11
    • 0027409335 scopus 로고
    • Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity
    • Lyss, A. P., Lilenbaum, R. C., Harris, B. E., and Diasio, R. B. Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity. Cancer Investig., 11: 239-240, 1993.
    • (1993) Cancer Investig. , vol.11 , pp. 239-240
    • Lyss, A.P.1    Lilenbaum, R.C.2    Harris, B.E.3    Diasio, R.B.4
  • 12
    • 0028281781 scopus 로고
    • 5-ethynyluracil modulation of the efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao, S., Rustum, Y. M., and Spector, T. 5-Ethynyluracil modulation of the efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res., 54: 1507-1510, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3
  • 14
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to 5-fluorouracil
    • Beck, A., Etienne, M. C., Cheradame, S., Fischel, J. L., Formento, P., Renee, N., and Milano, G. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to 5-fluorouracil. Eur. J. Cancer, 30: 1517-1522, 1994.
    • (1994) Eur. J. Cancer , vol.30 , pp. 1517-1522
    • Beck, A.1    Etienne, M.C.2    Cheradame, S.3    Fischel, J.L.4    Formento, P.5    Renee, N.6    Milano, G.7
  • 15
    • 0027408915 scopus 로고
    • Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: A phase II study in patients with disseminated gastrointestinal cancers
    • Leichman, C. G., Leichman, L., Spears, C. P., Rosen, P. J., Jeffers, S., and Groshen, S. Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a Phase II study in patients with disseminated gastrointestinal cancers. J. Natl. Cancer Inst., 85: 41-44, 1993.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 41-44
    • Leichman, C.G.1    Leichman, L.2    Spears, C.P.3    Rosen, P.J.4    Jeffers, S.5    Groshen, S.6
  • 16
    • 0027076295 scopus 로고
    • Southwest oncology group standard response criteria, endpoint definitions, and toxicity criteria
    • Green, S., and Weiss, G. R. Southwest Oncology Group standard response criteria, endpoint definitions, and toxicity criteria. Investig. New Drugs, 10: 239-253, 1992.
    • (1992) Investig. New Drugs , vol.10 , pp. 239-253
    • Green, S.1    Weiss, G.R.2
  • 19
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston, P. G., Lenz, H-J., Leichman, C. G., Danenberg, K. D., Allegra, C. J., Danenberg, P. V., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.-J.2    Leichman, C.G.3    Danenberg, K.D.4    Allegra, C.J.5    Danenberg, P.V.6    Leichman, L.7
  • 22
    • 0020341898 scopus 로고
    • 2 statistics for small samples
    • 2 statistics for small samples. Biometrics, 38: 1017-1023, 1982.
    • (1982) Biometrics , vol.38 , pp. 1017-1023
    • Halpern, J.1
  • 24
    • 0028060451 scopus 로고
    • The relationship between an objective response to chemotherapy and survival in advanced colorectal cancer
    • Graf, W., Pählman, L., Bergstrom, R., and Glimelius, B. The relationship between an objective response to chemotherapy and survival in advanced colorectal cancer. Br. J. Cancer, 70: 559-563, 1994.
    • (1994) Br. J. Cancer , vol.70 , pp. 559-563
    • Graf, W.1    Pählman, L.2    Bergstrom, R.3    Glimelius, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.